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The power of a healthy lifestyle for cancer prevention:the example of colorectal cancer

Cancer Biology & Medicine 2022年第11期19卷 1586-1597页

作者： Xuechen Chen Jie Ding Hengjing Li Prudence R.Carr michael hoffmeister Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty Heidelberg Heidelberg UniversityHeidelberg 69120Germany School of Public Health and Preventive MedicineMonash UniversityMelbourneVIC 3004Australia German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Division of Preventive Oncology German Cancer Research Center(DKFZ)and National Center forTumorDiseases(NCT)Heidelberg 69120Germany

Objective:We aimed to directly compare the estimated effects of adherence to a healthy lifestyle with those of risk predisposition according to known genetic variants affecting colorectal cancer(CRC)risk,to support effective risk communication for cancer prevention.Methods:A healthy lifestyle score(HLS)was derived from 5 lifestyle factors:smoking,alcohol consumption,diet,physical activity,and body adiposity.The association of lifestyle and polygenic risk score(PRS)(based on 140 CRC-associated risk loci)with CRC risk was assessed with multiple logistic regression and compared through the genetic risk equivalent(GRE),a novel approach providing an estimate of the effects of adherence to a healthy lifestyle in terms of percentile differences in PRS.Results:A higher HLS was associated with lower CRC risk(4,844 cases,3,964 controls).Those adhering to all 5 healthy lifestyle factors had a 62%(95%CI 54%-68%)lower CRC risk than those adhering to≤2 healthy lifestyle factors.The estimated effect of adherence to all 5 compared with≤2 healthy lifestyle factors was as strong as the effect of having a 79 percentile(GRE 79,95%CI 61-97)lower PRS.The association between a healthy lifestyle and CRC risk was independent of PRS level but was particularly pronounced among those with a family history of CRC in≥1 first-degree relative(P-interaction=0.0013).Conclusions:A healthy lifestyle was strongly inversely associated with CRC risk.The large GRE indicated that CRC risk determined by polygenic risk may be offset to a substantial extent by adherence to a healthy lifestyle.

关键词： Colorectal cancer healthy lifestyle score polygenic risk score family history genetic risk equivalent

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Beyond familial risk: deriving risk-adapted starting ages of screening among people with a family history of colorectal cancer

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Cancer Communications 2023年第12期43卷 1377-1380页

作者： Xuechen Chen Thomas Heisser Rafael Cardoso Julia Hibbert michael hoffmeister Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany Medical Faculty Heidelberg Heidelberg University Heidelberg Germany Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany

Dear Editor,Colorectal cancer(CRC)is the third most common cancer globally[1],even though a large proportion of those cancers would be preventable by screening.Among those with a family history(FH)of CRC,it is commonly recommended to start screening at younger ages,e.g.,at age 40 or 10 years younger than the age at diagnosis of the youngest affected first-degree relative[2–5].Even within the group of those with a FH,risk of CRC is not homogeneous and depends on factors such as the number of affected relatives and the age at which the relatives were diagnosed with CRC[6,7],lifestyles,and genetic background profiles.However,these metrics except genetic factors may change over lifetime,which limits their use for defining starting ages of screening.The aim of this study was to evaluate whether a polygenic risk score(PRS),which combines information from CRC-related risk variants[8]and genetically determined sex(2 constant and established CRC risk factors),could effectively contribute to enhanced risk stratification.We also aimed to determine if it could assist in defining risk-adapted starting ages for CRC screening,even in individuals with a FH of CRC.The assessment was performed using the wellestablished metric of risk advancement periods(RAPs)[9],which measures the impact of an exposure on the relation of age to disease.

关键词： starting adapted younger

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A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment

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Cancer Communications 2023年第8期43卷 947-950页

作者： Tobias Niedermaier Elizabeth Alwers Xuechen Chen Thomas Heisser michael hoffmeister Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)HeidelbergBaden-WürttembergGermany Medical Faculty Heidelberg Heidelberg UniversityHeidelbergBaden-WürttembergGermany Division of Preventive Oncology German Cancer Research Center(DKFZ)HeidelbergBaden-WürttembergGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)HeidelbergBaden-WürttembergGermany

Dear Editors,Large-scale genome-wide association studies have identified an increasing number of single nucleotide polymorphisms(SNPs)that are associated with colorectal cancer(CRC)risk[1].Polygenic risk scores(PRS)based on all established SNPs enable clinically relevant risk assessment that may help to develop novel risk-adapted prevention and screening strategies.

关键词： colorectal prevention cancer

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Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt

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World Journal of Gastroenterology 2019年第43期25卷 6430-6439页

作者： Julian Nikolaus Bucher Marcus Hollenbach Steffen Strocka Gereon Gaebelein michael Moche Thorsten Kaiser michael Bartels Albrecht hoffmeister Department of Surgery Munich University Hospital at GroβhadernBavariaMunich 81377Germany Medical Department Ⅱ-Gastroenterology HepatologyInfectious DiseasesPulmonologyUniversity of Leipzig Medical CenterSaxonyLeipzig 04103Germany Department of Diagnostic and Interventional Radiology University of Leipzig Medical CenterSaxonyLeipzig 04103Germany Department of General VisceralVascular and Pediatric SurgeryUniversity of SaarlandSaarlandHomburg 66421Germany Department of Diagnostic and Interventional Radiology BavariaNuernberg 90411Germany Institute of Laboratory Medicine Clinical Chemistry and Molecular DiagnosticsUniversity of Leipzig Medical CenterSaxonyLeipzig 04310Germany Department for General and Visceral Surgery Helios Park-Klinikum LeipzigSaxonyLeipzig 04289Germany Medical Department Ⅱ-Gastroenterology HepatologyInfectious DiseasesPulmonologyUniversity of Leipzig Medical CenterLeipzig 04103SaxonyGermany

BACKGROUND Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt(TIPS)(SIC-T),is a rare complication of this technique and only referred by case reports.Thus,we conducted a systematic,retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct compression.AIM To assess prevalence and outcome of SIC-T in a large TIPS-cohort.METHODS In this retrospective cohort study,we screened the institutional databases for all consecutive patients that were treated by TIPS-placement or TIPS-revision between January 2005 and August 2013.We analyzed radiologic images for signs of biliary congestion.Cases that were indicative of SIC-T were reviewed by two independent radiologists and additional patient data was collected.Descriptive statistics of patient demographics,indications for TIPS and procedural details were registered.Logistic regression analysis was performed to identify predictors for the development of SIC-T.RESULTS We analyzed 135 cirrhotic patients who underwent TIPS(mean age 55 years,79%male gender).Etiology of cirrhosis was alcohol in most cases and indications for TIPS were mainly refractory ascites and recurrent variceal bleeding.TIPS revision was necessary in 31 patients.We identified 4 cases(2.9%)of SIC-T in direct proximity of the TIPS-stent.Diagnosis was confirmed by CT-scan,MRI or endoscopic retrograde cholangio pancreaticography(ERCP).In two patients TIPS was implanted via the right and in one through the medial hepatic vein.One patient received TIPS-prolongation by multiple revisions.Most patients were asymptomatic but one cholangitic abscess necessitated a transhepatic drain.Logistic regression analysis identified TIPS-placement other than from medial hepatic vein to right portal vein as risk factor(OR 21.0)for SIC-T.CONCLUSION SIC-T ads to(mostly late)complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses.Patients,particularly with multiple interventions,s

关键词： Transjugular intrahepatic portosystemic shunt Cirrhosis Ascites Bleeding Cholestasis Biliary congestion

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纺织工业废水处理——HUBERSE公司为Bamberger Kaliko纺织企业提供污水回用完整解决方案

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流程工业 2012年第4期 24-27页

作者： Ralph TECKENBERG Thomas POHLERS Klaus FOSSMANN michael hoffmeister

超滤膜技术使得纺织工业企业重新利用生产用水，在这一整体方案中也包括了热能的回收再利用，达标、节能、减排全部实现。

关键词：工业废水处理纺织企业 SE公司污水回用回收再利用整解纺织工业企业超滤膜技术

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