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An Example Using Improved Lefschetz Duality

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1269-1274页

作者： Pascal LAMBRECHTS Jeremy lane Donald STANLEY Pascal Lambrechts Institut Mathmatique Universit de Louvain Department of Mathemtics University of Toronto Department of Mathematics and Statistics University of Regina

A theorem of Lambrechts and Stanley is used to find the rational cohomology of the complement of an embedding S^(4n-1)→ S^(2n)× S^m as a module and demonstrate that it is not necessarily determined by the map induced on cohomology by the embedding, nor is it a trivial extension. This demonstrates that the theorem is an improvement on the classical Lefschetz duality.

关键词： Lefschetz duality Embedding Extension problem

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Understanding p53 functions through p53 antibodies

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Journal of Molecular Cell Biology 2019年第4期11卷 317-329页

作者： Kanaga Sabapathy David P.lane Laboratory of Molecular Carcinogenesis Division of Cellular & Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore Singapore 169610 Singapore Cancer and Stem Cell Biology Program Duke-NUS Medical School Singapore 169857 Singapore Department of Biochemistry National University of Singapore (NUS) Singapore 117597 Singapore Institute of Molecular and Cellular Biology Singapore 138673 Singapore p53 Laboratory Singapore 138648

TP53 is the most frequently mutated gene across all cancer types. Our understanding of its functions has evolved since its discovery four decades ago. Initially thought to be an oncogene, it was later realized to be a critical tumour suppressor. A significant amount of our knowledge about p53 functions have come from the use of antibodies against its various forms. The early anti-p53 antibodies contributed to the recognition of p53 accumulation as a common feature of cancer cells and to our understanding of p53 DNA-binding and transcription activities. They led to the concept that conformational changes can facilitate p53’s activity as a growth inhibitory protein. The ensuing p53 conformational-specific antibodies further underlined p53’s conformational flexibility, collectively forming the basis for current efforts to generate therapeutic molecules capable of altering the conformation of mutant p53. A subsequent barrage of antibodies against post-translational modifications on p53 has clarified p53’s roles further, especially with respect to the mechanistic details and context-dependence of its activity. More recently, the generation of p53 mutation-specific antibodies have highlighted the possibility to go beyond the general framework of our comprehension of mutant p53-and promises to provide insights into the specific properties of individual p53 mutants. This review summarizes our current knowledge of p53 functions derived through the major classes of anti-p53 antibodies, which could be a paradigm for understanding other molecular events in health and disease.

关键词： antibodies conformation mutant p53 post-translational modifications

Role of retinoids in the prevention and treatment of colorectal cancer

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World Journal of Gastrointestinal Oncology 2015年第10期7卷 184-203页

作者： Catherine C Applegate Michelle a.lane School of Family and Consumer Sciences Nutrition and Foods Program Texas State University

Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in progression and metastasis, resulting in aberrant Wnt/β-catenin signaling, gain-of-function mutations in K-ras and phosphatidylinositol-3-kinase/Akt, cyclooxygenase-2 over-expression, reduction of peroxisome proliferatoractivated receptor γ activation, and loss of p53 function. Dysregulation leads to increased cellular proliferation and invasion and decreased cell-cell interaction and differentiation. Retinoids affect these pathways by various mechanisms, many involving retinoic acid receptors(RAR). RAR bind to all-trans-retinoic acid(ATRA) to induce the transcription of genes responsible for cellular differentiation. Although most research concerning the chemotherapeutic efficacy of retinoids focuses on the ability of ATRA to decrease cancer cell proliferation, increase differentiation, or promote apoptosis; as CRC progresses, RAR expression is often lost, rendering treatment of CRCs with ATRA ineffective. Our laboratory focuses on the ability of dietary vitamin A to decrease CRC cell proliferation and invasion via RAR-independent pathways. This review discusses our research and others concerning the ability of retinoids to ameliorate the defective signaling pathways listed above and decrease tumor cell proliferation and invasion through both RAR-dependent and RAR-independent mechanisms.

关键词： Colorectal cancer Retinoid Vitamin A β-catenin Pho

Leptospirosis: A clinical review of evidence based diagnosis, treatment and prevention

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World Journal of Clinical Infectious Diseases 2016年第4期6卷 61-66页

作者： Alison B lane michael M Dore Walter Reed National Military Medical Center Department of Medicine Naval Hospital Guam

Leptospirosis is a zoonotic disease with worldwide distribution and increasing prevalence. Infection is caused by the spirochete Leptospira, with common exposure being contaminated fresh water. Most infections are asymptomatic, but symptoms range from a mild, self-limiting, non-specific febrile illness to fulminant respiratory and renal failure with a high mortality rate. The combination of jaundice, renal failure, and hemorrhage is known as Weil's disease and is the most characteristic pattern associated with severe leptospirosis. Clinical suspicion alone may be enough to warrant empiric antibiotic treatment in many cases. Serological methods are the most commonly used means of confirming a diagnosis of leptospirosis. The "gold standard" is the microscopic agglutination test. Typical treatment for mild causes is oral doxycycline, though azithromycin and oral penicillins are reasonable alternatives. Intravenous penicillin G has long been the standard of care for severe cases though limited studies show no benefit compared to third generation cephalosporins. We review the clinical presentation, diagnosis, treatment and prevention of leptospirosis.

关键词： Leptospirosis Tropical diseases Infectious disease

From Democracy to Bureaucracy： The Baojia in Nationalist Thought and Practice, 1927-1949

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Frontiers of History in China 2013年第4期8卷 517-557页

作者： lane J. Harris History and Asian Studies Departments Furman University Greenville SC 29613 USA

In the 1939 New County Reforms, the Nationalist government made the baojia system the lowest level of self-government in the country. This decision was the result of more than ten years of discussion among Nationalist administrators and writers who were searching for a tutelary system to train the people in their political rights in preparation for constitutional rule. In the 1920s and 1930s, Nationalist writers claimed to be following Sun Zhongshan＇s （Sun Yat-sen） philosophy by reinventing the baojia as a form of democracy. Harkening back to a reimagined national past, they ＂discovered＂ that the imperial baojia was not a system of local control, but a traditional model of bureaucratically-designed local self-government. Nationalist writers dovetailed this new baojia with Sun Zhongshan＇s philosophy in order to rationalize its position as the foundation of the Three Principles of the People State. Once philosophically legitimized, Nationalist writers endorsed the baojia as a top-down bureaucratic system that would transform the political, social, and economic life of the country; it would become the core political unit of their state-making and nation-building projects. In so doing, the baojia came to represent the Nationalists＇ deeply-held belief in the power of human agency to create state institutions capable of entirely remaking society and transforming the nation.

关键词： baojia self-government bureaucracy state-making nation-building,Nationalist Party Sun Zhongshan

法庭植物学——植株、罪犯、害虫、毒物和盆盆罐罐

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世界科学 1991年第4期 46-49页

作者： Meredith a.lane Loran C.Anderson 何新华

植物材料的鉴定在解决犯罪案件中日渐重要世界上的绿色背景常常为人们视而不见和经见不怪,这是理所当然的了.在不声不息地吸收二氧化碳、放出氧气和提供食物的过程中,植物被过多地忽视了.然而,存在于作案罪犯的衣服或所有物上的植物碎... 详细信息

植物材料的鉴定在解决犯罪案件中日渐重要世界上的绿色背景常常为人们视而不见和经见不怪,这是理所当然的了.在不声不息地吸收二氧化碳、放出氧气和提供食物的过程中,植物被过多地忽视了.然而,存在于作案罪犯的衣服或所有物上的植物碎屑破片能够成为法庭见证.作为主要见证材料的植物也

关键词：植物学受害者植物学家植物种类大麻属有毒植物罪犯法庭审判庭植株

We Have No Art the Mutual Influence of Corita Kent's Pedagogy and Creative Practice

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We Have No Art the Mutual Influence of Corita Kent's Pedagog...

作者： BRITTANY CATHERINE lane 中国美术学院

学位级别：硕士

科里塔·肯特(1918-1986)是美国艺术家和教育家。现有的关于肯特的评论文献大多关注其作品在艺术史中的地位,或者她在罗马天主教圣母圣心修女会中的生活。肯特曾在修女会的附属文理学院任教32年,在此期间她也持续创作了大量的艺术作品... 详细信息

科里塔·肯特(1918-1986)是美国艺术家和教育家。现有的关于肯特的评论文献大多关注其作品在艺术史中的地位,或者她在罗马天主教圣母圣心修女会中的生活。肯特曾在修女会的附属文理学院任教32年,在此期间她也持续创作了大量的艺术作品。为了弥补研究上的空白,本文对肯特教育学所产生的背景、理论和实现方式进行了研究,研究发现这与她同一时期艺术作品的材料、创作过程和作品内容具有相关性。肯特的教学和艺术实践都致力于持续性的学习,这种学习在合作条件下更加推崇个人自主意识;直接的视觉感官刺激被用作培养创造力的关键工具。以上两种方式都与当代艺术和社会息息相关,而科里塔·肯特的教学方法和艺术创作则为此打开了一个入口。

关键词：科里塔·肯特教育丝网印刷创造力视觉艺术协作过程

Robotic surgery in pediatric urology

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Asian Journal of Urology 2017年第1期4卷 55-67页

作者： Adam Howe Zachary Kozel lane Palmer Steven and Alexandra Cohen Children’s Medical Center Ringgold Standard Institution e Pediatric Urology Center for Advanced Medicine Smith Institute for UrologyNew Hyde ParkNYUSA Long Island Jewish Medical Center Ringgold Standard Institution e Urology Center for Advanced Medicine Smith Institute for UrologyNew Hyde ParkNYUSA Steven and Alexandra Cohen Children’s Medical Center Ringgold Standard Institution e Pediatric Urology Pediatric Urology AssociatesNew Hyde ParkNYUSA

While robotic surgery has shown clear utility and advantages in the adult population,its role in pediatrics remains ***-sized robotic instruments and equipment are not readily available yet,so certain modifications can be made in order to make robotic surgery successful in *** the cost of robotic surgery remains high compared to open procedures,patients experience greater satisfaction and quality of life with robotic *** pyeloplasty is a standard of care in older children,and has even been performed in infants and re-do *** robotic procedures performed in children include heminephroureterectomy,ureteroureterostomy,ureteral reimplantation,urachal cyst excision,bladder diverticulectomy,and bladder reconstructive procedures such as augmentation,appendicovesicostomy,antegrade continence enema,bladder neck reconstruction and sling,as well as other *** surgery has also been used in oncologic cases such as partial nephrectomy and retroperitoneal lymph node *** improvements in technology with production of pediatric-sized robotic instruments,along with increases in robotictrained pediatric urologists and surgeon experience along each’s learning curve,will help to further advance the field of robotic surgery in pediatric urology.

关键词： Robotic Robotic-assisted Pediatric Children Urology

Electron microscopic observation and rotational diffusion measurement of bacteriorhodopsin in lipid vesicles

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Science China Chemistry 2001年第6期44卷 663-669页

作者：胡坤生王敖金 lane.G.Morrison RichardJ.Cherry 1. Institute of Biophysics Chinese Academy of Sciences 100101 Beijing China 2. Department of Biological Science University of Essex UK

The morphology of bacteriorhodopsin reconstituted into dimyristoylphosphatidylcholine and egg-phosphatidylcholine vesicles was observed by freeze-fracture electron microscopy. The rotational diffusion of bacteriorhodopsin at different concentrations of melittin was measured by observing flash-induced transient dichroism in dimyristoylphosphatidylcholine vesicles. In the presence of melittin, bacteriorhodopsin molecules in dimyristoylphosphatidylcholine vesicles were aggregated into large particles or patches, and the ability of rotational diffusion of bacteriorhodopsin in vesicles was decreased. This suggests that melittin produces its effect via direct electrostatic interaction with bacteriorhodopsin. Low temperature-induced aggregation of bacteriorhodopsin was also observed in dimyristoylphosphatidylcholine vesicles. Low temperature may cause phase separation. Bacteriorhodopsin was also successfully reconstituted into egg-phosphatidylcholine vesicles, but low temperature-induced aggregation of bacteriorhodopsin in dimyristoylphosphatidylcholine cannot appear in egg-phosphatidylcholine vesicles. This suggests that different lipids have different effects on bacteriorhodopsin in vesicles.

关键词： Bacteriorhodopsin Melittin electron microscopy rotational diffusion

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