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Aggregate 2023年第5期4卷 152-160页

作者： Zixiang He su Shen Gong Zhang Tengfei miao Xiaoxiao Cheng Zhao Wang Qingping Song Wei Zhang State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Engineering Laboratory of Novel Functional Polymeric MaterialsSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouP.R.China School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhuP.R.China College of Physics Optoelectronics and Energy Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouP.R.China

The preparation of monodisperse azobenzene(Azo)polymer microspheres by dispersion polymerization was *** photo-induced fusion of Azo polymer microspheres was successfully achieved during the process of reversible trans-cistrans photoisomerization of Azo units,and induced various unique“microsphere molecular”clusters or“microsphere polymers”.Encouraged by this interesting phenomenon,microsphere clusters of different topological structures were stabilized by the in situ acetal cross-linking *** photo-induced fusion polymerization of monodisperse polymer microspheres provides a new strategy for designing photo-responsive clusters and allows for control over the mechanical properties of microspheres with high spatiotemporal resolution.

关键词： azobenzene dispersion polymerization fusion polymerization microsphere clusters polymer microspheres

Q-Learning Based Routing Protocol for Congestion Avoidance

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Computers, Materials & Continua 2021年第9期68卷 3671-3692页

作者： Daniel Godfrey Beom-su Kim Haoran miao Babar Shah Bashir Hayat Imran Khan Tae-Eung sung Ki-Il Kim Department of Computer Science and Engineering Chungnam National UniversityKorea College of Technological Innovation Zayed UniversityAbu DhabiUAE Institute of Management Sciences PeshawarPakistan Department of Electrical Engineering University of Engineering and TechnologyPeshawarPakistan Department of Computer and Telecommunications Engineering Yonsei UniversityKorea

The end-to-end delay in a wired network is strongly dependent on congestion on intermediate *** lots of feasible approaches to avoid congestion efficiently,congestion-aware routing protocols tend to search for an uncongested path toward the destination through rule-based approaches in reactive/incident-driven and distributed ***,these previous approaches have a problem accommodating the changing network environments in autonomous and self-adaptive operations *** overcome this drawback,we present a new congestion-aware routing protocol based on a Q-learning algorithm in software-defined networks where logically centralized network operation enables intelligent control and management of network *** a proposed routing protocol,either one of uncongested neighboring nodes are randomly selected as next hop to distribute traffic load to multiple paths or Q-learning algorithm is applied to decide the next hop by modeling the state,Q-value,and reward function to set the desired path toward the destination.A new reward function that consists of a buffer occupancy,link reliability and hop count is ***,look ahead algorithm is employed to update the Q-value with values within two hops *** approach leads to a decision of the optimal next hop by taking congestion status in two hops into account,***,the simulation results presented approximately 20%higher packet delivery ratio and 15%shorter end-to-end delay,compared to those with the existing scheme by avoiding congestion adaptively.

关键词： Congestion-aware routing reinforcement learning Q-learning Software defined networks

Preparation Technology of Solvent-free Polyurethane:A Mini-Review

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Chinese Journal of Structural Chemistry 2020年第12期39卷 2057-2067,2053页

作者： su Yu-miao WANG Ting DING Yu-Lin HUANG Jia-Jing LI Wen-Mu Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Normal University College of Chemistiy and Material ScienceFuzhou 350007China Provincial Key Laboratory of Eco-Industrial Green Technology Wuyi University 354300China

Solvent-free polyurethanes are synthesized under certain conditions via a rapid reaction between liquid *** this process the molecular weight of the polymer is rapidly increased to produce polymeric materials containing a carbamate-based structure at a very fast *** organic solvents are completely avoided in the solvent-free polyurethane synthesis process,thus avoiding all the problems associated with the use of organic ***-free polyurethane synthetic leather is extruded directly without adding solvents in the production and processing process,which has the advantages of low VOC emission and environmentally *** review brings together theoretical and experimental research on the application and synthesis and preparation of solvent-free polyurethanes to generate an understanding of the theory and synthesis and preparation techniques associated with solvent-free *** review includes(i)the application and development direction of solvent-free polyurethane,(ii)an overview of the technology of solvent-free polyurethane synthetic leather preparation,(iii)a study of the modification and synthesis of solvent-free polyurethane prepolymers,(iv)a summary of the technology of rapid foam forming of solvent-free polyurethane and its influencing factors,(v)a review of the technology of solvent-free polyurethane synthetic leather *** addition to the review,a corresponding overview of the theoretical and experimental advances in solvent-free delayed foaming technology in recent years and a summary of the technology and experience in the preparation of solvent-free polyurethanes are also presented.

关键词： solvent-free polyurethane polyurethane synthetic leather rapid foaming molding delayed catalyst

Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer

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Military Medical Research 2022年第4期9卷 419-431页

作者： Dan-Dan Zhou Wei-Qi Bai Xiao-Tian Zhai Li-Ping sun Yong-su Zhen Zhuo-Rong Li Qing-Fang miao NHC Key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.1 Tiantan XilBeijing 100050China Department of Organic Chemistry Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.1 Tiantan XiliBeijing 100050China

Background:Triple-negative breast cancer(TNBC)is the most aggressive subtype and occurs in approximately 15%–20%of diagnosed breast *** is characterized by its highly metastatic and recurrent features,as well as a lack of specific targets and targeted *** growth factor receptor(EGFR)is highly expressed in a variety of tumors,especially in ***004-VC-MMAE is a new EGFR-targeting antibody–drug conjugate produced by our *** study aimed to evaluate its antitumor activities against EGFR-positive TNBC and further studied its possible mechanism of antitumor ***:LR004-VC-MMAE was prepared by coupling a cytotoxic payload(MMAE)to an anti-EGFR antibody(LR004)via a linker,and the drug-to-antibody ratio(DAR)was analyzed by *** gene expression of EGFR in a series of breast cancer cell lines was assessed using a publicly available microarray dataset(GSE41313)and Western ***-MB-468 and MDA-MB-231 cells were treated with LR004-VC-MMAE(0,0.0066,0.066,0.66,6.6 nmol/L),and the inhibitory effects of LR004-VC-MMAE on cell proliferation were examined by CCK-8 and colony *** migration and invasion capacity of MDA-MB-468 and MDA-MB-231 cells were tested at different LR004-VCMMAE concentrations(2.5 and 5 nmol/L)with wound healing and Transwell invasion *** cytometric analysis and tumorsphere-forming assays were used to detect the killing effects of LR004-VC-MMAE on cancer stem cells(MDA-MB-468 and MDA-MB-231 cells).The mouse xenograft models were also used to evaluate the antitumor efficacy of LR004-VC-MMAE in ***,BALB/c nude mice were subcutaneously inoculated with MDA-MB-468 or MDAMB-231 *** they were randomly divided into 4 groups(n=6 per group)and treated with PBS,naked LR004(10 mg/kg),LR004-VC-MMAE(10 mg/kg),or doxorubicin,*** sizes and the body weights of mice were measured every 4 *** effects of LR004-VC-MMAE on apoptosis and cell cycle distribution were analyzed

关键词： Triple-negative breast cancer Epidermal growth factor receptor Antibody–drug conjugate Targeted therapy Antitumor effect

Very-High Color Rendering Index Hybrid White Organic Light-Emitting Diodes with Double Emitting Nanolayers

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Nano-Micro Letters 2014年第4期6卷 335-339页

作者： Baiquan Liu miao Xu Lei Wang Hong Tao Yueju su Dongyu Gao Linfeng Lan Jianhua Zou Junbiao Peng Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology New Vision Opto-Electronic Technology Co. Ltd

A very-high color rendering index white organic light-emitting diode(WOLED) based on a simple structure was successfully fabricated. The optimized device exhibits a maximum total efficiency of 13.1 and 5.4 lm/W at 1,000 cd/m2. A peak color rendering index of 90 and a relatively stable color during a wide range of luminance were obtained. In addition, it was demonstrated that the 4,40,400-tri(9-carbazoyl) triphenylamine host influenced strongly the performance of this *** results may be beneficial to the design of both material and device architecture for high-performance WOLED.

关键词： White light Hybrid Color rendering index Organic light-emitting diodes Double emitting nanolayers

Development and validation of an online calculator to predict the pathological nature of colorectal tumors

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1271-1282页

作者： Ya-Dan Wang Jing Wu Bo-Yang Huang Chun-Mei Guo Cang-Hai Wang Hui su Hong Liu miao-miao Wang Jing Wang Li Li Peng-Peng Ding Ming-Ming Meng Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseasesBeijing 100050China Department of Gastroenterology Beijing Shijitan Hospitalthe Ninth Clinical Medicine Peking UniversityBeijing 100038China

BACKGROUND No single endoscopic feature can reliably predict the pathological nature of colorectal tumors(CRTs).AIM To establish and validate a simple online calculator to predict the pathological nature of CRTs based on white-light *** This was a single-center *** the identification stage,530 consecutive patients with CRTs were enrolled from January 2015 to December 2021 as the derivation *** regression analysis was performed.A novel online calculator to predict the pathological nature of CRTs based on white-light images was established and verified *** the validation stage,two series of 110 images obtained using white-light endoscopy were distributed to 10 endoscopists[five highly experienced endoscopists and five less experienced endoscopists(LEEs)]for external validation before and after systematic *** A total of 750 patients were included,with an average age of 63.6±10.4 *** colorectal cancer(ECRC)was detected in 351(46.8%)*** size,left semicolon site,rectal site,acanthosis,depression and an uneven surface were independent risk factors for *** C-index of the ECRC calculator prediction model was 0.906(P=0.225,Hosmer-Lemeshow test).For the LEEs,significant improvement was made in the sensitivity,specificity and accuracy(57.6%vs 75.5%;72.3%vs 82.4%;64.2%vs 80.2%;Psurface can accurately predict the pathological nature of ECRC.

关键词： Pathological nature Colorectal tumors White-light endoscopy Online calculator Early colorectal cancer

Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1194-1201页

作者： Xiaoying Zhang miao miao Ruijun Zhang Xu Liu Xiaozhen Zhao miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin su Xiaolin sun Jing He Zhanguo Li Department of Rheumatology and Immunology Peking University People’s Hospital100044 BeijingChina Department of Rheumatology and Immunology The First Affiliated Hospital of Wannan Medical College241000 WuhuAnhuiChina Department of Clinical Epidemiology and Biostatistics Peking University People’s Hospital100044 BeijingChina Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135) BeijingChina Peking-Tsinghua Center for Life Sciences BeijingChina State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina

Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse ***-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the *** randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active *** were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week *** cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week *** patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESRsults suggested that Ld-IL2 was effective and safe in *** number:NCT 02467504.

关键词： patients placebo methotrexate

Novel mutation c.980_983delATTA compound with c.986C>A mutation of the FRMD7 gene in a Chinese family with X-linked idiopathic congenital nystagmus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 479-486页

作者： Feng-wei SONG Bin-bin CHEN Zhao-hui suN Li-ping WU su-juan ZHAO Qi miao Xia-jing TANG Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College Department of Otolaryngology-Head and Neck surgery the First Affiliated HospitalWenzhou Medical College

Objective:To screen mutations in FERM domain-containing protein 7(FRMD7) gene in two Chinese families with X-linked idiopathic congenital nystagmus(XLICN).Methods:Common ophthalmic data and peripheral blood of two Chinese XLICN families(families A and B) were collected after informed *** DNA was prepared from the peripheral blood of members of the two families and from 100 normal *** in the FRMD7 gene were determined by directly sequencing polymerase chain reaction(PCR) ***:We identified a novel mutation c.980_983delATTA compound with c.986C>A mutation in the 11th exon of FRMD7 in family B,and a previously reported splicing mutation c.782G>C(p.R261G) in family *** mutations were detected in patients and female carriers,while they were absent in other relatives or in the 100 normal ***:Our results expand the spectrum of FRMD7 mutations in association with XLICN,and further confirm that the mutations of FRMD7 are the underlying molecular mechanism for XLICN.

关键词： Mutation Idiopathic congenital nystagmus FERM domain-containing protein 7(FRMD7)

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Advance in quality assessment of Chinese materia medica using microscopic and morphological methods

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Chinese Journal of Natural Medicines 2017年第9期15卷 653-663页

作者： miao Xiao-su CUI Qing-Yu WANG Zhao-Yi LIU Xiao-Na ZHAO An-Bang QIAO Yan-Jiang WU Zhi-Sheng Beijing University of Chinese Medicine Beijing 100102 China Key Laboratory of Traditional Chinese Medicine of information Engineering of State Administration Beijing 100102 China Binzhou Medical University Yantai 256603 China

Quality evaluation plays a vital role in ensuring safety and effectiveness of Chinese materia medica(CMM). Microscopic and morphological technologies can be used to distinguish CMM's characteristics, such as shape, size, texture, section, and smell, for authenticity and quality control of CMM. The microscopic and morphological applications of novel micro-technology, colorimeter, and texture analyzer for CMM identification are summarized and the future prospect is discussed in this paper. Various styles and complex sources of CMM are systemically reviewed, including cormophyte medicinal materials, fruit and seeds, pollen grain, and spore materials.

关键词： Chinese materia medica Micro-technology Colorimeter Texture analyzer

Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China

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World Journal of Gastroenterology 2024年第10期30卷 1346-1357页

作者： Jing-Feng Chen Zhuo-Qing Wu Hao-Shuang Liu su Yan You-Xiang Wang miao Xing Xiao-Qin Song su-Ying Ding Health Management Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Institute of Systems Engineering Dalian University of TechnologyDalian 116024Liaoning ProvinceChina College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471003Henan ProvinceChina

BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD *** A cohort of 3553 participants followed for four consecutive health examinations over 4 years was *** incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were *** proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset *** A total of 83.13%of participants with MAFLD had normal ALT *** incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT *** with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,*** Most participants with MAFLD had normal ALT ***-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Cumulative effect Cox proportional hazards regression Cohort study