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Establishment of a rat model of severe spontaneous intracerebral hemorrhage

Journal of Intensive Medicine 2024年第1期4卷 108-117页

作者： Shuixiang deng Shengjie Feng Yuewen Xin Yu He Yao Wang mi Tian Ye Gong Department of Critical Care Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina

Background:Severe intracerebral hemorrhage(ICH)is the most devastating subtype of stroke resulting in high mortality and disability.At present,the development of targeted treatments to minimize the high morbidity and mortality is limited partly due to the lack of a severe ICH animal model.In this study,we aimed to establish an accurate severe ICH model in rats and examine the pathological and physiological changes associated with ICH.Methods:A rat model of severe ICH model was established by intrastriatal injection of autologous blood using different blood volumes(ICH 100μL group,ICH 130μL group,ICH 160μL group,ICH 170μL group,and ICH 180μL group).The mortality was assessed during the 28-day post-ICH period.Short-and long-term neurological deficits were evaluated using the Longa method,foot fault,falling latency,and Morris water maze tests.Brain water content,hematoma volume,hemoglobin content,and magnetic resonance imaging were assessed to determine the extent of brain injury.Immunofluorescence staining was conducted to examine microglial activation and neuronal apoptosis.Hematoxylin and eosin(H&E)staining,lung water content,and western blotting were used to assess lung injury following ICH.Results:The mortality of ICH rats increased significantly with an increase in autologous blood injection.The 28-day mortality in the 100μL,130μL,160μL,170μL,and 180μL ICH groups were 5%,20%,40%,75%,and 100%,respectively.A significantly higher 28-day mortality was observed in the ICH 160μL group compared to the ICH 100μL group.The ICH 160μL group exhibited significantly increased neurological deficits,brain edema,hematoma volume,and hemoglobin content compared to the sham group.Compared with the sham operation group,the activation of microglia and neuronal death in ICH 160μL rats increased.The use of H&E staining and western blotting demonstrated that disruption of the intra-alveolar structure,alveolar edema,and infiltration of inflammatory cells and cytokines into the lung tissue were more severe in the ICH 160μL group than t

关键词： Severe spontaneous intracerebral hemorrhage Animal model Autologous blood injection Animal behavior Lung injury

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Myeloid checkpoints for cancer immunotherapy

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Chinese Journal of Cancer Research 2022年第5期34卷 460-482页

作者： Yixin Qian Ting Yang Huan Liang mi deng Peking University International Cancer Institute Health Science CenterPeking UniversityBeijing 100191China School of Basic Medical Sciences Health Science CenterPeking UniversityBeijing 100191China Peking University Cancer Hospital&Institute Peking UniversityBeijing 100142China

Myeloid checkpoints are receptors on the myeloid cell surface which can mediate inhibitory signals to modulate anti-tumor immune activities.They can either inhibit cellular phagocytosis or suppress T cells and are thus involved in the pathogenesis of various diseases.In the tumor microenvironment,besides killing tumor cells by phagocytosis or activating anti-tumor immunity by tumor antigen presentation,myeloid cells could execute protumor efficacies through myeloid checkpoints by interacting with counter-receptors on other immune cells or cancer cells.In summary,myeloid checkpoints may be promising therapeutic targets for cancer immunotherapy.

关键词： Cancer immune checkpoint myeloid checkpoint MDSC TAM immunotherapy

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Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus

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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： Hong-Xiao Wu Xiao-Yan Ding Ya-Wen Xu ming-Hua Yu Xiao-mi Li Na deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment responses.AIM To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with PVTT.METHODS From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan Hospital.They were distributed to either the PTL or TACE/Lenvatinib(TL)group.The median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary endpoints.RESULTS Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)groups.For a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),res-pectively.Moreover,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)patients.There were no treatment-related deaths or differences in adverse events in either group.CONCLUSION A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

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Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer

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Cancer Biology & Medicine 2023年第6期20卷 421-437页

作者： Mei Feng Fangyanni Wang Xinyu Liu Tingting Hao Ning Zhang mi deng Yisheng Pan Ruirui Kong Translational Cancer Research Center Peking University First HospitalBeijing 100034China Division of General Surgery Peking University First HospitalBeijing 100034China International Cancer Institute Peking University Health Science CenterBeijing 100191China Yunnan Baiyao Group Kunming 650500ChinaDivision of General SurgeryPeking University First HospitalBeijing 100034China

Objective:Liver cancer is a deadly malignancy associated with high mortality and morbidity.Less than 20%of patients with advanced liver cancer respond to a single anti-PD-1 treatment.The high heterogeneity of neutrophils in the tumor immune microenvironment in liver cancer may contribute to resistance to immune checkpoint blockade(ICB).However,the underlying mechanism remains largely unknown.Methods:We established an orthotopic liver cancer model by using transposable elements to integrate the oncogenes Myc and KrasG12Dinto the genome in liver cells from conditional Trp53 null/null mice(pTMK/Trp53^(-/-)).Flow cytometry and immunohistochemistry were used to assess the changes in immune cells in the tumor microenvironment.An ex vivo coculture assay was performed to test the inhibitory effects of tumor-associated neutrophils(TANs)on CD8^(+)T cells.The roles of neutrophils,T cells,and NK cells were validated through antibody-mediated depletion.The efficacy of the combination of neutrophil depletion and ICB was evaluated.Results:Orthotropic pTMK/Trp53^(-/-)mouse liver tumors displayed a moderate response to anti-Ly6G treatment but not PD-1 blockade.Depletion of neutrophils increased the infiltration of CD8^(+)T cells and decreased the number of exhausted T cells in the tumor microenvironment.Furthermore,depletion of either CD8^(+)T or NK cells abrogated the antitumor efficacy of anti-Ly6G treatment.Moreover,the combination of anti-Ly6G with anti-PD-L1 enhanced the infiltration of cytotoxic CD8^(+)T cells and thereafter resulted in a significantly greater decrease in tumor burden.Conclusions:Our data suggest that TANs may contribute to the resistance of liver cancer to ICB,and combining TAN depletion with T cell immunotherapy synergistically increases antitumor efficacy.

关键词： Liver cancer neutrophil PD-1,CD8^(+)T cell exhaustion

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LILRB4, an immune checkpoint on myeloid cells

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Blood Science 2022年第2期4卷 49-56页

作者： Ting Yang Yixin Qian Xiaoting Liang Jianbo Wu ming Zou mi deng Peking University International Cancer Institute Health Science CenterPeking UniversityBeijingChina Peking University Cancer Hospital and Institute Peking UniversityBeijingChina

Leukocyte immunoglobulin-like receptor B4(LILRB4)is an inhibitory receptor in the LILR family mainly expressed on normal and malignant human cells of myeloid origin.By binding to ligands,LILRB4 is activated and subsequently recruits adaptors to cytoplasmic immunoreceptor tyrosine inhibitory motifs to initiate different signaling cascades,thus playing an important role in physiological and pathological conditions,including autoimmune diseases,microbial infections,and cancers.In normal myeloid cells,LILRB4 regulates intrinsic cell activation and differentiation.In disease-associated or malignant myeloid cells,LILRB4 is significantly correlated with disease severity or patient survival and suppresses T cells,thereby participating in the pathogenesis of various diseases.In summary,LILRB4 functions as an immune checkpoint on myeloid cells and may be a promising therapeutic target for various human immune diseases,especially for cancer immunotherapy.

关键词： Autoimmune disease Cancer Immune checkpoint Immunotherapy Inhibitory receptor LILR LILRB4,MDSC Myeloid cell TAM

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Channel modeling for mi-based wireless underground sensor networks with conductive objects

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Science China(Information Sciences) 2024年第7期67卷 333-334页

作者： Shuhan deng Guanghua LIU Ziwei CHEN Huaijin ZHANG Tao JIANG Research Center of 6G Mobile Communications School of Cyber Science and EngineeringHuazhong University of Science and Technology School of Electronic Information and Communications Huazhong University of Science and Technology

Wireless underground sensor networks (WUSNs) are an emerging research field with promising applications. However, WUSNs links suffer from significant attenuation as the propagation of the signal needs to pass through soil, rock,and water. Magnetic induction (mi)-based transmission is proposed to overcome these issues as mi signal can penetrate most substances similarly without experiencing high path loss, which ensures the robustness of WUSNs links [1].

关键词： Wireless sensor networks

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深埋切顶自成巷道二次复用围岩稳定性研究

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地下空间与工程学报 2024年第1期20卷 320-328页

作者：童治鹏张向阳邓秘安徽理工大学矿业工程学院安徽淮南232001 淮河能源集团煤业分公司张北矿生产技术二科安徽淮南232174

为研究深埋切顶自成巷道二次复用期间的围岩稳定性,通过数值模拟和现场实测对张北矿超前1615A工作面区段轨道顺槽围岩变形规律和应力分布特征进行了分析,结果表明:受切顶卸压及恒阻锚索补强支护的双重作用,留巷复用期间顶板较为稳定,主... 详细信息

为研究深埋切顶自成巷道二次复用期间的围岩稳定性,通过数值模拟和现场实测对张北矿超前1615A工作面区段轨道顺槽围岩变形规律和应力分布特征进行了分析,结果表明:受切顶卸压及恒阻锚索补强支护的双重作用,留巷复用期间顶板较为稳定,主要表现为底臌和实体煤侧帮臌,围岩呈非对称性变形,变形速率沿工作面推进方向呈三段式规律,巷内单体支承压力呈4个分区特征;工作面靠近留巷侧15 m内及超前煤壁40 m内的区域受采动应力影响较为显著,呈“L”形分布特征,超前压力峰值位于“L”形角点处;留巷复用期间应重点加强控底、控帮和离层监测;研究成果可为类似工程条件下巷道围岩控制提供科学依据。

关键词：切顶成巷二次复用围岩变形采动应力支承压力

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Solitary fibrous tumor: a 10-year retrospective analysis with several rare cases

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Chinese Medical Journal 2021年第8期134卷 1006-1008页

作者： Ke Zhang Hui-Juan Liu Zhang-Bo Cheng mi deng Jing Luo Xin Qi Departm ent of Pathology the Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Clinical Research Center of Ophthalmic Disease ChangshaHunan 410011China Department of Cardiovascular Surgery Fujian Provincial HospitalFujian Medical SchoolFuzhouFujian 350001China

To the Editor:Solitary fibrous tumors(SFTs)are mesenchymal neoplasms and were first described in pleura,then subsequently found in extrapleural organs,such as peritoneum,lung,parotid gland,paranasal sinuses,orbit,skin,and intracranial areas.1 However,extrapleural SFTs are limited to isolated case reports.Because of the rarity of them,the related information is far from sufficient and thus,leading this tumor under fully recognized.According to the World Health Organization(WHO)classification,SFTs are pluripotent neoplasms that could be benign,intermediate,or malignant.All of above drive us to further understand the epidemiology,clinical characteristics,medical therapy,and prognosis of this disease.

关键词： neoplasms epidemiology organs

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人造沸石对服务区污水氨氮的吸附特性试验研究

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水处理技术 2024年第6期50卷 63-68页

作者：曾波任天成赵红邓利智吴永明邓觅江西省交通运输科学研究院有限公司江西南昌330200 南昌大学资源与环境学院鄱阳湖环境与资源利用教育部重点实验室江西南昌330031 江西省科学院微生物研究所江西南昌330096

从材质、投加量、固体悬浮物等方面考察了人造沸石(1#、2#)、红火山石和天然沸石四种常见吸附材料对高速公路服务区污水中氨氮的去除影响。结果表明:人造沸石(1#、2#)对氨氮去除效果明显优于红火山石和天然沸石;振荡有利于提高氨氮的去... 详细信息

从材质、投加量、固体悬浮物等方面考察了人造沸石(1#、2#)、红火山石和天然沸石四种常见吸附材料对高速公路服务区污水中氨氮的去除影响。结果表明:人造沸石(1#、2#)对氨氮去除效果明显优于红火山石和天然沸石;振荡有利于提高氨氮的去除效率,其中80 r/min振荡速度较静置状态提升了23.57%;投加量增大,不仅能提高氨氮去除率,也可以缩短处理时间,其中,4 g/L实验组较2 g/L实验组缩短约17 h达到相似去除效果,而50 g/L实验组则在反应前1 h就可以使氨氮降至27.35 mg/L并趋近24 h时对应浓度23.95 mg/L,去除率达66.53%。污水中固体悬浮物(SS)对沸石降低氨氮效果无明显影响,但沸石具有一定的氨氮去除限度,浓度无法持续降低。进一步的吸附动力学和热力学分析表明,人造沸石1#对氨氮的反应过程更符合准二级动力学,R^(2)>0.93,且理论吸附量q_(e)(cal)更接近实验吸附量q_(e)(exp),而热力学实验证明人造沸石1#吸附氨氮属于吸热反应(△H为3693.92 J/mol),温度升高有利于反应的进行。

关键词：沸石高速公路服务区污水氨氮

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新能源崛起对中国新能源产业战略的影响

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中国软科学 2024年第2期 1-8页

作者：张娜米倩玉邓嘉纬赵晓军北京交通大学北京产业安全与发展研究基地北京100044 北京交通大学经济管理学院北京100044 同济大学经济与管理学院上海200092

全球新能源加速发展的时代已经来到,传统能源消费的绝对量、占比和成本将开始下降,围绕能源而开展的竞争将逐步转移到新能源领域。新能源的崛起将导致能源生产国与消费国之间、发达国家与发展中国家之间、发达国家和发展中国家内部出现... 详细信息

全球新能源加速发展的时代已经来到,传统能源消费的绝对量、占比和成本将开始下降,围绕能源而开展的竞争将逐步转移到新能源领域。新能源的崛起将导致能源生产国与消费国之间、发达国家与发展中国家之间、发达国家和发展中国家内部出现利益分化和政治关系重组。中国要利用在新能源设备制造业领域的绝对优势,选择适合的产业战略,促进新能源产业发展,积极推动全球碳减排,帮助包括中国在内的发展中国家实现能源自给和能源清洁化,并降低工业化和现代化的成本。

关键词：新能源地缘政治产业安全产业战略

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