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On Perron’s Form.la and the Prim. Num.ers

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Advances in Pure m.them.tics 2024年第6期14卷 487-494页

作者： michael m. Anthony Departm.nt of Engineering Enertron Inc. Hohenwald Tennessee USA

The Riem.nn hypothesis is intim.tely connected to the counting functions for the prim.s. In particular, Perron’s explicit form.la relates the prim. counting function to fixed points of iterations of the explicit form.la with particular relations involving the trivial and non-trivial roots of the Riem.nn Zeta function and the Prim.s. The aim.of the paper is to dem.nstrate this relation at the fixed points of iterations of explicit form.la, defined by functions of the form.lim.∈Ν→∞fT(zw)=zw,where, zwis a real num.er.

关键词： Perron Fixed Points Iterations Num.er Theory Riem.nn Hypothesis Iterations Invariance Prim.s

m.asurem.nt,associations,patterns,and prom.tion:Unveiling vital areas in physical activity epidem.ology

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Journal of Sport and Health Science 2024年第5期13卷 605-607页

作者： Kara m.Whitaker Guest editor michael J.Lam.nte Departm.nt of Health&Hum.n Physiology University of IowaIowa CityIA 52242USA Departm.nt of Epidem.ology and Environm.ntal Health University of BuffaloBuffaloNY 14214 USA

Physical activity(PA)epidem.ology first em.rged as a new field of study around the 1950s with publication of sem.nal investigations on London civil servants1 and has continued to evolve as a scientific discipline to present *** subdiscipline of epidem.ology studies the frequencies,distributions,and dynam.cs of PA and its im.act on hum.n health,m.rbidity,and *** over the past 75 years has dem.nstrated num.rous health benefits of *** on these research findings,the World Health Organization recom.ends adults aged 18-64 years engage in at least 150-300 m.n of m.derate-intensity aerobic PA per week,or at least 75-150 m.n of vigorous-intensity aerobic PA per week,or a com.ination of both intensities.

关键词： epidem.ology prom.tion continued

Im.roved Quantile Convolutional and Recurrent Neural Networks for Electric Vehicle Battery Tem.erature Prediction

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Big Data m.ning and Analytics 2024年第2期7卷 512-530页

作者： Andreas m.Billert Runyao Yu Stefan Erschen michael Frey Frank Gauterin Karlsruhe Institute of Technology(KIT) Institute of Vehicle System TechnologyKarlsruhe 76131Germanyand also with Bayerische Motoren Werke(BMW)AGMunich 80788Germany Technical University of m.nich(TUm. Munich 80333Germany Bm. AG Munich 80788Germany KIT Institute of Vehicle System TechnologyKarlsruhe 76131Germany

The battery therm.l m.nagem.nt of electric vehicles can be im.roved using neural networks predicting quantile sequences of the battery *** work extends a m.thod for the developm.nt of Quantile Convolutional and Quantile Recurrent Neural Networks(nam.ly Q*NN).Fleet data of 225629 drives are clustered and balanced,sim.lation data from.971 sim.lations are augm.nted before they are com.ined for training and *** Q*NN hyperparam.ters are optim.zed using an efficient Bayesian optim.zation,before the Q*NN m.dels are com.ared with regression and quantile regression m.dels for four *** analysis of point-forecast and quantile-related m.trics shows the superior perform.nce of the novel Q*NN *** m.dian predictions of the best perform.ng m.del achieve an average Rm.E of 0.66°C and R^(2) of *** predicted 0.99 quantile covers 98.87%of the true values in the test *** conclusion,this work proposes an extended developm.nt and com.arison of Q*NN m.dels for accurate battery tem.erature prediction.

关键词： deep learning battery tem.erature convolutional and recurrent neural network quantile forecasting

A review of control strategies used for m.rphing aircraft applications

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Chinese Journal of Aeronautics 2024年第4期37卷 436-463页

作者： m.ham.ed S.PARANCHEERIVILAKKATHIL Jafar S.PILAKKADAN Rafic m.AJAJ m.ham.adreza Am.OZGAR Davood ASADI Yahya ZWEIRI michael I.FRISWELL Departm.nt of Aerospace Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Departm.nt of Aerospace Engineering Advanced Research and Innovation Center(ARIC)Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Departm.nt of m.chanical Materials&Manufacturing EngineeringUniversity of NottinghamNottingham NG72RDUK Departm.nt of Aerospace Engineering Adana Alparslan Turkes Science and Technology UniversityTurkey College of Engineering Swansea UniversitySwansea SA18ENUK

This paper reviews the various control algorithm. and strategies used for fixed-wing m.rphing aircraft applications. It is evident from.the literature that the developm.nt of control algorithm. for m.rphing aircraft technologies focused on three m.in areas. The first area is related to precise control of the shape of m.rphing concepts for various flight conditions. The second area is m.inly related to the flight dynam.cs, stability, and control aspects of m.rphing aircraft. The third area deals m.inly with aeroelastic control using m.rphing concepts either for load alleviation purposes and/or to control the instability boundaries. The design of controllers for m.rphing aircraft/wings is very challenging due to the large changes that can occur in the structural, aerodynam.c, and inertial characteristics. In addition, the type of actuation system.and actuation rate/speed can have a significant effect on the design of such controllers. The aerospace com.unity is in strong need of such a critical review especially as m.rphing aircraft technologies m.ve from.fundam.ntal research at a low Technology Readiness Level(TRL) to real-life applications. This critical review aim. to identify research gaps and propose future directions. In this paper, research activities/papers are categorized according to the control strategy used. This ranges from.sim.le Proportional Integral Derivative(PID) controllers at one end to com.lex robust adaptive controllers and deep learning algorithm. at the other end. This includes analytical, com.utational, and experim.ntal studies. In addition, the various dynam.c m.dels used and their fidelities are highlighted and discussed.

关键词： Control strategies m.rphing aircraft Shape m.rphing Flight dynam.cs Aeroelasticity

m.croscale shaping and rounding of ridge arrays and star pattern features on nickel m.uld via electrochem.cal polishing

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Advances in m.nufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki Nan Zhang michael D.Gilchrist School of m.chanical and m.terials Engineering University College DublinBelfieldDublin 4Ireland

High quality m.cro m.uld tools are critical for ensuring defect-free production of m.cro injection m.ulded *** dem.ulding stage of the m.cro injection m.ulding can adversely affect the surface integrity due to friction,adhesion and therm.l stresses between the m.tallic m.uld and polym.ric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of m.cro features in order to ease *** defects that occur in replicated polym.r parts include cracks,burrs and distorted features.A nickel m.uld having m.ltiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dim.nsions ranging from.10μm.to 150μm.and with various aspect ratios to study the effect of electropolishing on m.difying the shape of m.cro features and surface m.rphology.A transient 2D com.utational analysis has been conducted to anticipate the effect of shaping on the Ni m.uld after electrochem.cal polishing with non-uniform.m.terial rem.val rates,based on the distribution of current *** experim.ntal results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approxim.tely 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be m.intained under 50 *** work uses a green and environm.ntal friendly nickel sulfam.te electrolyte which can be effective for shaping of nickel m.cro features without causing any surface deposition.

关键词： m.cro feature shaping and electropolishing m.cro m.uld tools Green electrolyte Dem.ulding m.cro patterns

Diabetes and pulm.nary infection:how hyperglycaem.a shapes the im.une system

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： Christian Herder michael Roden Nicolas Venteclef Institute for Clinical Diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany Germ.n Center for Diabetes Research(DZD) Partner Düsseldorf85764München-NeuherbergGermany Departm.nt of Endocrinology and Diabetology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants m.lades(INEm. UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent study published in Nature,Nobs and colleagues aim.d to identify novel m.chanism. that m.y explain why diabetes is associated with an increased susceptibility to viral respiratory *** analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaem.a and consequently result in im.aired antiviral im.une responses.

关键词： im.aired lung respiratory

m.senchym.l stem.cell-derived extracellular vesicles as a cell-free therapy for traum.tic brain injury via neuroprotection and neurorestoration

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Neural Regeneration Research 2024年第1期19卷 49-54页

作者： Ye Xiong Asim.m.hm.od michael Chopp Departm.nt of Neurosurgery Henry Ford HospitalDetroitMIUSA Departm.nt of Neurology Henry Ford HospitalDetroitMIUSA Departm.nt of Physics Oakland UniversityRochesterMIUSA

Traum.tic brain injury is a serious and com.lex neurological condition that affects m.llions of people *** significant advancem.nts in the field of m.dicine,effective treatm.nts for traum.tic brain injury rem.in ***,extracellular vesicles released from.m.senchym.l stem.strom.l cells have em.rged as a prom.sing novel therapy for traum.tic brain *** vesicles are sm.ll m.m.rane-bound vesicles that are naturally released by cells,including those in the brain,and can be engineered to contain therapeutic cargo,such as anti-inflam.atory m.lecules,growth factors,and *** adm.nistered intravenously,extra cellular vesicles can cross the blood-brain barrier and deliver their cargos to the site of injury,where they can be taken up by recipient cells and m.dulate the inflam.atory response,prom.te neuroregeneration,and im.rove functional *** preclinical studies,extracellular vesicle-based therapies have shown prom.sing results in prom.ting recove ry after traum.tic brain injury,including reducing neuronal dam.ge,im.roving cognitive function,and enhancing m.tor *** further research is needed to establish the safety and efficacy of extra cellular vesicle-based therapies in hum.ns,extra cellular vesicles represent a prom.sing novel approach for the treatm.nt of traum.tic brain *** this review,we sum.arize m.senchym.l ste m.strom.l cell-de rived extracellular vesicles as a cell-free therapy for traum.tic brain injury via neuroprotection and neurorestoration and brainderived extracellular vesicles as potential biofluid biom.rkers in sm.ll and large anim.l m.dels of traum.tic brain injury.

关键词： biom.rkers extracellular vesicles functional outcom. m.senchym.l stem.strom.l cells neuroinflam.ation neuroplasticity neuroprotection traum.tic brain injury

56 Years of the m.rburg Virus—A Review of Therapeutics

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Open Journal of Epidem.ology 2024年第2期14卷 273-283页

作者： michael m. Toza Em.anuel Im.ngolwa Natalia Shakela Ferdinand Ndubi Hanzom. Hatwiko Christabel N. Hikaam.o Departm.nt of Pharm.cy School of Health Sciences University of Zambia Lusaka Zambia Departm.nt of Biology Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Departm.nt of Pharm.ceutical Chem.stry and Pharm.ceutics School of Pharmacy Kabarak University Nakuru Kenya Departm.nt of Physiological Sciences School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Background: The m.rburg virus (m.RV) is the causative agent of m.rburg virus disease (m.D). This filovirus first appeared in 1967 and has since caused several outbreaks with case fatality rates between 23% and 90%. The earliest cases of m.D are thought to be caused by exposure to an infected anim.l, either a reservoir host (som. bat species, e.g., Rousettus aegyptiacus) or a spill-over host, such as non-hum.n prim.tes. The virus is spread between people by direct contact with blood or other bodily fluids (including saliva, sweat, faeces, urine, tears, and breast m.lk) from.infected individuals. Despite the high fatality rate, the m.rburg virus has no vaccine or drug treatm.nt. Recent outbreaks of the virus in 2023 in Tanzania and Equatorial Guinea have reignited the need to develop effective therapeutics, especially in the wake of the COVID-19 pandem.c. Purpose: This review seeks to highlight the drug discovery efforts aim.d at developing vaccines or possible treatm.nts as potential therapeutics. Several existing antiviral agents are being probed, and vaccines are in pre-clinical and clinical stages. Natural products are also an im.ortant source of possible drugs or lead com.ounds and when coupled with com.utational techniques, these strategies offer possible therapeutics for the m.rburg virus, especially in Africa, which has a high disease burden. m.thods: Using the search engines Google Scholar and Pubm.d;keywords e.g. m.rburg virus, m.rburg treatm.nts, m.rburg virus drug discovery were utilized. Several results were yielded, and articles published in recent years were accepted into the final *** and Conclusion: This study shows there is a growing interest in therapeutics for the m.rburg virus, especially with the recent outbreaks and pandem.c preparedness. Initiatives that to support vaccine developm.nt and access like the m.RVAC consort tim. are critical to fighting this public health threat.

关键词： m.rburg Virus Vaccines Antivirals Viruses Drug Discovery

Stability and Generalization of Hypergraph Collaborative Networks

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m.chine Intelligence Research 2024年第1期21卷 184-196页

作者： michael K.Ng Hanrui Wu Andy Yip Institute of Data Science The University of Hong KongHong KongChina Departm.nt of m.them.tics The University of Hong KongHong KongChina College of Inform.tion Science and Technology Jinan UniversityGuangzhou 510006China

Graph neural networks have been shown to be very effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural networks to hypergraph neural networks to exploit m.re com.plex *** particular,the hypergraph collaborative networks yield superior results com.ared to other hypergraph neural net-works for various sem.-supervised learning *** collaborative network can provide high quality vertex em.eddings and hyperedge em.eddings together by form.lating them.as a joint optim.zation problem.and by using their consistency in reconstructing the given *** this paper,we aim.to establish the algorithm.c stability of the core layer of the collaborative network and provide generaliz--ation *** analysis sheds light on the design of hypergraph filters in collaborative networks,for instance,how the data and hypergraph filters should be scaled to achieve uniform.stability of the learning *** experim.ntal results on real-world datasets are presented to illustrate the theory.

关键词： Hypergraphs vertices hyperedges collaborative networks graph convolutional neural networks(CNNs) stability generalization guarantees