Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosis

作     者：Yini Bao Qiyuan Shan Keda Lu Qiao Yang Ying Liang Haodan Kuang Lu Wang Min Hao Mengyun Peng Shuosheng Zhang Gang Cao Yini Bao;Qiyuan Shan;Keda Lu;Qiao Yang;Ying Liang;Haodan Kuang;Lu Wang;Min Hao;Mengyun Peng;Shuosheng Zhang;Gang Cao

作者机构：School of PharmacyZhejiang Chinese Medical UniversityHangzhou310053China The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310009China College of Chinese Materia Medica and Food EngineeringShanxi University of Chinese MedicineJinzhongShanxi030600China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2024年第14卷第8期

页      面：1099-1109页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(Grant No.:82204625) the Natural Science Foundation of Zhejiang Province(Grant Nos.:LQ23H280013 and LZ22H280001) the Chinese Medicine Research Program of Zhejiang Province(Program Nos.:2021ZZ009,2023ZR009,and 2021ZQ023) the Youth Natural Science Program of Zhejiang Chinese Medical University(Program No.:2021RCZXZK14) 

主　　题：Renal tubular epithelial cells Quality control Renal fibrosis Telomere homeostasis Autophagy Mitochondria 

摘      要：Renal fibrosis is a devastating consequence of progressive chronic kidney disease,representing a major public health challenge *** underlying mechanisms in the pathogenesis of renal fibrosis remain unclear,and effective treatments are still *** tubular epithelial cells(RTECs)maintain kidney function,and their dysfunction has emerged as a critical contributor to renal *** quality control comprises several components,including telomere homeostasis,ubiquitin-proteasome system(UPS),autophagy,mitochondrial homeostasis(mitophagy and mitochondrial metabolism),endoplasmic reticulum(ER,unfolded protein response),and *** in the cellular quality control of RTECs,including DNA,protein,and organelle damage,exert profibrotic functions by leading to senescence,defective autophagy,ER stress,mitochondrial and lysosomal dysfunction,apoptosis,fibroblast activation,and immune cell *** this review,we summarize recent advances in understanding the role of quality control components and intercellular crosstalk networks in RTECs,within the context of renal fibrosis.