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Molecular ferroelectric/semiconductor interfacial memristors for artificial synapses

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npj Flexible Electronics 2022年第1期6卷 185-193页

作者： Yichen Cai Jialong Zhang mengge yan Yizhou Jiang Husnain Jawad Bobo Tian Wenchong Wang Yiqiang Zhan Yajie Qin Shisheng Xiong Chunxiao Cong Zhi-Jun Qiu Chungang Duan Ran Liu Laigui Hu School of Information Science and Technology Fudan UniversityShanghai 200433P.R.China Key Laboratory of Polar Materials and Devices(MOE) Department of ElectronicsEast China Normal UniversityShanghai 200241China Physikalisches Institut and Center for Nanotechnology Universität MünsterWilhelm-Klemm-Straße 1048149 MünsterGermany.

With the burgeoning developments in artificial intelligence,hardware implementation of artificial neural network is also gaining *** this pursuit,ferroelectric devices(i.e.,tunneling junctions and transistors)with voltage thresholds were recently proposed as suitable ***,their development is hindered by the inherent integration issues of inorganic ferroelectrics,as well as poor properties of conventional organic *** contrast to the conventional ferroelectric synapses,here we demonstrated a two-terminal ferroelectric synaptic device using a molecular ferroelectric(MF)/semiconductor *** interfacial resistance can be tuned via the polarization-controlled blocking effect of the semiconductor,owing to the high ferroelectricity and field amplification effect of the *** synaptic features including spike timing-dependent plasticity are *** introduction of the semiconductor also enables the attributes of optoelectronic synapse and in-sensor computing with high image recognition *** interfaces may pave the way for the hardware implementation of multifunctional neuromorphic devices.

关键词： polarization ferroelectric artificial

Efficient photocatalytic degradation of statin via optimization on ZnIn_(2)S_(4)/Bi_(2)WO_(6) Z-scheme heterostructure

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Journal of Advanced Dielectrics 2024年第4期14卷 104-114页

作者： Tingting Liu Libing Cao mengge yan Yushan Hu Tianlong Ren Zheng Wu School of Environmental and Chemical Engineering Xi’an Key Laboratory of Textile Chemical Engineering Auxiliaries Engineering Research Center of Biological Resources Development and Pollution Control Universities of Shaanxi Province Key Laboratory of Textile Dyeing Wastewater Treatment Universities of Shaanxi Province Xi’an Polytechnic University No.19Jin Hua RoadXi’an710048P.R.China Key Laboratory of Northwest Water Resource Environment and Ecology MOE Xi’an University of Architecture and Technology No.13Yan Ta RoadXi’an710055P.R.China Northwest Branch of Beijing CCI Architectural Design Co. Ltd No.26Gao Xin RoadXi’an 710065P.R.China Xi’an Capital Water Company Limited No.368 Kun Ming RoadXi’an 710086P.R.China

Statins are widely used in the treatment of hyperlipidemia disease,which are refractory in the municipal sewage treatment *** photocatalytic degradation of statins by the Z-scheme heterostructured photocatalyst is confirmed,but the degradation mechanism of statins needs to be further *** this study,the effects of photocatalyst dosage,solution pH and humic acid(HA)on the photocatalysis of fluvastatin by ZnIn_(2)S_(4)/Bi_(2)WO_(6) Z-scheme heterostructured photocatalyst(ZIS/BWO photocatalyst)were investigated and the degradation mechanism was *** showed that adsorption of fluvastatin was improved with the increase of photocatalyst dosage,but photoinduced desorption and light scattering resulted in the decrease of the removal of fluvastatin with high dosage.0.2 g/L of the ZIS/BWO photocatalyst was optimal dosage.65.21%of fluvastatin was removed at pH=9,because high concentration of OH^(-)was conducive to produce·*** change of pH,competition of photons and active sites,and trapping of reactive oxygen species(ROS)by carboxyl group of HA combined to inhibit the photocatalysis of fluvastatin in the presence of *** C–C,C=C and C–N bonds of fluvastatin were attacked by a variety of ROS to generate degradable intermediates that were easily mineralized to H_(2)O and CO_(2).

关键词： Fluvastatin photocatalytic technology Z-scheme heterostructured photocatalyst reaction condition degradation mechanism

识字量和词汇知识在儿童阅读发展中的相对重要性

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心理发展与教育 2020年第3期36卷 311-317页

作者：闫梦格李虹李宜逊周雪莲回懿程亚华伍新春应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)未来教育高精尖创新中心北京师范大学心理学部北京100875 美国马里兰大学学院公园分校人类发展与定量方法学系美国20742 广州越秀区朝天小学广州510180 宁波大学心理学系暨研究所宁波315211

本研究基于简单阅读观理论,以两个样本共计666名大班至四年级的汉语儿童为研究对象,探索了识字量和词汇知识在儿童阅读能力发展中的作用及相对重要性的变化。结果显示,在阅读学习早期,识字量对阅读理解的重要性高于词汇知识。随着年级... 详细信息

本研究基于简单阅读观理论,以两个样本共计666名大班至四年级的汉语儿童为研究对象,探索了识字量和词汇知识在儿童阅读能力发展中的作用及相对重要性的变化。结果显示,在阅读学习早期,识字量对阅读理解的重要性高于词汇知识。随着年级的升高,识字量的重要性降低,而词汇知识的重要性增加。这一发现证实简单阅读观理论也适用于解释汉语阅读能力的发展,并对今后的语文教学具有重要的启示意义。

关键词：识字量词汇知识简单阅读观阅读理解阅读发展

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Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao Sun mengge Wang Qiuxia Sun yan Liu Shuhan Duan Zhiyong Wang Yunyu Zhou Jun Zhong Yuguo Huang Xinyu Huang Qingxin yang Xiangping Li Haoran Su yan Cai Xiucheng Jiang Jing Chen Jiangwei yan Shengjie Nie Liping Hu Junbao yang Renkuan Tang Chuan-Chao Wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation

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Preparation,characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral

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Fundamental Research 2022年第2期2卷 321-328页

作者： mengge Feng Yulan Wang yan Wei Xiaoxin Zhang Leyi Xiao Zijjian Gong Masako Fujioka-Kobayashi Anton Sculean Richard J Miron Scott Froum Yufeng Zhang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan University Department of Oral and Mxillfacial Surgery The Nippon Dental University School of Life Dentistry at TokyoTokyoJapan Department of Periodontology University of BernBernSwitzerland Clinical Assistant Professor State University of New York Story Brook Department of PeriodontologyPrivate Practice New YorkNew YorkUSA Medical Research Institute School of MedicineWuhan UniversityWuhan 430071China

Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry,with a need for development of optimal bone biomaterials to predictably rebuild these *** address this problem,we fabricated a novel bone block using platelet-rich fibrin(PRF)and Deproteinized Bovine Bone Mineral(DBBM),and characterized their mechanical and biological *** bone block was prepared by mixing DBBM,Liquid-PRF,and Solid-PRF fragments in various combinations as follows:(1)BLOCK-1 made with Solid-PRF fragments+DBBM,(2)BLOCK-2 made with Liquid-PRF+DBBM,(3)BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+*** time for solidification and the degradation properties were subsequently *** electron microscopy(SEM)and tensile tests were carried out to investigate the microstructure and mechanical properties of each *** bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay,cell migration assay,alkaline phosphatase(ALP)staining,and alizarin red staining(ARS),as well as by real-time PCR for genes encoding runt-related transcription factor 2(RUNX2),ALP,collagen type I alphal(COLIv41)and osteocalcin(OCN).BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM had by far the fastest solidification period(over a 10-fold increase)as well as the most resistance to *** and tensile tests also revealed that the mechanical properties of BLOCK-3 were superior in strength when compared to all other groups and further induced the highest osteoblast migration and osteogenic differentiation confirmed by ALP,ARS and real-time *** bone blocks made through the combination of Solid-PRF fragments+Liquid-PRF+DBBM had the greatest mechanical and biological properties when compared to either used *** clinical studies are warranted to further support the clinical application of PRF bone blocks in bo

关键词： Blood Platelet-rich fibrin Bone formation Dental implant Regeneration

A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy

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Cancer Communications 2024年第3期44卷 438-442页

作者： Yingqiang Liu Linjiang Tong mengge Zhang Qi Zhang Qiupei Liu Fang Feng yan Li Mengzhen Lai Haotian Tang Yi Chen Meiyu Geng Wenhu Duan Jian Ding Hua Xie Division of Antitumor Pharmacology&State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China University of Chinese Academy of Sciences BeijingP.R.China Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingboZhejiangP.R.China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdongP.R.China Shandong Laboratory of yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandongP.R.China Small-Molecule Drug Research Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiP.R.China

Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune *** in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug *** emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors.

关键词： alterations KRAS sarcoma

Preparation and Properties of Nanocomposite Hydrogel by Photoinitiated Polymerization

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Preparation and Properties of Nanocomposite Hydrogel by Phot...

Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma

中国材料大会2012

作者： mengge Xia Sheng Liu Yiheng Wang yan Zhang Yongtao Wu Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and EngineeringDonghua University

ISBN: (纸本)9783037856079;3037856076

A novel hybrid hydrogel (SAT gel) based on covalent crosslinking was prepared by photoinitiated polymerization. Photoactive polystyrene (PS) nanoparticles were successfully synthesized by grafting photoinitiator 2-[p-(2-hydroxy-2-methylpropiophenone)] ethylene glycol methacrylate (HMEM) onto the surface of PS nanoparticles, and characterized by nuclear magnetic resonance (NMR), fourier transform infrared spectroscopy (FTIR), high resolution transmission electron microscope (HRTEM) and dynamic light scattering (DLS). In the presence of monomer (AAm), PS nanoparticles acting as multifunctional cross-linking agents, and in-situ polymerization was carried out on the surface of photoactive particles. This study focused on the effect of photoactive PS nanoparticles concentration and illumination time on the morphology and swelling behavior of SAT hydrogels. It revealed that the three-dimensional structure and swelling ratio decreased with the increasing concentration of PS nanoparticles. Moreover, the pore size compressed with extending the illumination time. Embedding photoactive nanoparticles into hydrogels network to prepare novel hydrogels had advantages of controllable polymerization process and short forming time. This method provided a new way to prepare soft materials and to design the intelligent hydrogels.

关键词： Nanocomposite hydrogel Photoactive PS nanoparticles Photoinitiated polymerization

来源： cnki会议评论

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4748-4764页

作者： Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng yan Li mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su yanyan Shen Yiming Sun Xinying yang Yi Chen Shanyan Yao Hanyu yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding Division of Antitumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Shanghai Runshi Pharmaceutical Technology Co. Ltd.Shanghai 201218China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China University of Chinese Academy of Sciences Beijing 100049China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly *** studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM ***,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against ***1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in ***1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive ***,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM ***,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 *** a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I *** data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380).

关键词： Small molecule inhibitor Glioblastoma VEGFR CSF1R Angiogenesis Macrophage Tumor microenvironment Immune-checkpoint inhibitor

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政府创新补贴、社会责任与企业高质量发展

统计与决策 2023年第6期39卷 161-166页

作者：闫俊周杜梦阁齐念念郑州航空工业管理学院商学院郑州450015 上海大学管理学院上海200444

文章利用我国2010—2019年高新技术上市公司数据,实证分析了政府创新补贴对企业高质量发展的影响,考察分析了社会责任和社会责任分维度指标对二者关系的调节作用,并探讨了产权异质性对企业社会责任调节作用的影响。研究表明:政府创新补... 详细信息

文章利用我国2010—2019年高新技术上市公司数据,实证分析了政府创新补贴对企业高质量发展的影响,考察分析了社会责任和社会责任分维度指标对二者关系的调节作用,并探讨了产权异质性对企业社会责任调节作用的影响。研究表明:政府创新补贴对高新技术企业高质量发展具有“U”型影响,企业社会责任水平的提升能够使二者的“U”型关系变得平缓。企业对股东、员工、供应商和消费者履行社会责任对政府创新补贴与高新技术企业高质量发展的“U”型关系具有显著调节作用,而企业对环境、政府和公众履行社会责任对二者关系的调节作用并不显著。非国有企业社会责任对政府创新补贴与企业高质量发展的“U”型关系具有显著调节作用,国有企业向股东履行社会责任的调节作用强于非国有企业,非国有企业向员工、供应商和消费者、政府和公众履行社会责任的调节作用强于国有企业。

关键词：政府创新补贴企业社会责任企业高质量发展高新技术企业

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