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Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development

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World Journal of methodology 2021年第4期11卷 144-159页

作者： Renee J Dufault mesay m wolle H m Skip Kingston Steven G Gilbert Joseph A murray Food Ingredient and Health Research Institute NaalehuHI 96772United States College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Chemistry and Biochemistry Duquesne UniversityPittsburghPA 15282United States Institute of Neurotoxicology and Neurological Disorders SeattleWA 98105United States Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States

Pre-natal and post-natal chemical exposures and co-exposures from a variety of sources including contaminated air,water,soil,and food are common and associated with poorer birth and child health *** diet is a contributing factor in the development of child behavioral *** behavior and learning can be adversely impacted when gene expression is altered by dietary transcription factors such as zinc insufficiency or deficiency or by exposure to toxic substances permitted in our food supply such as mercury,lead,or organophosphate pesticide *** with autism spectrum disorder and attention deficit hyperactivity disorders exhibit decreased or impaired PON1 gene activity which is needed by the body to metabolize and excrete neurotoxic organophosphate *** this current review we present an updated macroepigenetic model that explains how dietary inorganic mercury and lead exposures from unhealthy diet may lead to elevated blood mercury and/or lead levels and the development of symptoms associated with the autism and attention deficithyperactivity ***1 gene activity may be suppressed by inadequate dietary calcium,selenium,and fatty acid intake or exposures to lead or *** model may assist clinicians in diagnosing and treating the symptoms associated with these childhood neurodevelopmental *** for future research are provided based on the updated model and review of recently published literature.

关键词： Autism Paraoxonase 1 Selenium Inorganic mercury Lead Attention deficit hyperactivity disorder

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