Oxidative stress factors in Parkinson's disease

作     者：Jolanta Dorszewska Marta Kowalska Michał Prendecki Thomas Piekut Joanna Kozłowska Wojciech Kozubski Jolanta Dorszewska;Marta Kowalska;Micha? Prendecki;Thomas Piekut;Joanna Koz?owska;Wojciech Kozubski

作者机构：Laboratory of NeurobiologyDepartment of NeurologyPoznan University of Medical SciencesPoznanPoland Chair and Department of NeurologyPoznan University of Medical SciencesPoznanPoland 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第7期

页      面：1383-1391页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the grant of NCBi R(European Union)  No.POWR.03.01.00-00-T006/18-00 

主　　题：genetic factors molecular parameters oxidative stress Parkinson's disease pharmacotherapy surgical therapies 

摘      要：Parkinson s disease(PD) is the second most common cause of *** the last two decades, various hypotheses have been proposed to explain the etiology of *** these is the oxidant-antioxidant theory, which asserts that local and systemic oxidative damage triggered by reactive oxygen species and other free radicals may promote dopaminergic neuron *** reactive oxygen species formation, one of the underlying causes of pathology in the course of PD has been evidenced by various studies showing that oxidized macromolecules including lipids, proteins, and nucleic acids accumulate in brain tissues of PD *** oxidation may produce various lesions in the course of *** incurred as a result of DNA oxidation may further enhance reactive oxygen species production in the brains of PD patients, exacerbating neuronal loss due to defects in the mitochondrial electron transport chain, antioxidant depletion, and exposure to toxic oxidized *** protein products of SNCA, PRKN, PINK1, DJ1, and LRRK2 genes are associated with disrupted oxidoreductive homeostasis in *** is the first gene linked with familial PD and is currently known to be affected by six mutations correlated with the disorder: A53T, A30P, E46K, G51D, H50Q and *** encodes Parkin, an E3 ubiquitin ligase which mediates the proteasome degradation of redundant and disordered proteins such as glycosylated α-*** 100 mutations have been found among the 12 exons of ***1, a mitochondrial kinase highly expressed in the brain, may undergo loss of function mutations which constitute approximately 1–8% of early onset PD *** than 50 PD-promoting mutations have been found in *** in DJ-1, a neuroprotective protein, are a rare cause of early onset PD and constitute only 1% of *** 20 mutations have been found in DJ1 among PD patients thus *** in the LRRK2 gene are the most common known cause of familial autosomal d