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Primary gastric non-Hodgkin lymphomas:Recent advances regarding disease pathogenesis and treatment

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World Journal of Gastroenterology 2021年第35期27卷 5932-5945页

作者： michael d diamantidis Maria Papaioannou Evdoxia Hatjiharissi department of Hematology Thalassemia and Sickle Cell Disease UnitGeneral Hospital of LarissaLarissa 41221ThessalyGreece division of Hematology First Department of Internal MedicineAHEPA General HospitalAristotle University of ThessalonikiThessaloniki 54636Greece

Primary gastric lymphomas(PGLs)are distinct lymphoproliferative neoplasms described as heterogeneous entities clinically and *** main histological types are diffuse large B-cell lymphoma(dLBCL)or mucosaassociated lymphoma *** has been one of the main fields of clinical research of our group in recent *** gastric dLBCLs are frequent,sufficient data to guide optimal care are *** today,a multidisciplinary approach has been applied,including chemotherapy,surgery,radiotherapy or a combination of these *** this minireview article,we provide an overview of the clinical manifestations,diagnosis and staging of these diseases,along with their molecular pathogenesis and the most important related clinical published *** then discuss the scientific gaps,perils and pitfalls that exist regarding the aforementioned studies,in parallel with the unmet need for future research and comment on the proper methodology for such retrospective *** to fill this gap,we retrospectively evaluated the trends in clinical presentation,management and outcome among 165 patients with dLBCL PGL who were seen in our institutions in *** study cohort was divided into two subgroups,comparing the main 2 therapeutic options[cyclophosphamide doxorubicin vincristine prednisone(CHOP)vs rituximab-CHOP(R-CHOP)].A better outcome with immunochemotherapy(R-CHOP)was *** the next 2 mo,we will present the update of our study with the same basic conclusion.

关键词： Primary gastric lymphoma Extranodal non-Hodgkin’s lymphoma diffuse large B-cell lymphoma Mucosa-associated lymphoid tissue Immunochemotherapy Rituximab-cyclophosphamide doxorubicin vincristine prednisone

Statistical variability and fragility assessment of ballistic perforation of steel plates for 7.62 mm AP ammunition

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defence Technology（防务技术） 2020年第3期16卷 503-513页

作者： Mark G.Stewart michael dNetherton Centre for Infrastructure Performance and Reliability The University of NewcastleNew South Wales2038Australia

The paper describes field test results of 7.62×51 mm M61 AP(armour piercing) ammunition fired into mild steel targets at an outdoor *** targets varied from 10 mm to 32 mm in *** tests recorded penetration depth,probability of perforation(i.e.,complete penetration),muzzle and impact velocities,bullet mass,and plate yield strength and *** measured penetration depth exhibited a variability of approximately±12%.The paper then compared ballistic test results with predictive models of steel penetration depth and thickness to prevent *** parameters were derived for muzzle and impact velocity,bullet mass,plate thickness,plate hardness,and model error.A Monte-Carlo probabilistic analysis was then developed to estimate the probability of plate perforation of 7.62 mm M61 AP ammunition for a range of impact velocities,and for mild steels,and High Hardness Armour(HHA) *** perforation fragility analysis considered the random variability of impact velocity,bullet mass,plate thickness,plate hardness,and model *** a probabilistic analysis allows for reliability-based design,where,for example,the plate thickness with 95% reliability(*** 1 in 20 shots will penetrate the wall) can be estimated knowing the probabilistic distribution of ***,it was found that the plate thickness to ensure a low 5% probability of perforation needs to be 11-15% thicker than required to have a 50/50 chance of perforation for mild steel *** would need to be 20-30% thicker if probability of perforation is reduced to zero.

关键词： Ballistics Probability Statistics Steel plates Armour steel Ammunition Experimental Perforation

Phenotypic differences between coryneform bacteria isolated from seminal fluid of healthy men and men with chronic prostatitis syndrome

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Asian Journal of Andrology 2009年第4期11卷 517-520页

作者： Iuri B Ivanov Viktor A Gritsenko michael d Kuzmin department of Human Microbiology Institute of Cellular and Intracellular Symbiosis Russian Academy of Sciences Orenburg 460056 Russia

We compared the potential phenotypic properties of coryneform bacteria associated with chronic prostatitis syndrome （CPS）, such as secretory inhibitor of lysozyme （SIL） and secretory inhibitor of platelet microbicidal protein （SIPMP）. A total of 110 clinical isolates of coryneform bacteria isolated from the seminal fluid of healthy men and men with CPS were tested. SIPMP production was tested by inhibiting platelet microbicidal protein （PMP） bioactivity against Bacillus subtilis, and was expressed as percentage of inhibition of PMP bactericidal activity. SIL production was tested by inhibiting lysozyme activity against Micrococcus lysodeikticus and was expressed in microgram per millilitre of inactivated lysozyme. A significantly higher proportion of CPS strains （58.7% vs. 19.2 %） was SIPMP-positive compared with non-CPS strains （P 〈 0.01）. Of the CPS strains tested, 77.8% were SIL-positive compared with 34% of the non- CPS isolates （P 〈 0.05）. These results suggest that the diagnosis of CPS should not rely solely on classical parameters, for example, the identification and counting of microorganisms, but the functional significance of these parameters must be estimated, possibly by the concentration of different bacterial substrains, detection of opportunistic microorganisms with pathogenic properties, such as pronounced resistance to the cationic antimicrobial peptides, and/or the ability to inhibit the antimicrobial host defence factors.

关键词： Corynebacterium spp lysozyme platelet microbicidal protein prostatitis

Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms

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World Journal of Gastroenterology 2011年第4期17卷 444-448页

作者： Olga Giouleme michael d diamantidis Marios G Katsaros department of Gastroenterology First Propedeutic Department of Internal Medicine Aristotle University of Thessaloniki AHEPA General Hospital

The possible relationship between diabetes mellitus (dM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between dM and CRC, led to the theory that dM might be a causal agent for CRC development. Various studies have connected type 2 dM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that dM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide.

关键词： 2型糖尿病分子机制病理生理胰岛素样生长因子大肠癌 CRC 他汀类药物危险因素

Acute right insular ischaemic lesions and poststroke left ventricular dysfunction

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Stroke & Vascular Neurology 2023年第4期8卷 301-306页

作者： Klemens Winder Carolina Villegas Millar Gabriela Siedler michael Knott Arnd dörfler Anna Engel Stephan Achenbach Max J Hilz Bernd Kallmünzer Stefan Schwab Frank Seifert Kilian Fröhlich Neurology University Hospital ErlangenFriedrich-Alexander-Universität(FAU)Erlangen-NürnbergErlangenGermany Neurology University Hospital and University of ZürichZürichSwitzerland Neuroradiology University Hospital ErlangenFriedrich-Alexander Universität(FAU)Erlangen-NürnbergErlangenGermany Cardiology University Hospital ErlangenFriedrich-Alexander-Universität(FAU)Erlangen-NürnbergErlangenGermany

Introduction Myocardial injury related to acute ischaemic stroke is common even without primary cardiac *** intended to determine associations between values of left ventricular ejection fraction(LVEF)and ischaemic stroke lesion *** Of a local database,patients with acute first-ever ischaemic stroke confirmed by brain imaging but without pre-existing heart disease were *** cardiac morphology and LVEF were obtained from transthoracic or transesophageal echocardiography,and impaired LVEF was categorised as mild(35%-50%),moderate(34%-25%)and severe(0.1 ng/mL),atrial fibrillation and cardiac wall motion abnormalities were assessed and compared between patients with and without impaired LVEF after stroke(significance:pd LVEF after stroke with sites of ischaemic *** Of 1209 patients who had a stroke,231(mean age 66.3±14.0 years)met the inclusion criteria;40 patients(17.3%)had an impaired LVEF after *** with impaired LVEF had higher infarct volumes(53.8 mL vs 30.0 mL,p=0.042),a higher prevalence of troponin increase(17.5%vs 4.2%,p=0.006),cardiac wall motion abnormalities(42.5%vs 5.2%,pd atrial fibrillation(60.0%vs 26.2%,p50%.The multivariate voxelwise lesion analysis yielded associations between decreased LVEF and damaged voxels in the insula,amygdala and operculum of the right *** Our imaging analysis unveils a prominent role of the right hemispheric central autonomic network,especially of the insular cortex,in the brain-heart *** results support preliminary evidence that acute ischaemic stroke in distinct brain regions of the central autonomic network may directly impair cardiac function and thus further supports the concept of a distinct stroke-heart syndrome.

关键词： impaired ischaemic ventricular

Epidemiology of shoulder dislocations presenting to United States emergency departments:An updated ten-year study

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世界骨科杂志:英文版 2023年第9期14卷 690-697页

作者： Cole M Patrick Josiah Snowden michael d Eckhoff Clare K Green John P Scanaliato John C dunn Nata Parnes department of Orthopaedics William Beaumont Army Medical CenterFort BlissTX 79918United States Burnett School of Medicine Texas Christian UniversityFort WorthTX 76129United States School of Medicine and Health Sciences George Washington UniversityWashingtonWA 20052United States department of Orthopaedic Surgery Carthage Area HospitalCarthageNY 13619United States

BACKGROUNd Glenohumeral dislocation is a common injury that may predispose patients to chronic pain and ***,there is a paucity of current data available regarding the epidemiological trends of this *** To provide an updated,comparative assessment of the epidemiology of shoulder dislocations presenting to emergency departments in the United *** also sought to analyze patient demographic risk factors and consumer products associated with dislocation *** data were obtained from the national electronic injury surveillance system database for glenohumeral dislocations between 2012 and ***,age,sex,and injury characteristics were analyzed using weighted population statistics as well as incidence rates and 95%confidence intervals(CI).RESULTS In total,an estimated 773039 shoulder dislocations(CI:640598-905481)presented to emergency rooms across the United States during the study *** annual incidence rate was 23.96 per 100000 persons and the average patient age at the time of injury was 37.1 *** more male patients sustained dislocations than female patients(537189,69.5%,vs 235834,30.5%,Pd to associated consumer products,sports and recreation equipment were involved in the highest proportion of incidents(44.31%),followed by home structures and construction materials(21.22%),and home furnishings,fixtures,and accessories(21.21%).Regarding product sub-groups,stairs,ramps,landings,floors was cited in the greatest number of cases(131745).CONCLUSION The national annual incidence rate of glenohumeral dislocations throughout the study period was approximately 23.92 per 100000 *** adolescents sustained the highest proportion of dislocations,with a peak incidence in age group 15-20 years,predominantly secondary to participation in sporting and recreational ***,women experienced a relatively consistent incidence of dislocation throughout their *** age 63,the i

关键词： Shoulder dislocation Epidemiology United States Emergency department Glenohumeral dislocation national electronic injury surveillance system

Hepatotoxicity reports in the FdA adverse event reporting system database:A comparison of drugs that cause injury via mitochondrial or other mechanisms

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3857-3868页

作者： Payal Rana michael d.Aleo Xuerong Wen Stephen Kogut drug Safety Research&development PfizerGrotonCT 06340USA University of Rhode Island College of PharmacyKingstonRI 02881USA

drug-induced liver injury(dILI) is a leading reason for preclinical safety attrition and postmarket drug ***-induced mitochondrial toxicity has been shown to play an essential role in various forms of dILI,especially in idiosyncratic liver *** study examined liver injury reports submitted to the Food and drug Administration(FdA) Adverse Event Reporting System(FAERS) for drugs associated with hepatotoxicity via mitochondrial mechanisms compared with non-mitochondrial mechanisms of *** frequency of hepatotoxicity was determined at a group level and individual drug level.A reporting odds ratio(ROR) was calculated as the measure of *** the two dILI groups,reports for dILI involving mitochondrial mechanisms of toxicity had a 1.43(95% CI 1.42-1.45;P dds compared to drugs associated with non-mitochondrial mechanisms of ***,antiviral,analgesic,antibiotic,and antimycobacterial drugs were the top five drug classes with the highest ROR *** the top 20 drugs with the highest ROR values included drugs with both mitochondrial and non-mitochondrial injury mechanisms,the top four drugs(ROR values> 18:benzbromarone,troglitazone,isoniazid,rifampin) were associated with mitochondrial mechanisms of *** major demographic influence for dILI risk was also *** was a higher mean patient age among reports for drugs that were associated with mitochondrial mechanisms of toxicity [56.1±18.33(Sd)] compared to non-mitochondrial mechanisms [48±19.53(Sd)](P dILI via mitochondrial mechanisms of *** logistic regression analysis showed that reports of liver injury were 2.2(odds ratio:2.2,95% CI 2.12-2.26) times more likely to be associated with older patient age,as compared with reports involving patients less than 65 years of *** to males,female patients were 37% less likely(odds ratio:0.63,95% CI

关键词： Mitochondrial toxicity FAERS database Adverse event reporting drug-induced liver injury Hepatotoxicity

The complex momentum representation approach and its application to low‑lying resonances in 17 O and^(29,31)F

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Nuclear Science and Techniques 2023年第1期34卷 43-50页

作者： Si‑Zhe Xu Shi‑Sheng Zhang Xiao‑Qian Jiang michael Scott Smith School of Physics Beihang UniversityBeijing 100191China Physics division Oak Ridge National LaboratoryOak RidgeTN 37831‑6354USA

Approaches for predicting low-lying resonances,uniformly treating bound,and resonant levels have been a long-standing goal in nuclear ***,we explored the viability of the complex momentum representation(CMR)approach coupled with new *** focus on predicting the energy of the low-lying 2p_(3∕2)resonance in 17 O,which is critical for s-process nucleosynthesis and missing in previous theoretical *** a Woods-Saxon potential based on the Koning-delaroche optical model and constrained by the experimental one-neutron separation energy,we successfully predicted the resonant energy of this level for the first *** predictions of the bound levels and 1d_(3∕2)resonance agree well with the measurement ***,we utilize this approach to study the near-threshold resonances that play a role when forming a two-neutron halo in^(29,31)*** found that the CMR-based predictions of the bound-level energies and unbound 1f7∕2 level agree well with the results obtained using the scattering phase shift ***,we successfully found a solution for the 2p_(3∕2)resonance with energy just above the threshold,which is decisive for halo formation.

关键词： Neutron capture Low-lying resonance Complex momentum representation Resonance energy

Improving sorghum digestion in broilers by targeting fermentation of xylan

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Animal Nutrition 2022年第3期10卷 198-206页

作者： Natalie K.Morgan Andrew Wallace michael R.Bedford University of New England School of Environmental and Rural ScienceArmidaleNew South WalesAustralia AB Vista Woodstock CourtBlenheim RoadMarlborough Business ParkMarlboroughWiltshireEnglandUnited Kingdom Curtin University Kent StreetBentleyWestern AustraliaAustralia

This study was to examine if it is possible to accelerate sorghum digestion in broiler chickens by targeting fermentation of the *** 500 broilers(n=960,80 birds per treatment)were fed 12 sorghumsoybean meal-based dietary treatments fed as 3 phases(starter d 0 to 12,grower d 13 to 23,finisher d 24 to 35),with 8 replicate pens of 10 birds per *** half of the treatments(n=6),10%of the sorghum in the diet was directly replaced with 10%wheat bran,as a source of fermentable *** diets were supplemented with either 0,50 or 2,000 mg/kg xylo-oligosaccharides(XOS),with or without xylanase *** weight gain(BWG),feed intake(FI)and feed conversion corrected for mortality(cFCR)was determined at d 0 to 35,and male and female body weight were measured on d *** d 35,ileum and caeca samples were collected from 2 birds per pen,for determination of caecal cellulase and xylanase activity,microbiota composition and short chain fatty acid(SCFA)concentration,and ileal XOS *** with 2,000 mg/kg XOS caused increased BWG at d 0 to 35(P=0.007)and enhanced caecal propionic,valeric and succinic acid concentration(Pd FI(P=0.018)and BWG(P=0.016),as well as caecal Bifidobacteria concentration(Pding combined wheat bran,2,000 mg/kg XOS,and xylanase,resulting in increased caecal total SCFA,acetic acid and butyric acid concentration,and xylanase and cellulase activity(Pdy present that feed efficiency in birds fed sorghum-based diets is improved as a consequence of supplementing with fermentable fibre,xylanase and XOS.

关键词： Xylanase Sorghum Oligosaccharides Broiler