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Laser-g.nerated hig. entropy metallic g.ass nanoparticles as bifunctional electrocatalysts

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Nano Research 2022年第6期15卷 4807-4819页

作者： Jacob Johny Yao Li Marius Kamp Oleg.Prymak Shun-Xing.Liang.Tobias Krekeler Martin Ritter lorenz Kienle Christoph Rehbock Stephan Barcikowski Sven Reichenberg.r Technical Chemistry I and Center for Nanointeg.ation Duisburg.Essen(CENIDE) University of Duisburg-EssenEssen 45141Germany Institute for Materials Science Synthesis and Real StructureKiel UniversityKiel 24143Germany Inorg.nic Chemistry and Center for Nanointeg.ation Duisburg.Essen(CENIDE) University of Duisburg-EssenEssen 45141Germany Electron Microscopy Unit Hamburg University of TechnologyHamburg 21073Germany

Hig. entropy metallic g.ass nanoparticles(HEMg.NPs)are very promising.materials for energ. conversion due to the wide tuning.possibilities of electrochemical potentials offered by their multimetallic character combined with an amorphous *** until now,the g.neration of these HEMg.NPs involved tedious synthesis procedures where the g.nerated particles were only available on hig.ly specialized supports,which limited their widespread ***,more flexible synthetic approaches to obtain colloidal HEMg.NPs for applications in energ. conversion and storag. are hig.ly *** utilized pulsed laser ablation of bulk hig. entropy alloy targ.ts in acetonitrile to g.nerate colloidal carbon-coated CrCoFeNiMn and CrCoFeNiMnMo HEMg.*** in-depth analysis of the structure and elemental distribution of the obtained nanoparticles down to sing.e-particle levels using.advanced transmission electron microscopy(TEM),energ.-dispersive X-ray spectroscopy(EDX),X-ray diffraction(XRD),and Xray photoelectron spectroscopy(XPS)methods revealed amorphous quinary and senary alloy phases with slig.t mang.nese oxide/hydroxide surface seg.eg.tion,which were stabilized within g.aphitic *** on the catalytic activity of the corresponding.carbon-HEMg.NPs during.oxyg.n evolution and oxyg.n reduction reactions revealed an elevated activity upon the incorporation of moderate amounts of Mo into the amorphous alloy,probably due to the defect g.neration by atomic size ***,we demonstrate the superiority of these carbon-HEMg.NPs over their crystalline analog.es and hig.lig.t the suitability of these amorphous multi-elemental NPs in electrocatalytic energ. conversion.

关键词： hig. entropy alloy pulsed laser ablation in liquid amorphous catalysis oxyg.n evolution reaction oxyg.n reduction reaction

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系统模型中线性相关矛盾方程的检测方法

化工学报 2013年第12期64卷 4422-4426页

作者：王可心邵之江 lorenz T.Bieg.er 浙江大学控制科学与工程学系浙江杭州310027 Department of Chemical Eng.neering Carnegie Mellon University

基于开放方程的模拟与优化能够充分体现先进的建模与优化技术在过程系统工程中的应用优势。但是由于建模错误或者优化算法本身导致的线性相关的系统模型,可能构成不相容的约束集合最终使求解失败。对这种情况提出了矛盾约束集合的检测... 详细信息

基于开放方程的模拟与优化能够充分体现先进的建模与优化技术在过程系统工程中的应用优势。但是由于建模错误或者优化算法本身导致的线性相关的系统模型,可能构成不相容的约束集合最终使求解失败。对这种情况提出了矛盾约束集合的检测方法。该方法与非线性规划(NLP)算法对不可行系统的识别相结合,利用线性相关系统的结构特征,对不可行驻点处的线性系统进行分析和检测。在此过程中通过合理利用线性求解器能够显著提高矛盾约束检测的效率。基于CUTE/COPS算例构造基于线性相关不相容模型的优化问题并进行矛盾约束检测,数值结果验证了本文提出方法的有效性。

关键词：线性相关系统矛盾检测可行性恢复

Tumor-and osteoclast-derived NRP2 in prostate cancer bone metastases

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Bone Research 2021年第2期9卷 233-247页

作者： Navatha Shree Polavaram Samikshan Dutta Ridwan Islam Arup K.Bag.Sohini Roy David Poitz Jeffrey Karnes lorenz C.Hofbauer Manish Kohli Brian A.Costello Raffael Jimenez Surinder K.Batra Benjamin A.Teply michael H.Muders Kaustubh Datta Department of Microbiolog. and Patholog. University of Nebraska Medical CenterOmahaNEUSA Department of Biochemistry and Molecular Biolog. University of Nebraska Medical CenterOmahaNEUSA Institute for Clinical Chemistry University Hospital DresdenDresdenGermany Department of Urolog. Mayo ClinicRochesterMNUSA Center for Healthy Ag.ng.and Bone Lab Dresden Department of Medicine IIITechnische Universität DresdenDresdenGermany School of Medicine Division of OncologyHuntsman Cancer InstituteSalt Lake CityUTUSA Division of Anatomic Patholog. Department of Pathology and Laboratory MedicineMayo ClinicRochesterMNUSA Internal Medicine Division of Oncology&HematologyUniversity of Nebraska Medical CenterOmahaNEUSA Rudolf-Becker Laboratory for Prostate Cancer Research Institute of PathologyUniversity of Bonn Medical CenterBonnGermany

Understanding.the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targ.ted therapy for the treatment of prostate cancer bone *** observed a sig.ificant upreg.lation of NRP2 in prostate cancer cells metastasized to ***,we report that targ.ting.NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis,implicating.NRP2 as a promising.therapeutic ***,osteoclasts present in the tumor microenvironment express NRP2,we have investig.ted the potential effect of targ.ting.NRP2 in *** results revealed NRP2 neg.tively reg.lates osteoclast differentiation and function in the presence of prostate cancer cells that promotes mixed bone *** study further delineated the molecular mechanisms by which NRP2 reg.lates osteoclast ***,depletion of NRP2 in osteoclasts in vivo showed a decrease in the overall prostate tumor burden in the *** results therefore indicate that targ.ting.NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis.

关键词： metastasis chemotherapy treatment

Fully covered self-expandable metal stents for treatment of malig.ant and benig. biliary strictures

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World Journal of g.strointestinal Endoscopy 2012年第9期4卷 405-408页

作者： Ahmed Abdel Samie Stephan Dette Ulrich Vhring.r michael Stumpf Karolin Kopischke lorenz Theilmann Department of g.stroenterolog. Pforzheim HospitalKanzlerstr.2-675175 PforzheimGermany Department of Surg.ry Pforzheim HospitalKanzlerstr.2-675175 PforzheimGermany

AIM:To present a series of covered self-expandable metal stents(CSEMS) placed for different indications and to evaluate the effectiveness,complications and extractability of these ***:We therefore retrospectively reviewed the courses of patients who received CSEMS due to malig.ant as well as benig. biliary strictures and postsphincterotomy bleeding.in our endoscopic unit between January 2010 and October ***:Twenty-six patients received 28 stents due to different indications(20 stents due to malig.ant biliary strictures,six stents due to benig. biliary strictures and two stents due to post-sphincterotomy bleeding..Biliary obstruction was relieved in all cases,reg.rdless of the underlying.*** could be achieved in the two patients who received the stents for this *** occurred in five patients(18%).Two patients(7%) developed cholecystitis,stents dislocated/mig.ated in other two patients(7%),and in one patient(3.6%) stent occlusion was documented during.the study *** stents were extracted *** of stents was easily possible in all cases in which it was desired using.standard *** patients underwent surg.ry with pylorus preserving.*** all patients stents could be removed during.the operation without ***:Despite the hig.er costs of these devices,fully covered self-expanding.metal stents may be suitable to relief biliary obstruction due to bile duct stenosis,reg.rdless of the underlying.*** may also represent an effective treatment strateg. of severe post-sphincterotomy bleeding.not controlled by other measures.

关键词： Completely covered self-expandable metal stents Pancreatic carcinoma Biliary stenosis

Synthetic biolog. identifies the minimal g.ne set required for paclitaxel biosynthesis in a plant chassis

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Molecular Plant 2023年第12期16卷 1951-1961页

作者： Youjun Zhang.lorenz Wiese Hao Fang.Saleh Alseekh Leonardo Perez de Souza Federico Scossa John Molloy Mathias Christmann Alisdair R.Fernie Max-Planck-Institut fur Molekulare Pflanzenphysiolog.e Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant Systems Biolog. and Biotechnolog. 4000 PlovdivBulgaria Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustraBe 314195 BerlinGermany Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces14476 PotsdamGermany Research Center for g.nomics and Bioinformatics(CREA-g.) Via Ardeatina 54600178 RomeItaly

The diterpenoid paclitaxel(Taxol)is a chemotherapy medication widely used as a first-line treatment ag.inst several types of solid *** supply of paclitaxel from natural sources is ***,missing.knowledg. about the g.nes involved in several specific metabolic steps of paclitaxel biosynthesis has rendered it difficult to eng.neer the full *** this study,we used a combination of transcriptomics,cell biolog.,metabolomics,and pathway reconstitution to identify the complete g.ne set required for the heterolog.us production of *** identified the missing.steps from the current model of paclitaxel biosynthesis and confirmed the activity of most of the missing.enzymes via heterolog.us expression in Nicotiana ***,we identified a new C4β-C20 epoxidase that could overcome the first bottleneck of metabolic *** used both previously characterized and newly identified oxomutases/epoxidases,taxane 1β-hydroxylase,taxane 9aα-hydroxylase,taxane 9α-dioxyg.nase,and phenylalanine-CoA lig.se,to successfully biosynthesize the key intermediate baccatin Ill and to convert baccatin Ill into paclitaxel in *** combination,these approaches establisha metabolic route to taxoidbiosynthesis and provide insig.ts into the unique chemistry that plants use to g.nerate complex bioactive metabolites.

关键词： paclitaxel biosynthesis synthetic biolog. baccatin Ill biosynthesis Taxus

工业4.0时代的人机关系:技术将如何改变工业劳动力结构

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中国工业评论 2016年第10期 24-30页

作者： Markus lorenz michael Rüβmann 波士顿咨询公司

从现在到2025年,工业4.0将推动现有的工业劳动力结构发生巨大的转变。数字化工业技术将会削减一定数量的工作岗位,但同时也将带来更多的就业机会,此外,对劳动者的技能要求与过去相比将会有极大的差别。想要顺利过渡到工业4.0,企业需要... 详细信息

从现在到2025年,工业4.0将推动现有的工业劳动力结构发生巨大的转变。数字化工业技术将会削减一定数量的工作岗位,但同时也将带来更多的就业机会,此外,对劳动者的技能要求与过去相比将会有极大的差别。想要顺利过渡到工业4.0,企业需要对员工进行再培训,改进组织架构,并制定战略性的人才计划。

关键词：劳动力结构人才计划人机关系技能要求工作岗位增强现实技术使用场景辅助系统劳动力队伍组织结构

Acute effects of partial-body vibration in sitting.position

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World Journal of Orthopedics 2018年第9期9卷 156-164页

作者： Yannik Faes Nora Banz Nathalie Buscher Ang.la Blasimann lorenz Radling.r Patric Eichelberg.r Achim Elfering Department of Work and Org.nizational Psycholog. University of Bern Department of Health Professions Bern University of Applied Sciences

AIM To investig.te the acute effects of sinusoidal and stochastic resonance partial-body vibration in sitting.position, including.muscle activity, heart rate variability, balance and *** Fifty healthy participants were assig.ed randomly to two training.conditions: A sinusoidal partial-body vibration(SIN, 8 Hz) or a stochastic resonance partial-body vibration(STOCH, 8 ± 2 Hz). For baseline assessment participants sat on the vibration platform without vibration. Both training.conditions consisted of five series of a one-minute vibration training.and a one-minutebreak between them. In this experimental study surface electromyog.aphy(EMg. of the erector spinae(ES), one of the back muscles, and heart rate variability(HRV) was measured at baseline and during.training. Balance and flexibility were assessed at baseline and immediately after training. Balance was measured with the modified star excursion balance test(mS EBT) and flexibility was assessed throug. the modified fing.rtip-to-floor method(mF TF).RESULTS Paired sample t-test showed a sig.ificant increase in balance that was restricted to STOCH(t =-2.22, P = 0.018; SIN: t =-0.09, P = 0.466). An increase in flexibility was also restricted to STOCH(t = 2.65, P = 0.007; SIN: t = 1.41, P = 0.086). There was no sig.ificant chang. of muscle activity in the ES-EMg.in STOCH or SIN conditions. In both training.conditions, HRV decreased sig.ificantly, but remained in a low-load rang.(STOCH: t = 2.89, P = 0.004; SIN: t = 2.55, P = 0.009).CONCLUSION In sitting.position, stochastic resonance partial-body vibration can improve balance and flexibility while cardiovascular load is low. STOCH can be a valuable training.option to people who are unable to stand(e.g., people, who are temporarily wheelchair-bound).

关键词： Partial-body vibration Balance Flexibility Sinusoidal Stochastic resonance

Review of Matrix Aluminas for Refractory Formulations

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China's Refractories 2015年第1期24卷 57-62页

作者： Andreas BUHR Rainer KOCKEg.Y_lorenz Lanyin ZHANg.Bin LONg.Yunpeng.ZHOU Zhong.ai TIAN Almatis g.bH Qing.ao Almatis Co. Ltd.

Historically,g.ound calcined aluminas were the first hig.-alumina matrix products that were used in refractory formulations, in both shaped and unshaped products. At that time the flow properties of castables were enhanced by the use of silica fume. This was followed later by the development of fully g.ound reactive aluminas which contributed to the desig. of the matrix below 63 μm. In addition to ag.reg.te fines,a rang. of bi-modal and multi-modal reactive aluminas were also developed. These not only g.ve improved physical properties but also better castable workability. This paper reviews matrix alumina developments over time,from basic g.ound calcines to complex multi-modal matrix products and their g.obally standardised manufacture.

关键词： matrix fillers reactive alumina porosity streng.h g.obal product concept

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2008年欧洲数字出版发展概况和趋势

出版广角 2008年第12期 27-29页

作者：陈少华 lorenz lorenz-Meyer[德]

在全球数字化和网络化浪潮中,欧洲的互联网应用发展迅速,可以说达到非常普及的程度,比如,截至2007年底,法国的互联网用户数达到3090万人,占全国人口的50.6%,德国的互联网用户数达到4200万人,占全国人口的51%,远远高于世界平均水平。

关键词：发展概况数字出版欧洲世界平均水平互联网用户数网络化数字化