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Novel Cyclopeptide Bolaamphiphile for Constructing Supramolecular Nanotubes

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Chinese Journal of Chemistry 2014年第1期32卷 22-26页

作者： Siyong Qin Qingrong Wang Yi Pei mengyun peng Renxi Zhuo Xianzheng Zhang[*] Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Wuhan University Wuhan Hubei 430072 China Email: Xianzheng Zhang (xz-zhang@***)[*]Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Wuhan University Wuhan Hubei 430072 China

A novel dicyclopeptide-based bolaamphiphile was *** hydrophilic cyclopeptide fragments were linked to an alkyl chain 1,6-bis(maleimido)hexane,which acted as a hydrophobic *** transmission electron microscopy (TEM) observation indicated that the cyclopeptide bolaamphiphile (CPB) self-assembled into the nanotubes with a thickness of about 3 *** on the optimized molecular conformation obtained via MM2 method,the length of CPB was demonstrated to be around 4 nm,implying that the nanotubes were *** transform infrared spectroscopy (FT-IR) and circular dichroism (CD) analysis showed that the cyclopeptides in CPB mainly acted as the hydrophilic headgroups,rather than providing the well-ordered hydrogen bonding interaction responsible for β-sheet *** investigate the special self-assembly behavior of CPB,the single cyclopeptide (CP) without the connection of the linker was *** investigation indicated that the CP molecules can not form tubular structures but nanofibers.

关键词： cyclopeptide bolaamphiphile self-assembly nanotube

Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosis

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Journal of Pharmaceutical Analysis 2024年第8期14卷 1099-1109页

作者： Yini Bao Qiyuan Shan Keda Lu Qiao Yang Ying Liang Haodan Kuang Lu Wang Min Hao mengyun peng Shuosheng Zhang Gang Cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou310053China The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou310009China College of Chinese Materia Medica and Food Engineering Shanxi University of Chinese MedicineJinzhongShanxi030600China

Renal fibrosis is a devastating consequence of progressive chronic kidney disease,representing a major public health challenge *** underlying mechanisms in the pathogenesis of renal fibrosis remain unclear,and effective treatments are still *** tubular epithelial cells(RTECs)maintain kidney function,and their dysfunction has emerged as a critical contributor to renal *** quality control comprises several components,including telomere homeostasis,ubiquitin-proteasome system(UPS),autophagy,mitochondrial homeostasis(mitophagy and mitochondrial metabolism),endoplasmic reticulum(ER,unfolded protein response),and *** in the cellular quality control of RTECs,including DNA,protein,and organelle damage,exert profibrotic functions by leading to senescence,defective autophagy,ER stress,mitochondrial and lysosomal dysfunction,apoptosis,fibroblast activation,and immune cell *** this review,we summarize recent advances in understanding the role of quality control components and intercellular crosstalk networks in RTECs,within the context of renal fibrosis.

关键词： Renal tubular epithelial cells Quality control Renal fibrosis Telomere homeostasis Autophagy Mitochondria

From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H_(2)O_(2) and targeting nanotherapeutics

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Bioactive Materials 2023年第5期23卷 187-205页

作者： Meiyu Shao Yifan Wang Hongyan Dong Lu Wang Xiaoqing Zhang Xin Han Xianan Sang Yini Bao mengyun peng Gang Cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou310000PR China

Liver fibrosis and hepatocellular carcinoma(HCC)have been worldwide threats *** fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic *** pathological liver,excessive H_(2)O_(2) is generated and accumulated,which impacts the functionality of hepatocytes,Kupffer cells(KCs)and hepatic stellate cells(HSCs),leading to genesis of fibrosis and HCC.H_(2)O_(2) accumulation is associated with overproduction of superoxide anion(O_(2)^(·-))and abolished antioxidant enzyme *** of therapeutics focused on H_(2)O_(2) have shown satisfactory effects against liver fibrosis or HCC in different *** review summarized the reasons of liver H_(2)O_(2) accumulation,and the role of H_(2)O_(2) in genesis of liver fibrosis and ***,nanotherapeutics targeting H_(2)O_(2) were summarized for further consideration of antifibrotic or antitumor therapy.

关键词： Liver fibrosis Hepatocarcinogenesis Nanotherapeutics H_(2)O_(2)accumulation Oxidative stress

Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 758-771页

作者： Xin Han Yan Ning Xinyue Dou Yiwen Wang Qiyuan Shan Kao Shi Zeping Wang Chuan Ding Min Hao Kuilong Wang mengyun peng Haodan Kuang Qiao Yang Xianan Sang Gang Cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou311400China

Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying *** vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw *** ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-QTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)*** note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and *** interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through *** conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.

关键词： Liver fibrosis SIRT3 Cornus officinalis AMPK Caspase6

玛湖凹陷北、西斜坡区百口泉组储集层对比及勘探启示

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新疆石油地质 2022年第1期43卷 18-25页

作者：陈程彭梦芸赵婷王金罡中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000 中国石油新疆油田分公司风城油田作业区新疆克拉玛依834000 新疆宇澄热力股份有限公司新疆克拉玛依834000

玛湖凹陷的玛北斜坡区油气勘探取得了重大突破,而与之相邻的玛西斜坡区勘探效果甚微。为此,根据岩心、薄片、扫描电镜等资料,对玛北与玛西斜坡区百口泉组储集层的岩石学特征、成岩作用对比分析,认为储集层物性特征及其控制因素存在明显... 详细信息

玛湖凹陷的玛北斜坡区油气勘探取得了重大突破,而与之相邻的玛西斜坡区勘探效果甚微。为此,根据岩心、薄片、扫描电镜等资料,对玛北与玛西斜坡区百口泉组储集层的岩石学特征、成岩作用对比分析,认为储集层物性特征及其控制因素存在明显差异,压实作用、胶结作用与溶蚀作用是造成储集层物性差异的根本原因。玛西斜坡区含油气远景优于玛北斜坡区,玛西斜坡区深层是有利储集层分布区,扇体两翼和玛中1井区是下一步油气勘探的重点。

关键词：玛湖凹陷玛北斜坡区玛西斜坡区百口泉组储集层特征控制因素勘探启示

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日本心血管疾病患者的安宁疗护及启示

中华护理杂志 2024年第5期59卷 533-539页

作者：彭梦云原田奈穂子齋藤信也岡山大学保健学研究科日本岡山市7008558 岡山大学医学部保健学科日本岡山市7008558

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高... 详细信息

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高患者及家庭成员的生活质量。该文介绍了日本心血管疾病患者安宁疗护的发展历程、规模及需求、团队成员及协作、介入时间、评估与筛查、服务内容与流程、质量评价及困境等,提出对国内心血管疾病患者实施安宁疗护的启示,为开展心血管疾病患者的安宁疗护提供借鉴。

关键词：心血管疾病安宁疗护姑息护理

脑瘫患儿父母照护体验质性研究的Meta整合

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中国护理管理 2020年第9期20卷 1379-1385页

作者：彭梦云吴丽赵方方关红大连医科大学附属第二医院护理部辽宁省116021

目的:系统评价脑瘫患儿父母的照护体验。方法:计算机检索PubMed、Web of Science、EBSCO、ScienceDirect、万方、知网和维普数据库,搜集关于脑瘫患儿父母照护体验的质性研究。采用“澳大利亚JBI循证卫生保健中心(2008)质性研究质量评价... 详细信息

目的:系统评价脑瘫患儿父母的照护体验。方法:计算机检索PubMed、Web of Science、EBSCO、ScienceDirect、万方、知网和维普数据库,搜集关于脑瘫患儿父母照护体验的质性研究。采用“澳大利亚JBI循证卫生保健中心(2008)质性研究质量评价标准”评价,以汇集性整合方法对结果进行整合。结果:共纳入12项研究,提炼36个完好明确的研究结果,归纳组合成11个新的类别,并综合成3个整合结果。整合结果1:父母作为脑瘫患儿的主要照顾者,照护中面临的挑战和经济负担使其身心疲惫。整合结果2:父母在照护中缺乏家庭支持,不被理解;感知能力有限,积极渴望得到外界支持与帮助。整合结果3:伴随照护时间的推移,父母不断自我调整,获得积极心理成长并逐渐适应照顾者角色。结论:医护人员需重视脑瘫患儿父母的照护体验,在其进行心理、身体及生活调适过程中,主动给予心理疏导并提供照护知识技能指导,协助其胜任照顾者这一角色,促进脑瘫患儿健康成长。

关键词：脑瘫患儿父母照护体验质性研究 Meta整合

应对适应能力在急诊留观患者疾病不确定感与心理应激反应间的中介效应

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中国实用护理杂志 2020年第11期36卷 855-860页

作者：吴丽赵方方彭梦云关红大连医科大学附属第二医院护理部 116023

目的探讨急诊留观患者疾病不确定感、应对适应能力与心理应激反应间的关系,为降低患者心理应激水平提供参考。方法采用一般资料调查表、中文版Mishel疾病不确定感量表、中文版简易罗伊应对适应能力量表及心理应激反应问卷对大连医科大... 详细信息

目的探讨急诊留观患者疾病不确定感、应对适应能力与心理应激反应间的关系,为降低患者心理应激水平提供参考。方法采用一般资料调查表、中文版Mishel疾病不确定感量表、中文版简易罗伊应对适应能力量表及心理应激反应问卷对大连医科大学附属第二医院260例急诊留观患者进行问卷调查,并对结果进行分析。结果应对适应能力在急诊留观患者疾病不确定感与心理应激反应间起部分中介作用,中介效应占总效应的32.23%;应对适应能力可通过情绪及行为反应路径减少疾病不确定感对心理应激反应的正性增强作用。结论疾病不确定感可直接或通过应对适应能力间接影响急诊留观患者的心理应激反应,可通过降低疾病不确定感、提高应对适应能力来减少心理应激反应对患者心身功能的影响。

关键词：急诊留观患者疾病不确定感应对适应能力心理应激反应中介效应

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患者口渴感护理评估的研究进展

中国护理管理 2019年第10期19卷 1590-1593页

作者：赵方方吴丽彭梦云关红大连医科大学附属第二医院护理部

本文对患者口渴感护理评估的国内外研究进展进行综述,阐明患者口渴感的相关概念、发生机制,归纳评估口渴感相关的普适性及特异性测评量表、客观体征及检查指标等内容,以期为我国临床护理实践和研制本土化的患者口渴感护理评估工具及方... 详细信息

本文对患者口渴感护理评估的国内外研究进展进行综述,阐明患者口渴感的相关概念、发生机制,归纳评估口渴感相关的普适性及特异性测评量表、客观体征及检查指标等内容,以期为我国临床护理实践和研制本土化的患者口渴感护理评估工具及方法提供参考。

关键词：口渴感护理评估量表综述