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Nuance of inward rectifying potassium(Kir) channel dysfunctions in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： Benjamin Garland Linlin ma Griffith Institute for Drug Discovery & School of Environment and Science Griffith University

Neurodegenerative disorders are highly prevalent and diverse in nature. Their manifestation largely depends on the cell types involved, with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological traits. The two most prevalent neurodegenerative diseases worldwide,

关键词： K-ATP CHANNELS PARKINSONS-DISEASE MODEL

A Tropical View on Landau-Ginzburg Models

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Acta mathematica Sinica,English Series 2024年第1期40卷 329-382页

作者： michael CARL max PUMPERLA Bernd SIEBERT Alfred-Delp-Str.2 73430 AalenGermany IU Internationale Hochschule Juri-Gagarin-Ring 15299084 ErfurtGermany AnyscaleInc.2080 Addison St Ste 7BerkeleyCA 94704USA Department of mathematics The Univ.of Texas at Austin2515 SpeedwayAustinTX 78712USA

This paper,largely written in 2009/2010,fits Landau-Ginzburg models into the mirror symmetry program pursued by the last author jointly with mark Gross since *** point of view transparently brings in tropical disks of maslov index 2 via the notion of broken lines,previously introduced in two dimensions by mark Gross in his study of mirror symmetry for P2.A ma jor insight is the equivalence of properness of the Landau-Ginzburg potential with smoothness of the anticanonical divisor on the mirror *** obtain proper superpotentials which agree on an open part with those classically known for toric *** include mirror LG models for non-singular and singular del Pezzo surfaces,Hirzebruch surfaces and some Fano threefolds.

关键词： Landau-Ginzburg model mirror symmetry tropical disk broken line wall structure scattering diagram Gross-Siebert program del Pezzo surface toric degeneration

Tacrolimus combined with arsenic trioxide provides a three-in-one drug-eluting coronary stent integrating anti-restenosis,pro-endothelialization and anti-inflammation

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Medicine in Novel Technology and Devices 2024年第1期21卷 110-119页

作者： Yaojia Zhang Hongchi Yu Li Deng Zhe Hou Jie Yang Fei Fang michael ZMiao Wenjun Li Xin Shen Dongyun Hao Xiaoyi ma Lifeng Zhou Fugui He Xiaoheng Liu a1Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu610041China Division of Oral&Craniofacial Health Sciences Adams School of DentistryUniversity of North Carolina at Chapel HillNC27599USA Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine Beijing100021China

The limitations of current drug-eluting stent technologies in selectively inhibiting vascular smooth muscle cell proliferation,which often leads to inflammation,call for innovative approaches in coronary artery disease *** the present work,we propose a revolutionary solution:a three-in-one platform for vascular stents,combining arsenic trioxide(ATO)and tacrolimus(TAC)to address anti-proliferation,pro-endothelialization,and anti-inflammation *** findings demonstrate that the synergistic action of ATO and TAC effectively suppresses aberrant vascular smooth muscle cell proliferation and mitigates endothelial cell ***,the combination treatment of TAC/ATO enhances endothelial cell migration and adhesion ***,our TAC/ATO-eluting stent exhibits superior re-endothelialization and anti-restenosis effects in a rabbit and porcine stent implantation *** in vitro and in vivo results solidify the notion that the TAC/ATO-eluting stent ensures rapid re-endothelialization and significantly reduces the incidence of in-stent ***,this study represents a promising and novel multifunctional platform with immense potential in the therapy of coronary artery disease.

关键词： Tacrolimus Arsenic trioxide Drug-eluting stent

The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on HL-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 maarten DE BOCK manfred von HELLERmaNN michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the HL-2A Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the HL-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. Modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

The energetics of cellular life transitions

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Life Metabolism 2024年第3期3卷 12-20页

作者： Anna S.Monzel michael Levin martin Picard Department of Psychiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Discovery Center at Tufts University MedfordMA 02155United States Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York State Psychiatric Institute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

major life transitions are always difficult because change costs *** findings have demonstrated how mitochondrial oxidative phosphorylation(OxPhos)defects increase the energetic cost of living and that excessive integrated stress response(ISR)signaling may prevent cellular identity transitions during *** this perspective,we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift *** energetic cost of cellular differentiation has not been directly quantified,representing a gap in *** propose that the ISR is an energetic checkpoint evolved to(i)prevent OxPhos-deficient cells from engaging in excessively costly transitions and(ii)allow ISR-positive cells to recruit systemic energetic resources by signaling via GDF15 and the brain.

关键词： energy mitochondria signaling pathway growth differentiation factor 15 energy balance development

Endo-hepatology:An emerging field

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World Journal of Gastrointestinal Endoscopy 2021年第8期13卷 296-301页

作者： Daniel E Hogan michael ma David Kadosh Alisha Menon Kana Chin Arun Swaminath Division of Gastroenterology Lenox Hill HospitalNorthwell HealthNew YorkNY 10075United States Department of Internal Medicine Lenox Hill HospitalNorthwell HealthNew YorkNY 10075United States Department of Internal Medicine Long Island Jewish Forest HillsNorthwell HealthNew YorkNY 11375United States

Gastroenterologists have long been spearheading the care of patients with various forms of liver *** diagnosis and management of liver disease has traditionally been a combination of clinical,laboratory,and imaging findings coupled with percutaneous and intravascular procedures with endoscopy largely limited to screening for and therapy of esophageal and gastric *** the applications of diagnostic and therapeutic endoscopic ultrasound(EUS)have evolved,it has found a particular niche within hepatology now *** we discuss several EUS-guided procedures such as liver biopsy,shear wave elastography,direct portal pressure measurement,paracentesis,as well as EUSguided therapies for variceal hemorrhage.

关键词： Endoscopic ultrasound Therapeutic endoscopic ultrasound Hepatology Liver disease Liver biopsy

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生命之糖——海藻糖

中国食品添加剂 2007年第G期18卷 136-137页

作者： michael Sen Jack ma 思多励贸易（上海）有限公司

糖类作为与人们日常饮食息息相关的食品原料，始终吸引着国内外的食品工作者致力于其实用性和功能性的研究。而海藻糖由于其许多特殊的功能特性，在食品、医药等许多领域有着极为良好的应用前景，从而引起了人们的浓厚兴趣。各国纷纷投... 详细信息

糖类作为与人们日常饮食息息相关的食品原料，始终吸引着国内外的食品工作者致力于其实用性和功能性的研究。而海藻糖由于其许多特殊的功能特性，在食品、医药等许多领域有着极为良好的应用前景，从而引起了人们的浓厚兴趣。各国纷纷投入大量的人力和物力对其生产技术和应用开发进行研究，日本林原公司首次实现了以淀粉为原料工业化生产海藻糖的技术。作为充分安全性的食品原料，海藻糖通过了一系列国际性食品安全健康认证，包括美国食品药品管理局（FDA）认证、FDA安全健康食品（GRAS）称号、联合国粮农组织和食品添加剂联合委员会（JECFA）认证、中国和日本（NOVELFOODS）认证等。今天，思多励贸易（上海）有限公司将它引人中国，必将引发我国的食品工业的一次巨大变革。海藻糖是天然的糖类，在自然界中广泛存在，包括大量人们常吃的食物中，其中菌类、海藻和酵母中含量丰富，面包和啤酒等发酵食品及虾类等也含有海藻糖。与其它的食品原料相比，海藻糖有着更多的功能特性，因此在食品、医药等行业有着广泛的用途。

关键词：海藻糖美国食品药品管理局食品原料联合国粮农组织生命功能特性生产技术工业化生产

Anion cascade reactions Ⅲ:Synthesis of 3-isoquinuclidone bridged polycyclic lactams

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Chinese Chemical Letters 2024年第2期35卷 426-430页

作者： Zhiguo Zhang Bingbing Shi Xiyang Cao Nana ma Hao Wu Xingjie Zhang Guisheng Zhang Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Centre of Henan Province for Green Manufacturing of Fine ChemicalsNMPA Key Laboratory for Research and Evaluation of Innovative DrugSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China

Bridged polycyclic lactams are important structural units in organic functional materials,natural products,and pharmaceuticals.A flexible and efficient anion cascade reaction was developed for the preparation of bridged polycyclic lactams from readily available malonamides and 1,4‑*** highly substituted bridged polycyclic lactams were synthesized in good to excellent yields by tandem nucleophilic sequences in the presence of t BuOK in commercially available EtOH solvent at 60℃.Notably,the simple reactions can be run on a gram ***,bis-michael addition reaction and hemiaminalization reactions are involved in the tandem transformation.

关键词： Anion cascade reactions 3-Isoquinuclidone Bridged polycyclic lactams Bis-michael addition reaction Hemiaminalization

Self-healable and Robust Film Based on Electroactive Polymer Brush as Electrode for Flexible Supercapacitor

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Chinese Journal of Polymer Science 2024年第8期42卷 1049-1059页

作者： maria P.Sokolova Vitaly K.Vorobiov Nikolay N.Smirnov Ivan S.Kuryndin Natalya V.Bobrova michael A.Smirnov Institute of macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

The aim of this study was to develop self-healable and robust elect roconductive film based on polyaniline copolymer for application as electrode in flexible *** this purpose,the electroconductive polymer brushes(EPB)was *** synthesis of EPB is based on graft polymerizations of acrylamide(AAm)on poly(vinyl alcohol)(PVA)with formation of PVA-PAAm polymer brush and subsequent graft copolymerization of aniline and p-phenylenediamine on PVA-PAAm resulting in formation of EPB with electroconducting copoly(aniline-co-pphenylenediamine)(PAPh DA).It was found that the ratio between PVA and PAAm at the first stage greatly influence the electrochemical performance of the *** films were prepared by casting of EPB solution with subsequent *** of electrical current distribution through the film with AFM reveal more uniform distribution of PAPhDA in EPB in comparison with reference PVA-PAPhDA and PAAm-PAPhDA *** was demonstrated that mechanical cha racteristics and electrical conductivity values of films restore at large extent after curring and self-healing under optimal relative humidity level(58%).The flexile supercapacitor cell with EPB film electrodes demon strate specific capacitance 602 mF·cm^(-2)at the current density of 1 ma·cm^(-2)and retention 94%of initial capacitance after 5000 charge/discharge cycles.

关键词： Polymer brush Polyaniline Flexible supercapacitor Self-healing Electroconducting film