检索结果-南通市图书馆

Surface defect-rich ceria quantum dots anchored on sulfur-doped carbon nitride nanotubes with enhanced charge separation for solar hydrogen production

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第1期30卷 51-59,I0003页

作者： mengru li Changfeng Chen liping Xu Yushuai Jia Yan liu Xin liu Institute of Advanced Materials College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022JiangxiChina

Designing defect-engineered semiconductor heterojunctions can effectively promote the charge carrier ***,novel ceria(CeO2) quantum dots(QDs) decorated sulfur-doped carbon nitride nanotubes(SCN NTs) were synthesized via a thermal polycondensation coupled in situ depositionprecipitation method without use of template or *** structure and morphology studies indicate that ultrafine CeO2 QDs are well distributed inside and outside of SCN NTs offering highly dispersed active sites and a large contact interface between two *** leads to the promoted formation of rich Ce^(3+) ion and oxygen vacancies as confirmed by *** photocatalytic performance can be facilely modulated by the content of CeO2 QDs introduced in SCN matrix while bare CeO2 does not show activity of hydrogen *** optimal catalyst with 10% of CeO2 loading yields a hydrogen evolution rate of 2923.8 μmol h-1 g-1 under visible light,remarkably higher than that of bare SCN and their physical *** studies reveal that the abundant surface defects and the created 0 D/1 D junctions play a critical role in improving the separation and transfer of charge carriers,leading to superior solar hydrogen production and good stability.

关键词： Photocatalytic hydrogen evolution Ceria quantum dots Sulfur-doped carbon nitride nanotubes Surface defects Charge separation

Improvement of NIR models for quality parameters of leech and earthworm medicines using outlier multiple diagnoses

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2018年第1期11卷 22-36页

作者： Chunyan Wu Jiashan Chen mengru li Yongjiang Wu Xuesong liu College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058P.R.China

Leeches and earthworms are the main ingredients of Shuxuetong injection compositions,whichare natural *** infrared(NIR)diffuse reflection spectroscopy has been used forquality assurance of Chinese *** the present work,NIR spectroscopy was proposed as arapid and nondestructive technique to assess the moisture content(MC),soluble solid content(SSC)and hypoxanthine content(HXC)of leeches and *** study goal was toimprove NIR models for accurate quality control of leech and earthworm using outlier multiplediagnoses(OMD).OMD was composed of four outlier detection methods:spectrum outlier di-agnostic(MD),leverage diagnostic(LD),principal component scores diagnostic(PCSD)andfactor loading diagnostic(FLD),Conventional outlier diagnoses(MD,LD)and OMD werecompared,and the best NIR models were those based on *** correlation coefficients(R)for leech were 0.9779,0.9616 and 0.9406 for MC,SSC and HXC,*** values ofrelative standard error of prediction(RSEP)for leech were 2.3%,5.1%and 9.0%for MC,SSC and HXC,*** values of R for earthworm were 0.9478,0.9991 and 0.9605 for MC,SSC and HXC,*** values of RSEP for earthworm were 8.8%,2.4%and 12%for MC,SSC and HXC,*** performance of the NIR models was certainly improved by OMD.

关键词： Leech earthworm near-infrared spectroscopy outlier multiple diagnoses

Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2020年第11期13卷 2958-2966页

作者： Shiyang Shen li Zhang mengru li Zhizi Feng Huixia li Xiao Xu Shiqi lin Ping li Can Zhang Xiaojun Xu Ran Mo State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Advanced Pharmaceuticals and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 *** lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin ***,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory *** nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)*** obtained cNC displays significantly higher stability than *** moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA ***-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse ***-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice.

关键词： small interfering RNA(siRNA)delivery collaborative assembly nanomedicine insulin resistance diabetes

Study of screening,transport pathway,and vasodilation mechanisms on angiotensin-Ⅰconverting enzyme inhibitory peptide from Ulva prolifera proteins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2023年第11期42卷 98-106页

作者： Zhiyong li Yuan He Hongyan He Caiwei Fu mengru li Aiming Lu Dongren Zhang Tuanjie Che Songdong Shen School of Biology&Basic Medical Sciences Soochow UniversitySuzhou 215101China Key Laboratory of Functional Genomic and Molecular Diagnosis of Gansu Province Lanzhou 730030China

In this study,Ulva prolifera protein was used for preparing angiotensin-I converting enzyme(ACE)-inhibitory peptide via virtual gastrointestinal digestion and in silico *** parameters of the obtained peptide,such as inhibition kinetics,docking mechanism,stability,transport pathway,were explored by lineweaver-Burk plots,molecular docking,in vitro stimulate gastrointestinal(GI)digestion and Caco-2 cells monolayer model,***,a novel anti-ACE peptide LDF(IC_(50),(1.66±0.34)μmol/L)was screened and synthesized by chemical *** was a no-competitive inhibitor and its anti-ACE inhibitory effect mainly attributable to four Conventional Hydrogen Bonds and Zn701 *** could keep activity during simulated GI digestion in vitro and was transported by peptide transporter PepT1 and passive-mediated ***,it could activate Endothelial nitric oxide synthase(eNOS)activity to promote the production of NO and reduce Endothelin-1(ET-1)secretion induced by AngiotensinⅡ(AngⅡ)in Human Umbilical Vein Endothelial Cells(HUVECs).Meanwhile,it could promote mice splenocytes proliferation in a concentration-dependent *** study indicated that this peptide was a potential ingredient functioning on vasodilation and enhancing immunity.

关键词： Ulva prolifera protein ACE-inhibitory peptide in vitro GI digestion vasodilation mechanism immunomodulation

Sr(Cr_(0.2)Mn_(0.2)Fe_(0.2)C_(0.2)Ni_(0.2))O_(3):A novel high-entropy perovskite oxide with enhanced electromagnetic wave absorption properties

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2024年第6期10卷 1176-1185页

作者： mengru li Qing Zhi Jinlu li Chengwen Wu Xuewen Jiang Zhiyu Min Rui Zhang Hailong Wang Haibin Wang Bingbing Fan School of Materials Science and Engineering Zhengzhou University Zhengzhou450001China School of Material Science and Engineering Luoyang Instiute pf Science and TechnologyLuoyang471023HenanChina Institute of Advanced Ceramics Henan Acaderry of SciencesZhengzhou450046China

Perovskite materials(ABO_(3))possess a wealth of elements selectable and exhibit a diverse range of octahedral *** emergence of high-entropy perovskite ceramics provides a fresh perspective for advancing the field of wave-absorbing *** this study,we concentrate on the wet chemical synthesis of a high-entropy perovskite oxide,Sr(Cr_(0.2)Mn_(0.2)Fe_(0.2)C_(0.2)Ni_(0.2))O_(3),and investigate its crystal structure,microstructure,chemical composition,magnetic properties,and microwave absorbing *** results indicate that when sintered at a temperature of 1,350℃,the sample achieves a minimum reflection loss of-54.0 dB at a frequency of 9.68 GHz,accompanied by a maximum effective absorption bandwidth(EAB)of 7.44 GHz at the thickness of 1.8 *** high-entropy design of the B-site induces distortions of oxygen vacancy and octahedral structure of the perovskite *** leads to the fine tuning of its dielectric and magnetic properties,thereby endowing perovskite with excellent electromagnetic wave absorption ***,perovskite emerges as a promising new electromagnetic wave absorption material with significant potential.

关键词： High-entropy ceramics Perovskite Microwave absorption Magnetism

Next‑Generation Sequencing‑Based Copy Number Variation Analysis in Chinese Patients with Primary Ciliary Dyskinesia Revealed Novel DNAH5 Copy Number Variations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenomics 2024年第1期4卷 24-33页

作者： Weicheng Chen Zhuoyao Guo mengru li Wei Sheng Guoying Huang Cardiovascular Center Children’s Hospital of Fudan University399 Wanyuan RoadShanghai 201102China Respirology Department Children’s Hospital of Fudan UniversityShanghai 201102China

Primary ciliary dyskinesia(PCD)is a rare disorder characterized by extensive genetic ***,in the genetic pathogenesis of PCD,copy number variation(CNV)has not received sufcient attention and has rarely been reported,especially in ***-generation sequencing(NGS)followed by targeted CNV analysis was used in patients highly suspected to have PCD with negative results in routine whole-exome sequencing(WES)*** real-time polymerase chain reaction(qPCR)and Sanger sequencing were used to confrm these *** further characterize the ciliary phenotypes,high-speed video microscopy analysis(HSVA),transmission electron microscopy(TEM),and immunofuorescence(IF)analysis were *** 1(F1:II-1),a 0.6-year-old girl,came from a nonconsanguineous *** presented with situs inversus totalis,neonatal respiratory distress,and *** nasal nitric oxide level was markedly *** respiratory cilia beat with reduced *** revealed shortened outer dynein arms(ODA)of ***5:13717907-13722661del spanning exons 71–72 was identifed by NGS-based CNV *** 2(F2:IV-4),a 37-year-old man,and his eldest brother Patient 3(F2:IV-2)came from a consanguineous *** had sinusitis,bronchiectasis and situs inversus *** respiratory cilia of Patient 2 and Patient 3 were found to be uniformly immotile,with ODA *** novel homozygous deletions chr5:13720087_13733030delinsGTTTTC and chr5:13649539_13707643del,spanning exons 69–71 and exons 77–79 were identifed by NGS-based CNV *** in DNA copy number were confrmed by qPCR *** showed that the respiratory cilia of Patient 1 and Patient 2 were defcient in dynein axonemal heavy chain 5(DNAH5)protein *** report identifed three novel DNAH5 disease-associated variants by WES-based CNV *** study expands the genetic spectrum of PCD with DNAH5 in the Chinese population.

关键词： Primary ciliary dyskinesia DNAH5 gene Copy number variation Phenotypic heterogeneity

Improved Prediction and Understanding of Glass-Forming Ability Based on Random Forest Algorithm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Quantum Computing 2021年第2期3卷 79-87页

作者： Chenjing Su Xiaoyu li mengru li Qinsheng Zhu Hao Fu Shan Yang School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengduChina School of Physics University of Electronic Science and Technology of ChinaChengdu610054China Department of Chemistry Physicsand Atmospheric SciencesJackson State UniversityJacksonUSA

As an ideal material,bulk metallic glass(MG)has a wide range of applications because of its unique properties such as structural,functional and biomedical ***,it is difficult to predict the glass-forming ability(GFA)even given the criteria in theory and this problem greatly limits the application of bulk MG in industrial *** this work,the proposed model uses the random forest classification method which is one of machine learning methods to solve the GFA prediction for binary metallic *** with the previous SVM algorithm models of all features combinations,this new model is successfully constructed based on the random forest classification method with a new combination of features and it obtains better prediction ***,it further shows the degree of feature parameters influence on ***,a normalized evaluation indicator of binary alloy for machine learning model performance is put forward for the first *** result shows that the application of machine learning in MGs is valuable.

关键词： GFA random forest binary alloy machine learning

甲基丙烯酸乙酰乙酰氧基乙酯改性丙烯酸酯乳液压敏胶的制备及其性能

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

化工新型材料 2019年第8期47卷 74-79页

作者：杜方凯李梦汝广西民族大学化学化工学院广西高校食品安全与药物分析化学重点实验室广西林产化学与工程重点实验室南宁530008 广州宏昌胶粘带厂广州510800

采用预乳化半连续工艺合成了乙酰乙酰氧基丙烯酸酯压敏胶乳液,以乙二胺为交联剂对其进行了交联改性。探讨了交联单体甲基丙烯酸乙酰乙酰氧基乙酯(AAEM)用量对乳液及胶膜压敏粘接性能的影响。研究结果表明:随着AAEM含量的增加,乳液的粒... 详细信息

采用预乳化半连续工艺合成了乙酰乙酰氧基丙烯酸酯压敏胶乳液,以乙二胺为交联剂对其进行了交联改性。探讨了交联单体甲基丙烯酸乙酰乙酰氧基乙酯(AAEM)用量对乳液及胶膜压敏粘接性能的影响。研究结果表明:随着AAEM含量的增加,乳液的粒径变大,乳胶膜耐水性能显著提高。当AAEM用量为单体总量的3%(wt,质量分数)时,所制备的压敏胶带具有很好的压敏粘接性能平衡和耐高温性能。

关键词：共聚改性乳液交联甲基丙烯酸乙酰乙酰氧基乙酯压敏胶

A network pharmacological study to investigate the combination of LHQW-XYS in the treatment of COVID-19 olfactory impairment-associated

在线全文

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2024年第7期33卷 631-646页

作者： Xiaoyu Wei Luhang Yu mengru li Qiang Xu Tianjin University of Traditional Chinese Medicine Tianjin 301617China Chinese PLA Medical School Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381China Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China

To explore the target of action of LHQW-XYS on the main components of COVID-19 olfactory impairment by using network pharmacological methods and try to reveal its mechanism of action in the treatment related to COVID-19 induced olfactory impairment,we used the TCMSP platform to obtain potential active ingredients through oral utilization and drug-like properties screening;the Swiss TargetPrediction platform to predict the targets of the active ingredients and construct a drug-ingredient-target network,and then obtained the gene targets of COVID-19 olfactory injury through GeneCards,OMIM,and TTD platforms to intersect the drug targets and disease genes to obtain common *** drug targets and disease genes were intersected to obtain common *** and Cytoscape 3.8.2 software were used to construct the target-disease gene PPI network,screen the key targets and core gene clusters,and analyze the key targets by GO and KEGG enrichment analyses with the help of the Metascape platform,and then map the screened core active ingredients and their targets into the pathway to construct the core active ingredients-targets-pathway *** core active ingredient-target-pathway network was constructed,and finally,molecular docking was carried *** results showed that there were 4669 potential targets,5609 disease targets,and 17 drug-disease cross-targets for the active ingredients of *** GO and KEGG enrichment analyses indicated that the mechanism of LHQW-XYS in the treatment of olfactory impairment in COVID-19 may be due to the regulation of related signaling pathways,such as Serotonergic synapse and Regulation of lipolysis in *** docking showed that six active components(quercetin,luteolin,kaempferol,7-methoxy-2-methylisoflavone,wogonin,medicarpin)and two key genes(PTGS2,PPARG)had good binding *** the end,we conclude that LHQW-XYS may act on Serotonergic synapse and Regulation of lipolysis in adipocyte pathways to achieve an

关键词： LHQWXYS COVID-19 olfactory impairment-associate Network pharmacology Molecular docking