Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation

作     者：Ruici Yang Dandan Cao Jinlong Suo Lingli Zhang Chunyang Mo Miaomiao Wang Ningning Niu Rui Yue Weiguo Zou Ruici Yang;Dandan Cao;Jinlong Suo;Lingli Zhang;Chunyang Mo;Miaomiao Wang;Ningning Niu;Rui Yue;Weiguo Zou

作者机构：State Key Laboratory of Cell BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Institute for Regenerative MedicineShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Institute of Microsurgery on Extremitiesand Department of Orthopedic SurgeryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China 

出 版 物：《骨研究:英文版》 (Bone Research)

年 卷 期：2023年第11卷第3期

页      面：560-573页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (NSFC) (82230082,81991512 to W.Z.,82202742 to J.S.,82070108 to R.Y.) the National Key Research and Development Program of China (2022YFA0806600 to W.Z.,2022YFA1103200 to R.Y.) CAS Project for Young Scientists in Basic Research (YSBR077 to W.Z.) 

主　　题：sensation progenitor mec 

摘      要：A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult ***,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be ***,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone ***,Acan-associated Z24 depletion caused only trabecular bone ***-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)*** premature SSPC populations exhibited apoptotic signaling pathway activation and decreased *** exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone *** study identified two populations of SSPCs that are responsible for premature aging-related bone *** impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging.