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Effects of methyl palmitate and lutein on LPS-induced acute lung injury in rats

World Journal of Respirology 2013年第2期3卷 20-28页

作者： El-Sayed m Ammar maha H Sharawy Asem A Shalaby Dina S El-Agamy Department of Pharmacology and Toxicology Faculty of PharmacyMansoura University Mansoura 35516 Egypt Department of Pathology Faculty of Medicine Mansoura University Mansoura 35516 Egypt

AIm: To investigate the effects of methyl palmitate and lutein on lipopolysaccharide(LPS)-induced acute lung injury(ali) in rats and explore the possible mechanisms. mETHODS: male Sprague-Dawley rats were divided into 4 groups:(1) control;(2) LPS;(3) methyl palmitate; and(4) Lutein groups. methyl palmitate(300 mg/kg, ip) was administered 3 times per week on alternating days while lutein(100 mg/kg, oral) was given once daily. After 1 wk of vehicle/methyl palmitate/lutein treatment, ali was induced by a single dose of LPS(7.5 mg/kg, iv). After 24 h of LPS injection, animals were sacrificed then biochemical parameters and histopathology were assessed. RESULTS: Treatment with methyl palmitate attenuated ali, as it significantly decreased the lung wet/dry weight(W/D) ratio, the accumulation of the inflammatory cells in the bronchoalveolar lavage fluid(BALF) andhistopathological damage. However, methyl palmitate failed to decrease lactate dehydrogenase(LDH) activity in BALF. On the other hand, lutein treatment produced significant anti-inflammatory effects as revealed by significant decrease in accumulation of inflammatory cells in lung, LDH level in BALF and histopathological damage. methyl palmitate and lutein significantly increased superoxide dismutase(SOD) and reduced glutathione(GSH) activities with significant decrease in the lung malondialdehyde(mDA) content. Importantly, methyl palmitate and lutein decreased the level of the inflammatory cytokine tumor necrosis factor-α(TNF-α) in the lung. Lutein also reduced LPS-mediated overproduction of pulmonary nitrite/nitrate(NO-2/NO-3), which was not affected by methyl palmitate pretreatment. CONCLUSION: These results demonstrate the potent protective effects of both methyl palmitate and lutein against LPS-induced ali in rats. These effects can be attributed to potent antioxidant activities of these agents, which suppress inflammatory cell infiltration and regulated cytokine effects.

关键词： Acute lung injury Lipopolysaccharide methyl palmitate Lutein Rats

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皱纹盘鲍4个群体与九孔鲍16S rRN A基因遗传差异分析

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水产科学 2014年第11期33卷 702-707页

作者：陈丽申欣向治楚秦银银林权享孟学平江苏省海洋资源开发研究院江苏连云港 222005 江办省海洋生物产业技术协同创新中心江苏连去港 222005 淮海工学院海洋学院江苏连云港222005

采用PCR方法扩增了皱纹盘鲍（4个群体）和九孔鲍（1个群体）共5个群体（53个样本）16S rRNA基因片段（16S），测序获得了1000 bp核苷酸序列，其中669 bp核苷酸序列用于遗传差异分析，旨在评估我国皱纹盘鲍不同群体间及其与九孔鲍间的遗... 详细信息

采用PCR方法扩增了皱纹盘鲍（4个群体）和九孔鲍（1个群体）共5个群体（53个样本）16S rRNA基因片段（16S），测序获得了1000 bp核苷酸序列，其中669 bp核苷酸序列用于遗传差异分析，旨在评估我国皱纹盘鲍不同群体间及其与九孔鲍间的遗传差异。从52个序列中共检测到17种单倍型，其中皱纹盘鲍4个群体有13种单倍型，九孔鲍1个群体（9个样本）有4种单倍型。单倍型核苷酸序列比对显示，变异位点占比对位点的20．5％，基于单倍型的皱纹盘鲍4个群体间的遗传距离为0．002～0．011，平均为0．005；九孔鲍群体内的平均遗传距离为0．004，两种鲍间的平均遗传距离为0．218；两种鲍间的遗传分化系数 F‐统计量 FST平均为0．982，皱纹盘鲍4群体间的 FST值为0．0051～0．0065。本研究显示2种鲍群体内16S变异很小。系统发育分析鲍属11种鲍的聚类关系，显示皱纹盘鲍与盘鲍、日本鲍交叉聚为一支，九孔鲍与杂色鲍也交叉聚为一支，4个种类未聚成单系支。

关键词：皱纹盘鲍九孔鲍 16S rRNA基因遗传差异

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肾素抑制剂aliskiren单用和与缬沙坦联用的降压疗效

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心血管病学进展 2007年第4期28卷 655-655页

作者： Pool JL Schmieder RE Azizi m 罗雪琚（摘译）不详四川大学华西医院

为一多中心随机双盲安慰剂对照试验,共8周,1123例轻中度高血压病,随机分入安慰剂、肾素抑制剂aliskiren(ali)单药(75、150或300mg),缬沙坦(valsartan,val)单药(80、160或320mg),ali联合val,和val联合双氢克尿噻(HCTZ)(160/12.5mg)组。结果:1天1次口服ali 300mg比安慰剂显著的降低平均收缩压及舒张压(Pali单药治疗显示与安慰剂相似的安全性。ali及val单用和联用产生剂量相关的收缩压/舒张压的下降,联用ali和val比任一单药产生更大的降压效果。结论:ali单药具降压疗效,耐受性同安慰剂,ali和val联用降压效果更好而且保持耐受性。[第一段]

关键词： aliskiren 肾素抑制剂降压疗效随机双盲安慰剂对照试验缬沙坦单用轻中度高血压病平均收缩压

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压力支持通气和双相气道正压通气通过肺血流重新分布从而提高氧合

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麻醉与镇痛 2012年第1期8卷 67-77页

作者： Alysson R. Carvalho, PhD Peter m. Spieth, mD Paolo Pelosi, mD, PhD Alessandro Beda, PhD Agnaldo J. Lopes, mD, DSc Boriana Neykova, mD Axel R. Heller, mD, PhD Thea Koch, mD, PhD marcelo Gama de Abreu, mD, mSc, PhD, DEAA 王琦（翻译） Clinic of Anesthesiology and Intensive Care medicine University Clinic Carl Gustav Carus Dresden Germany University Augusto motta Rio de Janeiro Brazil Department of Ambient Health and Safety University of Insubria Varese Italy Institute of Radiology University Clinic Carl Gustav Carus Technical University Dresden Dresden Germany

背景机械通气时保留自主呼吸（spontaneousbreathing，SB）可改善气体交换，主要是因为这种通气方式可使萎陷的肺复张。在保留SB的机械通气中，常选择压力支持通气（pressuresupportventilation，PSV）和双相气道正压通气（biphasicposi... 详细信息

背景机械通气时保留自主呼吸（spontaneousbreathing，SB）可改善气体交换，主要是因为这种通气方式可使萎陷的肺复张。在保留SB的机械通气中，常选择压力支持通气（pressuresupportventilation，PSV）和双相气道正压通气（biphasicpositiveairwaypressure，BIPAP）。但医师对这些辅助性机械通气方式改善肺功能的机制却不甚了解。我们评价了采用PSV和BIPAP改善氧合的机制。方法5头猪（25-29．3kg）于仰卧位行机械通气，并通过清除肺表面活性物质诱发其发生急性肺损伤（acutelung砸jury，Au）。状态稳定后，给予BIPAP通气，初期较低持续气道正压设置为5cmH2O，随后逐渐增加持续气道正压至维持潮气量在6-8ml／kg。减浅麻醉深度，当SB≥每分通气量的20％时，随机进行1小时的PSV或BIPAP＋SB通气。于呼气末行全胸螺旋式计算机体层扫描，并记录肺功能参数。静脉给予荧光微球体来记录肺血流（pulmonarybloodflow，PBF），并利用空间聚类分析来评估每种通气方式对PBF重新分布的影响。结果Au损伤肺功能并加大了下肺萎陷或不张组织的面积（P〈0．05）。和对照组比较，PSV和BIPAP＋SB的通气模式提高了氧合并减少了静脉血掺杂（P〈0．05）。尽管如此，我们观察到自主呼吸时下肺的不张肺组织或通气不良组织明显增加，而可正常通气的肺组织减少。观察到6例中有5例行PSV或sB＋BIPAP通气时PBF由下至上重新分布，肺通气也较好。结论在ali模型中采用PSV或BIPAP＋SB行机械通气可改善氧合，减少静脉血掺杂的原因为PBF由下至上的重新分布，而不是因为下肺复张。

关键词：双相气道正压通气压力支持通气肺血流氧合 BIPAP通气保留自主呼吸持续气道正压肺功能参数

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一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统

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科学新闻 2019年第2期 33-33页

作者： Daniel S.Kermany michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex mcKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong made K.Prasadha Jacqueline Pei magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang michael A. Singer Xiaodong Sun Jie Xu ali Tafreshi m. Anthony Lewis Huimin Xia 张康美国加州大学圣地亚哥分校人类基因组医学研究所

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜... 详细信息

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)

关键词： AI 深度学习

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello muhammad Akram Nawab ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano max Buesken mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin marco Grassi Christian Grewing maxim Gromov Vasily Gromov minghao Gu Xiaofei Gu Yu Gu mengyun Guan Nunzio Guardone maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 meV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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奥胡斯住宅综合体

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当代建筑 2020年第5期 60-69页

作者： Agne Rapkeviciute Aaron Hales Agne Tamasauskaite Alberte Danvig Aleksander Wadas Ana Vindfeldt Anna Wisborg Annette Jensen Ariel Joy Norback Wallner Brigitta Gulyás Claes Robert Janson Enea michelesio Frederike Werner Hsiao Rou Huang Ioana Fartadi Scurtu Jacob Lykkefold Aaen Jakob Lange Jakob Andreassen Jakob Ohm Laursen Jan magasanik Jesafa Templo Jesper Boye Andersen Kamilla Heskje Katarina mácková Katerina Joannides Katrine Juul Kekoa Charlot Kristoffer Negendahl Lise Jessen Lucian Racovitan Lucian Tofan Roberto Outumuro Sergiu Calacean Sofie maj S?rensen Spencer Hayden Teodor Javanaud Emden Tobias Hjortdal Tore Banke Xuefei Yan Yehezkiel Wiliardy Ella murphy Ricardo Oliveira Dominiq Oti BIG建筑设计事务所

项目名称:奥胡斯住宅综合体建设地点:丹麦奥胡斯业主:Kilden&mortensen APS设计单位:BIG建筑设计事务所用地面积:26 500 m2合作设计:mT H?jgaard建筑设计公司,mOE建筑设计公司主管合伙人:Bjarke Ingels, Finn N?rkj?r, Andreas Klok Ped...

项目名称:奥胡斯住宅综合体建设地点:丹麦奥胡斯业主:Kilden&mortensen APS设计单位:BIG建筑设计事务所用地面积:26 500 m2合作设计:mT H?jgaard建筑设计公司,mOE建筑设计公司主管合伙人:Bjarke Ingels, Finn N?rkj?r, Andreas Klok Pedersen项目负责人:S?ren martinussen项目经理:ali Arvanaghi, Jesper Bo Jensen

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Epidemiological survey of echinococcosis in Tibet Autonomous Region of China

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Infectious Diseases of Poverty 2019年第2期8卷 23-33页

作者： Bin Li Gongsang Quzhen Chui-Zhao Xue Shuai Han Wei-Qi Chen Xin-Liu Yan Zhong-Jie Li mLinda Quick Yong Huang Ning Xiao Ying Wang Li-Ying Wang Gesang Zuoga Bianba Gangzhu Bing-Cheng ma Gasong Xiao-Gang Wei Niji Can-Jun Zheng Wei-Ping Wu Xiao-Nong Zhou Tibet Autonomous Region Center for Diseases Control and Prevention Lhasa 850000Tibet Autonomous RegionChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMOHHuangpu DistrictShanghai 200025China Henan Center for Diseases Control and Prevention ZhengzhouShanghai 450000HenanChina Yunnan Institute of Diseases Control and Prevention Kunming 650000YunnanChina Chinese Center for Diseases Control and Prevention ChangpingBeijing 102200China Center for Diseases Control and Prevention AtlantaGA 30328USA Shandong Institute of Parasitic Diseases Jining 272033ShandongChina Lhasa Center for Diseases Control and Prevention Lhasa 850000Tibet Autonomous RegionChina Shigatse Center for Diseases Control and Prevention Sangzhuzi District 857000Tibet Autonomous RegionChina Shannan Center for Diseases Control and Prevention Shannan 856000Tibet Autonomous RegionChina Linzhi Center for Diseases Control and Prevention Linzhi 860000Tibet Autonomous RegionChina Changdu Center for Diseases Control and Prevention Changdu 854000Tibet Autonomous RegionChina Naqu Center for Diseases Control and Prevention Naqu 852000Tibet Autonomous RegionChina ali Center for Diseases Control and Prevention Ali 859000Tibet Autonomous RegionChina Beijing China

Background:The echinococcosis is prevalent in 10 provinces/autonomous region in western and northern *** survey of echinococcosis in China in 2012 showed the average prevalence of four counties in Tibet Autonomous Region(TAR)is 4.23%,much higher than the average prevalence in China(0.24%).It is important to understand the transmission risks and the prevalence of echinococcosis in human and animals in ***:A stratified and proportionate sampling method was used to select samples in *** selected residents were examined by B-ultrasonography diagnostic,and the faeces of dogs were tested for the canine coproantigen against Echinococcus *** enzyme-linked immunosorbent *** internal organs of slaughtered domestic animals were examined by visual examination and *** awareness of the prevention and control of echinococcosis among of residents and students was investigated using *** data were inputted using double entry in the Epi Info database,with error correction by double-entry comparison,the statistical analysis of all data was processed using SPSS 21.0,and the map was mapped using ArcGIS 10.1,the data was tested by Chi-square test and Cochran-Armitage trend ***:A total of 80384 people,7564 faeces of dogs,and 2103 internal organs of slaughtered domestic animals were *** prevalence of echinococcosis in humans in TAR was 1.66%,the positive rate in females(1.92%)was significantly higher than that in males(1.41%),(X2=30.31,Pmen(3.66%)and monks(3.48%).The average positive rate of Echinococcus coproantigen in TAR was 7.30%.The positive rate of echinococcosis in livestock for the whole region was 11.84%.The average awareness rate of echinococcosis across the region was 33.39%.Conclusions:A high prevalence of echin

关键词： Tibet Echinococcosis Prevalence Ultrasonography

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