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Defence Technology（防务技术） 2024年第12期42卷 12-30页

作者： Jiahao Zhang mengmeng guo Sheng Zhou Chao Ge Pengwan Chen Qingbo Yu China State Key Laboratory of Explosion Science and Safety Protection Beijing Institute of TechnologyBeijing100081China

Compared with PELE with inert fillings such as polyethylene and nylon,reactive PELE(RPELE)shows excellent damage effects when impacting concrete targets due to the filling deflagration *** present work,an analytical model describing the jacket deformation and concrete target damage impacted by RPELE was presented,in which the radial rarefaction and filling deflagration reaction were *** impact tests of RPELE on concrete target in the 592-1012 m/s were carried out to verify the analytical *** on the analytical model,the angle-length evolution mechanism of the jacket bending-curling deformation was revealed,and the concrete target damage was further *** can find out that the average prediction errors of the front crater,opening and back crater are 6.8%,8.5%and 7.1%,***,the effects of radial rarefaction and deflagration were *** was found that the neglect of radial rarefaction overestimates the jacket deformation and concrete target damage,while the deflagration reaction of filling increases the diameter of the front crater,opening and back crater by 25.4%,24.3%and 31.1%,*** research provides a valuable reference for understanding and predicting the jacket deformation and concrete target damage impacted by RPELE.

关键词： Reactive PELE Concrete target Jacket deformation Radial rarefaction Enhanced damage mechanism

Thermal processing induced release and degradation of paralytic shellfish toxin from mussels Mytilus edulis

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Journal of Oceanology and Limnology 2022年第6期40卷 2267-2276页

作者： Chenfan DONG Haiyan WU Jixing PENG mengmeng guo Yuxiu ZHAI Zhijun TAN College of Food Science and Technology Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality Ministry of AgricultureYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Understanding the risk factors associated with shellfish consumption is a relevant public health concern because of the potential adverse ef fects of paralytic shellfish toxins(PSTs).This work aims to study the effects of the five most common heating treatments(steaming,boiling,frying,water-bath heating,and microwaving),for different processing times and temperature/power settings,on the content of PSTs in mussels(Mytilus edulis)collected in Qinhuangdao,*** toxin concentration,removal percentages,and toxin distribution in the cooking liquor and meat were *** five processing modes effectively accelerated toxin release into the cooking *** average percentage removal was 73.53%±16.50%from *** led to the most significant toxin degradation among the methods *** findings should facilitate risk assessment of PSTs in mussels.

关键词： processing mode mussels removal percentage toxin distribution

First observation of domoic acid and its isomers in shellfish samples from Shandong Province,China

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Journal of Oceanology and Limnology 2022年第6期40卷 2231-2241页

作者： Guanchao ZHENG Haiyan WU mengmeng guo Jixing PENG Yuxiu ZHAI Zhijun TAN Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality Ministry of Agriculture and Rural Aff airsYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

A total of 133 shellfish samples were collected in seven cities of Shandong Province,China,from May to October,*** domoic acid(DA)concentrations were determined by liquid chromatographytandem mass spectrometry(LC-MS/MS),and their distribution characteristics were *** concentration was detected high in over 1/3(36.1%)of the samples of four kinds of shellfish in all three seasons in range from 0 to 102μg/*** highest DA concentrations were 102,101,36.7,and 10.2μg/kg in Crassostrea gigas,Chlamys farreri,Mactra veneriformis,and Mytilus edulis,***,Yantai(22.0μg/kg)and Weihai(16.9μg/kg)showed relatively high concentrations of DA,whereas Rizhao and Dongying presented only 0.85-and 1.76-μg/kg DA,*** concentrations in the shellfish samples were strongly related to seasonal changes,being significantly higher in autumn and summer than that in *** DA risk exposure assessments indicate that dietary seafood consumption did not pose a health threat to general human *** addition,three isomers(isoA,isoD,isoE)and 5′-epimer DA were detected in 3.00%-15.80%of the shellfish *** study is the first to observe DA and its isomers in shellfish samples of Shandong *** results demonstrate that DA contamination is very common and should be continuously monitored.

关键词： domoic acid shellfi sh liquid chromatography-tandem mass spectrometry(LC-MS/MS) Shandong Province

The role and its mechanism of intermittent fasting in tumors:friend or foe?

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Cancer Biology & Medicine 2021年第1期18卷 63-73页

作者： Xu Zhao Jing Yang Ruoyu Huang mengmeng guo Ya Zhou Lin Xu Special Key Laboratory of Gene Detection and Therapy&Base for Talents in Biotherapy of Guizhou Province Zunyi 563000China Department of Immunology Zunyi Medical UniversityZunyi 563000China

Intermittent fasting(IF)is becoming a prevailing topic worldwide,as it can cause changes in the body’s energy metabolism processes,improve health,and affect the progression of many diseases,particularly in the circumstance of *** research has shown that IF can alter the energy metabolism of tumor cells,thereby inhibiting tumor growth and improving antitumor immune ***,IF can increase cancer sensitivity to chemotherapy and radiotherapy and reduce the side effects of these traditional anticancer *** is therefore emerging as a promising approach to clinical cancer ***,the balance between long-term benefits of IF compared with the harm from insufficient caloric intake is not well *** this article,we review the role of IF in tumorigenesis and tumor therapy,and discuss some scientific problems that remain to be clarified,which might provide some assistance in the application of IF in clinical tumor therapy.

关键词： Intermittent fasting energy metabolism tumor immune escape immunotherapy

Advanced unconventional techniques for sub-100 nm nanopatterning

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InfoMat 2022年第8期4卷 25-53页

作者： mengmeng guo Zhiyuan Qu Fanyi Min Zheng Li Yali Qiao Yanlin Song Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)BeijingPR China State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalArmy Medical UniversityChongqingPR China

Patterned nanostructures with ultrasmall features endow functional devices with unique nanoconfinement and performance *** increasing demand for miniaturization has stimulated the development of sub-100 nm nanopatterning *** conventional lithography—which is limited by unavoidable factors—advanced patterning techniques have been reported to produce nanoscale features down to molecular or even atomic *** this review,unconventional techniques for sub-100 nm nanopatterning are discussed,in particular the principles by which to achieve the desired patterns(among other important issues).Such techniques can be classified into three categories:template-replica,template-induced,and template-free ***,multi-dimensional nanostructures consist of various building materials,the unique properties of which are ***,the remaining challenges and opportunities for large-scale patterning,the improvement of device perfor-mance,the multi-dimensional nanostructures of biocompatible materials,molecular-scale patterning,and the carbon footprint requirements for future nanofabrication processes are discussed.

关键词： functional devices high resolution nanoconfinement nanostructure patterning techniques sub-100 nm unconventional lithography

Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

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Genes & Diseases 2024年第4期11卷 411-425页

作者： mengmeng guo Pan Hu Jiayi Xie Kefu Tang Shixiu Hu Jialiang Sun Yundong He Jing Li Weiqiang Lu Huirong Liu Mingyao Liu Zhengfang Yi Shihong Peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characterized by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 exhibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model

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Animal Nutrition 2022年第3期10卷 111-123页

作者： Ke Zhang Yangbin Xu Yuxin Yang mengmeng guo Ting Zhang Bo Zong Shuhong Huang Langda Suo Baohua Ma Xiaolong Wang Yujiang Wu Daniel Brugger Yulin Chen Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling712100China College of Veterinary Medicine Northwest A&F UniversityYangling712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa850009China Institute of Animal Nutrition and Dietetics Vetsuisse-FacultyUniversity of Zurich8057ZurichSwitzerland

Early weaning induces intestinal injury,leading to a series of long-term symptoms such as inflammation,malabsorption and *** this study,we hypothesized that microbes and theirmetabolitesmodulate the host's inflammatory response to early weaning stress in a goatmodel.A total of 18 female Tibetan goat kids(n?9)wereweaned fromtheirmothers at 28 d(D28)and 60 d(D60)postpartum.D60 and D28 groupswere fed the same solid diet ad libitum fromweaning to 75 d of *** colonic epithelium was subject to RNAsequencing,the caecal digesta metabolomics were assessed by liquid chromatographyetandem mass spectrometry(LC-MS/MS),and the caecal microbiota composition was analysed by 16S ribosomal RNA gene *** foundthatearlyweaningsubstantially increased the colonic pro-apoptotic gene expressionof B-cell lymphoma associated X(Bax),caspase-9,and caspase-3,and decreased the expression of zonula occludens-1(ZO-1)and claudin-1(P<0.01).In addition,a significant Bacteroides acidifaciens enrichmentwas observed in the hindgut of early-weaned goats(P<0.01),which negatively correlated with lysophosphatidylcholine ***,the chemokine signaling,IL-17 signaling,and peroxisome proliferatorsactivated receptor(PPAR)signaling pathways were upregulated in the colonic mucosa of the early-weaned *** applying caecal microbiota transplantation from goats to defaunated C57/6J mice,we confirmed that caecalmicrobiota of D28 goat kids increased the relative abundance of *** and significantly upregulated the genes of Bax,G proteinecoupled receptor(GPR)109A,GPR 43,fatty acid binding protein 6,nuclear receptor subfamily 1 group H member 3,angiotensin converting enzyme 2,and IL-6 expression(P<0.05),and decreased ZO-1,and claudin-1 protein expression in the mice jejunum and colon(P<0.001).These results proposed that the hindgut microbiota andmetabolites mediate the barrier functionweakening duringearlyweaning,and the relative abundance of *** negatively corr

关键词： Hindgut microbiome Ruminant Dysbiosis Inflammation Colon

The enhanced antitumor response of combination of pimozide with IDO inhibitor L-MT in melanoma

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The enhanced antitumor response of combination of pimozide w...

MicroRNA-7 deficiency enhanced the activation and function of CD4+T cells

第十二届全国免疫学学术大会

作者： wei tian guo Jing guo mengmeng Feng Yuchen Feng Zhiwei Immunology of xinxiang medical college Pathology of Xinxiang Medical college

Melanoma is one of the deadliest and therapy resistant *** new candidates to improve patient survival is a continuous *** studies showed that the effect of pimozide was not satisfieding when treated with melanoma and find the way to enhance the treatment is *** is an immunosuppressive intracellular rate-limiting enzyme which contributes to tumor immune tolerance in a variety of tumors including melanoma and may be a novel therapeutic strategy when combination with *** this study,pimozide was assessed for its anti-tumor activity in vitro and the combination effect with L-MT in *** had potent antitumor activity through regulation of proliferation,apoptosis and ***,pimozide induced antitumor effect was enhanced when combined with L-MT not only via proliferation,apoptosis and migration regulation,but also via immune ***,pimozide could also regulate the tumor immunity which may through inhibiting activity of Stat3 and ***,we propose the use of pimozide in combination with IDO inhibitor as a potential new treatment strategy for melanoma therapy.

关键词： melanoma pimozide IDO inhibitor L-MT combination therapy

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MicroRNA-7 deficiency enhanced the activation and function o...

第十二届全国免疫学学术大会

作者： zhao juanjuan Yue Dongxu guo mengmeng Xu Lin Zunyi Medical University

Accumulating evidence showed that microRNA-7(miRNA-7),a unique member of miRNAs,played an important role in biological function of various types of ***,the potential role of miR-7 in development and function of CD4T c... 详细信息

关键词： miR-7 CD4+T cell activation Mapk4

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胆汁淤积性肝病的治疗靶点及药物应用前景

临床肝胆病杂志 2019年第2期35卷 262-265页

作者：郭濛濛谢雯首都医科大学附属北京地坛医院肝病中心北京100015

胆汁淤积性肝病是由胆管的破坏、胆汁酸的积聚和炎症过程的持续导致胆管细胞及肝细胞的损伤而引起。若不及时治疗,胆汁淤积会导致肝纤维化、肝硬化甚至出现终末期肝病。原发性胆汁性胆管炎(PBC)和原发性硬化性胆管炎(PSC)是成人中最常见... 详细信息

胆汁淤积性肝病是由胆管的破坏、胆汁酸的积聚和炎症过程的持续导致胆管细胞及肝细胞的损伤而引起。若不及时治疗,胆汁淤积会导致肝纤维化、肝硬化甚至出现终末期肝病。原发性胆汁性胆管炎(PBC)和原发性硬化性胆管炎(PSC)是成人中最常见的2种胆汁淤积性肝病,其病因目前尚不明确。虽然熊去氧胆酸(UDCA)可以较好地改善PBC患者的预后,延长患者肝移植的存活率,但存在部分患者对UDCA治疗无应答的现象。此外,目前尚无有效药物治疗PSC。随着近年来胆汁酸调节分子机制的研究进展及免疫途径的理解加深,涌现了越来越多新的药物。介绍了近年来PBC及PSC新兴治疗靶点及相关药物方面的研究进展。

关键词：胆汁淤积肝硬化,胆汁性胆管炎,硬化性治疗学