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Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl4 induced hepatic damage in rats

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 249-255页

作者： Amel Laouar Fahima Klibet Ezzeddine Bourogaa Amel Benamara Amel Boumendjel Azzedine Chefrour messarah mahfoud Laboratory of Biochemistry and Environmental Toxicology Faculty of SciencesUniversity of Badji MokhtarAnnaba 23000Algeria Department of Biochemistry and Biological Cellular and Molecular Faculty of SciencesUniversity of MentouriBP 25000 ConstantineAlgeria Laboratoryof Animal Ecophysiology Faculty of SciencesSfaxSoukra road-Km 3.5BP 8023018 SfaxTunisia Department of Applied Biology Faculty of Natural Sciences and LifeUniversity of Larbi TebessiTebessa 12000Algeria Laboratory of pharmaceutical preparations for hospital use Department of PharmacyFaculty of MedicineUniversity of Badji Mokhtar-Annaba 23000Algeria Department of Biology Faculty of Natural Sciences and LifeUiversity of Mohamed Cherif MesaadiaSouk Ahras 41000Algeria

Objective:To investigate the antioxidant and hepatoprotective properties of Juniperus phoenicea(***)berries against CCl_4-induced oxidative damage in ***:Hepatotoxicity was induced in albino Wistar rats by single dose of CCl_4 dissolved in olive oil(1 mL/kg BW,1/1 in olive oil,ip).Aqueous extract of *** berries(AEJP)was administered at the dose of 250 mg/kg/day by gavage for 12 ***:Obtained results revealed that administration of CCl_4 caused a significant increase in plasma ASAT,ALAT,ALP and LDH activities and total bilirubin concentration,compared to the control ***,albumin and total protein concentration were significantly ***,a significant decrease in the level of hepatic GSH,GPx and GST activities associated with a significant increase of MDA content in CCl_4 group than those of the ***,the treatment of experimental rats with AEJP prevented these alterations and maintained the antioxidant *** histopathological observations supported the biochemical evidences of ***:The results of the present investigation indicate that *** possesses hepatoprotective activity and this effect was may be due to its antioxidant proprerties.

关键词： Juniperus phoenicea Oxydative stress Antioxydant Lipid peroxidation Hepatoprotective Biochemical parameters

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