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circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate PI3K/AKT-mTOR and MAPK pathways

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Journal of Integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui Liu Jiuzeng Cui mengyao wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui Ba Langda Suo Yuxuan Song Lei Zhang Division of Laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) proliferation

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基于知识图谱构建的面料图像多样化检索系统

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棉纺织技术 2024年第4期52卷 40-45页

作者：魏萌瑶张宁潘如如江南大学江苏无锡214122

为了提高纺织行业筛选面料的效率,满足用户多样化的检索需求,解决面料检索结果单一、耗时久、精度低等问题,通过知识建模将面料的文本信息结构化表示,构建面料图文数据集,导入图数据库中实现面料知识图谱可视化。基于知识图谱构建了面... 详细信息

为了提高纺织行业筛选面料的效率,满足用户多样化的检索需求,解决面料检索结果单一、耗时久、精度低等问题,通过知识建模将面料的文本信息结构化表示,构建面料图文数据集,导入图数据库中实现面料知识图谱可视化。基于知识图谱构建了面料图像多样化检索系统,该系统将用户提供的检索字段和知识图谱中的面料节点匹配,输出相应面料实体及其一阶近邻实体,实现了面料图像检索多样化。选取了50个文本关键词进行检索试验,结果表明:前8幅图像的查准率为80.7%,mAP值为0.852,平均多样性值为5.8,检索的平均响应时间仅为2.26 s,验证了该系统的有效性和可行性。

关键词：知识建模知识图谱面料图像图文数据图像检索

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Impacts of different surface features on soil detachment in the subtropical region

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International Soil and Water Conservation Research 2021年第4期9卷 555-565页

作者： Qianhong Ma Keli Zhang Zihao Cao Zhicheng Yang mengyao wei Zaike Gu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China School of Teacher Education Hebei Normal UniversityShijiazhuangHebei 050024China Guizhou Provincial Monitoring Station of Soil and Water Conservation GuiyangGuizhou 550002China

Near-surface features have a great influence on runoff and detachment processes by overland flow,but the contributions are still unclear on steep slopes with yellow soil in subtropical humid *** scouring experiments were conducted to investigate how near-surface features affect hydraulic parameters and detachment rate by overland *** treatments and a baseline(disturbed rootless bare cropland)were designed to identify the contributions from stem-leaves,litter,biological soil crusts(BSCs),root systems and non-disturbance,*** results showed that(1)the values of velocity,Reynolds number and Froude number for vegetated slopes were significantly lower than that of baseline,and stem-leaves made a greater contribution(average of 47.30%)to reducing kinetic energy than the other features;(2)the total contribution rate of grassland was 99.38%,and of this total,1.19,1.44,2.49,49.79 and 44.47%reductions were attributed to the stem-leaves,litter,BSCs,root systems and non-disturbance,*** system and non-disturbance dominated the detachment rate reduction;(3)with increasing flow rate or slope gradient,the total contribution rate remained between 98%and 100%;and(4)for each treatment,the relationship between detachment rate and hydraulic parameters remained constant,and the stream power was the best predictor to detachment *** study results are helpful in evaluating the effects of near-surface features on erosion control and providing reference for government decision-makers to choose appropriate soil conservation and management practices.

关键词： Vegetation Soil tillage Soil erosion Detachment rate Yellow soil

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绵羊奶生物活性成分的功能分析

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中国乳品工业 2024年第1期52卷 40-46页

作者：朱重师牛晨刘佳欣卫梦瑶王晓飞张磊宋宇轩西北农林科技大学动物科技学院陕西杨凌712100

绵羊奶的营养成分丰富,蛋白质、脂肪等干物质含量与钙、镁等元素含量均高于牛奶与山羊奶。它含有多种生物活性成分:表皮生长因子、乳铁蛋白、生物活性肽等,具有独特的保健功能,可以有效预防糖尿病、癌症等疾病,同时绵羊奶在胃肠道、抗... 详细信息

绵羊奶的营养成分丰富,蛋白质、脂肪等干物质含量与钙、镁等元素含量均高于牛奶与山羊奶。它含有多种生物活性成分:表皮生长因子、乳铁蛋白、生物活性肽等,具有独特的保健功能,可以有效预防糖尿病、癌症等疾病,同时绵羊奶在胃肠道、抗菌等方面也发挥重要作用。随着绵羊奶越来越受消费者青睐,绵羊奶产业也逐渐受到行业关注并开始在国内发展,虽然在我国刚刚起步,但是发展迅猛、未来市场空间广阔,绵羊奶特质性成分的功能也逐渐被挖掘。因此,对绵羊奶的常规营养成分、特征成分、生物活性成分功能以及绵羊乳制品的加工特性与市场前景进行概述,重点分析绵羊奶中生物活性成分的功能特点,以期为探究绵羊奶的更多功能提供理论支撑和思路,推动绵羊奶的普及,促进我国奶绵羊产业的发展。

关键词：绵羊奶生物活性成分营养价值健康功能分析

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On the bramble way to Mg metal anodes in secondary Mg ion batteries

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Journal of Materials Science & Technology 2023年第19期150卷 175-189页

作者： Guodong Zou Jiawen Feng Xue Zhao Jinming Wang Yangyang Wang weihao Yang mengyao wei Yimin Wang Lanjie Li Liqun Ren Carlos Fernandez Qiuming Peng State Key Laboratory of Metastable Materials Science and Technology School of Materials Science and EngineeringYanshan UniversityQinhuangdao 066004China Department of General Surgery First Hospital of QinhuangdaoHebei Medical UniversityQinhuangdao 066000China Chengde Iron and Steel Group Co. Ltd.HBIS Group Co.Ltd.Chengde 067102China Laboratory of Spinal Cord Injury and Rehabilitation Chengde Medical UniversityChengde 067000China School of Pharmacy and Life Sciences Robert Gordon UniversityAberdeen AB107GJUnited Kingdom

As a prospective alternative to lithium-ion batteries,rechargeable magnesium metal batteries(RMBs)have many unparalleled advantages,including direct use of Mg metal as the electrode;large nature abundance;intrinsically safe merits;high theoretical volumetric ***,there exist a large number of challenges on electrodes for their *** them,surface passivation,uneven deposition/dissolution,and corrosion are critical issues that severely hinder the development of Mg anodes in *** review gives a specific comprehensive,and in-depth summary of mechanisms relative to these ***,it displays the protection progresses of the Mg metal anode via three-dimensional host nanostructure fabrication,Mg alloys anode design,current collector modification,artificial solid-electrolyte interphase construction,and electrolyte ***,future perspectives and outlooks in developing the other blossom of these strategies for rechargeable Mg batteries are also *** overview provides significant guidance for designing and fabricating high-performance Mg metal anodes in secondary Mg batteries and boosting their commercial applications.

关键词： Mg metal anode Mg alloys Deposition/dissolution Dendrite Artificial solid-electrolyte interphase Mg ion battery

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A novel molybdenite depressant for efficient selective flotation separation of chalcopyrite and molybdenite

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International Journal of Mining Science and Technology 2024年第8期34卷 1179-1196页

作者： mengyao Qi weijun Peng wei Wang Yijun Cao Longyu Zhang Yukun Huang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Zhengzhou UniversityZhengzhou 450001China The Key Lab of Critical Metals Minerals Supernormal Enrichment and Extraction Ministry of EducationZhengzhou 450001China

A novel small molecule depressant(M-DEP)was used to separate chalcopyrite and molybdenite via *** results showed that M-DEP had an excellent selective depression on molybdenite,while had little effect on the flotation of *** adsorption capacity of M-DEP on the surface of molybdenite was greater than that on chalcopyrite *** adsorption of M-DEP reduced the floatability of molybdenite and had less effect on the floatability of chalcopyrite,which was due to its different adsorption modes on the surface of the two ***,the interaction between chalcopyrite and M-DEP was mainly chemical interaction,and almost all of the adsorbed M-DEP molecules were removed and replaced by sodium butyl xanthate(SBX).By contrast,hydrophobic interaction was the main way in which M-DEP was adsorbed on the molybdenite surface with little chemical interaction,which was less interfered by SBX ***,M-DEP had a super selective depression on *** study provided a novel depressant and approach for the deep separation of chalcopyrite and molybdenite via flotation.

关键词： Novel molecule depressant Molybdenite Chalcopyrite Flotation separation Selective depression

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老年住院高血压病患者不同认知衰弱分型现状及其影响因素分析

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中华现代护理杂志 2024年第26期30卷 3566-3573页

作者：唐淑奥魏梦瑶许露丹赵鑫宇韩斌如王燕秋首都医科大学宣武医院护理部北京100053 首都医科大学护理学院北京100069 首都医科大学宣武医院老年综合科北京100053

目的探讨住院高血压病老年人不同认知衰弱分型的患病率及影响因素。方法采用便利抽样法, 选取2022年4-10月首都医科大学宣武医院心脏内科、老年病(综合)科、内分泌科收治的300例患有高血压病的老年患者为研究对象。采用一般资料调查表... 详细信息

目的探讨住院高血压病老年人不同认知衰弱分型的患病率及影响因素。方法采用便利抽样法, 选取2022年4-10月首都医科大学宣武医院心脏内科、老年病(综合)科、内分泌科收治的300例患有高血压病的老年患者为研究对象。采用一般资料调查表、衰弱表型量表、简易精神状态检查量表、主观认知功能下降问卷-9、Morisky服药依从性量表、匹兹堡睡眠质量指数、医院焦虑抑郁量表、社会支持评定量表、微型营养评定法对患者进行调查。结果本研究共发放问卷300份, 回收有效问卷300份, 问卷有效回收率为100.00%(300/300)。300例高血压病老年人中74例老年人患可逆性认知衰弱(RCF), 98例老年人患潜在可逆性认知衰弱(PRCF)。Logistic回归显示, 日常锻炼情况、是否使用噻嗪类药物是老年住院高血压病患者RCF的影响因素(P<0.05);年龄、退休前从事职业、日常锻炼情况、睡眠情况、Barthel评分、血清白蛋白是老年住院高血压病患者PRCF的影响因素(P<0.05)。结论住院高血压病老年人RCF和PRCF的患病率均较高, 不同认知衰弱分型的影响因素有所差异, 可依据二者共同及各自特异性的影响因素制订针对性干预措施, 以逆转或延缓高血压病老年人认知衰弱的进展。

关键词：高血压病老年人认知衰弱可逆性认知衰弱潜在可逆性认知衰弱影响因素

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基于DRGs的外科病区护理人力资源模型的构建与验证

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护理管理杂志 2024年第4期24卷 351-354,359页

作者：李梦文鱼星锋魏梦瑶韩斌如孙宁吴红娟陕西省人民医院护理部西安市710068 首都医科大学宣武医院护理部北京市100053

目的探索DRGs权重与护理工作量的关系,利用DRGs相关指标构建外科病区护理人力资源配置模型。方法采用实地调研收集患者住院期间的总护理工作量及DRGs相关信息进行多元回归分析形成基于DRGs的外科病区护理人力资源配置模型。结果共收集45... 详细信息

目的探索DRGs权重与护理工作量的关系,利用DRGs相关指标构建外科病区护理人力资源配置模型。方法采用实地调研收集患者住院期间的总护理工作量及DRGs相关信息进行多元回归分析形成基于DRGs的外科病区护理人力资源配置模型。结果共收集450例患者(建模组)住院期间的护理工作量,年龄、入院自理能力评分、入院护理级别、麻醉方式以及DRGs权重是护理时间的影响因素,能够解释55.52%的变量。继续收集184例患者(验证组)信息带入护理人力资源配置模型,两组总工时比较差异无统计学意义(P>0.05)。结论形成的基于DRGs的外科病区护理人力资源配置模型较为科学、客观,能够将代表病种资源消耗与服务能力的DRGs权重与护理工作量进行联系,可为今后科学配置护理人力提供依据。

关键词：疾病诊断相关分组护理工作量人力资源配置

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KIF5B-mediated internalization of FMDV promotes virus infection

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Virologica Sinica 2024年第3期39卷 378-389页

作者： wei Zhang Fan Yang Yang Yang weijun Cao Wenhua Shao Jiali Wang mengyao Huang Zhitong Chen Xiaoyi Zhao weiwei Li Zixiang Zhu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou 730046China

Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV internalization after infection remains *** this study,we found that kinesin family member 5B(KIF5B)plays a vital role during FMDV ***,we confirmed the interaction between KIF5B and FMDV structural protein VP1 by co-immunoprecipitation(Co-IP)and co-localization in FMDV-infected *** particular,the stalk[amino acids(aa)413–678]domain of KIF5B was indispensable for KIF5B-VP1 ***,overexpression of KIF5B dramatically enhanced FMDV replication;consistently,knockdown or knockout of KIF5B suppressed FMDV ***,we also demonstrated that KIF5B promotes the internalization of FMDV via regulating clathrin ***5B also promotes the transmission of viral particles to early and late endosomes during the early stages of *** conclusion,our results demonstrate that KIF5B promotes the internalization of FMDV via regulating clathrin uncoating and intracellular *** study may provide a new therapeutic target for developing FMDV antiviral drugs.

关键词： FMDV VP1 protein KIF5B Endosome Clathrin

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Heat stress impairs floral meristem termination and fruit development by affecting the BR-SlCRCa cascade in tomato

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Plant Communications 2024年第4期5卷 208-223页

作者： Junqing Wu Pengxue Li Meng Li Danyang Zhu Haochuan Ma Huimin Xu Shuang Li Jinbo wei Xinxin Bian mengyao Wang Yixuan Lai Yuxin Peng Haixiao Li Abidur Rahman Shuang Wu College of Horticulture Haixia Institute of Science and TechnologyFujian Agriculture and Forestry UniversityFuzhou 350002China Department of Plant Bio-Sciences Faculty of AgricultureIwate UniversityMorioka 020-8550Japan United Graduate School of Agricultural Sciences Iwate UniversityMorioka 020-8550Japan These authors contributed equally to this article

Floral meristem termination is a key step leading to carpel initiation and fruit *** frequent occurrence of heat stress due to global warming often disruptsfloral determinacy,resulting in defective fruit ***,the detailed mechanism behind this phenomenon is largely ***,we identify CRABS CLAW a(SlCRCa)as a key regulator offloral meristem termination in *** func-tions as an indispensablefloral meristem terminator by suppressing SlWUS activity through the TOMATO AGAMOUS 1(TAG1)–KNUCKLES(SlKNU)–INHIBITOR OF MERISTEM ACTIVITY(SlIMA)network.A direct binding assay revealed that SlCRCa specifically binds to the promoter and second intron of WUSCHEL(SlWUS).We also demonstrate that SlCRCa expression depends on brassinosteroid homeostasis in theflo-ral meristem,which is repressed by heat stress via the circadian factor EARLY FLOWERING 3(SlELF3).These results provide new insights intofloral meristem termination and the heat stress response inflowers and fruits of tomato and suggest that SlCRCa provides a platform for multiple protein interactions that may epigenetically abrogate stem cell activity at the transition fromfloral meristem to carpel initiation.

关键词： heat stress floral meristem termination BR-CRC fruit development

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