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Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum

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Genes & Diseases 2024年第1期11卷 53-56页

作者： ye Cheng lei Zhang Xiaolong Wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu Xinru Xiao Jie Bai Yaming Wang Zeliang Hu leiming Wang Qingtang lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical ***,the molecular landscape underlying this difference remains *** analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and *** of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

装配式X形钢板活塞阻尼器受力性能试验及应用研究

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建筑结构学报 2024年第8期45卷 205-215页

作者：周方圆胡宇博叶昆吕云辉华中科技大学土木与水利工程学院湖北武汉430074

为了克服传统弯曲型、剪切型金属阻尼器无法在肘节式等位移放大装置安装使用的现状,提出一种基于X形钢板屈服耗能的装配式活塞阻尼器(X-shaped piston metal damper,XPMD),其由一组平行的金属环片(X形钢板为主要耗能元件)、内部传动杆... 详细信息

为了克服传统弯曲型、剪切型金属阻尼器无法在肘节式等位移放大装置安装使用的现状,提出一种基于X形钢板屈服耗能的装配式活塞阻尼器(X-shaped piston metal damper,XPMD),其由一组平行的金属环片(X形钢板为主要耗能元件)、内部传动杆及外部套筒共同组成。具有耗能功效的金属环片通过高强螺栓与内部传动杆及外部套筒相互连接,具有较好的装配性及易于更换的特点。通过试验系统研究了X形钢板端头宽度、缩颈宽度、纵向长度及厚度等参数对XPMD阻尼器滞回性能的影响规律,同时提出了XPMD阻尼器的理论力学评估模型。以多层框架为例,对比分析了在地震作用下安装XPMD阻尼器前后其位移响应、层间剪力的变化特点,验证了XPMD阻尼器对框架结构的减震效果。研究结果表明:在循环荷载作用下XPMD阻尼器具有稳定的滞回性能,在较小变形下地震输入能量主要通过X形钢板弯曲变形实现能量耗散,在较大变形条件下X形钢板拉伸变形逐渐增大使得XPMD阻尼器等效刚度有所增加;安装XPMD阻尼器可明显降低框架结构在地震作用下的位移及层间剪力响应。

关键词：活塞阻尼器装配式 X形钢板消能减震滞回曲线

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Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan linhan ye Qiaolin li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

Simulations of electron zebra stripes in the inner radiation belt using a composite empirical electric field model

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Science China Earth Sciences 2024年

作者： Ziyang WANG Ying lIU Qiugang ZONG Hong ZOU Yuguang ye Xuzhi ZHOU Chao YUE Shan WANG Institute of Space Physics and Applied Technology Peking University State Key laboratory of lunar and Planetary Science Macau University of Science and Technology

The phenomenon termed “zebra stripes” manifests as regular patterns in the energy-space(l shell) spectrum of energetic electrons(ranging from tens to hundreds keV) within the inner radiation belt. These structures exhibit drift-periodic behavior and commonly arise from large-scale electric field perturbations near the substorm onsets. In this study, we introduce a composite electric field model and replicate the formation, structure, and evolution of zebra stripes using a bounce-averaged test particle code under this electric field model. High-resolution measurements of energetic electrons obtained from the Van Allen Probes and the recently launched Macao Science Satellites-1 are used as initial conditions and served to validate our test particle simulations. Comparative analyses between observed data and simulations demonstrate our test particle method's efficacy in capturing zebra stripes' general behavior. Moreover, the composite model proves capable of reproducing realistic variations in the electric field within the inner radiation belt to a certain extent. Nevertheless, subtle differences emerge in the flux strength and the positions of stripes. These disparities primarily stem from limitations inherent in the electric field model and the initial conditions of the simulation. Acknowledging that the model represents an average case, it is conceivable that real-world scenarios may deviate from the average, thereby introducing variations in the observed phenomena.

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Role of the Alleviating Aβ Toxicity in the Anti-AD Effect of Brown Wolfberry

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Food Science and Human Wellness 2024年

作者： Miaosi Zhang Rui liu Ran Yang Jilite Wang Xiaozhi liu Baorui li ye Zhang Hao Wang State Key laboratory of Food Nutrition and Safety Tianjin University of Science and Technology (TUST) Department of Agriculture Hetao College Tianjin Key laboratory of Epigenetic for Organ Development of Preterm Infants Tianjin Fifth Central Hospital High Altitude Characteristic Medical Research Institute Huangnan Tibetan Autonomous Prefecture People's Hospital Institute of Food & Nutrition Science and Technology Shandong Academy of Agricultural Sciences/Key laboratory of Agro-Products Processing Technology of Shandong Province/Key laboratory of Novel Food Resources Processing Ministry of Agriculture and Rural Affairs/Shandong Engineering Research Center of Food for Special Medical Purpose

Wolfberry (lycium barbarum l.) is a medicinal herb with anti-aging and neuroprotective effects. The purpose of this study was to explore the enhanced neuroprotective effects of wolfberry water extract (RW)， and brown wolfberry water extract (BBW). The reduced percentage of reducing sugar in BBW was shown to be 62.8%， 64.3%， 39.8%， and 11.6% for glucose， fructose， maltose， and lactose compared to those of RW， as well as free amino acids. And the contents of total phenols and total flavonoids were increased by 62.0% and 33.1%. Melanoidins (1% ± 0.05%) were first isolated from BBW. RW and BBW increased anti-stress abilities (oxidative stress: 24.2% vs 35.7%， and heat stress: 10.9% vs 19.1%) while decreasing the ROS levels in vivo. RW and BBW reduced the rate of paralysis and odor cognitive deficits. At the same time， RW and BBW reduced the number of fluorescent spots of Aβ::GFP. The RW and BBW activated autophagy by upregulating the gene levels (bec-1， lgg-1， lgg-2， unc-51， vps-34， atg-5， atg-18， and sqst-1). Additionally， BBW promoted the nuclear-cytoplasmic ratio of DAF-16::GFP and fluorescence intensity of SOD-3::GFP by 39.4 fold and 1.16 fold. This study laid a new insight for exploring the Maillard reaction in improving the anti-AD activity of wolfberry.

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UWlPIPE: Ultra-wide Bandwidth low-frequency Pulsar Data Processing Pipeline

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Research in Astronomy and Astrophysics 2024年第7期24卷 148-160页

作者： Ya-Zhou Zhang Hai-long Zhang Jie Wang Jian li Xin-Chen ye Shuang-Qiang Wang Xu Du Han Wu Ting Zhang Shao-Cong Guo Xinjiang Astronomical Observatory Chinese Academy of Sciences University of Chinese Academy of Sciences Key laboratory of Radio Astronomy Chinese Academy of Sciences National Astronomical Data Center Southeast University

For real-time processing of ultra-wide bandwidth low-frequency pulsar baseband data, we designed and implemented an ultra-wide bandwidth low-frequency pulsar data processing pipeline(UWlPIPE) based on the shared ringbuffer and GPU parallel technology. UWlPIPE runs on the GPU cluster and can simultaneously receive multiple 128 MHz dual-polarization VDIF data packets preprocessed by the front-end FPGA. After aligning the dual-polarization data, multiple 128M subband data are packaged into PSRDADA baseband data or multi-channel coherent dispersion filterbank data, and multiple subband filterbank data can be spliced into wideband data after time alignment. We used the Nanshan 26 m radio telescope with the l-band receiver at964 ～ 1732 MHz to observe multiple pulsars. Finally, we processed the data using DSPSR software, and the results showed that each subband could correctly fold out the pulse profile, and the wideband pulse profile accumulated by multiple subbands could be correctly aligned.

关键词： (stars:) pulsars: general methods: data analysis techniques: miscellaneous

Intervention effect of Cigu Xiaozhi prescription(慈菇消脂方)on ceramide lipoapoptosis in non-alcoholic fatty liver disease

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Journal of Traditional Chinese Medicine 2024年第1期44卷 63-69页

作者： YANG Shaojun MA Yanhua BAI Zhouxia YU ye FANG Buwu ZHANG li WANG li Department of Spleen and Stomach Diseases Beihai Traditional Chinese Medicine hospitalBeihai 536000China the First Clinical Medical College of Gansu University of Traditional Chinese Medicine Lanzhou 730000China Department of Clinical laboratory Affiliated Hospital of Gansu University of Traditional Chinese MedicineLanzhou 730000China Department of Pharmacology School of Basic MedicineTianjin Medical UniversityTianjin 300070China

OBJECTIVE:To explore the mechanism of the Chinese medicine Cigu Xiaozhi prescription(慈菇消脂方,CGXZ)in the treatment of the non-alcoholic fatty liver disease(NAFlD)by detoxification and phlegm-reducing,the effect of CGXZ prescription on ceramide-mediated lipid apoptosis in Hep G2 cells with ***:The experiment was randomly divided into 6groups:normal control group,model group,CGXZ prescription medicated serum high,medium,and low dose groups,and pioglitazone positive control *** 500μmol/l free fatty acid(FFA)mixture to induce Hep G2 cells to establish NAFlD cell model,respectively,with 2%,4%,and 6%concentration of CGXZ prescription medicated serum intervention for 24 *** changes in organelles and lipid droplet accumulation were observed under the electron ***,Td T-mediated d UTP Nick-End labeling method was used to assay hepatocyte apoptosis;Biochemical determination of glutamic-pyruvic transaminase,glutamic oxalacetic transaminase,triglycerides,and FFA levels in Hep G2cells;the content of ceramide was determined by highperformance thin-layer ***,Western Blot and quantitative real-time polymerase chain reaction(q RT-PCR)were used to determine the protein and gene expression levels,such as inducible nitric oxide synthase(i NOS),nuclear factorκB(NF-κB),B cell lymphoma 2(Bcl-2)and Bcl-2-associated X(Bax).RESUlTS:Under the electron microscope,the cells in the model group showed moderate-to-severe steatosis,and apoptotic bodies could be *** model group had greater improvements in the apoptosis rate(Plevels of ceramide C2 and FFA in the cytoplasm(Pl control *** protein expressions of NF-κB,i NOS,and Bax were significantly up-regulated(Ple the Bcl-2 had no significant change(P>0.05).Compared with the model group,the levels of ceramide C2 and FFA(Plitazone pos

关键词： non-alcoholic fatty liver disease ceramides Cigu Xiaozhi prescription detoxification and phlegm removal

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lDACS系统基于循环谱和残差神经网络的频谱感知方法

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系统工程与电子技术 2024年第9期46卷 3231-3238页

作者：王磊张劲叶秋炫中国民航大学民航航班广域监视与安全管控技术重点实验室天津300300

针对l波段数字航空通信系统(l-band digital aeronautic communication system,lDACS)可用频谱资源有限且易受大功率测距仪(distance measuring equipment,DME)信号干扰的问题,提出一种基于降维循环谱和残差神经网络的频谱感知方法。首... 详细信息

针对l波段数字航空通信系统(l-band digital aeronautic communication system,lDACS)可用频谱资源有限且易受大功率测距仪(distance measuring equipment,DME)信号干扰的问题,提出一种基于降维循环谱和残差神经网络的频谱感知方法。首先理论推导分析了DME信号的循环谱特征;然后利用Fisher判别率(Fisher discriminant rate,FDR)提取循环频率能量最大的向量,通过主成分分析(principal component analysis,PCA)进行预处理特征增强;最后给出数据处理后的循环谱向量与卷积神经网络相结合的实现过程,实现了DME信号的有效检测。仿真结果表明,该方法对噪声不敏感,当信噪比不低于-15 dB时,平均检测概率大于90%。当信噪比不低于-14 dB,检测概率接近100%。

关键词： l波段数字航空通信系统测距仪频谱感知循环谱残差神经网络

食用油脂热烹饪油烟组分特征、健康风险及其影响因素的研究进展

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食品科学 2024年第12期45卷 324-339页

作者：叶展罗舒凡吕亚萍熊远夷刘元法江南大学食品学院食品科学与资源挖掘全国重点实验室江苏无锡214122

热烹饪是中式烹饪中食用油最主要的应用场景之一。食用油在加热烹饪过程中产生的烹饪油烟,是由多种有机物和固体颗粒物等组成的复杂固液气成分,对室内空气和人体健康产生不良影响。本文首先综述了食用油脂烹饪油烟中两大类主要危害物,... 详细信息

热烹饪是中式烹饪中食用油最主要的应用场景之一。食用油在加热烹饪过程中产生的烹饪油烟,是由多种有机物和固体颗粒物等组成的复杂固液气成分,对室内空气和人体健康产生不良影响。本文首先综述了食用油脂烹饪油烟中两大类主要危害物,即颗粒物和挥发性气体成分的组分特征,及其在油脂热烹饪过程中的排放情况,并进一步总结了热烹饪油烟暴露程度对人群呼吸系统疾病和其他健康风险的影响;其次,从热烹饪方式、烹饪食材种类和食用油品质和基本性质的角度,探讨了食用油热烹饪油烟的主要影响因素;最后,对基于食用油热烹饪油烟气组分特征优化油脂加工技术,开拓未来油脂加工新工艺、新材料、新途径,实现食用油脂精准适度加工和绿色低耗加工,制造高品质营养健康中式烹饪食用油进行了展望。本文将为未来油脂科技发展提供一定参考,对于提升我国食用油营养品质和食用安全性,助力实现“健康中国”和“双碳”战略目标可能具有一定的指导意义。

关键词：食用油烹饪油烟油脂品质健康风险未来油脂绿色加工技术

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