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基于风险-质量的高原湖泊流域生态分区构建--以滇池流域为例

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生态学报 2024年第3期44卷 1052-1066页

作者：武燕吴映梅李琛高彬嫔郑可君王梦娇云南师范大学地理学部昆明650500 云南省社会科学院昆明650000

随着人类足迹不断延伸,高原湖泊流域人地系统三生空间冲突显著。以滇池流域为例,顾及流域三生空间冲突风险,基于三生空间景观格局和生态环境质量的变化,尝试引入四象限模型,结合热点分析,划分风险-质量综合生态环境分区。结果表明:(1)... 详细信息

随着人类足迹不断延伸,高原湖泊流域人地系统三生空间冲突显著。以滇池流域为例,顾及流域三生空间冲突风险,基于三生空间景观格局和生态环境质量的变化,尝试引入四象限模型,结合热点分析,划分风险-质量综合生态环境分区。结果表明:(1)滇池流域三生空间冲突风险类型以较强为主,冲突曲线指数呈现倒“U”型,较强冲突比重不断下降。三生空间类型转换明显,生活空间共增长了312.23km^(2),主要是由于高原湖泊流域的快速城镇化使得生活空间大量挤占了生产和生态空间。(2)滇池流域生态环境质量总体呈现下降趋势,空间上以滇池为中心呈现高-低-高的分布特征。较高质量和高质量区面积减少了136.66km^(2);低质量区和较低质量区由699.65km^(2)上升到930.51km^(2),约占流域总面积的1/3。(3)基于三生空间冲突风险和生态环境质量两个维度将生态分区分为综合生态环境优质、良好、一般、劣质四类,四类区的空间分布连续性相对较好,尤以劣质区面积连续扩展的态势最为典型。针对不同生态分区提出差异化管理措施,为流域人地协调发展提供实践指导。

关键词：三生空间生态分区空间冲突四象限模型滇池流域

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深部热疗对老年食管癌调强放疗患者放射性肺炎的影响

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中华放射肿瘤学杂志 2024年第3期33卷 218-225页

作者：王梦姣陈胜东朱国民焦旸周菊英秦颂兵王利利苏州大学附属第一医院放疗科苏州215006 宜兴市肿瘤医院放疗科无锡214200 苏州大学苏州医学院放射医学与防护学院苏州215123

目的探讨深部热疗对老年食管癌调强放疗患者发生放射性肺炎情况的影响。方法回顾性分析2017年8月1日—2023年2月6日在苏州大学附属第一医院、宜兴市肿瘤医院接受调强放疗的177例老年(≥60岁)食管癌患者,根据患者是否行深部热疗分为热疗... 详细信息

目的探讨深部热疗对老年食管癌调强放疗患者发生放射性肺炎情况的影响。方法回顾性分析2017年8月1日—2023年2月6日在苏州大学附属第一医院、宜兴市肿瘤医院接受调强放疗的177例老年(≥60岁)食管癌患者,根据患者是否行深部热疗分为热疗组和非热疗组。两组均采用6 MV X射线常规调强放疗,热疗组在放疗前1 h内使用体外热疗设备HG-2000Ⅲ进行高频深部热疗,每周2次,加热温度为41~43℃,时间为40 min。通过倾向评分匹配校正组间混杂因素后,采用χ2检验比较两组患者的近期有效率;单因素分析及logistic多因素分析比较两组患者放射性肺炎的发生情况。结果倾向评分匹配后两组各42例患者,匹配后两组患者基线资料及放疗剂量参数的差异均无统计学意义(P>0.05)。热疗组客观缓解率显著高于非热疗组(83.3%∶64.3%,P=0.047)。单因素分析结果显示,热疗组发生放射性肺炎、症状性(≥2级)放射性肺炎概率均显著小于非热疗组(61.9%∶85.7%,P=0.013;21.4%∶47.6%,P=0.012)。logistic多因素分析结果显示,热疗是症状性放射性肺炎的独立保护因素(P=0.011)。结论老年食管癌患者调强放疗期间使用深部热疗不仅能提高肿瘤治疗效果,还能降低放射性肺炎的发生率及严重程度。

关键词：放射疗法热疗放射性肺炎食管肿瘤倾向评分匹配

Low-cost, green synthesis of highly porous carbons derived from lotus root shell as superior performance electrode materials in supercapacitor

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Journal of Energy Chemistry 2016年第1期25卷 26-34页

作者： Xin wang mengjiao wang Xuemei Zhang Hejun Li Xiaohui Guo Key Lab of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education and the College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710069ShaanxiChina School of Materials Science and Engineering the State Key Laboratory of Solidification ProcessingNorthwestern Polytechnical UniversityXi'an 710069ShaanxiChina

Facile production of high quality activated carbons from biomass materials has greatly triggered much attention presently. In this paper, a series of interconnected porous carbon materials from lotus root shells biomass are prepared via simple pyrolysis and followed by a KOH activation process. The prepared carbons exhibit high specific surface areas of up to 2961 m^2/g and large pore volume～1.47 cm3/g. In addition, the resultant porous carbons served as electrode materials in supercapacitor exhibit high specific capacitance and outstanding recycling stability and high energy density. In particular, their specific capacitance retention was almost 100% after 10500 cycles at a current density of 2 A/g. Remarkabely, the impact of the tailored specific surface areas of various carbon samples on their capacitive performances is systematically ***, it was believed that the highly-developed porosity features（including surface areas and pore volume and pore size-distributions）, together with the good conductivity of activated carbon species, play a key role in effectively improving the storage energy performances of the porous carbon electrode materials in supercapacitor.

关键词： Carbon Porous Biomass Surface area Capacity

Performance analysis of a solar-aided power generation(SAPG) plant using specific consumption theory

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Science China(Technological Sciences) 2016年第2期59卷 322-329页

作者： HOU HongJuan wang mengjiao YANG YongPing CHEN Si HU Eric National Thermal Power Engineering and Technology Research Center North China Electric Power University University of Kentucky Power and Energy Institute of Kentucky School of Mechanical Engineering University of Adelaide

In contrast to a traditional coal-fired power generation plant where steam extracted from a turbine is used to preheat the feedwater in all preheating stages, a solar-aided power generation(SAPG) plant uses solar heat to replace a part or all of the extracted steam in one or more preheating stages. The performance of an SAPG plant with different replacements is investigated in this study by using specific consumption theory(SCT). Fuel-specific and cost-specific consumption models for SAPG plants are built based on the SCT. A typical 330 MW coal-fired power plant is used as the study case. The performance of the SAPG plant in terms of specific consumption, with steam obtained from the first through the eighth(except for the fourth) stages of extraction replaced by solar heat, is compared with that of the reference coal-fired power plant. The fuel-specific consumption of the SAPG plant is determined to be lower than that of the reference coal-fired power plant. The fuel-specific consumption accrual distribution in SAPG plants is used to assess the effect of each individual replacement. Effective strategies to reduce the specific costs of the SAPG and coal-fired power plants are proposed based on the results of this study.

关键词： solar-aided power generation specific consumption theory fuel-specific consumption cost-specific consumption

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改良虹膜环扎术治疗青光眼术后永存瞳孔散大

手术电子杂志 2024年第1期11卷 8-10页

作者：冯晴王梦娇孙新成南京医科大学附属常州第二人民医院眼科

本文主要介绍1例急性闭角型青光眼大发作后的患者,经过小梁切除及虹膜周边切除术,并二期行白内障超声乳化联合人工晶状体植入,术后残存瞳孔散大出现畏光不适等症状,通过改良虹膜环扎术进行治疗。手术要点主要是通过做4个角膜缘透明切口... 详细信息

本文主要介绍1例急性闭角型青光眼大发作后的患者,经过小梁切除及虹膜周边切除术,并二期行白内障超声乳化联合人工晶状体植入,术后残存瞳孔散大出现畏光不适等症状,通过改良虹膜环扎术进行治疗。手术要点主要是通过做4个角膜缘透明切口,将虹膜分为4段进行环扎缝合,根据瞳孔形态和虹膜周切口的位置调整缝线松紧后打结。术后效果良好,瞳孔外形呈类圆形,也避免了因虹膜周边切口被牵拉至角膜中央区致双瞳孔现象。

关键词：虹膜环扎术瞳孔散大青光眼

Generating multi-layer nested chaotic attractor and its FPGA implementation

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Chinese Physics B 2021年第6期30卷 236-241页

作者： Xuenan Peng Yicheng Zeng mengjiao wang Zhijun Li School of Physics and Optoelectronic Engineering Xiangtan UniversityXiangtan 411105China School of Automation and Electronic Information Xiangtan UniversityXiangtan 411105China

Complex chaotic sequences are widely employed in real world, so obtaining more complex sequences have received highly interest. For enhancing the complexity of chaotic sequences, a common approach is increasing the scroll-number of attractors. In this paper, a novel method to control system for generating multi-layer nested chaotic attractors is *** first, a piecewise(PW) function, namely quadratic staircase function, is designed. Unlike pulse signals, each level-logic of this function is square constant, and it is easy to realize. Then, by introducing the PW functions to a modified Chua's system with cubic nonlinear terms, the system can generate multi-layer nested Chua's attractors. The dynamical properties of the system are numerically investigated. Finally, the hardware implementation of the chaotic system is used FPGA *** results show that theoretical analysis and numerical simulation are right. This chaotic oscillator consuming low power and utilization less resources is suitable for real applications.

关键词： multi-layer nested attractors composited attractors multi-scroll attractors FPGA realization

Enrichment and analysis of circulating tumor cells by integrating multivalent membrane nano-interface and endogenous enzyme-signal amplification

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Chinese Chemical Letters 2023年第1期34卷 574-577页

作者： mengjiao wang Dayong Li Chengjie Duan Jin Jiao Youjing Gong Xiaoping wang Zhongyun wang Yang Xiang State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China Department of Neurology Tongren HospitalShanghai JiaoTong University School of MedicineShanghai 200336China Department of Anesthesiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

For circulating tumor cells(CTCs)-based cancer diagnosis and monitoring,effective enrichment and specific analysis of CTCs present significant *** biomembrane interfaces can enhance the highaffinity interactions between various receptors and ligands in life activities by mediating the rearrangement and positioning of membrane-bound components through its *** by this,we have constructed a multivalent membrane nano-interface using aptamer-linked liposomes for the efficient capture of ***,the subsequent introduction of rolling circle amplification(RCA)reaction has increased the number of aptamers and extended them to the surrounding space to improve the affinity of the membrane nano-interface for *** CTCs are enriched,alkaline phosphatase overexpressed on the surface of tumor cells is used as endogenous enzyme-mediated signal amplification by catalyzing 4-nitrophenyl phosphate(p NPP)with color change,achieving the analysis of ***,the enrichment and visual analysis of human hepatocellular carcinoma(HepG2)with a detection limit of 10 cells/m L can be obtained by integrating the multivalent membrane nano-interface and endogenous enzyme signal *** detection of the target in the serum proved this method has the potential for further clinical application and provides a potential method for studying the correlation between alkaline phosphatase dimer and cancer progression.

关键词： CTCs Nano-interface Alkaline phosphatase dimer Signal amplification Liposomes

Highly-efficient photosensitizer based on AIEgen-decorated porphyrin for protein photocleaving

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Chinese Chemical Letters 2019年第11期30卷 1965-1968页

作者： Qiang wang Qingqing Chen Guoyu Jiang Mengting Xia mengjiao wang Yongdong Li Xiaoming Ma Jianguo wang Xinggui Gu College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Key Laboratory of Organo-Pharmaceutical Chemistry Gannan Normal UniversityGanzhou 341000China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China

An AIEgen decorated porphyrin(TPETPyP)was easily obtained through a one-step *** bulky TPE in TPETPyP greatly impeded the intermolecularπ-πstacking of the porphyrin core,which significantly suppressed aggregation-caused quenching(ACQ)effect of TPETPyP in aqueous *** four pyridinium salts formed in TPETPyP also render the whole molecule water solubility,which eliminated its *** exhibited 1O2 quantum yield as high as 0.85 in ***,it also showed high binding affinity to proteins,the major biotarget of *** high 1O2 quantum yield plus the great binding ability of TPETPyP toward proteins makes it a highly-efficient protein photocleaving *** electrophoresis experiments demonstrated that TPETPyP can photocleave BSA upon visible light irradiation,indicating that TPETPyP can act as a promising photosensitizer(PS)in *** work here will provide a facile strategy to utilize AIEgens modified traditional PSs for photodynamic therapy(PDT).

关键词： AIEgen Porphyrin Singlet oxygen quantum yield Protein photoclevage

385例PD-1抗肿瘤治疗的安全性研究及风险因素分析

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中国药物警戒 2024年第4期21卷 447-450,460页

作者：杨波王梦娇胡丽丽王来成李倩孔飞飞吕冬梅沈佳妮徐州市检验检测中心不良反应监测中心江苏徐州221018 徐州医科大学附属医院药学部江苏徐州221006 徐州医科大学药学院江苏徐州221000

目的探讨国产PD-1免疫相关不良反应(irAE)相关危险因素,以期为临床PD-1安全用药提供预判因素和经验。方法收集某院2020年6月至2022年12月所有使用PD-1药物肿瘤患者的性别、年龄、体重指数、肿瘤类型、既往病史、PD-1品类等信息,开展随访... 详细信息

目的探讨国产PD-1免疫相关不良反应(irAE)相关危险因素,以期为临床PD-1安全用药提供预判因素和经验。方法收集某院2020年6月至2022年12月所有使用PD-1药物肿瘤患者的性别、年龄、体重指数、肿瘤类型、既往病史、PD-1品类等信息,开展随访,鉴别和评估irAE种类和严重程度。通过单因素分析和多因素Logistic回归分析,分析危险因素。结果共收集385例,irAE 134例(34.81%),非irAE 251例(65.19%),≥3级irAE 29例(7.53%)。单因素分析显示,irAE的发生率与年龄,吸烟,原患疾病类型有关(P<0.05),多因素分析显示,年龄<65岁患者发生irAE的风险增加1.590倍(95%CI:1.006,2.512),吸烟患者风险增加1.920倍(95%CI:1.021,3.611),呼吸系统疾病较易发生irAE,风险增加2.061倍(95%CI:1.205,3.527),相比信迪利、替雷利珠与特瑞普利,卡瑞利珠发生irAE的风险较高(P<0.05)。结论年龄<65岁、吸烟、呼吸系统疾病为PD-1安全用药的高危因素,卡瑞利珠发生近期irAE风险偏高,应重视该类人群irAE的监护和处理。

关键词： PD-1药物药品不良反应免疫相关不良反应发生率安全性评估风险因素恶性肿瘤