检索结果-南通市图书馆

Novel pneumatically assisted atomization device for living cell delivery:application of sprayed mesenchymal stem cells for skin regeneration

引用

Bio-Design and Manufacturing 2022年第1期5卷 220-232页

作者： Lixing Zhang Xintao Yan Li An Meijia Wang Xi Xu Zhonglin Ma mengting nie Fangzhou Du Jingzhong Zhang Shuang Yu Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhou 215163China Zhengzhou Institute of Engineering and Technology Affiliated with SIBET Zhengzhou 450001China Xuzhou Medical University Xuzhou 221004China Academy for Engineering and Technology Fudan UniversityShanghai 200433China

Large cutaneous wounds pose a severe medical problem and may be deadly in cases when regeneration is ***,topical stem cell therapy has been realized as a promising strategy for wound healing and skin ***,stem cells must be administrated uniformly to the wound area,otherwise treatment will be ineffective,which has been a limitation of current administration ***,the delivery pressure and nozzle features of most clinical cell spray devices are unknown,which may significantly affect the viability of sprayed cells and their capacity for ***,we developed a novel pneumatically assisted atomization device(PAAD)in which cell suspensions were uniformly atomized at a low delivery *** optimized the applied fluidic pressure and air pressure to maximize cell survival and function for the application of multiple cell types,while ensuring uniform dispersal across the wound ***,we found that the application of sprayed umbilical cord-derived mesenchymal stem cells to wound sites significantly accelerated wound healing and promoted appendage regeneration on an excisional cutaneous wound ***,the novel PAAD system delivered living cells uniformly and maintained the viability and differentiation of sprayed cells,strongly suggesting its potential for application in clinical cell therapy,especially for large,irregular,and severe skin wounds.

关键词： Cell delivery Skin wound Wound healing Spray application Cell-spray autografting Stem cell therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

引用

Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

引用

Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

引用

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wrinkling in graded core/shell systems using symplectic formulation

引用

Applied Mathematics and Mechanics(English Edition) 2023年第12期44卷 2057-2070页

作者： Yaqi GUO Guohua nie School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Wrinkles in flat graded elastic layers have been recently described as a timevarying Hamiltonian system by the energy *** core/shell structures can also undergo surface instabilities under the external *** this study,we show that by treating the radial direction as a pseudo-time variable,the graded core/shell system with radially decaying elastic properties can also be described within the symplectic *** combination with the shell buckling equation,the present paper addresses the surface wrinkling of graded core/shell structures subjected to the uniform external pressure by solving a series of ordinary differential equations with varying *** representative gradient distributions are showcased,and the predicted critical pressure and critical wave number are verified by finite element *** symplectic framework provides an efficient and accurate approach to understand the surface instability and morphological evolution in curved biological tissues and engineered structures.

关键词： wrinkling graded core/shell system symplectic analysis gradient distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami

引用

Chemical Research in Chinese Universities 2020年第5期36卷 983-984页

作者： nie Zhou State Key Laboratory of Chemo Bio-sensing and Chemometncs College of Chemistry and Chemical EngineeringHunan Provincial Key Laboratoty of Biomacromolecular Chemical BiologyHunan UniversityChangsha 410082P.R.China

To investigate the dynamic interaction between antibody and *** et *** designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the naiioscale and thus to monitor the transient binding kinetics of thedynamic antigen-antibody complexes at room *** study provides a straightforward,desigiiable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve theunderstanding toward thedesign of the next-generation antibodies and vaccines lor various biomedical *** work has been published online in Nature Communications on June 19,2020.

关键词： temperature. kinetics interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simulation and evaluation study of atmospheric aerosol nonsphericity as a function of particle size

引用

Particuology 2024年第7期90卷 281-291页

作者： Qianjun Mao Xin nie School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China College of New Energy and Materials Northeast Petroleum UniversityDaqing163318China

Aerosol nonsphericity causes great uncertainty in radiative forcing assessments and climate *** considerable studies have attempted to quantify this uncertainty,the relationship between aerosol nonsphericity and particle size is usually not considered,thus reducing the accuracy of the *** this study,a coupled inversion algorithm combining an improved stochastic particle swarm optimization algorithm and angular light scattering is used for the nonparametric estimation of aerosol nonsphericity variation with particle size,and the optimal sample selection method is employed to screen the *** on the verification of inversion accuracy,the variation of aerosol aspect ratio with particle size based on the ellipsoidal model in global regions has been obtained from Aerosol Robotic Network(AERONET)data,and the effect of nonsphericity on radiative forcing and dry deposition has been *** results show that the aspect ratio increases with particle size in all regions,with the maximum ranging from 1.4 to 1.8 in the desert,reflecting the differences in aerosol composition at different particle *** radiation calculations,considering aerosol nonsphericity makes the aerosol cooling effect weaker and surface radiative fluxes increase,but hardly changes the aerosol absorption,with maximum differences of 9.22%and 22.12%at the bottom and top of the atmosphere,***,the differences in radiative forcing between aspect ratios as a function of particle size and not varying with particle size are not significant,averaging less than 2%.Besides,the aspect ratio not varying with particle size underestimates the deposition velocity of small particles and overestimates that of large particles compared to that as a function of particle size,with maximum differences of 7%and 4%,respectively.

关键词： Aerosol nonsphericity Inversion Aspect ratio Radiative forcing Dry deposition velocity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forward-backward stochastic differential equation with subdifferential operator and associated variational inequality

引用

Science China Mathematics 2015年第4期58卷 729-748页

作者： nie TianYang School of Mathematics Shandong University School of Mathematics and Statistics University of Sydney

We study the existence and uniqueness of the solution to a forward-backward stochastic differential equation with subdifferential operator in the backward equation. This kind of equations includes, as a particular case, multi-dimensional forward-backward stochastic differential equation where the backward equation is reflected on the boundary of a closed convex(time-independent) domain. Moreover, we give a probabilistic interpretation for the viscosity solution of a kind of quasilinear variational inequalities.

关键词： backward stochastic differential equations variational inequalities subdifferential operators viscosity solutions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A procedure of the method of reverberation ray matrix for the buckling analysis of a thin multi-span plate

引用

Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 1055-1068页

作者： Zhiwei LI Guohua nie School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

A procedure of the method of reverberation ray matrix(MRRM)is developed to perform the buckling analysis of thin multi-span rectangular plates having internal line supports or stiffeners.A computation algorithm for the reverberation ray matrix in the MRRM is derived to determine the buckling ***,the analytical solutions are presented for the buckling of the structure having two opposite simply-supported or clamped-supported edges with spans,while the constraint condition of two remaining edges may be in any combination of free,simply-supported,and clamped boundary ***,based on the analysis of matrices relating to the unknown coefficients in the solution form for the deflection in terms of buckling modal functions,some recursive equations(REs)for the MRRM are introduced to generate a reduced reverberation ray matrix with unchanged dimension when the number of spans increases,which promotes the computation *** numerical examples are given,and the present results are compared with the known solutions to illustrate the validity and accurateness of the MRRM for the buckling analysis.

关键词： multi-span thin rectangular plate buckling method of reverberation ray matrix(MRRM) recursive equation(RE)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sum of squares methods for minimizing polynomial forms over spheres and hypersurfaces

引用

Frontiers of Mathematics in China 2012年第2期7卷 321-346页

作者： Jiawang nie Department of Mathematics University of California San DiegoLa Jolla CA 92093 USA

Abstract This paper studies the problem of minimizing a homogeneous polynomial （form） f（x） over the unit sphere Sn-1 = {x ∈ R^n：｜｜X｜｜2 = 1}. The problem is NP-hard when f（x） has degree 3 or higher. Denote by fmin （resp. fmax） the minimum （resp. maximum） value of f（x） on S^n-1. First, when f（x） is an even form of degree 2d, we study the standard sum of squares （SOS） relaxation for finding a lower bound of the minimum .fmin ：max γ s.t.f（x）-γ.｜｜x｜｜2^2d is *** fos be be the above optimal value. Then we show that for all n ≥ 2d,Here, the constant C（d） is independent of n. Second, when f（x） is a multi-form and ^-1 becomes a muilti-unit sphere, we generalize the above SOS relaxation and prove a similar bound. Third, when f（x） is sparse, we prove an improved bound depending on its sparsity pattern; when f（x） is odd, we formulate the problem equivalently as minimizing a certain even form, and prove a similar bound. Last, for minimizing f（x） over a hypersurface H（g） = {x E lRn： g（x） = 1} defined by a positive definite form g（x）, we generalize the above SOS relaxation and prove a similar bound.

关键词： Approximation bound form hypersurface L2-norm G-norm,multi-form polynomial semidefinite programming sum of squ^res

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：