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High Voltage 2024年第1期9卷 163-171页

作者： Li Cai Yifeng Ke Wenchao Fan Ruisheng Yan mi zhou Jianguo Wang Yadong Fan Engineering Research Center of ministry of Education for Lightning Protection and Grounding Technology School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

As the wind turbine height increases,the probability of multiple upward leaders flashes within the wind farm increases.In this study,an upward lightning flash containing 21 upward positive leaders(UPLs)initiated from different wind turbines in Zhangbei Wind Farm was analysed.The average speed of the UPLs was 1.2×10^(5) m/s,which mostly decreased to zero before reaching the cloud height.Only four UPLs developed to cloud height,with prolonged periods of bright light on three of them and with a minimum duration of 126 ms.A total of nine return strokes occurred on the other two dissipated leader channels,and the numbers of strokes on the two channels was six and three,respectively.The average interstroke interval for the return strokes was 10.5 ms.Most of these nine return strokes had peak currents smaller than 10 kA.The high-speed video frames confirmed that competition does exist between the UPLs,and the range of shielding effects increases as the height of the ULs increases.The effect of fan rotation on the initiation of upward leaders and the shielding effect between the wind turbines and upward leaders are discussed.

关键词： flash return initiated

Carbon Emission Factors Prediction of Power Grid by Using Graph Attention Network

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Energy Engineering 2024年第7期121卷 1945-1961页

作者： Xin Shen Jiahao Li YujunYin Jianlin Tang Weibin Lin mi zhou Measurement Center Yunnan Power Grid Co.Ltd.Kunming650000China Electric Power Research Institute China Southern Power Grid Co.Ltd.Guangzhou510530China Guangdong Provincial Key Laboratory of Intelligent Measurement and Advanced Metering of Power Grid Guangzhou510530China

Advanced carbon emission factors of a power grid can provide users with effective carbon reduction advice,which is of immense importance in mobilizing the entire society to reduce carbon emissions.The method of calculating node carbon emission factors based on the carbon emissions flow theory requires real-time parameters of a power grid.Therefore,it cannot provide carbon factor information beforehand.To address this issue,a prediction model based on the graph attention network is proposed.The model uses a graph structure that is suitable for the topology of the power grid and designs a supervised network using the loads of the grid nodes and the corresponding carbon factor data.The network extracts features and transmits information more suitable for the power system and can flexibly adjust the equivalent topology,thereby increasing the diversity of the structure.Its input and output data are simple,without the power grid parameters.We demonstrated its effect by testing IEEE-39 bus and IEEE-118 bus systems with average error rates of 2.46%and 2.51%.

关键词： Predict carbon factors graph attention network prediction algorithm power grid operating parameters

Efficacy and safety of Huzhang Granule,a compound Chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

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Journal of Integrative Medicine 2024年第3期22卷 270-278页

作者： Hao Wang Si-ting Chen Xiao-jie Ding Le Kuai Liang Hua Xin Li Yi-fei Wang ming Zhang Bin Li Rui-ping Wang mi zhou Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Department of Dermatology the Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000Jiangxi ProvinceChina Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200443China Institute of Dermatology School of MedicineTongji UniversityShanghai 200443China

Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high prevalence.Typical medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse reactions.Huzhang Granule(HZG),a compound Chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse reactions.However,the efficacy and safety of HZG in AGA patients remains unknown.Objective:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA patients.Design,setting,participants and interventions:The current study was conducted as a noninferiority,randomized controlled clinical trial on 180 eligible enrolled participants.Participants were randomly assigned into the HZG and etoricoxib groups.Treatments were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and placebo HZG in the same ratio(1:1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment window.The pain level was measured via a visual analogue scale,ranging from 0 mm to 100 mm.The secondary outcomes comprised joint tenderness and swelling,reduction of inflammatory biomarkers,and the patient’s and investigator’s global evaluations of therapeutic response.Results:The mean reduction in pain was-51.22 mm(95%confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95%CI,[-54.06,-49.94]mm)for the etoricoxib groups.The mean difference between the two groups was 0.78 mm(95%CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of noninferiority.Patients in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etoricoxib group(4.44%vs 13.33%;P≤0.05).Conclusion:HZG and etoricoxib groups demonstrated similar levels of analgesic effectiveness

关键词： Acute gouty arthritis Huzhang Granule Randomized controlled trial Blind

RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration

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Neural Regeneration Research 2024年第8期19卷 1812-1821页

作者： Xinyang zhou Yehua Lv Huimin Xie Yan Li Chang Liu Mengru Zheng Ronghua Wu Songlin zhou Xiaosong Gu Jingjing Li Daguo mi Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and ministry of Education Co-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Orthopedic Nantong Traditional Chinese Medicine HospitalNantongJiangsu ProvinceChina Nantong Stomatological Hospital Affiliated to Nantong University NantongJiangsu ProvinceChina Department of General Practice Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after injury.Long non-coding RNAs(IncRNAs)have been reported to play a crucial role in axonal regeneration.Howeve r,the role of the IncRNA-microRNAmessenger RNA(mRNA)-competitive endogenous RNA(ceRNA)network in exosome-mediated axonal regeneration remains unclear.In this study,we performed RNA transcriptome sequencing analysis to assess mRNA expression patterns in exosomes produced by cultured fibroblasts(FC-EXOs)and Schwann cells(SCEXOs).Diffe rential gene expression analysis,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and protein-protein intera ction network analysis were used to explo re the functions and related pathways of RNAs isolated from FC-EXOs and SC-EXOs.We found that the ribosome-related central gene Rps5 was enriched in FC-EXOs and SC-EXOs,which suggests that it may promote axonal regeneration.In addition,using the miRWalk and Starbase prediction databases,we constructed a regulatory network of ceRNAs targeting Rps5,including 27 microRNAs and five IncRNAs.The ceRNA regulatory network,which included Ftx and miat,revealed that exsosome-derived Rps5 inhibits scar formation and promotes axonal regeneration and functional recovery after nerve injury.Our findings suggest that exosomes derived from fibro blast and Schwann cells could be used to treat injuries of peripheral nervous system.

关键词： ceRNA network exosomes fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells

Full-Scale Isogeometric Topology Optimization of Cellular Structures Based on Kirchhoff-Love Shells

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2479-2505页

作者： mingzhe Huang mi Xiao Liang Gao mian zhou Wei Sha Jinhao Zhang State Key Lab of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China

Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight ratio.In this paper,a full-scale isogeometric topology optimization(ITO)method based on Kirchhoff-Love shells for designing cellular tshin-shell structures with excellent damage tolerance ability is proposed.This method utilizes high-order continuous nonuniform rational B-splines(NURBS)as basis functions for Kirchhoff-Love shell elements.The geometric and analysis models of thin shells are unified by isogeometric analysis(IGA)to avoid geometric approximation error and improve computational accuracy.The topological configurations of thin-shell structures are described by constructing the effective density field on the controlmesh.Local volume constraints are imposed in the proximity of each control point to obtain bone-like cellular structures.To facilitate numerical implementation,the p-norm function is used to aggregate local volume constraints into an equivalent global constraint.Several numerical examples are provided to demonstrate the effectiveness of the proposed method.After simulation and comparative analysis,the results indicate that the cellular thin-shell structures optimized by the proposed method exhibit great load-carrying behavior and high damage robustness.

关键词： Cellular thin-shell structures isogeometric analysis full-scale topology optimization Kirchhoff–Love shells

Drug discovery by targeting the protein–protein interactions involved in autophagy

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4373-4390页

作者： Honggang Xiang mi zhou Yan Li Lu zhou Renxiao Wang Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

Autophagy is a cellular process in which proteins and organelles are engulfed in autophagosomal vesicles and transported to the lysosome/vacuole for degradation.Protein–protein interactions(PPIs)play a crucial role at many stages of autophagy,which present formidable but attainable targets for autophagy regulation.Moreover,selective regulation of PPIs tends to have a lower risk in causing undesired off-target effects in the context of a complicated biological network.Thus,small-molecule regulators,including peptides and peptidomimetics,targeting the critical PPIs involved in autophagy provide a new opportunity for innovative drug discovery.This article provides general background knowledge of the critical PPIs involved in autophagy and reviews a range of successful attempts on discovering regulators targeting those PPIs.Successful strategies and existing limitations in this field are also discussed.

关键词： Autophagy regulation Protein–protein interactions Small-molecule regulators Drug discovery

ER-Net:Efficient Recalibration Network for Multi-ViewMulti-Person 3D Pose Estimation

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 2093-2109页

作者： mi zhou Rui Liu Pengfei Yi Dongsheng zhou National and Local Joint Engineering Laboratory of Computer Aided Design School of Software EngineeringDalian UniversityDalian116622China School of Computer Science and Technology Dalian University of TechnologyDalian116024China

Multi-view multi-person 3D human pose estimation is a hot topic in the field of human pose estimation due to its wide range of application scenarios.With the introduction of end-to-end direct regression methods,the field has entered a new stage of development.However,the regression results of joints that are more heavily influenced by external factors are not accurate enough even for the optimal method.In this paper,we propose an effective feature recalibration module based on the channel attention mechanism and a relative optimal calibration strategy,which is applied to themulti-viewmulti-person 3D human pose estimation task to achieve improved detection accuracy for joints that are more severely affected by external factors.Specifically,it achieves relative optimal weight adjustment of joint feature information through the recalibration module and strategy,which enables the model to learn the dependencies between joints and the dependencies between people and their corresponding joints.We call this method as the Efficient Recalibration Network(ER-Net).Finally,experiments were conducted on two benchmark datasets for this task,Campus and Shelf,in which the PCP reached 97.3% and 98.3%,respectively.

关键词： Multi-view multi-person pose estimation attention mechanism computer vision

European Demand for NEVs Remains High

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China Today 2024年第6期73卷 52-54页

作者： zhou mi The Chinese Academy of International Trade and Economic Cooperation

THIS year,the International Energy Agency(IEA)published its Global EV Outlook report under the title“Moving Towards Increased Affordability.”It noted,“A rapid transition to EVs(electric vehicles)will require bringing to the market more affordable models.”Last year,the global sales of EVs approached 14 million,an increase of 35 percent from 2022,accounting for 20 percent of sales of all automobiles.The top three markets were China(60 percent),Europe(less than 25 percent),and the U.S.(10 percent).

关键词： Outlook market sales

Multi-wavelength nanowire micro-LEDs for future high speed optical communication

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Opto-Electronic Advances 2024年第3期7卷 1-3页

作者： Ayush Pandey Zetian mi Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48109USA

The future of optoelectronics is directed towards small-area light sources,foremost being microLEDs.However,their use has been inhibited so far primarily due to fabrication and integration challenges,which impair efficiency and yield.Recently,bottom-up nanostructures grown using selective area epitaxy have garnered attention as a solution to the aforementioned issues.Prof.Lan Fu et.***.have used this technique to demonstrate uniform p-i-n core-shell InGaAs/InP nanowire array light emitting diodes.The devices are capable of voltage and geometry-controlled multi-wavelength and high-speed operations.Their publication accentuates the wide capabilities of bottom-up nanostructures to resolve the difficulties of nanoscale optoelectronics.

关键词： communication high operations

Topological Dirac-vortex microcavity laser for robust on-chip optoelectronics

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Light(Science & Applications) 2024年第4期13卷 591-592页

作者： Yuanpeng Wu Zetian mi Department of Electrical Engineering and Computer Science University of Michigan1301 Beal AvenueAnn ArborMI 48109USA

Dirac-vortex microcavity laser based on InAs/InGaAs quantum dots have been experimentally realized on silicon substrate.The topological laser features a large spectral range and high robustness against variations such... 详细信息

关键词： laser optoelectronics cavity