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Low Ca diet leads to increased Ca retention by changing the gut flora and ileal pH value in laying hens

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Animal Nutrition 2023年第2期13卷 270-281页

作者： Sha Jiang Xinyu Zou miao mao Mi Zhang Wenjun Tu Meilan Jin Joint International Research Laboratory of Animal Health and Animal Food Safety College of Veterinary MedicineSouthwest UniversityChongqing400715China Immunology Research Center Medical Research InstituteSouthwest UniversityChongqing402460China Laboratory Animal Center Southwest UniversityChongqing400715China

Osteoporosis is a common degenerative metabolic bone disease in caged laying *** egg production mobilizing large amounts of Ca from bone for eggshell formation,consequently leading to Ca deficiency,has been recognized as a critical factor causing osteoporosis in commercial laying *** aim of this study was to examine the effect of Ca deficiency on the function of the gut microbiotaebone axis and related egg production traits and bone health in laying ***-four 48-week-old laying hens were fed a control diet(Control,3.72%)or a low Ca diet(LC,2.04%)for 60 d(n=12).Compared to the Control hens,the LC hens had higher levels of alkaline phosphatase and tartrate resistant acid phosphatase(P<0.05)with lower bone strength,eggshell thickness,and eggshell strength(P<0.05).In addition,the LC hens had higher plasma estradiol concentrations,while having lower concentrations of interleukin-1(IL-1)and *** LC hens also had a lower pH value in the ileum with an increased Ca *** principal co-ordinates analysis showed significantly separate cecal microbiota populations between the Control and LC *** Prevotellaceae_UCG-001,Subdoligranulum,Peptococcus,and Eubacterium_hallii_group(P<0.05)were higher,while the CHKC1001 and Sutterella(P<0.05)were lower at the genus level in the LC *** addition,Prevotellaceae_UCG-001,Subdoligranulum and Eubacter-ium_hallii_group had a negative correlation,while Sutterella was positively correlated with ileal pH *** transcriptome analysis revealed that the low Ca diet caused 20 and 31 genes to be signifi-cantly up-and down-regulated,*** gene expressions of cystic fibrosis transmembrane conductance regulator,solute carrier family 26 member 3 of the anion exchangers,and mitogen-activated protein kinase 12 of pro-inflammatory factors were lower in the LC birds,which was corre-lated with the lower ileal pH *** results suggest that the hens with low Ca diet-induced osteoporosis have an incr

关键词： Low Ca diet Ca retention Microbiota Transcriptional profiling Hen

New Periodic Wave Solutions to Generalized Klein-Gordon and Benjamin Equations

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Communications in Theoretical Physics 2007年第5X期48卷 815-818页

作者： WU Guo-Jiang HAN Jia-Hua ZHANG Wen-Liang ZHANG miao WANG Jun-mao School of Physics and Material Science Anhui University Hefei 230039 China

By making use of extended mapping method and auxiliary equation for finding new periodic wave solu tions of nonlinear evolution equations in mathematical physics, we obtain some new periodic wave solutions for generalized Klein-Cordon equation and Benjamin equation, which cannot be found in previous work. This method also can be used to find new periodic wave solutions of other nonlinear evolution equations.

关键词： auxiliary equation method extended mapping method nonlinear evolution equations periodic wave solutions

Pharmaceutical applications of framework nucleic acids

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Acta Pharmaceutica Sinica B 2022年第1期12卷 76-91页

作者： Liang Chen Jie Zhang Zhun Lin Ziyan Zhang miao mao Jiacheng Wu Qian Li Yuanqing Zhang Chunhai Fan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acids Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids(FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future.

关键词： DNA nanotechnology Self-assembly Framework nucleic acids DNA nanostructures Drug discovery Therapeutic molecules Drug delivery Drug analysis

One-step viscoelastic agent technique for ICL V4c implantation for myopia

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1359-1364页

作者： Hua-mao miao Feng Zhao Ling-Ling Niu Jing Zhao Xiao-Ying Wang Xing-Tao Zhou Department of Ophthalmology Eye and ENT Hospital of Fudan UniversityNHC Key Laboratory of Myopia(Fudan University)Research Center of Ophthalmology and OptometryShanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200021China

AIM:To investigate the safety and efficacy of using a onestep viscoelastic agent technique for posterior chamber phakic implantable collamer lens with a central hole(ICL V4 c)implantation for myopia ***:The one-step viscoelastic agent technique for ICL V4 c implantation was used in 100 eyes of 52 *** outcomes,intraocular pressure(IOP),corneal endothelial cell,and corneal densitometry values were evaluated at 1 d,1 wk,1 and 3 mo ***:All the surgeries were *** corrected distance visual acuity was lost after 3 *** was 16.12±3.18 mm Hg before surgery,and 14.74±3.08 mm Hg at 1d and 14.50±2.56 mm Hg at 3 mo after surgery(P0.05).The corneal densitometry values of the central 2 mm and 2 to 6 mm areas showed similar *** surgery,the values significantly increased at 1 d,then decreased to the preoperative values at 1 wk,and then continued to decrease at 3 mo(P<0.05).CONCLUSION:The one-step viscoelastic agent technique for ICL V4c implantation is found to be safe and effective for myopia correction and causes little disturbance to the cornea.

关键词： phakic intraocular lens V4c viscoelastic agent myopia intraocular pressure corneal endothelial cell corneal densitometry

Bio-inspired design of hierarchical FeP nanostructure arrays for the hydrogen evolution reaction

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Nano Research 2018年第7期11卷 3537-3547页

作者： Ya Yan Xue Rong Shi mao miao Ting He Ze Hua Dong Ke Zhan Jun He Yang Bin Zhao Bao Yu Xia School of Materials Science and Engineering University of Shanghai for Science and Technology 516 Jungong Road Yangpu District Shanghai 200093 China Key laboratory of Material Chemistry for Energy Conversion and Storage (Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology (HUST) 1037 Luoyu Road Wuhan 430074 China College of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China Institute of Physical Chemistry University of Innsbruck Innrain 80-82 Innsbruck A-6020 Austria Shanghai Innovation Institute for Materials Shanghai 200444 China Shenzhen Institute of Huazhong University of Science and Technology Shenzhen 518000 China

Hierarchical FeP nanoarray films composed of FeP nanopetals were successfully synthesized via a bio-inspired hydrothermal route followed by phosphorization. Glycerol as a crystal growth modifier, plays a significant role in controlling the morphology and structure of the FeO（OH） precursor during the biomineralization process, while the following transfer and pseudomorphic transformation of the FeO（OH） film successfully give rise to the FeP array film. The as-prepared FeP film electrodes exhibit excellent hydrogen evolution reaction （HER） performance over a wide pH range. Theoretical calculations reveal that the mixed P/Fe termination in the FeP film is responsible for the high catalytic activity of the nanostructured electrodes. This new insight will promote further explorations of efficient metal phosphoride-based catalysts for the HER. More importantly, this study bridges the gap between biological and inorganic self-assembling nanosystems and may open up a new avenue for the preparation of functional nanostructures with application in energy devices.

关键词： bio-inspired mineralization phosphorization FeP array hydrogen evolution density functional theory (DFT) calculations

Tetrahedral DNA nanostructures synergize with MnO_(2) to enhance antitumor immunity via promoting STING activation and M1 polarization

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2494-2505页

作者： Siping Liang Jiaying Li Zhengyu Zou miao mao Siqi Ming Fan Lin Ziyan Zhang Can Cao Jinyu Zhou Yuanqing Zhang Jiaping Li Minhao Wu Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine Guangdong Second Provincial General HospitalGuangzhou 510317China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Interventional Oncology The First Afﬁliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Stimulator of interferon genes(STING) is a cytosolic DNA sensor which is regarded as a potential target for antitumor immunotherapy. However, clinical trials of STING agonists display limited anti-tumor effects and dose-dependent side-effects like inflammatory damage and cell toxicity. Here,we showed that tetrahedral DNA nanostructures(TDNs) actively enter macrophages to promote STING activation and M1 polarization in a size-dependent manner, and synergized with Mn^(2+) to enhance the expressions of IFN-β and iNOS, as well as the co-stimulatory molecules for antigen presentation. Moreover, to reduce the cytotoxicity of Mn^(2+),we constructed a TDN-MnO_(2) complex and found that it displayed a much higher efficacy than TDN plus Mn^(2+) to initiate macrophage activation and anti-tumor response both in vitro and in vivo. Together, our studies explored a novel immune activation effect of TDN in cancer therapy and its synergistic therapeutic outcomes with MnO_(2).These findings provide new therapeutic opportunities for cancer therapy.

关键词： Tetrahedral DNA nanostructure Manganese MnO_(2) STING M1 polarization Antigen presentation Anti-tumor immunity Cancer therapy

Ultrafast carrier dynamics of Cu_(2)O thin film induced by two-photon excitation

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Chinese Physics B 2021年第11期30卷 348-351页

作者： Jian Liu Jing Li Kai-Jun Mu Xin-Wei Shi Jun-Qiao Wang miao mao Shu Chen Er-Jun Liang School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Cuprous oxide(Cu_(2)O)has attracted plenty of attention for potential nonlinear photonic applications due to its superior third-order nonlinear optical property such as two-photon *** this paper,we investigated the two-photon excitation induced carrier dynamics of a Cu_(2)O thin film prepared by radio-frequency magnetron sputtering,using the femtosecond transient absorption *** dynamics including an ultrafast carrier scattering(50 ps)were *** time constant of carrier scattering under two-photon excitation is larger than that under one-photon excitation,due to the different transition selection rules and smaller absorption coefficient of the two-photon excitation.

关键词： carrier dynamics cuprous oxide transient absorption two-photon absorption

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3-D视频的视差优化调整方法

清华大学学报（自然科学版） 2014年第10期54卷 1356-1361页

作者：毛苗秦开怀清华大学计算机科学与技术系北京100084

随着立体显示技术的发展,3-D视频越来越受到关注。3-D视频的内容通常是为特定的观看条件制作的,当实际观看条件改变时,不合理的视差范围不但会影响立体效果,还会使人产生头晕、不适感。为了保证3-D视频的最佳观看效果,该文提出了一种3-... 详细信息

随着立体显示技术的发展,3-D视频越来越受到关注。3-D视频的内容通常是为特定的观看条件制作的,当实际观看条件改变时,不合理的视差范围不但会影响立体效果,还会使人产生头晕、不适感。为了保证3-D视频的最佳观看效果,该文提出了一种3-D视频的视差优化调整方法。该方法首先提出视觉舒适区准则,根据给定的显示屏和观看距离计算视差舒适范围,采用匹配代价搜索和图像细分快速估计3-D视频图像对的视差范围,将原视差范围通过分段线性变换方法映射到视差舒适范围,并利用新的视差范围绘制出虚拟视图。该方法使给定的3-D视频能够适用于各种观看条件,在增强其立体效果的同时,不引起眼睛疲劳、头晕现象,并且用户可以根据个人偏好自主调节立体效果,以达到最佳观看效果。实验结果表明该方法实用有效。

关键词：视觉舒适区视差范围估计视差优化调整

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基于光场与几何混合绘制的3D视频显示算法

计算机辅助设计与图形学学报 2011年第1期23卷 91-96页

作者：毛苗秦开怀陈瑶清华大学计算机科学与技术系北京100084

提出一种基于光场与几何混合绘制的视频绘制算法.算法以光场绘制算法计算起始帧,以新视点的上一帧为基础更新前景;结合高斯混合背景建模和场景几何计算方法来计算新视点的当前帧的前景区域,避免了重复绘制占据图像大部分而变化缓慢的背... 详细信息

提出一种基于光场与几何混合绘制的视频绘制算法.算法以光场绘制算法计算起始帧,以新视点的上一帧为基础更新前景;结合高斯混合背景建模和场景几何计算方法来计算新视点的当前帧的前景区域,避免了重复绘制占据图像大部分而变化缓慢的背景区域,提高了视频绘制的效率.为了消除累积误差,采用"起始帧+后续帧"的循环模式,同时在循环中统计前景点在场景中的分布,自适应地划分下一个循环的场景层次.实验结果表明,文中算法效率高,所生成的图像质量好.

关键词：光场渲染几何计算前景检测自适应层次划分