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Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation

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骨研究:英文版 2023年第3期11卷 560-573页

作者： Ruici Yang Dandan Cao Jinlong Suo Lingli Zhang Chunyang Mo miaomiao wang Ningning Niu Rui Yue Weiguo Zou State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Institute for Regenerative Medicine Shanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Institute of Microsurgery on Extremities and Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult ***,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be ***,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone ***,Acan-associated Z24 depletion caused only trabecular bone ***-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)*** premature SSPC populations exhibited apoptotic signaling pathway activation and decreased *** exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone *** study identified two populations of SSPCs that are responsible for premature aging-related bone *** impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging.

关键词： sensation progenitor mec

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经鼻胃管肠内喂养对食管癌患者放化疗期间营养状况及身体状态的影响

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肿瘤代谢与营养电子杂志 2024年第4期11卷 553-558页

作者：程艳莉王苗苗钟慧娟陈莺歌袁高峰南京医科大学附属宿迁第一人民医院胸心外科江苏宿迁223800 南京鼓楼医院集团宿迁医院肿瘤科江苏宿迁223800 南京医科大学附属宿迁第一人民医院肿瘤科江苏宿迁223800

目的探讨经鼻留置胃管管饲(NGT)对食管癌患者放化疗期间营养状况及身体状态的影响。方法回顾性分析2020年1月至2023年12月南京医科大学附属宿迁第一人民医院收治的100例行同步放化疗的食管癌患者,按照营养治疗方法不同分为2组,分别接受... 详细信息

目的探讨经鼻留置胃管管饲(NGT)对食管癌患者放化疗期间营养状况及身体状态的影响。方法回顾性分析2020年1月至2023年12月南京医科大学附属宿迁第一人民医院收治的100例行同步放化疗的食管癌患者,按照营养治疗方法不同分为2组,分别接受NGT肠内喂养组(n=50)和口服营养补充(ONS)组(n=50)。比较两组患者干预8周前后的营养状态[营养风险筛查2002(NRS 2002)、患者主观整体评估(PG-SGA)、体质指数(BMI)及相关血清营养指标]、身体状态[Karnofsky功能状态(KPS)评分及放化疗不良反应发生率]。结果干预前两组NRS 2002、PG-SGA和KPS评分比较,差异无统计学意义(P>0.05);干预8周后NGT组NRS 2002及PG-SGA评分明显低于ONS组,而KPS评分明显高于ONS组(P0.05);干预8周后,NGT组血清白蛋白、血红蛋白、铁及前白蛋白水平明显高于ONS组(P0.05)。结论对接受放化疗的食管癌患者而言,早期NGT能有效改善患者的营养状况,提高身体状态,临床应用价值良好。

关键词：经鼻胃管肠内喂养食管癌营养状况身体状态营养风险筛查2002 患者主观整体评估体质指数放化疗

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Nano-alumina@cellulose-coated separators with the reinforcedconcrete-like structure for high-safety lithium-ion batteries

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Chinese Journal of Chemical Engineering 2024年第4期68卷 83-93页

作者： Zhihao Yang Li Chen Jian Xue miaomiao Su Fangdan Zhang Liangxin Ding Suqing wang Haihui wang Guangdong Provincial Key Lab of Green Chemical Product Technology School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China Beijing Key Laboratory of Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Separators play a critical role in the safety and performance of lithium-ion ***,commercial polyolefin separators are limited by their poor affinity with electrolytes and low melting *** this work,we constructed a reinforced-concrete-like structure by homogeneously dispersing nano-Al_(2)O_(3) and cellulose on the separators to improve their stability and *** this reinforcedconcrete-like structure,the cellulose is a reinforcing mesh,and the nano-Al_(2)O_(3) acts as concrete to support the *** constructing the reinforced-concrete-like structure,the separators exhibit good stability even at 200℃(thermal shrinkage of 0.3%),enhanced tensile strain(tensile stress of 133.4 MPa and tensile strains of 62%),and better electrolyte wettability(a contact angle of 6.5°).Combining these advantages,the cells with nano-Al_(2)O_(3)@cellulose-coated separators exhibit stable cycling performance and good rate ***,the construction of the reinforced-concretelike structure is a promising technology to promote the application of lithium-ion batteries in extreme environments.

关键词： Alumina Nanomaterials Lithium-ion batteries Membranes Cellulose Reinforced-concrete-like structure

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Solving the subset sum problem by the quantum Ising model with variational quantum optimization based on conditional values at risk

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 43-55页

作者： Qilin Zheng miaomiao Yu Pingyu Zhu Yan wang Weihong Luo Ping Xu Institute for Quantum Information and State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Hefei National Laboratory Hefei 230088China

The subset sum problem is a combinatorial optimization problem,and its complexity belongs to the nondeterministic polynomial time complete(NP-Complete)*** problem is widely used in encryption,planning or scheduling,and integer *** accurate search algorithm with polynomial time complexity has not been found,which makes it challenging to be solved on classical *** effectively solve this problem,we translate it into the quantum Ising model and solve it with a variational quantum optimization method based on conditional values at *** proposed model needs only n qubits to encode 2ndimensional search space,which can effectively save the encoding quantum *** model inherits the advantages of variational quantum algorithms and can obtain good performance at shallow circuit depths while being robust to noise,and it is convenient to be deployed in the Noisy Intermediate Scale Quantum *** investigate the effects of the scalability,the variational ansatz type,the variational depth,and noise on the ***,we also discuss the performance of the model under different conditional values at *** computer simulation,the scale can reach more than nine *** selecting the noise type,we construct simulators with different QVs and study the performance of the model with *** addition,we deploy the model on a superconducting quantum computer of the Origin Quantum Technology Company and successfully solve the subset sum *** model provides a new perspective for solving the subset sum problem.

关键词： subset sum problem quantum Ising model conditional values at risk variational quantum optimization

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原发性肝癌患者饮食治疗依从性及其影响因素的纵向研究

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中华全科医学 2024年第8期22卷 1328-1331,1358页

作者：王苗苗余慧茜傅凌雪马元锦王兆洪姚红响温州医科大学附属第二医院血管外科介入医学科浙江温州325000 温州医科大学附属第二医院肝胆胰外科

目的随访观察原发性肝癌患者饮食治疗依从性的变化轨迹,并分析其影响因素。方法采用方便抽样法于2021年3月—2022年4月选取在温州医科大学附属第二医院住院首次治疗的243例肝癌患者为研究对象。出院前(T0)完成第1次问卷调查,首次治疗后... 详细信息

目的随访观察原发性肝癌患者饮食治疗依从性的变化轨迹,并分析其影响因素。方法采用方便抽样法于2021年3月—2022年4月选取在温州医科大学附属第二医院住院首次治疗的243例肝癌患者为研究对象。出院前(T0)完成第1次问卷调查,首次治疗后1个月(T1)、3个月(T2)及6个月(T3)随访完成依从性量表调查。结果肝癌患者在T0、T1、T2和T3时点的饮食治疗依从性得分分别为(37.62±6.53)分、(37.82±6.34)分、(37.12±6.10)分和(34.43±5.76)分,T0-T1、T0-T2和T1-T2间的差异无统计学意义(P>0.05),而T0-T3、T1-T3、T2-T3间的差异有统计学意义(P<0.05)。使用潜类别增长模型可识别3个潜在轨迹类别:“紧紧跟随组”占比30.87%(75例),“放松警惕组”占比33.33%(81例),“重视不足组”占比35.80%(87例)。宗教信仰、营养不良风险、独居和健康信念是肝癌患者饮食治疗依从性潜在轨迹类别的影响因素。结论医护人员应尊重患者的宗教信仰,帮助重度营养不良风险的患者形成正确的疾病认知,配合社区开展独居患者精准关爱服务,准确评估患者的健康信念状况,提高饮食治疗的依从性。

关键词：原发性肝癌饮食治疗依从性纵向研究

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骨折联络服务对脆性骨折患者干预效果的系统评价

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老年医学研究 2024年第3期5卷 14-20页

作者：汪苗苗程溢芬段文静刘玉婷万青安徽中医药大学护理学院安徽合肥230038 安徽中医药大学第一附属医院骨伤二科安徽合肥230031

目的系统评价骨折联络服务(FLS)在脆性骨折患者中的应用效果。方法检索PubMed、Web of Sci-ence、中国知网、万方和维普数据库中2014年1月1日—2023年12月30日关于FLS对脆性骨折患者进行干预的相关文献。采用偏倚风险评估工具2.0和渥太... 详细信息

目的系统评价骨折联络服务(FLS)在脆性骨折患者中的应用效果。方法检索PubMed、Web of Sci-ence、中国知网、万方和维普数据库中2014年1月1日—2023年12月30日关于FLS对脆性骨折患者进行干预的相关文献。采用偏倚风险评估工具2.0和渥太华评价量表分别对随机对照研究和观察性研究进行偏倚风险评价和质量评价。最后,基于数据质量评估,使用RevMan5.4分析软件进行Meta分析。结果本研究共纳入24篇文献,总计18558例脆性骨折患者。Meta分析结果显示,FLS可以缓解脆性骨折患者的疼痛(SMD=-1.25,95%CI:-1.39~-1.12,P<0.05)、降低二次骨折发生率(RR=0.60,95%CI:0.48~0.75,P<0.05)、减少病死率(RR=0.86,95%CI:0.80~0.93,P<0.05)、提高骨质疏松确诊率(RR=2.24,95%CI:1.74~2.87,P<0.05)、改善生活质量(SMD=10.34,95%CI:7.26~13.42,P<0.05)。结论FLS有助缓解脆性骨折患者的疼痛,降低二次骨折风险,减少病死率,提高脆性骨折患者骨质疏松的确诊率,提升患者的整体生活质量。

关键词：骨折联络服务脆性骨折二次骨折疼痛骨质疏松

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The Incidence,Mortality,and DALYs Trends Associated with Esophageal Cancer-China,1990-2019

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China CDC weekly 2022年第43期4卷 956-961页

作者： Li Ma Xudong Li miaomiao wang Yingying Zhang Jing Wu Yuan He Xueqi Fan Bin Zhang Xiaolong Zhou Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina National Center for Chronic and Non-Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Esophageal cancer(EC)is one of the most common malignant tumors in *** new cases and deaths in China account for more than half of the world,and the disease burden of esophageal cancer is *** is added by this report?From 1990 to 2019,the disease burden of EC in China showed a decrease overall;it first increased between 1990 and 2004,but then decreased between 2004 and *** burden of EC in men was much higher than that in *** was an important factor affecting the burden of EC,with disease burden rising rapidly after 40 years *** are the implications for public health practices?The screening,early diagnosis,and treatment for EC should continue to be strengthened in *** and elderly men are high-risk groups of EC and should be a key population for EC prevention and control.

关键词： Esophageal prevention diagnosis

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Ethylene†and fruit softening

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Food Quality and Safety 2017年第4期1卷 253-267页

作者： Greg Tucker Xueren Yin Aidi Zhang miaomiao wang Qinggang Zhu Xiaofen Liu Xiulan Xie Kunsong Chen Don Grierson Division of Nutritional Biochemistry School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughboroughLE125RDUK Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityHangzhou 310058China Plant&Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughboroughLE125RDUK

This review is concerned with the mechanisms controlling fruit *** genetic regulators switch on the ripening programme and the regulatory pathway branches downstream,with separate controls for distinct quality attributes such as colour,flavour,texture,and *** plays a critical role as a ripening hormone and is implicated in controlling different facets of ripening,including texture change,acting through a range of transcriptional regulators,and this signalling can be blocked using 1-methylcyclopropene.A battery of at least seven cell-wall-modifying enzymes,most of which are synthesized de novo during ripening,cause major alterations in the structure and composition of the cell wall components and contribute to the softening *** differences between fruits may be related to the precise structure and composition of their cell walls and the enzymes recruited to the ripening programme during *** to slow texture change and reduce fruit spoilage by delaying the entire ripening process can often affect negatively other aspects of quality,and low temperatures,in particular,can have deleterious effects on texture *** silencing has been used to probe the function of individual genes involved in different aspects of ripening,including colour,flavour,ethylene synthesis,and particularly texture *** picture that emerges is that softening is a multi-genic trait,with some genes making a more important contribution than *** future,it may be possible to control texture genetically to produce fruits more suitable for our needs.

关键词： Cell walls Ethene Pectate lyase Polygalacturonase Tomato.

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反应堆压力容器J型焊缝焊条电弧焊缺陷产生机理及防治措施研究

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东方电气评论 2024年第5期38卷 60-66页

作者：王苗苗张斌戴光明江国焱陈洪李浩然东方电气(广州)重型机器有限公司广州511455 中广核工程有限公司

反应堆压力容器是反应堆冷却剂系统的重要承压设备。CRDM贯穿件通过J型焊缝与顶盖连接,结构形式复杂、拘束度大、残余应力大,J型焊缝的焊接技术是反应堆压力容器制造的关键。由于其结构特点,操作更为方便灵活的焊条电弧焊方法被广泛应... 详细信息

反应堆压力容器是反应堆冷却剂系统的重要承压设备。CRDM贯穿件通过J型焊缝与顶盖连接,结构形式复杂、拘束度大、残余应力大,J型焊缝的焊接技术是反应堆压力容器制造的关键。由于其结构特点,操作更为方便灵活的焊条电弧焊方法被广泛应用于该焊缝的焊接。因其特殊工况需要,耐腐蚀性能更优的ENiCrFe-7型镍基合金焊条作为其焊接填充材料。因其材料特性,焊接时容易出现热裂纹、气孔、夹杂等缺陷。尤其在J型焊缝这类拘束应力大的接头中,其制造难度进一步增大。本文对J型焊缝从结构特点、镍基合金材料的特性、工艺控制要点、过程管控措施等方面展开系统分析,并制定相应的控制措施,以达到提升J型焊缝焊接质量的目的。

关键词： J型焊缝 ENiCrFe-7 缺陷防治措施

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Heterostructured Co_(3)Se_(4)/CoSe_(2)@C nanoparticles attached on three-dimensional reduced graphene oxide as a promising anode towards Li-ion batteries

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Frontiers of Materials Science 2024年第2期18卷 101-115页

作者： Mingjun Pang Zhaoyang Song miaomiao Mao Shang Jiang Ruxia Zhang Runwei wang Jianguo Zhao Engineering Research Center of Coal-based Ecological Carbon Sequestration Technology of the Ministry of Education Shanxi Datong UniversityDatong 037009China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

In situ carbon-coated Co_(3)Se_(4)/CoSe_(2)(Co_(x)Se_(y))nanoparticles(NPs)attached on three-dimensional(3D)reduced graphene oxide(rGO)sheets were skillfully developed in this work,which involved the environment-friendly hydrothermal method,freeze drying,and selenide *** the structure,the glucose-derived carbon layer exhibited significantly homogeneous dispersion under an argon *** structure not only has enhanced stability,but also can effectively mitigate the volume swell of Co_(x)Se_(y) *** resulted Co_(3)Sea/CoSe_(2)@C/rGO(CSe@C/rGO)exhibited a specific surface area(SSA)of 240.9 m^(2)·g^(-1),offering more electrochemically active sites for the storage of energy related to lithium *** rGO matrix held exceptional flexibility and functional structural rigidity,facilitating the swift ion intercalation and ensuring the high conductivity and recyclability of the *** applied to anodes designed for lithium-ion batteries(LiBs),this material demonstrated distinguished rate and ultra-high reversible capacity(872.98 mA·h·g^(-1) at 0.5 A·g^(-1)).Meanwhile,its capacity retention reached 119.5%after 500 cycles at 2 A·g^(-1),with a coulombic efficiency of 100%.This work potentially paves the way for generating fast and powerful metal selenide anodes and initiating LiBs with good performance.

关键词： CSe@C/rGO lithium-ion battery reduced graphene oxide electrochemicalperformance heterostructure

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