检索结果-南通市图书馆

micro RNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第29期22卷 6652-6662页

作者： Jeongeun Hyun Youngmi jung Department of Biological Sciences College of Natural Science Pusan National University

Liver fibrosis is a repair process in response to damage in the liver; however, severe and chronic injury promotes the accumulation of fibrous matrix, destroying the normal functions and architecture of liver. Hepatic stellate cells(HSCs) are quiescent in normal livers, but in damaged livers, they transdifferentiate into myofibroblastic HSCs, which produce extracellular matrix proteins. Hedgehog(Hh) signaling orchestrates tissue reconstruction in damaged livers and contributes to liver fibrogenesis by regulating HSC activation. micro RNAs(mi RNAs), endogenous small non-coding RNAs interfering with RNA post-transcriptionally, regulate various cellular processes in healthy organisms. The dysregulation of mi RNAs is closely associated with diseases, including liver diseases. Thus, mi RNAs are good targets in the diagnosis and treatment of various diseases, including liver fibrosis; however, the regulatory mechanisms of mi RNAs that interact with Hh signaling in liver fibrosis remain unclear. We review growing evidence showing the association of mi RNAs with Hh signaling. Recent studies suggest that Hh-regulating mi RNAs induce inactivation of HSCs, leading to decreased hepatic fibrosis. Although mi RNAdelivery systems and further knowledge of interacting mi RNAs with Hh signaling need to be improved for the clinical usage of mi RNAs, recent findings indicate that the mi RNAs regulating Hh signaling are promising therapeutic agents for treating liver fibrosis.

关键词： micro RNA Liver fibrosis Hedgehog Hepatic stellate cell

Synthesis and electrochemical performance of (100-x)Li7P3S11-xLi2OHBr composite solid electrolyte for all-solid-state lithium batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2020年第8期29卷 307-316,I0011页

作者： Su-Yeon jung rajesh rajagopal Kwang-Sun Ryu Department of Chemistry University of UlsanDoowang-dongNam-gu 44776UlsanSouth Korea

Li7P3S11solid electrolytes with high lithium-ion conductivity are promising candidates for use in all-solidstate lithium ***,this electrolyte’s poor interfacial compatibility with lithium electrodes causes unstable *** this study,in order to address this problem,(100-x)Li7P3S11-xLi2OHBr(x=0,2,5,10,20,30,40,and 50)electrolytes are prepared by a high energy ball-milling technique and heat-treatment *** resulting(100-x)Li7P3S11-xLi2OHBr(x=2,5,10,20,30,40,and 50)electrolytes provide improved electrochemical performance with good cycling stability and a wide electrochemical window of up to 10 V(***/Li+).Moreover,these electrolytes have high ionic conductivity of 10-4–10-5S/cm at room ***,the 90Li7P3S11-10Li2OHBr electrolyte displays the highest conductivity of 4.4×10-4S/cm at room temperature as well as improved ***,90Li7P3S11-10Li2OHBr shows decreased interfacial resistance between the solid electrolyte and cathode electrode,which was revealed by Electrochemical Impedance Spectroscopy(EIS)*** initial discharge capacity of 90Li7P3S11-10Li2OHBr was found to be 135 m Ah/g when used in a In|solid electrolyte|Li(Ni0.6Co0.2Mn0.2)O2 all-solid-state lithium battery(ASSLB).Thus,we can conclude the addition of Li2OHBr into the Li7P3S11results in enhanced electrochemical properties.

关键词： All-solid-state lithium battery Solid electrolyte Solid sulfide electrolyte Li2OHBr Antiperovskite

CoolVox:Advanced 3D convolutional neural network models for predicting solar radiation on building facades

在线全文

学校读者我要写书评

暂无评论

Building Simulation 2022年第5期15卷 755-768页

作者： jung min Han Eun Seuk Choi Ali Malkawi Harvard University Graduate School of Design CambridgeUSA Harvard Center for Green Buildings and Cities CambridgeUSA Harvard John A.Paulson School of Engineering and Applied Sciences CambridgeUSA

Data-driven models have become increasingly prominent in the building,architecture,and construction *** area ideally suited to exploit this powerful new technology is building performance ***-based models have traditionally been used to estimate the energy flow,air movement,and heat balance of ***,physics-based models require many assumptions,significant computational power,and a considerable amount of time to output *** neural networks(ANNs)with prefabricated or simulated data are likely to be a more feasible option for environmental analysis conducted by designers during the early design *** ANNs require fewer inputs and shorter computation times and offer superior performance and potential for data augmentation,they have received increased attention for predicting the surface solar radiation on ***,ANNs can provide innovative and quick design solutions,enabling designers to receive instantaneous feedback on the effects of a proposed change to a building's *** research introduces deep learning methods as a means of simulating the annual radiation intensities and exposure level of buildings without the need for physics-based *** propose the CoolVox model to demonstrate the feasibility of using 3D convolutional neural networks to predict the surface radiation on building *** CoolVox model accurately predicted the radiation intensities of building facades under different boundary conditions and performed better than ARINet(with average mean square errors of 0.01 and 0.036,respectively)in predicting the radiation intensity both with(validation error=0.0165)and without(validation error=0.0066)the presence of boundary buildings.

关键词： artificial neural networks 3D convolutional neural networks solar radiation simulation building performance simulation

Quantitative comparison of similarity measure and entropy for fuzzy sets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第6期18卷 2045-2049页

作者： jung Dong-yean CHOI jung-Wook PARK Wook-Je LEE Sang-Hyuk Daeho Tech Changwon Gyeongnam Institute for Information and Electronics Research Inha University Department of Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University

Comparison and data analysis with the similarity measures and entropy for fuzzy sets were carried out. The distance proportional value between the fuzzy set and the corresponding crisp set was considered by the fuzzy entropy. The relation between the similarity measure and the entropy for fuzzy set was also analyzed. The fuzzy entropy was reformulated as the dissimilarity measure. Furthermore, crisp set having the minimum uncertainty with respect to the corresponding fuzzy set was also proposed. Finally, derivation of a similarity measure from entropy with the help of total information property was derived. A simple example shows the relation between similarity measure and fuzzy entropy, in which the summation of similarity measure and fuzzy entropy represents a constant value.

关键词： similarity measure fuzzy entropy minimum uncertainty quantitative comparison

microfluidic dual loops reactor for conducting a multistep reaction

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2018年第2期12卷 239-246页

作者： Si Hyung Jin Jae-Hoon jung Seong-Geun Jeong Jongmin Kim Tae jung Park Chang-Soo Lee Department of Chemical Engineering Chungnam National University Daejeon 34134 Korea Lotte Chemical R&D Center Daejeon 34110 Korea Department of Chemistry Chung-Ang University Seoul 06974 Korea

Precise control of each individual reaction that constitutes a multistep reaction must be performed to obtain the desired reaction product efficiently. In this work, we present a microfluidic dual loops reactor that enables multistep reaction by integrating two identical loop reactors. Specifically, reactants A and B are synthesized in the first loop reactor and transferred to the second loop reactor to synthesize with reactant C to form the final product. These individual reactions have nano-liter volumes and are carded out in a stepwise manner in each reactor without any cross-contamination issue. To pre- cisely control the mixing efficiency in each loop reactor, we investigate the operating pressure and the operating frequency on the mixing valves for rotary mixing. This microfluidic dual loops reactor is integrated with several valves to realize the fully automated unit operation of a multistep reaction, such as metering the reactants, rotary mixing, transportation, and collecting the product. For proof of concept, CdSeZn nanopartieles are successfully synthesized in a microfluidic dual loops reactor through a fully automated mukistep reaction. Taking all of these features together, this microfluidic dual loops reactor is a general microfluidic screening platform that can synthesize various materials through a multistep reaction.

关键词： microfluidics multistep reaction rotary mixing nanoparticle

Porous microspheres Comprising CoSe2 Nanorods Coated with N-Doped Graphitic C and Polydopamine-Derived C as Anodes for Long-Lived Na-Ion Batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-micro Letters 2022年第7期14卷 118-139页

作者： Jae Seob Lee rakesh Saroha jung Sang Cho Department of Engineering Chemistry Chungbuk National UniversityCheongjuChungbuk 361-763Republic of Korea

Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microspheres are introduced as anodes for excellent Na-ion batteries,particularly with long-lived cycle under carbonate-based electrolyte *** microspheres uniformly composed of ZIF-67 polyhedrons and polystyrene nanobeads(φ=40 nm)are synthesized using the facile spray pyrolysis technique,followed by the selenization process(P-CoSe_(2)@NGC NR).Further,the PDA-derived C-coated microspheres are obtained using a solution-based coating approach and the subsequent carbonization process(P-CoSe_(2)@PDA-C NR).The rational synthesis approach benefited from the synergistic effects of dual carbon coating,resulting in a highly conductive and porous nanostructure that could facilitate rapid diffusion of charge species along with efficient electrolyte infiltration and effectively channelize the volume ***,the prepared nanostructure exhibits extraordinary electrochemical performance,particularly the ultra-long cycle life *** instance,the advanced anode has a discharge capacity of 291(1000th cycle,average capacity decay of 0.017%)and 142 mAh g^(-1)(5000th cycle,average capacity decay of 0.011%)at a current density of 0.5 and 2.0 A g^(-1),respectively.

关键词： Spray pyrolysis Sodium-ion batteries Cobalt selenide nanorods Porous microspheres Dual carbon coating

Application of Thermodynamic Database to Corrosion of ZrO_(2) Containing Submerged Entry Nozzle in Steel Continuous Casting Process

在线全文

学校读者我要写书评

暂无评论

China's Refractories 2024年第2期33卷 10-15页

作者： In-Ho jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea

The CALPHAD thermodynamic databases are very useful to analyze the complex chemical reactions happening in high temperature material *** FactSage thermodynamic database can be used to calculate complex phase diagrams and equilibrium phases involving refractories in industrial *** this study,the FactSage thermodynamic database relevant to ZrO_(2)-based refractories was reviewed and the application of the database to understanding the corrosion of continuous casting nozzle refractories in steelmaking was presented.

关键词： thermodynamic database ZrO_(2)containing submerged entry nozzle continous casting

Effect of Hoechunyangkyeok-San Extract on Melanogenesis

在线全文

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2016年第3期6卷 85-95页

作者： mi Jin Kim Taek Kyu jung Hyun-Chul Park Kyung-Sup Yoon Skin Science R&D Center Saimdang Cosmetics Co. Ltd. Cheongju-si South Korea

Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, anti-aging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescription extract (a hydrolyzed extract of Hoechunyangkyeok-san: SID White HYC) on skin. The effects of SID White HYC were assessed the melanin contents in B161 melanoma cells and the pigmented equivalent with HMB45 and Fontana Masson staining in 3D skin model. Then, we examined the expression of major pigment enzymes regulating melanin synthesis and melanosome transport related proteins in B16F1 cells. SID White HYC significantly inhibited the melanin synthesis (56.7% and 30.6% inhibition at 100 μg/mL, intracellular and secreted, respectively) in B16F1 cells and 3D skin model. In addition, western blotting analysis showed that SID White HYC reduced the expression of melanin synthesis and melanosome transport related proteins in B16F1 cells. In clinical trials, the cream containing 0.05% SID White HYC showed skin depigmentation effect without any irritation. These results suggest that SID White HYC may be useful inhibition of melanogenesis and melanosome transport. Therefore, SID White HYC may have potential as a skin-whitening ingredient in cosmetics.

关键词： Hoechunyangkyeok-San (Formula Extract Containing Forsythia viridissima Fruit Platycodon grandiflorum Root Glycyrrhiza glabra Root Paeonia japonica Root Angelica gigas Root Scutellaria baicalensis Root Gardenia jasminoides Fruit Coptis chinensis Root Mentha arvensis Leaf Rehmannia glutinosa Root Poncirus trifoliate Fruit) Melanogenesis Melanosome Transport Melanin Whitening

Effect of expanding nanocellulose sponge on nasal mucosal defects in an animal model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2020年第1期7卷 47-52页

作者： JiWon Kim Kyungbae Woo Jeong mi Kim mi Eun Choi Young-Mo Kim Su-Geun Yang Bong Sup Shim Jeong-Seok Choi Department of Otorhinolaryngology Inha UniversityCollege of Medicine27 Inhang-roJung-guIncheon 22332Republic of Korea Department of Chemical Engineering Inha University100 InharoMichuholguIncheon 22212Republic of Korea Department of New Drug Development Inha UniversityCollege of MedicineB-308Chungsuk Bldg.366Seohae-DaeroJung-GuIncheon 22332Republic of Korea

Nanocellulose has emerged for a wide range of applications in biomedical engineering because of its water absorption capacity,appropriate *** investigated the hemostatic and regenerative abilities of an expanding polyvinyl alcohol(PVA)-nanocellulose sponge on nasal mucosal defects.A 3 mm-diameter nasal defect was made in experimental *** were divided into four groups with control,vaseline,PVA and PVA-nanocellulose packing *** the defect was created,bleeding times and amounts were *** materials were removed on experimental day(ED)*** ED 3,7 and 14,histological analysis and immunohistochemical study for neutrophils were *** cells were counted and epithelial thicknesses were *** amounts and times in the vaseline packing group were smaller than in the PVA ***-nanocellulose group showed less neutrophils than in the other groups on ED *** epithelium thickness in the PVA-nanocellulose group was significantly smaller than in the control group at ED 7,but at ED 14,there was no significant intergroup *** group had a significant lower inflammatory cell count than the control group on ED ***-nanocellulose sponge applied to nasal mucosal defects can significantly enhance mucosal regeneration during early wound healing.

关键词： polyvinyl alcohol nasal mucosa nanocellulose