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Nucleoside Analogues Alone or Combined with Vaccination Prevent Hepadnavirus Viremia and Induce Protective Immunity:Alternative Strategy for Hepatitis B Virus Post-exposure Prophylaxis

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Nucleoside Analogues Alone or Combined with Vaccination Prev...

中华医学会第十三次全国感染病学术会议

作者： Baoju Wang Zhenni Zhu Bin Zhu Juzhong Wang Zhitao Song Shunmei Huang Wei Fan Yuanqing Tao Zhongdong Wang Hu Wang mengji lu Dongliang Yang Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Qinghai Institute for Endemic Disease Prevention and Control Institut für Virologie University tsklinikum EssenUniversityt Duisburg-EssenEssen 45122Germany

Objectives The current strategies for hepatitis B virus(HBV)post-exposure prophylaxis(PEP)are not generally available in remote and rural areas of developing countries and/or carry potential risks for infection withblood-borne transmitted *** analogues(NAs)are successfully used for human immunodeficiency virus PEP,and maybe effective for HBV *** this study,we tested the NA-based strategies for HBV

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Genetic variation of mitochondrial cytochrome B is associated with the susceptibility to the experimental woodchuck hepatitis virus infection in Chinese woodchucks(***)

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Genetic variation of mitochondrial cytochrome B is associate...

中华医学会第十三次全国感染病学术会议

作者： Bin Zhu Junzhong Wang Shunmei Huang Zhenni Zhu Zhitao Song Wei Fan Yuanqing Tao Zhongdong Wang Hu Wang Baoju Wang mengji lu Dongliang Yang Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Institut für Virologie University tsklinikum EssenUniversity Duisburg-EssenEssen 45122Germany Qinghai Institute for Endemic Disease Prevention and Control

Woodchuck hepatitis virus(WHV)infected American woodchucks(***)are widely used for the study of hepatitis B virus(HBV)*** recently found Chinese woodchucks(***)are fully susceptible to the experimental WHV *** this study,we found that Chinese woodchucks from Tongren(TR)and Tongde(TD)areas had a high level of long-lasting viremia,while those from Guide(GI))and Wulan(WL)areas had a low level of transient viremia after WHV *** tree based on mitochondrial cytochrome B sequence indicated that all of the animals belonged to the same subspecies ***-

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Novel mouse models with a woodchuck hepatitis virus(WHV)transgene show sex-dependent WHV replicative activity and development of spontaneous immune responses to WHV proteins

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Novel mouse models with a woodchuck hepatitis virus(WHV)tran...

中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： Zhongji Meng Ejuan Zhang Anna D.Kosinska Zhiyong Ma Xiaoyong Zhang Tianlun Zhou Jun Wu Uta Dahmen Olaf Dirsch Dongliang Yang Michael Roggendorf mengji lu Department of Infectious Diseases Taihe HospitalHubei University of Medicine Institute of Virology University Hospital of EssenUniversity Duisburg-Essen Fox Chase Cancer Center Department of Infectious Disease Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of General Visceral and Vascular SurgeryUniversity Hospital of JenaFriedrich Schiller-University Jena Institute of Pathology University Hospital of JenaFriedrich Schiller-University Jena

Background & Aims The woodchuck model is an informative model for studies on hepadnaviral infection. In this study,woodchuck hepatitis virus(WHV) transgenic(Tg) mouse models based on C57BL/6 mice were established to study the pathogenesis associated with hepadnaviral *** C57BL/6 mice were used to establish WHV Tg *** replication intermediates were detected by Southern blotting. DNA vaccines against WHV proteins were applied by intramuscular ***-specific immune responses were analyzed by flow cytometry and *** Two lineages of WHV Tg mice harboring the WHV wild-

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慢性乙型肝炎治疗性疫苗研究进展

药学进展 2022年第10期46卷 761-770页

作者：陆蒙吉孙航杜伊斯堡-埃森大学医学院病毒研究所北莱茵-威斯特法伦州埃森45147 重庆医科大学附属第二医院病毒性肝炎研究所重庆400016

目前慢性乙型肝炎(CHB)抗病毒治疗的预定目标是“功能性治愈”。用目前可及的治疗药物,只有小部分CHB患者得以实现。针对乙肝病毒(HBV)的特异性免疫反应功能失调被认为是导致HBV持续感染的主要原因,调节宿主免疫系统以加强特定的细胞免... 详细信息

目前慢性乙型肝炎(CHB)抗病毒治疗的预定目标是“功能性治愈”。用目前可及的治疗药物,只有小部分CHB患者得以实现。针对乙肝病毒(HBV)的特异性免疫反应功能失调被认为是导致HBV持续感染的主要原因,调节宿主免疫系统以加强特定的细胞免疫反应可能有助于清除HBV。治疗性疫苗,包括蛋白质(HBsAg/preS和HBc Ag)、DNA和基于病毒载体的疫苗,能够诱导和加强针对HBV的特异性免疫反应。至今已进行50多项临床试验来评估CHB治疗中的治疗性疫苗,其中一些结果显示出免疫治疗的潜力。综述慢性HBV感染治疗性疫苗有关的基础和临床研究进展,讨论目前临床试验不理想的结果和未来策略。

关键词：乙肝病毒细胞免疫免疫疗法治疗性疫苗

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Establishment of a Functional Cell Line Expressing both Subunits of H1a and H2c of Human Hepatocyte Surface Molecule ASGPR

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第5期30卷 556-561页

作者：胡斌杨燕刘嘉马智勇黄红平刘慎沛余源郝友华王宝菊陆蒙吉杨东亮 Department of Clinical Laboratory of the First Affiliated Hospital of Xiamen University Experimental Medical Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Division of Clinical Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Microbiology Tongji Medical CollegeHuazhong University of Science and Technology Institute of Virology Medical School of Duisburg-Essen University

To better understand the effect of a new split variant of human asialoglycoprotein receptor (ASGPR H1b) on ASGPR ligands’ binding ability, we established a functional cell line which expresses *** full lengths of ASGPRH1a and H2c fragments from human liver were amplified by reverse transcript PCR (RT-PCR) and inserted into eukaryotic expression vector pIRES2EFP, pCDNA3.1 (Zeo+) *** recombinants were cotransfected into HeLa *** selection by using Neocin and Zeocin, a stably transfected cell line was established, which was designated *** transcription and expression of ASGPRH1a and H2c in 4-1-6 were confirmed by RT-PCR, Western blotting and *** endocytosis function of the artificial "ASGPR" on the surface of 4-1-6 was tested by *** was found that the cell line 4-1-6 could bind ASGPR natural ligand molecular asialo-orosomucoid (ASOR).After the eukaryotic plasmid H1b/pCDNA3.1 (neo) was transfected into cell line 4-1-6, H1b did not down-regulate the ligand binding ability of *** eukaryotic expression plasmid H1b/pcDNA3.1 (neo) and H2c/pcDNA3.1 (neo) were co-transfected transiently into Hela *** single H1b nor H1b and H2c could bind *** conclusion, a functional cell line of human asialoglycoprotein receptor (ASGPR) which expresses both H1a and H2c stably was *** new split variant H1b has no effect on ASGPR binding to ***1b alone can’t bind to ASOR, it yet can’t form functional complex with ASGPRH2c.

关键词： ASGPR eukaryotic expression vector function cell line split variant

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Polyinosinic-polycytidylic acid treatment leads to the Interferon-dependent clearance of hepatitis B virus in a hydrodynamic injection mouse model

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Polyinosinic-polycytidylic acid treatment leads to the Inter...

中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： Jun Wu Mingfa Chen Yong Lin Youchen Xia Chan Sun Xiaoli Zhao Xuecheng Yang Junzhong Wang Yan Guo Jingjiao Song Ejuan Zhang Baoju Wang Xin Zheng Joerg F.Schlaak mengji lu Dongliang Yang Department of Infectious Disease Union Hospital of Tongji Medical CollegeHuazhong University of Science and Technology Department of Gastroenterology and Hepatology University Hospital of Essen Institute of Virology University Hospital of Essen Division of Clinical Immunology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and Technology

We have previously shown that polyinosinic-polycytidylic acid(poly(I:C ) ) activates murine hepatic cells to produce interferon(IFN) and suppresses HBV replication in ***,we addressed the question whether poly(I:C) is able to induce the clearance of HBV in *** chronic HBV replication mouse model was established by hydrodynamic injection(HI) of pAAV-HBVl.2 into the tail veins of wide type,IFN-

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing lu Liutao Zhao Qiankun Zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu Liu Xingyu Wu lufan Zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm