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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Reproductive biology of harvestmen(Arachnida:Opiliones):a review of a rapidly evolving research field

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Current Zoology 2024年第1期70卷 115-135页

作者： Glauco Machado mercedes Burns LAGE do Departamento de Ecologia Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil Department of Biological sciences University of MarylandBaltimore CountyBaltimoreMDUSA

Harvestmen are a major arachnid order that has experienced a dramatic increase in biological knowledge in the 21st *** publication of the book Harvestmen:The Biology of Opiliones in 2007 stimulated the development of many behavioral *** the book is relatively recent,our understanding of the reproductive biology of harvestmen is already outdated due to the fast accumulation of new *** goal is to provide an updated review of the subject to serve as a benchmark for the following *** the pre-copulatory phase,we explore the evolu-tion of facultative parthenogenesis,the factors that may affect the types of mating system,and the role of nuptial gifts in *** the copulatory phase,harvestmen are unique arachnids because they have aflagellate spermatozoa and a penis with complex *** discuss the implications of these two features for sperm competition and cryptic female *** the post-copulatory phase,we connect ovi-position site selection and climate conditions to the widespread occurrence of resource defense polygyny,alternative reproductive tactics,and sexual dimorphism in several clades of tropical ***,we present the different forms of parental care in the order,and discuss the benefits and costs of this behavior,which can be performed either by females or *** the review,we indicate gaps in our knowl-edge and subjects that deserve further ***,the information synthesized here will stimulate researchers worldwide to embrace harvestmen as a study system and to improve our effort to unravel the mysteries of their reproductive biology.

关键词： alternative reproductive tactics nuptial gifts parental care parthenogenesis resource defense polygyny sexual dimorphism.

The relationship between DNA fragmentation and the intensity of morphologically abnormal human spermatozoa

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Asian pacific Journal of Reproduction 2024年第1期13卷 22-27页

作者： mercedes González-Martínez Pascual sánchez-Martín Carmen López-Fernández stephen D.Johnston Jaime Gosálvez Clínica Ginemed Unidad de ReproducciónSevillaSpain Department of Biology Universidad Autónoma de MadridCantoblancoMadridSpain school of Environment The University of QueenslandGattonAustralia school of Veterinary science The University of QueenslandGattonAustralia

Objective:To determine the relationship between teratozoospermia and sperm DNA fragmentation(sDF)in the human ***:This retrospective study included 100 normozoospermic men as a control cohort(abnormal forms>14%),210 patients with a high level of abnormal forms(≤4%)and 65 patients presenting with a moderate level of abnormal forms(>4%to≤14%)based on the World Health Organization *** morphology was assessed using bright field *** DNA fragmentation was assessed using the sperm chromatin dispersion ***-parametric analyses were conducted to examine the relationship between abnormal sperm morphology and sperm DNA fragmentation;receiver operating characteristic(ROC)analyses were conducted to assess sensitivity and specificity of this ***:A correlation analysis revealed that the higher the proportion of abnormal spermatozoa in the ejaculate,the higher the level of sDF(spearman's Rho=-0.230;Psignificant differences in the proportion of sDF were found when all cohorts were compared(Pse significant differences were also retained when the different cohorts were compared *** analysis showed a moderate but significant predictive value for sDF to differentiate patients with different levels of ***:Although analysis of a more continuous range of values for teratozoospermia would help further clarify any causal relationship with sDF,there is clearly a synergistic or coincident affiliation between these variables that needs to be acknowledged by the clinician when interpreting the spermiogram.

关键词： Teratozoospermia sperm morphology sperm DNA fragmentation Male factor Human reproduction Human fertility

Tailored optical propulsion forces for controlled transport of resonant gold nanoparticles and associated thermal convective fluid flows

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Light(science & Applications) 2020年第1期9卷 256-266页

作者： Jose A.Rodrigo mercedes Angulo Tatiana Alieva Facultad de Ciencias Fisicas Ciudad Universitaria s/nUniversidad Complutense de Madrid28040 MadridSpain

Noble metal nanoparticles illuminated at their plasmonic resonance wavelength turn into heat *** phenomenon has prompted the development of numerous applications in science and *** optical manipulation of such resonant nanoparticles could certainly extend the functionality and potential applications of optothermal *** this article,we experimentally demonstrate optical transport of single and multiple resonant nanoparticles(colloidal gold spheres of radius 200 nm)directed by tailored transverse phase-gradient forces propelling them around a 2D optical *** show how the phase-gradient force can be designed to efficiently change the speed of the *** have found that multiple hot nanoparticles assemble in the form of a quasi-stable group whose motion around the laser trap is also controlled by such optical propulsion *** assembly experiences a significant increase in the local temperature,which creates an optothermal convective fluid flow dragging tracer particles into the ***,the created assembly is a moving heat source controlled by the propulsion force,enabling indirect control of fluid flows as a micro-optofluidic *** existence of these flows,probably caused by the temperature-induced Marangoni effect at the liquid water/superheated water interface,is confirmed by tracking free tracer particles migrating towards the *** propose a straightforward method to control the assembly size,and therefore its temperature,by using a nonuniform optical propelling force that induces the splitting or merging of the group of *** envision further development of microscale optofluidic tools based on these achievements.

关键词： thermal fluid transport

A note on the consistency of a behavioral play marker in piglets

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Journal of Animal science and Biotechnology 2014年第2期5卷 245-250页

作者： Wendy mercedes Rauw Departamento de Mejora Genetica Animal Instituto Nacional de Investigaciony Tecnologia Agrariay AlimentariaCrtadela Corunakm 7.5Madrid 28040Spain

Background： Play behavior has been proposed as a new potential indicator of animal welfare. Animals play only if they are in a relaxed state. Play may improve adaptability to challenging environments which may be of interest in the breeding objective. Little information is available on play behavior in livestock species. The aim of the present study is to investigate whether play behavior in post-weaned piglets can be induced instantly in the presence of additional space and whether play markers are body weight, sex, and litter dependent, it is investigated whether playfulness is elicited by the moment or if this measure is consistent over different days. Methods： Thirty two piglets from four litters were released into a corridor and video recorded for eight min at 37, 41, 44 and 48 d of age. The first test was considered as an adjustment period and was not included in the analysis. In the second to the fourth test, joyful brusque movements （jumping, turning and running） were recorded with a camera and total number of movements （JOY#） and total time （JOYtime） were estimated individually. Animals were weighed at 41 d of age. Results： Females had higher scores of JOY# and JOYtime than males but this was significant only for JOY# at 41 d of age （P 〈 0.05）. The effect of age was highly significant both for JOY# and JOYtime （P 〈 0.01）. Animals with a higher JOY# and JOYtime also expressed a higher JOY# and JOYtime in the other tests, but this was significant only between 44 and 48 d of age （P〈 0.01）. Body weight at 41 d of age was not significantly related to JOY# and JQYtime in any of the tests. Conclusions： Locomotor play was induced instantly by the provision of increased space allowance. Litter origin had a significant effect on play behavior. In addition, locomotor play scores were consistent between two of the three tests.

关键词： Behavior Locomotor play Pigs Play marker Welfare

Alzheimer’s disease risk after COVID-19:a view from the perspective of the infectious hypothesis of neurodegeneration

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Neural Regeneration Research 2023年第7期18卷 1404-1410页

作者： Eugenia Olivera Albany sáez Lila Carniglia Carla Caruso mercedes Lasaga Daniela Durand Instituto de Investigaciones Biomédicas INBIOMED UBA-CONICET Facultad de MedicinaUniversidad de Buenos AiresArgentina

In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term *** wondered how sARs-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the *** also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.

关键词： Alzheimer amyloid beta antimicrobial cognitive decline COVID-19 infectious hypothesis long-term sequelae neurodegeneration neuroinflammation neurological symptoms neurotropism sARs-CoV-2

Fountain-Gould Left Orders for Associative Pairs

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Acta Mathematica sinica,English series 2006年第3期22卷 641-652页

作者： José A.ANQUELA Teresa CORTs Miguel GóMEZ LOZANO mercedes sILEs MOLINA Departamento de Matemáticas Universidad de Oviedo Departamentode lgebra Geometríay TopologíaFacultad de CienciasUniversidad de MálagaCampus de Teatinos29071 MálagaSpain

In this paper, we introduce a notion of weak Fountain-Gould left order for associative pairs and give a Goldie-like theory of associative pairs which are weak Fountain Gould left orders in semiprime pairs coinciding w... 详细信息

关键词： Fountain-Gould left order Associtive pair Goldie theory

Tourism versus nature conservation: reconciliation of common interests and objectives——an analysis through Picos de Europa National Park

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Journal of Mountain science 2018年第11期15卷 2505-2516页

作者： LóPEZ Iván PARDO mercedes Department of Psychology and sociology University of Zaragoza Department of social Analysis University Carlos Ⅲ of Madrid

Nature tourism and particularly tourism in national parks have acquired significant importance in contemporary societies. Post-Fordist consumers have reevaluated the meanings of ‘nature' and ‘natural spaces' and now avoid standardization to seek singularity. Tourism in national parks is a consequence of this tendency and has both positive and negative aspects. The purpose of this sociological research is to describe the most relevant conflicts in the Picos de Europa National Park(spain) involving the park's conservation, local economic development,and tourism. seven in-depth interviews and three focus groups were addressed to key local *** this research were identified three chief areas of existing or potential inter-related conflicts and the main actors interacting with them. The first is on population, particularly, the negative consequences of depopulations on the local socio-economic development and the environment. A second source of conflicts identified is caused by the difficult conciliation between commercial exploitation and conservation of the protected natural area. More precisely, this specific form of tourism positively contributes to the economy of local communities whilst problems can arise for the conservation goals of National Parks. Thirdly, in this research is also analyzed the institutional governance and the inter and intra-governmental conflicts as well as with the Park's management body. These findings provide important information for the improved management of tourism and conflicting interests in natural parks.

关键词： National parks Environmental conservation Nature tourism Mountain traditional economy Picos de Europa spain

The Maximal Graded Left Quotient Algebra of a Graded Algebra

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Acta Mathematica sinica,English series 2006年第1期22卷 261-270页

作者： Gonzalo ARANDA PINO mercedes sILEs MOLINA Departamcnto de Algebra Geometriay Topologia Universidad de Mdlaga 29071 Mdlaga Espana

We construct the maximal graded left quotient algebra of every graded algebra A without homogeneous total right zero divisors as the direct limit of graded homomorphisms （of left A-modules） from graded dense left ideals of A into a graded left quotient algebra of A. In the case of a superalgebra, and with some extra hypothesis, we prove that the component in the neutral element of the group of the maximal graded left quotient algebra coincides with the maximal left quotient algebra of the component in the neutral element of the group of the superalgebra.

关键词： graded algebra graded left quotient algebra maximal graded left quotient algebra left quotieat algebra maximal left quotient algebra superalgebra