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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA j.mes l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain inj.ry(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Conservation laws for energy and momentum in curved spaces

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j.urnal of Zhej.ang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 665-668页

作者： lóPEZ-BONIllA j. MORAlES j. OVANDO G. Section of Postgraduate Studies and Research Superior School of Mechanical and Electrical EngineeringNational Polytechnic InstituteCP 07738Mexico Division of Basic Sciences and Engineering Autonomous Metropolitan UniversityCP 02200Mexico

In arbitrary Riemannian 4-spaces, continuity equations are constructed which could be interpreted as conservation laws for the energy and momentum of the gravitational field. Special attention is given to general relativity to obtain, of natural manner, the pseudotensors of Einstein, landau-lifshitz, Moeller, Goldberg and Stachel, and also the conservation equations of Komar, Trautman, DuPlessis and Moss.

关键词： Noether theorem lagrangians in curved spaces Energy and momentum in Riemannian spaces Rund-lovelock identities

Development and application of functional gene arrays for microbial community analysis

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中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： Z. l. HE j. D. VAN NOSTRAND l.Y. WU j. Z. ZHOU Institute for Environmental Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microarray 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音，例如 oligonucleotide 探查设计， nucleic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

Microstructural Development and Deformation Mechanisms during Cold Rolling of a Medium Stacking Fault Energy TWIP Steel

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j.urnal of Materials Science & Technology 2013年第2期29卷 161-167页

作者： K.A. Ofei l. Zhao j. Sietsma Materials Innovation Institute M2i Mekelweg 2 2628 CD Delft The Netherlands Department of Materials Science and Engineering Delft University of Technology Mekelweg 2 2628 CD Delft The Netherlands

The magnetic response, microstructural and texture changes occurring during cold rolling of a Fe-14Mn-0.64C-2.4AI-0.25Si medium stacking fault energy TWlP （twinning induced plasticity） steel have been studied by X-ray diffraction and magnetic techniques. The changes in the sub-grain size （Ds）, probability of stacking fault formation （Psf） and microstrain in the material as cold rolling progressed were determined by using a modified version of the Williamson and Hall equation. A strong development of the crystallographic texture with increasing deformation was observed. Deformation-induced formation of a small fraction α＇-martensite was observed, indicating that the steel also exhibits γ→α＇-martensite transformation during cold rolling, which is discussed via the changes of the stacking-fault probability and the texture development during cold rolling.

关键词： TWIP steel α'-Martensite Sub-grain size Probability of stacking fault formation Texture development

Farm buildings and agri-food transitions in Southern France:Mapping dynamics using a stakeholder-based diagnosis

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Geography and Sustainability 2024年第1期5卷 108-120页

作者： Orlane Rouquier Coline Perrin micha.l Pouzenc Valérie Olivier-Salvagnac UMR 5193 lISST(laboratoire Interdisciplinaire Solidarités SociétésTerritoires)Univ Toulouse-Jean JaurèsCNRSEHESSENSFEAINU ChampollionToulouseFrance UMR 0951 INNOVATION Univ MontpellierCIRADINRAEInstitut AgroMontpellierFrance UMR TlSE INP-INRAE 1248 AGIR(AGroécologie InnovationsTeRritoires)ToulouseFrance

This study's goal is to present a dynamic portrait of the farm-buildings environment in Occitania,in Southern France,in order to better identify the transitions underway in agri-food *** this end,we undertook a ter-ritorial diagnosis based on actor statements,using 28 semi-structured interviews across *** diagnosis was enriched by graphic modelling,which enabled the spatialization of the dynamics *** show that the process of standardisation of farm buildings prevails in the maj.rity of the territories *** phenomenon has intensified in recent years with the development of vast photovoltaic-roofed sheds,accentuating the farm-land conversion and soil *** the same time,in areas with strong environmental,landscape and heritage contexts,a'new adventure in farm buildings'(2022 survey)is taking *** is primarily driven by local short food chains,which rely on self-construction,repurposing and refurbishment,the sharing of tools and equipment,and which favour the use and reuse of local *** study shows that farm-buildings dynamics crystallise many challenges confronting the reterritorialisation of agriculture and food production.

关键词： Farm buildings Transition local food systems Occitania Cartographic modelling

An ensemble method for gene discovery based on DNA microarray data

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Science China(life Sciences) 2004年第5期47卷 396-405页

作者： Kathy l. MOSER Eric j. TOPOl Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technology has offered the promise of casting new insights onto deciphering secrets of life by monitoring activities of thousands of genes simulta-neously. Current analyses of microarray data focus on precise classification of biological types, for example, tumor versus normal tissues. A further scientific challenging task is to extract dis-ease-relevant genes from the bewildering amounts of raw data, which is one of the most critical themes in the post-genomic era, but it is generally ignored due to lack of an efficient approach. In this paper, we present a novel ensemble method for gene extraction that can be tailored to fulfill multiple biological tasks including (i) precise classification of biological types; (ii) disease gene mining; and (iii) target-driven gene networking. We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensemble decision,recursive partition tree,feature gene selection.

NUMERICAl SIMUlATION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl j.T

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： Carl l. Gardner Steven j. Dwyer School of Mathematical and Statistical Sciences Arizona State University Tempe AZ 85287 USA

Computational gas dynamical simulations using the WENO-lF method are applied to modeling the high Mach number astrophysical j.t XZ Tauri, including the effects of radiative cooling. Mach 55 simulations of the pulsed proto-j.t are presented and analyzed in terms of interacting nonlinear waves： terminal Mach disks, bow shocks, and Meshkov-Richtmyer instabilities of the leading j.t contact boundary.

关键词： astrophysical j.ts ENO. method gas dynamics

The effect of bacterial challenge on ferritin regulation in the yellow fever mosquito, Aedes aegypti

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Insect Science 2013年第5期20卷 601-619页

作者： Dawn l. Geiser Guoli Zhou j.nathan j. Mayo j.y j. Winzerling Department of Nutritional Sciences College of Agriculture and Life Sciences the University of Arizona Tucson Arizona 85721 USA

Secreted ferritin is the maj.r iron storage and transport protein in insects. Here, we characterize the message and protein expression profiles of yellow fever mosquito （Aedes aegypti） ferritin heavy chain homologue （HCH） and light chain homologue （lCH） subunits in response to iron and bacterial challenge. In vivo experiments demonstrated tissue-specific regulation of HCH and lCH expression over time post-blood meal （PBM）. Transcriptional regulation of HCH and lCH was treatment specific, with differences in regulation for na？ve versus mosquitoes challenged with heat-killed bacteria （HKB）. Translational regulation by iron regulatory protein （IRP） binding activity for the iron-responsive element （IRE） was tissue-specific and time-dependent PBM. However, mosquitoes challenged with HKB showed little change in IRP/IRE binding activity compared to na？ve animals. The changes in ferritin regulation and expression in vivo were confirmed with in vitro studies. We challenged mosquitoes with HKB followed by a blood meal to determine the effects on ferritin expression, and demonstrate a synergistic, time-dependent regulation of expression for HCH and lCH.

关键词： Aedes aegypti bacteria ferritin iron IRP mosquito