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The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer

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Chinese Journal of Natural Medicines 2019年第10期17卷 729-737页

作者： WAN Liang-qin tan Yan JIANG miao HUA Qian School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100029China

Non-small cell lung cancer(NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages(TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1(tumor-inhibitory) phenotype or M2(tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine(TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.

关键词： Lung cancer Tumor microenvironment Tumor-associated macrophages Traditional Chinese medicine (TCM) monomer Immunotherapy

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin qin Xin tan Xiao-Yan Sun Xu-Fang Ying Zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Factors influencing oil recovery by surfactant-polymer flooding in conglomerate reservoirs and its quantitative calculation method

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Petroleum Science 2022年第3期19卷 1198-1210页

作者： Feng-Qi tan Chun-miao Ma Jian-Hua qin Xian-Kun Li Wen-Tao Liu College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory Computational Geodynamics Chinese Academy of SciencesBeijing100049China Xinjiang Oilfield Company PetroChinaKaramayXinjiang834000China

This study aims to clarify the factors influencing oil recovery of surfactant-polymer(SP)flooding and to establish a quantitative calculation model of oil recovery during different displacement stages from water flooding to SP *** conglomerate reservoir of the Badaowan Formation in the seventh block of the Karamay Oilfield is selected as the research object to reveal the start-up mechanism of residual oil and determine the controlling factors of oil recovery through SP flooding experiments of natural cores and microetching *** experimental results are used to identify four types of residual oil after water flooding in this conglomerate reservoir with a complex pore structure:oil droplets retained in pore throats by capillary forces,oil cluster trapped at the junction of pores and throats,oil film on the rock surface,isolated oil in dead-ends of flow *** the four types of residual oil identified,the SP solution can enhance oil recovery by enlarging the sweep volume and improving the oil displacement ***,the viscosity-increasing effect of the polymer can effectively reduce the permeability of the displacement liquid phase,change the oil-water mobility ratio,and increase the water ***,the stronger the shear drag force of the SP solution,the more the crude oil in a porous medium is ***,the surfactant can change the rock wettability and reduce the absorption capacity of residual oil by lowering interfacial *** the same time,the emulsification further increases the viscosity of the SP solution,and the residual oil is recovered effectively under the combined effect of the above two *** the four start-up mechanisms of residual oil identified after water flooding,enlarging the sweep volume and improving the oil displacement efficiency are interdependent,but their contribution to enhanced oil recovery are *** SP flooding system primarily enlarges the sweep volume by increasing viscos

关键词： Conglomerate reservoir Water flooding Surfactant-polymer flooding Residual oil type Influencing factor Enhanced oil recovery Computational model

考虑风电爬坡限幅及频率安全约束的高比例风电电力系统多层级优化调度

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电力系统保护与控制 2025年第1期53卷 135-146页

作者：王佳旭苗世洪王廷涛姚福星谭昊宇陈池瑶华中科技大学电气与电子工程学院强电磁技术全国重点实验室湖北武汉430074

近年来,具有强不确定性、弱支撑能力的风电机组大规模并网,对新型电力系统的频率安全及稳定运行造成了严重冲击。为保障高比例风电电力系统安全、优质、经济运行,提出了一种考虑风电爬坡限幅与频率安全约束的电力系统多层级优化调度策... 详细信息

近年来,具有强不确定性、弱支撑能力的风电机组大规模并网,对新型电力系统的频率安全及稳定运行造成了严重冲击。为保障高比例风电电力系统安全、优质、经济运行,提出了一种考虑风电爬坡限幅与频率安全约束的电力系统多层级优化调度策略。首先,考虑风电预测误差与风电场并网要求,对相邻调度时段风电爬坡进行几何描述与特征分析。其次,提出日前-日内-实时多阶段风电场站-电力系统级联合调度架构,进一步建立考虑风电爬坡限幅约束的场站级优化调度模型与计及频率安全约束的系统级优化调度模型。最后,基于改进IEEE 39节点系统开展算例分析,验证了所提策略的有效性。

关键词：风电爬坡限幅约束频率安全约束优化调度储能电站高比例风电调频

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内源性衍生物对碳点化学传感性能的影响

分析化学 2025年第1期53卷 94-103页

作者：覃迎喜王昱杨莉花刘紫薇覃爱苗冯亮桂林理工大学材料科学与工程学院中国科学院大连化学物理研究所分离分析化学中国科学院重点实验室

以间苯二胺和1,2,3-丙烷三甲酸为原料，采用气流辅助的熔融态聚合法和一步水热法分别合成了蓝色荧光碳点（TMCDs）和青绿色荧光碳点（TMCDs-H2O）。气流吹扫能够有效地抑制副反应，减少产物碳点（CDs）中的衍生结构。通过液体核磁共振... 详细信息

以间苯二胺和1,2,3-丙烷三甲酸为原料，采用气流辅助的熔融态聚合法和一步水热法分别合成了蓝色荧光碳点（TMCDs）和青绿色荧光碳点（TMCDs-H2O）。气流吹扫能够有效地抑制副反应，减少产物碳点（CDs）中的衍生结构。通过液体核磁共振、质谱和透射电镜等表征技术对这两种材料的结构与形貌进行了表征。与TMCDs-H2O的平均粒径(（3.12±0.63） nm)相比，TMCDs的平均粒径更小(（1.85±0.02） nm)。采用核磁共振与质谱分析两种CDs的化学结构，发现二者虽然主体结构相似，但是TMCDs的结构更简单，聚合度相对较高。这些结果表明，在TMCDs-H2O的颗粒中可能通过超分子相互作用引入了大量的小分子衍生物，因此表现出低聚合度、多亚结构和大粒径的特点。将两种CDs用于金属离子的化学传感时，线性范围为1×10–5～5×10–4mol/L, TMCDs和TMCDs-H2O对Fe3+的检出限分别为3.3×10–6mol/L和3.8×10–6mol/L。对自来水实际样品进行加标回收实验，结果表明，两种CDs的回收率相差不大，并且均与ICP-OES的回收率相近，但TMCDs的相对标准偏差较大。本研究结果表明，CDs中的内源性衍生结构可以提高其对金属离子的传感检测性能。

关键词：内源性衍生物碳点化学传感金属离子检测 Fe3+传感机理

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pH Readout enhanced ELISA for point-of-care testing of cardiac troponin I

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Chinese Chemical Letters 2017年第9期28卷 1878-1880页

作者： Luyang miao Lianhua Zhang Lei Jiao Xiaofeng tan qin Wei He Li School of Chemistry and Chemical Engineering University of Jinan Department of Urology Renji HospitalSchool of MedicineShanghai Jiao Tong University

Enzyme-linked immunosorbent assay（ELISA） as a conventional method for protein quantification has its characteristic properties,however,it is challenging to implement excellent portability and sensitivity at the same *** this study,we described a pH ELISA using synthetic melanin nanoparticles（SMNPs） for the co-immobilization of glucose oxidase（GOx） and second antibody（Ab_2） as signal labels,portable pH meter as signal readout device for point-of-care testing（POCT） of cardiac troponin I（cTnI）.In accordance with the varying amount of cTnI,following sandwich type immunoassay,proportional SMNPs-GOx-Ab_2 were immobilized specifically resulting in corresponding decrease of pH values owing to GOx loaded on SMNPs can high-efficiency convert glucose into gluconic *** assay is easy-to-use,portable,sensitive and able to realize POCT,affording a linear range from 0.5 pg/m L to 10 ng/m L and low limit of detection（LOD） of 0.15 pg/m L towards cTnI,which was demonstrated the significant promising in the early diagnosis and screening of acute myocardial infarction.

关键词： pH meter Synthetic melanin nanoparticles Polydopamine nanospheres Biomarker Immunosensor

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乙酰丙酸乙酯复配燃料理化特性研究

太阳能学报 2025年第1期46卷 208-214页

作者：苗长林吴鹏庄新姝谭雪松李惠文中国科学院广州能源研究所中国科学院可再生能源重点实验室广东省新能源和可再生能源研究开发与应用重点实验室广州510640 沈阳航空航天大学能源与环境学院辽宁省清洁能源重点实验室沈阳110136

对不同比例乙酰丙酸乙酯与0#石化柴油复配混合燃料的互溶性、密度、运动黏度、闭口闪点、馏程、冷凝点、冷滤点等理化性质进行测试研究。结果表明:低温下乙酰丙酸乙酯与0#柴油互溶性较差,5℃时最大互溶比仅为7%,随着温度升高,溶解度有... 详细信息

对不同比例乙酰丙酸乙酯与0#石化柴油复配混合燃料的互溶性、密度、运动黏度、闭口闪点、馏程、冷凝点、冷滤点等理化性质进行测试研究。结果表明:低温下乙酰丙酸乙酯与0#柴油互溶性较差,5℃时最大互溶比仅为7%,随着温度升高,溶解度有所上升,在35℃条件下最大互溶比为15%。随着复配燃料中乙酰丙酸乙酯所占比例增加,复配燃料的十六烷值逐渐降低;对馏程影响不明显,密度增幅不大;闪点较石化柴油有所提高,这有利于燃料的安全储存;热值出现小幅下降;运动黏度、凝点和冷滤点低温流动性改善明显。总体来看:掺混比小于或等于7%的乙酰丙酸乙酯复配燃料基本符合国六柴油GB 19147—2016标准;如需提高乙酰丙酸乙酯复配比例,有必要对热值、十六烷值等指标进行改进,以满足国六柴油标准要求。

关键词：生物质能乙酰丙酸乙酯石化柴油复配燃料理化特性

Synthesis,characterization,and antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt

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Journal of Oceanology and Limnology 2022年第1期40卷 284-295页

作者： Xueqi SUN Jingjing ZHANG Yingqi MI qin miao Wenqiang tan qing LI Zhanyong GUO Key Laboratory of Coastal Biology and Bioresource Utilization Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

To improve the solubility and bioactivity of chitosan,a new class of carboxymethyl chitosan derivatives possessing sulfonium salts was successfully designed and synthesized,including Methyl sulfi de carboxymethyl chitosan(MCMCS),Ethyl sulfi de carboxymethyl chitosan(ECMCS),Propyl sulfi de carboxymethyl chitosan(PCMCS),and Butyl sulfi de carboxymethyl chitosan(BCMCS).To determine the structure of the new class of the derivatives,methods of the Fourier transform infrared spectroscopy(FT-IR),^(1)H nuclear magnetic resonance spectrometer(^(1)H NMR),and^(13)C nuclear magnetic resonance spectrometer(^(13)C NMR)were ***,the antioxidant activity of the derivatives for three types of free radicals,i.e.,hydroxyl radical,superoxide radical,and 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical was evaluated in *** addition,the L929 cells were adopted to test the cytotoxicity of chitosan and its derivatives by CCK-8 *** class of the carboxymethyl chitosan derivatives showed a strong scavenging ability against the three free radicals at 1.6 mg/mL,with scavenging rate of over 70%and some up to 100%.At this high rate,the overall cell viability in the toxicity test reached more than 80%,indicating that the synthetic derivative had a little *** results show that the introduction of carboxymethyl group to chitosan increased the water-solubility of chitosan,and the combination of sulfonate ions with diff erent chain lengths further enhanced the antioxidant activity of ***,the sulfonium-containing carboxymethyl chitosan derivatives had excellent bioactivity with good application prospects in food,biomedicine,and medical fi elds.

关键词： antioxidant activity carboxymethyl chitosan derivative sulfonium salts structural characteristics/synthesis

学生视角下的大语言模型赋能外语个性化学习研究——机遇与挑战

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上海理工大学学报(社会科学版) 2025年第1期47卷 15-21页

作者：刘芹谭佳豪上海理工大学外语学院上海200093

个性化学习是依据学习者的个性特征和发展潜能,采取灵活的方法以满足个体需求的学习。从学生视角探讨大语言模型在外语个性化学习中的应用,通过比较六个维度的表现,评估国内外不同大语言模型的赋能效果。结果显示:国内外大语言模型在处... 详细信息

个性化学习是依据学习者的个性特征和发展潜能,采取灵活的方法以满足个体需求的学习。从学生视角探讨大语言模型在外语个性化学习中的应用,通过比较六个维度的表现,评估国内外不同大语言模型的赋能效果。结果显示:国内外大语言模型在处理知识查询等简单学习需求时表现相当;但在自然语言生成和上下文理解方面,国外模型更为出色,能够准确把握语境,灵活应对多样化的交互场景,而国内模型在开放式对话中显得相对僵硬;大语言模型在促进个性化体验、降低学习门槛和增强交际意愿等方面的优势可以促进外语个性化学习效果,但也存在技术依赖、信息真实性、学术不端等问题。基于此,未来的外语教育应融合技术与人文,充分发挥大语言模型的潜力,同时规避潜在风险。

关键词：大语言模型个性化学习学生视角