Polyinosinic-polycytidylic acid treatment leads to the Interferon-dependent clearance of hepatitis B virus in a hydrodynamic injection mouse model

作     者：Jun Wu Mingfa Chen Yong Lin Youchen Xia Chan Sun Xiaoli Zhao Xuecheng Yang Junzhong Wang Yan Guo Jingjiao Song Ejuan Zhang Baoju Wang Xin Zheng Joerg F.Schlaak Mengji Lu Dongliang Yang 

作者单位：Department of Infectious DiseaseUnion Hospital of Tongji Medical CollegeHuazhong University of Science and Technology Department of Gastroenterology and HepatologyUniversity Hospital of Essen Institute of VirologyUniversity Hospital of Essen Division of Clinical ImmunologyTongji Hospital of Tongji Medical CollegeHuazhong University of Science and Technology 

会议名称：《中华医学会第十六次全国病毒性肝炎及肝病学术会议》

会议日期：2013年

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

摘      要：We have previously shown that polyinosinic-polycytidylic acid(poly(I:C ) ) activates murine hepatic cells to produce interferon(IFN) and suppresses HBV replication in ***,we addressed the question whether poly(I:C) is able to induce the clearance of HBV in *** chronic HBV replication mouse model was established by hydrodynamic injection(HI) of pAAV-HBVl.2 into the tail veins of wide type,IFN-