Drug discovery by targeting the protein–protein interactions involved in autophagy

作     者：Honggang Xiang Mi Zhou Yan Li Lu Zhou Renxiao Wang Honggang Xiang;Mi Zhou;Yan Li;Lu Zhou;Renxiao Wang

作者机构：Department of Medicinal ChemistrySchool of PharmacyFudan UniversityShanghai 201203China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第11期

页      面：4373-4390页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supports by the National Natural Science Foundation of China (Grant Nos.81725022,82173739,81430083,21661162003,21472227) the Ministry of Science and Technology of China (Grant No.2016YFA0502302) Science and Technology Commission of Shanghai Municipality (Grant No.20S11900500,China) 

主　　题：Autophagy regulation Protein–protein interactions Small-molecule regulators Drug discovery 

摘      要：Autophagy is a cellular process in which proteins and organelles are engulfed in autophagosomal vesicles and transported to the lysosome/vacuole for ***–protein interactions(PPIs)play a crucial role at many stages of autophagy,which present formidable but attainable targets for autophagy ***,selective regulation of PPIs tends to have a lower risk in causing undesired off-target effects in the context of a complicated biological ***,small-molecule regulators,including peptides and peptidomimetics,targeting the critical PPIs involved in autophagy provide a new opportunity for innovative drug *** article provides general background knowledge of the critical PPIs involved in autophagy and reviews a range of successful attempts on discovering regulators targeting those *** strategies and existing limitations in this field are also discussed.