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On determining the weight of edges in map-representing graphs-applications of heuristic methods in planning escape routes

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 1027-1043页

作者： Marta Borowska-Stefańska michałKowalski Filip Turoboś Szymon Wiśniewski Institute of the Built Environment and Spatial Policy Faculty of Geographical SciencesUniversity of LodzŁódź90–137Poland Institute of Mathematics Lodz University of TechnologyŁódź90–924Poland

In the paper we discuss and compare two commonly used methods of finding the shortest paths in networks,namely Dijkstra’s and A**** compare their effectiveness in terms of traversing road network in circumstances that require swift decision making in the event of dynamically changing road conditions on the basis of studies conducted for evacuation *** build a proper model of such a network,a method of appropriate edge-weighting is introduced,based on empirical data collected by other ***,we use the basics of the theory of quasimetric spaces to introduce a heuristic to such graphs,which is easy to calculate *** heuristic we obtain is both admissible and consistent,which allows us to use it efficiently in A*search *** developed application can be used in studies into evacuation from hazardous *** this case,optimum calculative efficiency is achievable with a simultaneous reduction of calculation time(when compared to Dijkstra’s algorithm).Our application can be applied during the first stage,i.e.,prior to the occurrence of a disaster,since this is an appropriate time for preparation by planning,drilling,early warning,and designating the rescue services that are to participate in the following stages.

关键词： A*algorithm Dijkstra Heuristic methods Mathematical modelling Quasimetric spaces Planning escape routes

Direct, remote and combined ischemic conditioning in liver surgery

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World Journal of Hepatology 2021年第5期13卷 533-542页

作者： Rafał Stankiewicz michał Grąt Department of General Transplant and Liver SurgeryMedical University of WarsawWarsaw 02-097Poland

Liver ischemia-reperfusion injury is a major cause of postoperative liver dysfunction,morbidity and mortality following liver resection and *** conditioning has been shown to ameliorate ischemiareperfusion injury in small animal *** can be applied directly or remotely when cycles of ischemia and reperfusion are applied to a distant site or *** timing of the procedure,different protocols are *** preconditioning refers to that performed before the duration of ischemia of the target *** perconditioning is performed over the duration of ischemia of the target *** postconditioning applies brief episodes of ischemia at the onset of reperfusion following a prolonged *** studies pointed towards suppressing cytokine release,enhancing the production of hepatoprotective adenosine and reducing liver apoptotic response as the potential mechanisms responsible for the protective effect of direct tissue *** between neural,humoral and systemic pathways all lead to the protective effect of remote ischemic *** promising animal studies,none of the aforementioned protocols proved to be clinically effective in liver surgery with the exception of morbidity reduction in cirrhotic patients undergoing liver *** human clinical trials with application of novel conditioning protocols and combination of methods are warranted before implementation of ischemic conditioning in day-to-day clinical practice.

关键词： Ischemic preconditioning Ischemia-reperfusion injury Hepatectomy Liver transplant Morbidity Mortality

The impact of frailty on in-hospital complications in elderly patients with acute coronary syndrome

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Journal of Geriatric Cardiology 2023年第3期20卷 174-184页

作者： Wojciech Nowak Ilona Kowalik michał Nowicki Tomasz Cichocki Janina Stępińska Department of Intensive Cardiac Therapy National Institute of CardiologyWarsawPoland Clinical Research Support Center National Institute of CardiologyWarsawPoland Department of Coronary Artery Disease and Cardiac Rehabilitation National Institute of CardiologyWarsawPoland

BACKGROUND Acute coronary syndrome(ACS)is linked to a range of in-hospital complications,and age is recognized as risk factor for adverse *** between physiological and chronological age are explained by ***,the relationship between frailty and in-hospital complications is not *** Assessment of frailty in patients was carried out using the FRAIL ***-hospital complications assessed included,bleeding,infection,arrhythmia,acute kidney injury(AKI),delirium,stroke/transient ischemic attack(TIA),liver injury,hypoglycemia,length of stay in the cardiac care unit(CCU).RESULTS Of the 174 patients,frailty was identified in 39.1%and pre-frailty in 29.9%.Frailty was associated with a higher incidence of all types of bleeding(frail ***:45.5%vs.16.7%,P3 days)(OR:3.7[1.9-7.3]).CONCLUSIONS Frailty was associated with an increased risk of numerous in-hospital complications in elderly patients who had been

关键词： patients complications coronary

Nitrogen and Carbon Isotope Data of Olenekian to Anisian Deposits from Kamenushka/South Primorye, Far-Eastern Russia and Their Palaeoenvironmental Significance

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Journal of Earth Science 2018年第4期29卷 837-853页

作者： Yuri D Zakharov micha Horacek Alexander M Popov Liana G Bondarenko Far Eastern Geological Institute of Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia BLT Wieselburg Research Center HBLFA Francisco-Josephinum Wieselburg 3250 Austria Institute of Lithospheric Research Vienna University Vienna 1090 Austria

The Kamenushka Formation, exposed in the northern part of South Primorye （Kamennshka-1 and Kamenushka-2 sections）, is one of the few localities in the world with richly fossiliferous Lower-Upper Olenekian sedimentary successions. Lower to Middle Triassic ammonoid-, brachiopod- and conodont-bearing silty-clayey deposits of the Kamenushka-1 and Kamenushka-2 sections have been isotope-geochemically investigated in detail. As a result, these sections, together with the previously investigated Abrek Section, exposed in the southern part of South Primorye, provide almost complete ^15Non- and ^13Corg- records for the Lower Triassic of this region. Nine N- isotope intervals and the five negative C-isotope excursions, reflecting, apparently, unstable climatic and hydrological conditions, have been distinguished in the Lower Triassic of South Primorye. On the basis of the new C-isotope data the Mesohedenstroemia bosphorensis Zone （upper part）, Shimanskyites shimanskyi and Neocolumbites insignis zones of South Primorye are correlated now with the Lower Smithian part of the Yinkeng Formation, the Upper Smithian part of the Helongshan Formation and the Middle Spathian part of the Nanlinghu Formation in South China, respectively, as has been observed in the Abrek, Kamenushka-2, West Pingdingshan and Majiashan sections.

关键词： Triassic N- and C-isotopes palaeoclimatology bio- and chemostratigraphy Pri- morye Russia.

Oxidative stress factors in Parkinson's disease

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Neural Regeneration Research 2021年第7期16卷 1383-1391页

作者： Jolanta Dorszewska Marta Kowalska michał Prendecki Thomas Piekut Joanna Kozłowska Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical SciencesPoznanPoland

Parkinson's disease(PD) is the second most common cause of *** the last two decades, various hypotheses have been proposed to explain the etiology of *** these is the oxidant-antioxidant theory, which asserts that local and systemic oxidative damage triggered by reactive oxygen species and other free radicals may promote dopaminergic neuron *** reactive oxygen species formation, one of the underlying causes of pathology in the course of PD has been evidenced by various studies showing that oxidized macromolecules including lipids, proteins, and nucleic acids accumulate in brain tissues of PD *** oxidation may produce various lesions in the course of *** incurred as a result of DNA oxidation may further enhance reactive oxygen species production in the brains of PD patients, exacerbating neuronal loss due to defects in the mitochondrial electron transport chain, antioxidant depletion, and exposure to toxic oxidized *** protein products of SNCA, PRKN, PINK1, DJ1, and LRRK2 genes are associated with disrupted oxidoreductive homeostasis in *** is the first gene linked with familial PD and is currently known to be affected by six mutations correlated with the disorder: A53T, A30P, E46K, G51D, H50Q and *** encodes Parkin, an E3 ubiquitin ligase which mediates the proteasome degradation of redundant and disordered proteins such as glycosylated α-*** 100 mutations have been found among the 12 exons of ***1, a mitochondrial kinase highly expressed in the brain, may undergo loss of function mutations which constitute approximately 1–8% of early onset PD *** than 50 PD-promoting mutations have been found in *** in DJ-1, a neuroprotective protein, are a rare cause of early onset PD and constitute only 1% of *** 20 mutations have been found in DJ1 among PD patients thus *** in the LRRK2 gene are the most common known cause of familial autosomal d

关键词： genetic factors molecular parameters oxidative stress Parkinson's disease pharmacotherapy surgical therapies

Serum adipokines in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第22期20卷 6912-6917页

作者： Marek Waluga Marek Hartleb Grzegorz Boryczka micha Kukla Krystyna Zwirska-Korczala Department of Gastroenterology and Hepatology Medical University of Silesia40-752 KatowicePoland Department of Physiology Zabrze Medical University of Silesia40-055 KatowicePoland

AIM: To investigate serum adipokine levels in inflammatory bowel disease (IBD) patients before treatment and after achieving clinical remission.

关键词： Adipokines Tumor growth factor-β 1 Crohn’ s disease Ulcerative colitis Inflammatory bowel disease

Western Tethyan Epeiric Ramp Setting in the Early Triassic： An Example from the Central Dinarides (Croatia)

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Journal of Earth Science 2018年第4期29卷 806-823页

作者： Dunja Aljinovic micha Horacek Leopold Krystyn Sylvain Richoz Tea Kolar-Jurkovsek Duje Smircic Bogdan Jurkovsek University of Zagreb Faculty of Mining Geology and Petroleum Engineering Pierottijeva 6 Zagreb 10000 Croatia BLT Wieselburg HBLFA Francisco-Josephinum Rottenhauserstr. 1 Wieselburg 3250 Austria Institute of Paleontology Vienna University A lthanstrafle 14 Vienna 1090 Austria Lund University Lithosphere and Biosphere science Solvegatan 12 Lund 22362 Sweden Geological Survey of Slovenia Dimiceva Ulica 14 Ljubljana 1000 Slovenia

In the central part of the External Dinarides in Plavno, Croatia, near Knin, a remarkably thick （927.5 m） Early Triassic depositional sequence was investigated. The Plavno sequence starts in the EarlyGriesbachian and ends with a continuous transition into the Anisian strata. A complete 13C isotope curve has been achieved and combined with conodonts, bivalves and ammonoids to establish and correlate stage and substage boundaries. The 613C curve is consistent with former studies. It displays a general increase from the Griesbachian to a prominent maximum beyond the ＋8%0 amplitude around the Dienerian-Smithian boundary （DSB）, followed by a steep and continuous decline to low, negative values in the Smithian. Around the Smithian-Spathian boundary （SSB） a steep rise to a second maximum occurred. It is followed by a saw-tooth shaped decline in the Spathian and a similar increase to a peak at the Spathian-Anisian boundary （SAB）. Sedimentologically, the Plavno sequence is interpreted as having been deposited on an extensive epeiric ramp under long-term transgressive conditions, sharing depositional characteristics of both the epeiric platform and the carbonate ramp. The entire Plavno sequence was deposited above the storm-wave base and was storm influenced. Three informal members are differentiated： 1） the dolostone member （Early Griesbachian）; 2） the silicielastic member （red-coloured shale, siltstone, sandstone with oolitic/bioclastie grainstone intercalations）, which can be further divided into lower, middle and upper intervals （Late Griesbachian, Dienerian and Smithian）; and 3） the mudstone member （grey lime mudstones, marls and calcisiltites with common ammonoids and gastropods- Spathian）. The Plavno sequence is compared with other western Tethyan sections. Observed differences stem from local controls on deposition in the overall shallow marine environment.

关键词： Early Triassic Dinarides epeiric ramp 6Z3C isotope curve litho- and biostratigraphy.

Invasive oaks escape pre-dispersal insect seed predation and trap enemies in their seeds

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Integrative Zoology 2018年第3期13卷 228-237页

作者： michałBOGDZIEWICZ Raul BONAL Josep MESPELTA Ewa M.KALEMBA michael A.STEELE RafałZWOLAK Department of Systematic Zoology Faculty of BiologyAdam Mickiewicz UniversityPoznańPoland CREAF Cerdanyola del VallesCataloniaSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Laboratory of Seed Biochemistry Institute of DendrologyPolish Academy of SciencesKórnikPoland Department of Biology Wilkes UniversityWilkes-BarrePennsylvaniaUSA

Species introduced to habitats outside their native range often escape control by their natural *** competing with native species,an alien species might also affect the native herbivores by introducing a new source of different quality ***,we describe the case of northern red oak(Quercus rubra)invasion in *** collected data on insect(moth Cydia *** weevil Curculio spp.)seed predation of northern red oak in its native(USA,North America)and invasive(Poland,Europe)range,as well as for sessile oaks(Quercus petrea)in *** also evaluated the quality of acorns as hosts for weevil larvae by collecting infested acorns and measuring weevil developmental success,and quantifying acorn traits such as seed mass,tannins,lipids and protein *** used DNA barcoding to identify insects to the species *** predation by moths was similar and very low in both species and in both ***,red oaks escape pre-dispersal seed predation by weevils in *** infestation rates of northern red oak acorns in their invasive range were 10 times lower than that of sessile oaks,and also 10 times lower than that of red oaks in North ***,even when weevils oviposited into northern red oaks,the larvae failed to develop,suggesting that the exotic host created a trap for the *** phenomenon might gradually decrease the local abundance of the seed predator,and further aid the invasion.

关键词： biotic invasions ecological trap enemy release hypothesis seed predation weevils

New perspectives on World Heritage management in the GCC legislation

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Built Heritage 2022年第1期6卷 30-41页

作者： michat Marcin Wosinski Principal Archaeology and Cultural Heritage Specialis JacobsCracowPoland

New legislative acts on heritage protection have been published in several Arab Countries in the last *** this is a positive trend in general,what remains to be seen is the factual impact of the new legislation on the pressing issues of heritage management,including the holistic and integrated approaches,monitoring,enforcement and *** paper compares the new legislative solutions from Gulf Arab Countries to the older ones and determines whether the new trends have potential of improving the heritage management *** findings of this paper are intended to increase the awareness of the still-marginal issue of heritage management in the heritage legislation of Arab region and promote the successful measures among the countries with outdated statutory heritage protection.

关键词： Heritage management Heritage law Antiquities law Arab States GCC