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Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract

Asian Pacific Journal of Tropical Medicine 2011年第12期4卷 959-963页

作者： Nagaraj selvaraj Baskar Lakshmanan Papiya Mitra Mazumder Muthukumar Karuppasamy Simon Santosh Jena Ashok Kumar Pattnaik Department of Pharmaceutical Sciences Birla Institute of TechnologyMesraRanchiJharkhand-835215India

Objective:To evaluate the wound healing and antimicrobial activity of root extracts of Ixora coccinea(***).Methods:To investigate the wound healing efficacy of root extract of *** Linn,five groups of animals were divided each containing six *** wound models including incision and excision wound models were used in this *** parameters studied were tensile strength on incision wound model and in terms of wound contraction for excision wound model were compared with standard Nitrofurazone(NFZ) ointment(0.2%w/w). Six extracts(***,petroleum ether,benzene,chloroform and ethyl acetate ) of I. coccinea were screened for in vitro growth inhibiting activity against different bacterial strains riz. Staphylococcia *** pumilius,Enterococcus *** coli,Salmonella typhi and Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger were compared with the standard drugs ciprofloxacin and chloramphenicol for antibacterial and griscofulvin for antifungal *** serial dilution and cup(or) well plate methods were used for the antimicrobial study and mic was ***:The ethanolic extract showed significant (Pmicrobes to invade through the wound thus the protection of wound occurs against the infection of the various or

关键词： Ixora coccinea Wound contraction Tensile strength Antimicrobial activity Ethanolic extract

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