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Dynamical distribution of continuous service time model involving non-Maxwellian collision kernel and value functions

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Chinese Physics B 2024年第9期33卷 340-348页

作者： Minfang Zhao Lingting Kong miao liu Shaoyong Lai School of Mathematics and Statistics Yili Normal UniversityYining 835000China Institute of Applied Mathematics Yili Normal UniversityYining 835000China School of Mathematics Southwestern University of Finance and EconomicsChengdu 611130China

The distribution of continuous service time in call centers is investigated.A non-Maxwellian collision kernel combining two different value functions in the interaction rule are used to describe the evolution of continuous service time,*** the statistical mechanical and asymptotic limit methods,Fokker–Planck equations are derived from the corresponding Boltzmann-type equations with non-Maxwellian collision *** steady-state solutions of the Fokker–Planck equation are obtained in exact *** experiments are provided to support our results under different parameters.

关键词： kinetic theory service time Fokker–Planck equation value function

Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

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BIOCELL 2024年第3期48卷 513-523页

作者： PEI QIN miao liu XIN WANG JIANHUA MA Geriatrics Department Chengde Central HospitalChengde067000China

Background:L-dopa(Levodopa)is well known for managing PD(Parkinson’s disease);however,its prolonged use caused dyskinesia(LID).Due to the varied presentation of LID,effective treatment options are *** reported their neuroprotective activity by ameliorating acetylcholinesterase,monoamine oxidase,and neuroinﬂ*** is anotherﬂavonoid bearing these ***:To evaluate neuroprotective activity of kaempferol in dyskinetic ***:PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid(10µL)+6-OHDA(12µg)in medial forebrain bundle to induce neuronal damage in substantial nigra(SNr).LID was induced by administrating combination of L-dopa(20 mg/kg)+benserazide HCl(5 mg/kg)for 42 *** were concomitantly treated with amantadine(40 mg/kg)or kaempferol(25,50,and 100 mg/kg,p.o.).Results:Kaempferol(50 and 100 mg/kg)markedly(p<0.05)inhibited LID-induced abnormal involuntary movements(AIMs)and alternation in motor *** administration considerably(p<0.05)inhibited reduced mitochondrial complex activities,serotonin and dopamine levels,Bcl-2,and Tyrosine hydroxylase protein expressions in ***,kaempferol considerably(p<0.05)attenuated increased cFOS,FosB,Parkin,and Pdyn mRNAs expressions,Bax,cleaved caspase-3,caspase-3,and pJNK proteins levels;DOPAC and 5-HIAA levels in SNr.A positive correlation was reported between cFOS,FosB,Parkin,Pdyn,apoptosis,and TH with ***:Kaempferol effectively attenuated L-dopa-induced AIMs and dyskinesia via amelioration of alterations in cFOS,FosB,Parkin,Pdyn,Tyrosine hydroxylase,and apoptosis in the brain SNr.

关键词： AIMs cFOS Kaempferol Levodopa-induced dyskinesia Pdyn

Sedimentary environment shift and organic matter enrichment mechanism in response to volcanic ash influence: A case study of the Permian Lucaogou Formation, Santanghu Basin,NW China

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Journal of Palaeogeography 2024年第4期13卷 793-822页

作者： miao Yu Gang Gao miao liu Hui Liang Ji-Lun Kang Xiong-Fei Xu Xin-Ying Zhao College of Geosciences China University of Petroleum (Beijing) National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) Petro China Tuha Oilfield Company

The second member of the Lucaogou Formation （P2l2） in the Tiaohu and Malang Sags of the Santanghu Basin （study area） underwent periodic volcanic activity and frequent lithological *** study comprehensively analyzed the organic geochemistry,mineral composition,organic matter （OM） types,volcanic cycle,and palaeoenvironment of shale in the study *** such as total organic carbon （TOC）,rock pyrolysis （Rock-Eval）,organic petrology,scanning electron microscopy （SEM） with energydispersive spectrum （EDS） analysis,X-ray diffraction （XRD）,trace elements,and saturated hydrocarbon gas chromatography and mass spectrometry （GC-MS） were *** findings suggest that limited terrigenous input during the sedimentary period of the P2l2led to the deposition of a distinctive mixture of volcanic ash （felsic） and carbonate （dolomite and calcite）,with a low average clay mineral content of 6%.The P2l2shale emerged as a high-quality source rock,predominantly composed of type I and II kerogens,with moderate OM *** deposition environment was characterized by hot and arid conditions,high salinity,and intensive reducibility,which was favorable for algae development and conducive to OM ***,two lamalginite types,labeled as lamalginite“A”and lamalginite“B,”were ***“B”-rich shales were deposited in a hotter and drier climate compared to lamalginite“A”-rich ***“B”-rich shale inexhibited high levels of C28regular sterane and β-carotenes,distinguishing it from lamalginite“A”-rich shale.A comprehensive analysis involving organic petrology,SEM,sedimentary environment,and biomarker characteristics suggests that lamalginite“B”may be a salt-tolerant green alga,while lamalginite“A”may be a ***,an OM enrichment model for the P2l2shale was established.

关键词： Volcanic ash Geochemistry Petrology Palaeoenvironment Lamalginite

Hydrocarbon Generation Characteristics of Coal-measure Source Rocks and their Contribution to Natural Gas:A Case Study of Middle and Lower Jurassic Targets from the Southern Junggar Basin Margin

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Acta Geologica Sinica(English Edition) 2024年第5期98卷 1270-1284页

作者： YU miao GAO Gang liu miao MA Wanyun TIAN Anqi FAN Keting GUO liulinbo HE Dan ZHANG Youjin College of Geosciences China University of Petroleum National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum Research Institute of Experimental Testing Xinjiang Oilfield Company PetroChina Xinjiang Conglomerate Reservoir Laboratory Key Laboratory of Exploration and Development of Conglomerate Reservoirs

In order to study the hydrocarbon generation（HCGE） characteristics of coal-bearing basins, the coal-measure source rocks of the Middle Jurassic–Lower Jurassic（MLJ） of the piedmont thrust belt in the southern margin of the Junggar Basin in Northwest China are taken as research objects. More than 60 MLJ samples were collected from outcrops and wells. Total organic carbon（TOC）, rock pyrolysis（Rock–Eval）, organic petrological, vitrinite reflectance（%Ro）, and hydrous pyrolysis were performed to analyze the relevant samples. The pyrolysis gases and liquid products were measured, and then the chemical composition, as well as carbon isotopes of the gases, were analyzed. The results indicate that the MLJ source rocks have the capacity for large-scale gas generation. In addition, for coal-measure source rocks, the heavier the carbon isotope of kerogen(δ13Ckerogen), the lower the liquid hydrocarbon and hydrocarbon gas yield, and the easier it is to produce non-hydrocarbon gas. It is worth noting that when the δ13Ckerogenin organic matter（OM） is relatively heavier, the fractionation of its products may become weaker in the evolutionary process. The vital contribution of the MLJ source rock to natural gas resources in the study area was further confirmed by comparing it with the Jurassic source gas.

关键词： carbon isotope coal-bearing basins hydrous pyrolysis Jurassic source rock upstream natural resources/energy Xinjiang province

BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

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Current Medical Science 2024年第2期44卷 333-345页

作者： Jun-li ZHAO Lin ZHAO Qiu-nan ZHAN miao liu Ting ZHANG Wen-wen CHU Department of Nephrology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to ***:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of *** and Masson staining were performed to evaluate the extent of *** therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function ***-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%*** were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 ***:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to *** RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD *** found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD *** with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious f

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

Beyond Gender Perspectives:A More Comprehensive Examination of Yang Yi’s Translation of Wuthering Heights

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Sino-US English Teaching 2024年第7期21卷 332-336页

作者： liu miao Guangdong University of Foreign Studies GuangzhouChina

The renowned translator Yang Yi passed away in *** scholars argue that,influenced by their biological gender,female translators often employ translation methods in adherence to feminist translation or reflect characteristics typical of female *** study examines the translation of Wuthering Heights by Yang Yi,focusing on whether there is a definite influence of gender on translator *** existing literature primarily analyzes Yang Yi’s work through a feminist lens,this research takes a broader *** considering the translator’s social background and translation practice,this paper challenges the assumption that her work strictly aligns with feminist translation ***,this study emphasizes the importance of considering diverse factors when interpreting translated works,moving beyond a singular gender-based standpoint.

关键词： gender translation Yang Yi Wuthering Heights feminism

Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： miao liu Haiqing Zhang Zhichao Wang Tingting Mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang Department of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime>10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

Predicting structure-dependent Hubbard U parameters via machine learning

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Materials Futures 2024年第2期3卷 161-169页

作者： Guanghui Cai Zhendong Cao Fankai Xie Huaxian Jia Wei liu Yaxian Wang Feng liu Xinguo Ren Sheng Meng miao liu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190People’s Republic of China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190People’s Republic of China Songshan Lake Materials Laboratory DongguanGuangdong 523808People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Tencent AI Lab TencentShenzhen 518057People’s Republic of China Department of Materials Science and Engineering University of UtahSalt Lake CityUT 84112United States of America

DFT+U is a widely used treatment in the density functional theory(DFT)to deal with correlated materials that contain open-shell elements,whereby the quantitative and sometimes even qualitative failures of local and semi-local approximations can be corrected without much computational ***,finding appropriate U parameters for a given system and structure is non-trivial and computationally intensive,because the U value has generally a strong chemical and structural *** this work,we address this issue by building a machine learning(ML)model that enables the prediction of material-and structure-specific U values at nearly no computational *** Mn–O system as an example,the ML model is trained by calibrating DFT+U electronic structures with the hybrid functional results of more than 3000 *** model allows us to determine an accurate U value(MAE=0.128 eV,R^(2)=0.97)for any given Mn–O *** analysis reveals that M–O bond lengths are key local structural properties in determining the U *** approach of the ML U model is universally applicable,to significantly expand and solidify the use of the DFT+U method.

关键词： DFT+U machine learning Bayesian optimization

Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis

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World Journal of Clinical Cases 2024年第5期12卷 875-879页

作者： Yan-miao liu Jing Zhang Jing-Jing Wu Wei-Wei Guo Fu-Shan Tang The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Respiratory Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung *** condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few *** lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant *** optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains *** this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage ***,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender *** mutations may also impact therapeutic *** research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related *** measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life.

关键词： COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration Timing Dosage