Optimised NSAIDs-loaded Biocompatible Nanoparticles

作     者：V.Gaelle ROULLIN Maaite CALLEWAERT Michael MOLINARI Franck DELAVOIE Aurelie SECONDE Marie-Christine ANDRY 

作者机构：Institut de Chimie Mole culaire de ReimsCNRS UMR 6229UFR Pharmacie Reims Laboratoire de Microscopies et d’Etudes des NanostructuresUFR des SciencesUniversitéde Reims Champagne-Ardenne Laboratoire de Microscopie Electronique AnalytiqueINSERM UMRS 92621 rue Clement Ader51685 Reims Cedex 2France 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2010年第2卷第4期

页      面：247-255页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：financially supported by the European Erasmus program 

主　　题：Drug delivery systems(DDS) Biocompatible Emulsion-solvent diffusion method PLGA Glycofurol Non steroidal anti-inflammatory drugs(NSAIDs) 

摘      要：In this formulation study,biocompatible non steroidal anti-inflammatory(NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization.A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation *** parameters,such as lactide/glycolide ratio,polymer concentration,solvent/non solvent ratio and non solvent phase,as well as the non ionic tensioactive P188 co-precipitation composition were systematically *** optimized formulation(mean size:145 nm,surface charge:-13 m V) was employed to encapsulate various amounts of NSAIDs in a simple and scalable *** drug release was characterized in vitro by a complete release for 48 *** results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.