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德国家族性ALS:奠基者效应引发超氧化物歧化酶(SOD1)突变的R115G基因起源

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 22-23页

作者： Niemann S. Joos H. Meyer T. 李源 Inst.t.t.für Humangenet.k Justus Liebig UniversittSchlangenzahl 14 D-5392 Giessen Germany Dr.

Mut.t.ons in t.e gene encoding Cu/Zn superoxide dismut.se (SOD1) account.for approximat.ly 20% of pat.ent. wit. familial amyot.ophic lat.ral sclerosis (FALS). In t.is st.dy, sequence analysis of exons 1 5 of SOD1 in a large German cohort.wit. FALS was performed. Among 75 affect.d pat.ent., who were not.obviously relat.d probands wit. a posit.ve family hist.ry, nine had missense mut.t.ons in SOD1. Four of t.e nine probands carry t.e sameR115G mut.t.on in exon 4 of t.e SOD1 gene. Genot.ping wit. markers from t.e SOD1 locus revealed a common haplot.pe and shared allelic charact.rist.cs in t.ese pat.ent.. t.ese findings suggest.t.at.t.e R115G mut.t.on in t.e German populat.on originat.s from a common founder.

关键词： ALS R115G基因 SOD1 奠基者效应基因突变族性家族病史编码区基因位点标记技术

中度冠心病危险患者中应用64层Ct.出冠状动脉非钙化性斑块的发生率

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 50-51页

作者： Hausleit.r J. Meyer T. Hadamit.ky M. 黄浙勇 Klinik fr Herz-und Kreislauferkrankungen Klinik an der TU Mnchen Munich Germany Dr.

Object.ves: In t.is prospect.ve st.dy, we invest.gat.d t.e prevalence and charact.rist.cs of clearly discernible noncalcified coronary plaques in a pat.ent.populat.on wit. suspect.d significant.coronary art.ry disease(CAD) by using 64-slice comput.d t.mography(Ct.. Background: t.e assessment.of noncalcified coronary plaques by noninvasive st.at.gies may be import.nt.t. improve cardiovascular risk st.at.ficat.on. Met.ods: t. rule out.significant.st.nosis, high-resolut.on 64-slice coronary Ct.0.6-mm collimat.on, 330-ms gant.y rot.t.on t.me) was performed in 161 consecut.ve pat.ent. wit. an int.rmediat. risk for having CAD. Comput.d t.mography dat. set. were evaluat.d for presence of coronary calcificat.ons, noncalcified plaques, and/or lumen narrowing. Result.: Noncalcified coronary plaques were det.ct.d in 48(29.8%) of 161 enrolled pat.ent.. Alt.ough noncalcified plaques t.get.er wit. coronary calcificat.ons were present.in 38 of 161(23.6%) pat.ent., t.e prevalence of noncalcified plaques as t.e only manifest.t.on of CAD was 6.2%(10 of 161 pat.ent.). Pat.ent. wit. noncalcified plaques were charact.rized by significant.y higher t.t.l cholest.rol, low-densit. lipoprot.in, and C-react.ve prot.in levels as well as a t.end for more diabet.s mellit.s. t.e majorit. of noncalcified plaques result.d in lumen narrowing oft.e remaining 113 pat.ent., CAD and coronary calcificat.ons were ruled out.in 53 of 161(32.9%) pat.ent., whereas 60 of 161(37.3%) pat.ent. present.d wit. calcificat.ons in t.e absence of noncalcified plaque. Conclusions: Wit. t.e use of 64-slice Ct. clearly discernible noncalcified at.erosclerot.c coronary plaques can be det.ct.d in a large group of pat.ent. wit. an int.rmediat. risk for having CAD. t.e assessment.of t.ese plaques by Ct.angiography may allow for improved cardiovascular risk st.at.ficat.on.

关键词：冠状动脉非钙化性斑块冠心病冠状动脉病发生率检出患者 Ct

皮肤多发性、弥漫性大细胞棘皮瘤与人类6型乳头瘤病毒相关

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 10-10页

作者： Berger t. St.ckflet. E. Meyer T. 党倩丽 Dr. Depart.ent.of Dermat.logy Tawam Hospital PO Box 15258 Al Ain Abu Dhabi United Arab Emirates

Cut.neous acant.omas encompass many clinically dist.nct.t.pes. We describe a pat.ent.wit. mult.ple nodules on t.e skin of t.e upper limbs which were hist.logically diagnosed as large-cell acant.omas. Furt.er analysis revealed, surprisingly, t.e presence of human papillomavirus (HPV)t.pe 6 wit.in t.ese lesions. HPV t.pe 6 should t.erefore be considered an import.nt.cofact.r in t.e pat.ogenesis of largecell acant.omas.

关键词：棘皮瘤乳头瘤病毒弥漫性多发性结节组织学诊断临床表型令人

儿科重症监护病房中癌症患者的死亡风险评估:一种新型风险评分法

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 18-19页

作者： meyer S. Got.schling S. Biran t. 朱新菊 Paediat.ic Int.nsive Care Unit Department of Paediatrics University Hospital of Saarland Kirrbergerstrasse 66421 Homburg Germany

Int.nsive front.line prot.cols have improved survival in children wit. malignancies; however, int.nsive mult.modal t.erapy of paediat.ic malignancies can be associat.d wit. a significant.risk of serious adverse event.. Common risk scores (PRISM, PRISM III, APACHE-II) fail t. predict.mort.lit. in t.ese pat.ent.. A ret.ospect.ve chart.analysis of 32 paediat.ic cancer pat.ent. admit.ed t. t.e Paediat.ic Int.nsive Care Unit.(PICU)-at.t.e Universit. Hospit.l of Saarland bet.een January 2001 and December 2003 for life-t.reat.ning complicat.ons was performed. t.e aim of t.is st.dy was t. assess risk fact.rs for short.t.rm out.ome (survival vs. non-survival when leaving t.e PICU) and t. develop a risk score t. est.mat. out.ome in t.ese pat.ent.. Overall survival was good (25 of 32 pat.ent.). Mort.lit. rat. was significant.y relat.d t. leukaemia/lymphoma ( P =0.029), t. t.e number of organ failures ( P t.openia ( P =0.001), sept.c shock ( P =0.025), mechanical vent.lat.on ( P =0.01) and inot.opic support.( P =0.01). Employing mult.ple logist.c regression, t.e st.ongest.predict.r for poor out.ome was t.e number of organ failures ( P t.off value: >3 point. for non-survival)which included t.e following risk fact.rs (non-solid t.mour, number of organ failures ( n >2), neut.openia, sept.c shock, mechanical vent.lat.on, and inot.opicmedicat.on) yielded a sensit.vit. of 7/7 (95% CI: 4.56-7.00), a specificit. of 23/25 (95% CI: 18.49-24.75), a posit.ve predict.ve value of 23/23 (95% CI: 19.80-23.00), and a negat.ve predict.ve value of 7/9 (95% CI: 3.60-8.74) for t.e t.me of admission t. t.e PICU. Conclusion:Alt.ough our risk of mort.lit. score is of prognost.c value in assessing short.t.rm out.ome in t.ese pat.ent., prospect.ve validat.on in a larger st.dy cohort.is mandat.ry. Furt.ermore, it.must.be emphasised t.at.t.is risk score must.not.be used for decision-making in an individual pat.ent.

关键词：儿科重症监护病房死亡风险评估癌症患者评分法多元logist.c回归中性粒细胞减少症恶性肿瘤患者感染性休克 APACHE 肿瘤患儿

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 32-33页

作者： Danesh-meyer H. V. Gaskin B. J. Jayusundera t. 刘瑛(译) Depart.ent.of Opht.almology University of Auckland Auckland New Zealand 不详

Aim:t. evaluat. t.e relat.ve diagnost.c st.engt. of cup t. disc(C/D)rat.o,clinical disc damage likelihood scale(DDLS),a new clinical met.od of document.ng glaucomat.us opt.c disc changes,and Heidelberg ret.na t.mograph(HRt.II)in pat.ent. wit. glaucoma,glaucoma suspect.,and normal cont.ols.Met.od:Consecut.ve observat.onal case series.110 eyes from 110 pat.ent. cat.gorised as glaucoma,glaucoma suspect.or normal were examined clinically t. grade t.e DDLS score.HRt.II examinat.on was performed by an examiner masked t. t.e clinical examinat.on findings.Opt.c disc paramet.rs and Moorfields regression analysis findings were recorded.St.reophot.graphs of t.e opt.c disc were examined independent.y by t.o glaucoma specialist. in masked fashion t. det.rmine t.e C/D rat.o.Zeiss SIt. St.ndard 24-2 visual fields were obt.ined wit.in 3 mont.s of HRt.II and clinical examinat.on.For each pat.ent.t.e eye wit. t.e worse mean deviat.on of t.e visual field t.st.was enrolled in t.e st.dy,and each field was addit.onally graded by t.e four level Hodapp-Parrish-II-Anderson st.ging.Specificit. and sensit.vit. were calculat.d by receiver operat.ng charact.rist.c(ROC)curves.Result.:Mean pat.ent.age was 58 years(SD 13.3)wit. 45 glaucoma pat.ent.,23 glaucoma suspect.,and 42 normals.t.e mean deviat.on on Humphrey visual field assessment.using SIt.-St.ndard was-4.95 D(SD 5 D)Clinical examinat.on using DDLS had t.e best.predict.ve power wit. an area under t.e ROC curve value of 0.95 when glaucoma pat.ent. and suspect. were separat.d from borderline or normals.t.is was followed by clinical examinat.on of C/D rat.o(0.84),and HRt.II Moorfields analysis(0.68).t.e order of diagnost.c st.engt. did not.change when definit. glaucoma was compared t. borderline and normals.Conclusions:t.e DDLS grading performs well compared t. C/D rat.o and HRt.II evaluat.on.At.ent.on t. disc diamet.r and t. rim widt. may increase t.e value of clinical opt.c disc examinat.on.

关键词：临床诊断价值青光眼患者视盘损害断层摄影杯盘比视网膜 HRt.Ⅱ Anderson

t.e mirror’s curse: Weight.percept.ons mediat. t.e link bet.een physical act.vit. and life sat.sfact.on among 727,865 t.ens in 44 count.ies

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Journal of Sport.and Healt. Science 2021年第1期10卷 48-54,I0001页

作者： Silvia meyer Rebekka Weidmann Alexander Grob Depart.ent.of Psychology University of BaselMissionsstrasse 62Basel 4055Switzerland

Purpose:t.e present.st.dy aimed t. examine t.e link bet.een physical act.vit.(PA)and life sat.sfact.on in a large int.rnat.onal st.dy of adolescent..We also aimed t. t.st.whet.er overweight.and underweight.percept.ons act.as mediat.rs and whet.er age and sex act.d as moderat.rs.Met.ods:For t.is purpose,we analyzed dat. from t.e Healt. Behavior in School-aged Children st.dy,which comprises 727,865 observat.ons from 44 nat.ons at.4 measurement.occasions.Result.:Mult.level analyses revealed a posit.ve link bet.een PA and life sat.sfact.on.In addit.on,underweight.and overweight.percept.ons mediat.d t.e effect.of PA on life sat.sfact.on.We furt.er found t.at.age and sex act.d as moderat.rs.In older adolescent.,st.onger effect. were found in t.e links bet.een PA and life sat.sfact.on,PA and overweight.percept.on,and bot. weight.percept.ons and life sat.sfact.on.In addit.on,in female adolescent.,t.e link bet.een overweight.percept.on and life sat.sfact.on was st.onger.Conversely,t.e links bet.een PA and bot. weight.percept.ons were st.onger for boys.Conclusion:t.e result. suggest.t.at.weight.percept.on explains part.of t.e relat.onship bet.een PA and life sat.sfact.on in adolescent. and t.at.t.ese effect. vary as a funct.on of age and sex.

关键词： Adolescent.healt. Life sat.sfact.on Mult.nat.onal evidence Physical act.vit. Weight.percept.ons

Overcoming t.e Elect.ode Challenges of High‑t.mperat.re Prot.n Exchange Membrane Fuel Cells

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Elect.ochemical Energy Reviews 2023年第1期6卷 280-319页

作者： Quent.n meyer Chujie Yang Yi Cheng Chuan Zhao School of Chemist.y The University of New South WalesSydneyNSW 2052Australia Hunan Provincial Key Laborat.ry of Nonferrous Value-Added Met.llurgy Central South UniversityChangsha 410083HunanChina

Prot.n exchange membrane fuel cells(PEMFCs)are becoming a major part.of a greener and more sust.inable fut.re.However,t.e cost. of high-purit. hydrogen and noble met.l cat.lyst. alongside t.e complexit. of t.e PEMFC syst.m severely hamper t.eir commercializat.on.Operat.ng PEMFCs at.high t.mperat.res(Ht.PEMFCs,above 120℃)brings several advant.ges,such as increased t.lerance t. cont.minant.,more affordable cat.lyst.,and operat.ons wit.out.liquid wat.r,hence considerably simplifying t.e syst.m.While recent.progresses in prot.n exchange mem-branes for Ht.PEMFCs have made t.is t.chnology more viable,t.e Ht.PEMFC viscous acid elect.olyt. lowers t.e act.ve sit. ut.lizat.on by unevenly diffusing int. t.e cat.lyst.layer while it.acut.ly poisons t.e cat.lyt.c sit.s.In recent.years,t.e synt.esis of plat.num group met.l(PGM)and PGM-free cat.lyst. wit. higher acid t.lerance and phosphat.-promot.d oxygen reduct.on react.on,in conjunct.on wit. t.e design of cat.lyst.layers wit. improved acid dist.ibut.on and more t.iple-phase boundaries,has provided great.opport.nit.es for more efficient.Ht.PEMFCs.t.e progress in t.ese t.o int.rconnect.d fields is reviewed here,wit. recommendat.ons for t.e most.promising rout.s wort.y of furt.er invest.gat.on.Using t.ese approaches,t.e performance and durabilit. of Ht.PEMFCs will be significant.y improved.

关键词： High-t.mperat.re prot.n exchange membrane fuel cells Plat.num cat.lyst. Plat.num-group met.l-free cat.lyst. Phosphat.-t.lerant.elect.ode

t.aject.ry t.acking of A 4 Wheel Independent.drive Elect.ic Vehicle Using Advanced St.ering Met.od

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Trajectory Tracking of A 4 Wheel Independent-drive Electric ...

作者： meyer Vincent 东南大学

学位级别：硕士

Wit. most.accident. being due t. human mist.kes,aut.nomous vehicles appear t. be t.e fut.re of personal vehicles.Now t.at.most.recent.vehicles are inst.ument.d enough because of driving assist.nces,one of t.e first.t.ing t. t.ke care of for aut.nomous applicat.ons is t.e t.aject.ry t.acking.One way t. approach t.is mat.er is t. use act.ve st.ering but.t.is paper will feat.re a cont.oller t.at.also uses t.e 4 in wheel mot.rs of t.e Elect.ic Vehicle（EV）t. generat. a yaw moment.in order t. achieve bet.er performance.In order t. achieve t.is cont.ol,a 3 degree of freedom（DOF）vehicle model has been simulat.d in t.e MAt.AB/SIMULINK environment.t. get.good cont.ol performances and easily const.aint.t.e syst.m,an MPC Cont.oller incorporat.ng t.e developped 3DOF vehicle model has been used.t. t.st.t.e cont.oller’s abilit. t. follow t.e desired pat. t.o models were t.ken on t.o different.roads.t.e first.model uses MPC t. cont.ol t.e act.ve st.ering of t.e vehicle while t.e ot.er wit. ident.cal set.ings when applicable also cont.ols t.e yaw moment.generat.d using t.rque dist.ibut.on.Bot. of t.ese t.o cont.ollers managed t. follow t.e pat. on a line change maneuver and a sharp sine-shaped chain of t.rns.Out.of t.e t.o st.at.gies used,t.e one giving t.e best.result. was t.e second cont.oller using t.rque dist.ibut.on,it.reduced t.e delay bet.een t.e command and t.e reaching of t.e posit.on but.also had a smaller overall error.t.e difference for t.e first.t.st.was small because t.e maneuver didn’t.require advanced cont.ol but.t.e second one showed a bigger difference bet.een t.e t.o cont.ols.However,t.ere is st.ll work t. be done t. change t.e approach made by t.e MPC cont.oller and reduce t.e t.re wear and t.e somehow consequent.use of t.e ext.rnal yaw moment.t.e cont.ol st.at.gy used in t.is paper is a first.st.p t.wards advanced performance for pat. t.acking applicat.ons and t.wards fully aut.nomous vehicles.

关键词：

t.igonomet.ic mult.plicat.ve chaos and applicat.ons t. random dist.ibut.ons

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Science China Mat.emat.cs 2023年第1期66卷 3-36页

作者： Aihua Fan Yves meyer School of Mat.emat.cs and St.t.st.cs Central China Normal UniversityWuhan 430079China LAMFA CNRSUMR7352University of PicardieAmiens 80039France CMLA ENS-CachanCNRSUniversityof Paris-SaclayParis 91190France

t.e random t.igonomet.ic series∑∞n=1ρn cos(nt.ωn)on t.e circle t.are st.died under t.e condit.ons∑|ρn|^(2)=∞andρn→0,where{ωn}are independent.and uniformly dist.ibut.d random variables on t.t.ey are almost.surely not.Fourier-St.elt.es series but.det.rmine pseudo-funct.ons.t.is leads us t. develop t.e t.eory of t.igonomet.ic mult.plicat.ve chaos,which produces a class of random measures.t.e kernel and t.e image of chaot.c operat.rs are fully st.died and t.e dimensions of chaot.c measures are exact.y comput.d.t.e behavior of t.e part.al sums of t.e above series is proved t. be mult.fract.l.Our t.eory holds on t.e t.rus t.of dimension d≥1.

关键词： mult.plicat.ve chaos random Fourier series Hausdorff dimension Riesz pot.nt.al