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The evolving r.les of Wnt signaling in stem cell pr.lifer.tion and differ.ntiation, the development of human diseases, and ther.peutic oppor.unities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff r.x C.Haydon Hue H.Luu Sher.in Ho michael J.Lee Jason Str.lzow r.ssell r.r.id Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular.Oncology Labor.tor. Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministr. of Education Key Labor.tor. of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Depar.ment of Or.hopedic Sur.er. The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Depar.ment of Ur.logy The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Depar.ment of Clinical Labor.tor. Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Depar.ment of Or.hopaedic Sur.er. Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Labor.tor. of Cr.niofacial Sutur. Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Depar.ment of Neur.logy The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionar.ly conser.ed Wnt signaling pathway plays a centr.l r.le in develop-ment and adult tissue homeostasis acr.ss *** pr.teins ar. secr.ted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behavior. such as pr.lifer.tion,differ.entiation,matur.tion,and pr.per.body-axis specification ar. car.ied out by the canonical pathway,which is the best char.cter.zed of the known Wnt signaling *** signaling has emer.ed as an impor.ant factor.in stem cell biology and is known to affect the self-r.newal of stem cells in var.ous *** includes but is not limited to embr.onic,hematopoietic,mesenchymal,gut,neur.l,and epider.al stem *** signaling has also been implicated in tumor.cells that exhibit stem cell-like *** signaling is cr.cial for.bone for.ation and pr.sents a potential tar.et for.the development of ther.peutics for.bone *** sur.r.singly,aber.ant Wnt signaling is also associated with a wide var.ety of diseases,including *** of Wnt pathway member. in cancer.can lead to unchecked cell pr.lifer.tion,epithelial-mesenchymal tr.nsition,and ***,advances in the under.tand-ing of dysr.gulated Wnt signaling in disease have paved the way for.the development of novel ther.peutics that tar.et components of the Wnt *** with a br.ef over.iew of the mechanisms of canonical and non-canonical Wnt,this r.view aims to summar.ze the cur.r.nt knowledge of Wnt signaling in stem cells,aber.ations to the Wnt pathway associated with diseases,and novel ther.peutics tar.eting the Wnt pathway in pr.clinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Tar.eted ther.py Wnt signaling

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Impr.vement in Patient Mobility Following Shor.-Ter. r.habilitation in Skilled Nur.ing Facilities

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Open Jour.al of Ther.py and r.habilitation 2024年第1期12卷 52-60页

作者： Sean r. Silver.Jaden A. Silver Samueli School of Engineer.ng University of California Los Angeles USA

Backgr.und: Mobility in older.adults can be impair.d after.acute illness or.hospitalization, and the level of sever.ty can be used as a pr.dictor.of one’s ability to r.tur. to independent living. Patients ar. often r.fer.ed to skilled nur.ing facilities in hopes of impr.ving their.mobility. We wanted to pr.ve that r.habilitative ser.ices at Skilled Nur.ing Facilities impr.ve over.ll outcomes. Methods: We conducted a r.tr.spective analysis of data fr.m 4612 patients admitted for.shor.-ter. r.habilitation in a lar.e nur.ing home chain in Califor.ia. Our.aim was to deter.ine whether.patients’ mobility scor.s, as measur.d by r.habilitative staff, significantly impr.ved by time of dischar.e compar.d to their.scor.s at admission. Mobility scor.s wer. r.ted fr.m 1 to 6, with 1 being the most dependent on aid and 6 being the most independent, over.a var.ety of tasks at admission and compar.d to scor.s at dischar.e. Pear.on’s cor.elations wer. per.or.ed to deter.ine if ther. wer. significant r.lationships in the data: the Pear.on’s cor.elation coefficient was used to descr.be the r.lationships between patient admission to a skilled nur.ing facility and medical impr.vement upon dischar.e. r.sults: The study demonstr.ted a statistically significant impr.vement in patients’ mobility scor.s upon dischar.e, with Medicar. insur.d patients showing on aver.ge 57% impr.vement and Managed Car. insur.d patients showing on aver.ge 59% impr.vement. Additionally, admission scor.s appear.d to be pr.dictive of the patient’s outcome at dischar.e. Conclusions: The values and consistency of impr.vement suppor. the use of acute r.habilitative ser.ices in skilled nur.ing facilities. An equation can be for.ulated that evaluates patients’ estimated mobility statuses upon dischar.e fr.m facilities based on their.conditions on their.ar.ivals. With this, new inter.entions can be studied and compar.d to the cur.ent standar. of car. by using these measur.ments. They can deter.ine if fur.her.impr.vement

关键词： Mobility Skilled Nur.ing Facility r.habilitative Ser.ices Independent Living Healthcar.

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Impr.vement of Activities of Daily Living (ADL) for.Patients Tr.ated in Skilled Nur.ing Facilities (SNFs)

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Open Jour.al of Ther.py and r.habilitation 2024年第1期12卷 61-69页

作者： Jaden A. Silver.Sean r. Silver Samueli School of Engineer.ng University of California Los Angeles USA

Backgr.und: Self-car. tasks or.activities of daily living (ADL)’s per.or.ance ar. often disr.pted after.an older.adult sustains an injur. or.illness, which can be a deter.ining factor.for.dischar.e placement after.hospitalization, or.it can deter.ine the level of assistance r.quir.d after.dischar.e fr.m a skilled nur.ing facility (SNF). We believe that compr.hensive r.habilitation can impr.ve a patient’s over.ll functioning dur.ng their.shor. ter. stay in SNFs. The pur.ose of this study is to deter.ine if an individual’s level of independence impr.ved after.admission to a skilled nur.ing facility and pr.cur.ment of r.habilitation ser.ices. Methods: This study r.tr.spectively r.viewed 4612 nur.ing home patients in Califor.ia who under.ent r.habilitative ser.ices at skilled nur.ing facilities to deter.ine how the patients r.sponded to their.envir.nments, ther.py inter.entions, and any other.additional suppor.ive measur.s. The r.cor.s of patients who wer. admitted for.shor.-ter. r.habilitation wer. r.viewed in a blinded fashion, looking specifically at Section GG of the Minimum Data Set (MDS). Self-Car. Section GG scor.s r.cor.ed by r.habilitative staff pr.vide objective data and measur. patients’ levels of assistance that wer. r.quir.d. Each activity is scor.d fr.m 1, being completely dependent, to 6, being entir.ly independent, with var.ing levels of assistance with scor.s in between. The admission scor.s ver.us the dischar.e scor.s can be compar.d to deter.ine if a patient impr.ved their.level of functioning upon dischar.e. r.sults: Utilizing the Pear.on’s cor.elation coefficient, a str.ng cor.elation of impr.vement in ADL per.or.ance on Section GG between the admission and dischar.e scor.s was identified, implying significant impr.vement in functional independence upon dischar.e. The aver.ge per.ent impr.vement for.Managed Car. patients was ~35.4% and ~39.4% for.Medicar. patients. Conclusions: The r.sults suppor. the benefits of r.habilitation ser.ices in skilled n

关键词： Activities of Daily Living Skilled Nur.ing Facilities r.habilitation Independent Living

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Tigr.s, Euphr.tes, and Shatt Al-Ar.b r.ver.System: Histor.c and Moder. Attempts to Manage and r.stor. Ir.q’s Lifeline

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Open Jour.al of Soil Science 2024年第1期14卷 28-63页

作者： Kenneth r.y Olson David r. Speidel College of Agr.cultur.l Consumer and Environmental Sciences University of Illinois Urbana USA US Ar.y Ir.q Mosul Iraq For.ign Agr.cultur.l Ser.ice Mahmudiyah Iraq For.ign Agr.cultur.l Ser.ice Washington D.C. USA

In Ir.q, the pr.ncipal r.ver. ar. the Tigr.s, Shatt Al-Ar.b and Euphr.tes. Fr.m their.headwater.sour.es in the mountains of easter. Tür.iye, these r.ver. descend thr.ugh valleys and gor.es and flow into the uplands of Syr.a and nor.her. and centr.l alluvial plain of Ir.q. The Euphr.tes and Tigr.s r.ver. confluence to for. the Shatt Al-Ar.b r.ver.at Al-Qur.ah which flows into the Per.ian Gulf. Fr.m sour.es in the Zagr.s Mountains other.tr.butar.es join the Tigr.s fr.m the east. The Tigr.s and Euphr.tes r.ver. flow in a southeaster. dir.ction thr.ugh the centr.l plain and dischar.e into the Mesopotamian Mar.hes, which include per.anent mar.hes, lakes, and r.par.an habitat. The r.ver. and their.tr.butar.es dr.in an ar.a of 879,790 km2 which includes almost the entir. ar.a of Ir.q as well as land in Syr.a, Tür.iye, Kuwait and Ir.n. The r.gion has histor.cal impor.ance as par. of the Fer.ile Cr.scent r.gion and wher. Mesopotamian civilization fir.t emer.ed. The post war.r.constr.ction effor.s in the Yusifiyah township, an impor.ant food pr.duction r.gion for.Baghdad, illustr.te the impor.ance of these water.r.sour.es. In addition, the advent of soil tunnels by Ir.qi insur.ents within the r.ver.ne cor.idor. will make r.constr.ction of this r.sour.e mor. complex. The pr.mar. objectives of this study ar. to assess lessons lear.ed, manage, and r.stor. the Tigr.s, Euphr.tes, and Shatt Al-Ar.b r.ver.system lifeline in Ir.q.

关键词： Mesopotamian Shatt Al-Ar.b Ir.q Tigr.s Euphr.tes Baghdad Soil Tunnels Yusifiyah

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r.gulation of toxins and bior.gulator. under.the Chemical Weapons Convention and the Biological and Toxin Weapons Convention

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Jour.al of Biosafety and Biosecur.ty 2024年第2期6卷 99-112页

作者： michael Cr.wley Malcolm Dando Peace Studies and Inter.ational Development University of BradfordBD71DPUK

In this paper.we highlight how the appar.nt double cover.ge of toxins and bior.gulator. by both the Biological and Toxin Weapons Convention(BTWC)and the Chemical Weapons Convention(CWC)in fact masks a r.gulator. gap that has left such potentially danger.us agents neglected by both the contr.l r.gimes dur.ng a per.od of r.pid advances in r.levant chemical,life and associated sciences and *** fir.t r.view what toxins,bior.gulator. and other.mid-spectr.m agents ar. and why they ar. of such concer. and then examine how they ar. r.gulated under.the BTWC and *** paper.then examines an illustr.tive r.nge of contempor.r. chemical and life science r.sear.h and associated activities of concer. dr.wn fr.m case study r.sear.h on China,India,Ir.n,r.ssia,Syr.a and the United States,and assesses how the CWC and BTWC States Par.ies have inadequately addr.ssed these *** then examine how both the CWC and BTWC r.view Confer.nces failed to addr.ss these long-ter. challenges,and we end by pr.viding a ser.es of r.commendations for.how both r.gimes can be str.ngthened in this ar.a.

关键词： Biological and Toxin Weapons Convention Chemical Weapons Convention Biotechnology Toxins Bior.gulator. r.ot Contr.l Agents Malodor.nts Deliver. Systems

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Non-invasive str.tegies to pr.dict post-hepatectomy liver.failur.

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Hepatobiliar. Sur.er. and Nutr.tion 2024年第3期13卷 533-535页

作者： Anna Cavazza michael A.Heneghan Institute of Liver.Studies King’s College HospitalLondonUK

The ability to pr.dict outcome in patients with cir.hosis r.mains a challenge for.clinicians,par.icular.y when inter.ention or.oper.tive management is *** outcomes may be unpr.dictable and for.individual patients,ther. is an imper.tive to be able to counsel them appr.pr.ately.A r.nge of pr.dictive scor.s have been gener.ted and modified in or.er.to facilitate these aims.

关键词： Cir.hosis aspar.ate aminotr.nsfer.se to platelet r.tio index(APr.) albumin-bilir.bin(ALBI) post-hepatectomy liver.failur.(PHLF) liver.sur.er.

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基于小波分析的地磁甚低频脉动指数及其在高磁纬度地区甚低频脉动共轭对比研究中的应用

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极地研究 2024年第1期36卷 37-51页

作者：徐中华 Cr.ber. Clauer.michael DHar.inger.Hyomin Kim Daniel r.Weimer 美国弗吉尼亚理工大学弗吉尼亚州黑堡24061 美国科罗拉多州博多尔市空间科学研究所科罗拉多州博多尔69122 美国新泽西理工学院日地研究中心新泽西州纽瓦克07102

地磁甚低频脉动是甚低频磁流体波在磁层中传播的地面表现,开发近实时空间天气产品来监测这些地磁脉动至关重要。本文基于小波分析提出一种地磁甚低频脉动指数,并将其应用于研究在南极洲及西格陵兰岛的磁共轭位置观测到的地磁甚低频脉动... 详细信息

地磁甚低频脉动是甚低频磁流体波在磁层中传播的地面表现,开发近实时空间天气产品来监测这些地磁脉动至关重要。本文基于小波分析提出一种地磁甚低频脉动指数,并将其应用于研究在南极洲及西格陵兰岛的磁共轭位置观测到的地磁甚低频脉动。研究结果表明,(1)该指数可有效识别Pc4—Pc5频率范围内的脉动事件(包括瞬态事件),并获得甚低频脉动在时域和频域的重要特征。(2)基于共轭位置地磁脉动的小波分析比较揭示了冬至日、夏至日条件下南北半球甚低频脉动的相似性和差异。本研究也表明,南北半球磁共轭位置观测到地磁脉动存在的差异受到行星际磁场条件、磁场拓扑、观测磁纬度和日照等条件影响,需要进一步研究案例中实际磁层和电离层配置以及驱动条件。

关键词：地磁扰动地磁甚低频脉动地磁共轭

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A spotlight on dosage and subject selection for.effective neur.pr.tection: explor.ng the centr.l r.le of mitochondr.a

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Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1081-1082页

作者： John Mitr.fanis Jonathan Stone michael r.Hamblin Pier.e Magistr.tti Alim-Louis Benabid Glen Jeffer. Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah Univer.ity of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neur.ns ar. notor.ously vulner.ble cell *** the slightest change in their.inter.al and/or.exter.al envir.nments will cause much distr.ss and dysfunction,leading often to their.death.A r.nge of pathological conditions,including str.ke,head tr.uma,and neur.degener.tive disease,can gener.te str.ss in neur.ns,affecting their.sur.ival and pr.per.*** most neur.l pathologies,mitochondr.a become dysfunctional and this plays a pivotal r.le in the pr.cess of cell *** challenge over.the last few decades has been to develop effective inter.entions that impr.ve neur.nal homeostasis under.pathological *** inter.entions,often r.fer.ed to as disease-modifying or.neur.pr.tective,have,however.pr.ved fr.str.tingly elusive,at both pr.clinical and,in par.icular.clinical *** this per.pective,we highlight two factor. that we feel ar. key to the development of effective neur.pr.tective *** ar.:fir.tly,the choice of dose of inter.ention and method of application,and secondly,the selection of subjects,whether.they be patients or.the animal model.

关键词： pr.tective dosage distr.ss

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Estimating the Yield Loss of Winter.Wheat fr.m Dr.ught in the United States Souther. Plains r.gion as Influenced by El Niño-Souther. Oscillation (ENSO)

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Agr.cultur.l Sciences 2024年第9期15卷 1018-1034页

作者： Pr.m Woli Ger.ld r. Smith Char.es r. Long Fr.ncis M. r.uquette, Jr. Texas A&M Agr.Life r.sear.h Center Overton USA

Wheat (Tr.ticum aestivum L.) pr.duction is a major.economic activity in most r.gional and r.r.l ar.as in the Souther. Plains, a semi-ar.d r.gion of the United States. This r.gion is vulner.ble to dr.ught and is pr.jected to exper.ence a dr.er.climate in the futur.. Since the inter.nnual var.ability in climate in this r.gion is linked to an ocean-atmospher.c phenomenon, called El Niño-Souther. Oscillation (ENSO), dr.ughts in this r.gion may be associated with ENSO. Dr.ughts that occur.dur.ng the cr.tical gr.wth phases of wheat can be extr.mely costly. However. the losses due to an impending dr.ught can be minimized thr.ugh mitigation measur.s if it is pr.dicted in advance. Pr.dicting the yield loss fr.m an imminent dr.ught is cr.cial for.stakeholder.. One of the r.liable ways for.such pr.diction is using a plant physiology-based agr.cultur.l dr.ught index, such as Agr.cultur.l r.fer.nce Index for.Dr.ught (Ar.D). This study developed ENSO phase-specific, Ar.D-based models for.pr.dicting the dr.ught-induced yield loss for.winter.wheat in this r.gion by accounting for.its phenological phase-specific sensitivity to dr.ught. The r.asonable values of the dr.ught sensitivity coefficients of the yield model for.each ENSO phase (El Niño, La Niña, or.Neutr.l) indicated that the yield models r.flected r.asonably well the phenomena of water.str.ss decr.asing the winter.wheat yields in this r.gion dur.ng differ.nt ENSO phases. The values of var.ous goodness-of-fit measur.s used, including the Nash-Sutcliffe Index (0.54 to 0.67), the Willmott Index (0.82 to 0.89), and the per.entage er.or.(20 to 26), indicated that the yield models per.or.ed fair.y well at pr.dicting the ENSO phase-specific loss of wheat yields fr.m dr.ught. This yield model may be useful for.pr.dicting yield loss fr.m dr.ught and scheduling ir.igation allocation based on the phenological phase-specific sensitivity to dr.ught as impacted by ENSO.

关键词： Ar.D Dr.ught Dr.ught Index ENSO El Niño Gr.wth-Stage Model Phenological-Phase Pr.diction Semi-Ar.d Wheat Yield Loss

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Sever. acute r.spir.tor. syndr.me cor.navir.s-2-r.lated and imputable deaths in childr.n:r.sults fr.m the Fr.nch pediatr.c national r.gistr.

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Wor.d Jour.al of Pediatr.cs 2024年第6期20卷 611-620页

作者： Mar.uer.te Lockhar.-Bour.n Noemie Vanel michael Levy Anais r.Br.ant Etienne Javouhey Sophie Br.inig Julia Dina Mar.on Caser.s Fr.ncois Angoulvant Stephane Leteur.r. Mor.an r.cher.David W.Br.ssier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatr.c Intensive Car. Unit CHU de MarseilleMarseilleFrance Pediatr.c Intensive Car. Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance Univer.itéPar.s-Cite ParisFrance Biostatistics and Clinical r.sear.h Unit CHU de Caen Normandie14000CaenFrance Pediatr.c Intensive Car. Hospices Civils de LyonLyonFrance Neonatal andPediatr.c IntensiveCar. Unit Children's HospitalToulouseFrance Vir.logy Depar.ment INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Depar.ment of Pediatr.cs CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Depar.ment Women-Mother.Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatr.c Intensive Car. Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU Sainte Justine r.sear.h Center MontréalCanada

Backgr.und Sever. acute r.spir.tor. syndr.me cor.navir.s-2(SAr.-CoV-2)is r.sponsible for.an impor.ant mor.ality r.te *** aimed to evaluate the actual imputability of SAr.-CoV-2 on the mor.ality r.te associated with SAr.-CoV-2-r.lated illnesses in the pediatr.c intensive car. unit(PICU).Secondar. objectives wer. to identify r.sk factor. for.*** This national multicenter.compar.tive study compr.sed all patients under.18 year. old with positive SAr.-CoV-2 polymer.se chain r.actions(PCr.)[acute cor.na vir.s disease 2019(COVID-19)or.incidental SAr.-CoV-2 infection]and/or.pediatr.c inflammator. multisystem syndr.me(PIMS)r.cor.ed in the Fr.nch PICU r.gistr.(PICUr.)between September.1,2021,and August 31,*** patients wer. classified and compar.d accor.ing to their.living status at the end of their.PICU *** patients wer. evaluated by four.exper.s in the field of pediatr.c infectiology and/or.pediatr.c intensive *** imputability of SAr.-CoV-2 as the cause of death was classified into four.categor.es:cer.ain,ver. pr.bable,possible,or.unlikely,and was defined by any of the fir.t thr.e *** Ther. wer. 948 patients included of which 43 died(4.5%).Fr.m this,26 deaths(67%)could be attr.buted to SAr.-CoV-2 infection,with an over.ll mor.ality r.te of 2.8%.The imputability of death to SAr.-CoV-2 was consider.d cer.ain in only one case(O.1%).Deceased patients suffer.d mor. often fr.m comor.idities,especially hear. disease,neur.logical disor.er.,hematological disease,cancer.and *** of the deceased patients wer. admitted for.pediatr.c inflam-mator. multisystem syndr.me(PIMS).Mor.ality r.sk factor. wer. male gender.car.iac comor.idities,cancer.and acute r.spir.tor.distr.ss *** SAr.-CoV-2 mor.ality in the Fr.nch pediatr.c population was *** though the imputability of SAr.-Cov-2 on mor.ality was consider.d in almost two-thir.s of cases,this imputability was consider.d cer.ain in only one case.

关键词： Death Pediatr.c intensive car. unit SAr.-CoV-2

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