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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu Qu Guang-Yu Chen meng-zhou xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

Exploring the transformative impact of traditional Chinese medicine on depression:Insights from animal models

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World Journal of Psychiatry 2024年第5期14卷 607-623页

作者： Yan Yang Yan-Kun Chen meng-zhou xie School of Nursing Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Precision Medicine R&D Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina School of Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of TCM Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina

Depression,a prevalent and complex mental health condition,presents a significant global health *** is one of the most frequent mental disorders;deaths from it account for 14.3%of people *** recent years,the integration of complementary and alternative medicine,including traditional Chinese medicine(TCM),has gained attention as a potential avenue for addressing *** comprehensive review critically assesses the efficacy of TCM interventions in alleviating depressive *** in-depth look at different research studies,clinical trials,and meta-analyses is used in this review to look into how TCM practices like herbal formulations,acupuncture,and mindbody practices *** review looks at the quality of the evidence,the rigor of the methods,and any possible flaws in the current *** gives us an idea of where TCM stands right now in terms of treating *** comprehensive review aims to assess the efficacy of TCM interventions in alleviating depressive *** order to learn more about their possible healing effects,the study also looks into how different types of TCM work,such as herbal formulas,acupuncture,and mind-body practices.

关键词： Traditional Chinese medicine Depression Efficacy Treatment Holistic approach

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye xie Runxue zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue Li Ziliang xie Wenjiao zhou Huan Tong Dawen Yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期 13-20页

作者： DI Ke xie meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

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胃癌与慢性胃炎的唾液蛋白指纹图谱鉴别诊断模型

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世界华人消化杂志 2016年第13期24卷 1976-1983页

作者：谢梦洲贺佐梅黄飞娟周小青吴正治湖南中医药大学中医诊断研究所湖南2011数字中医药协同创新中心湖南省长沙市410007 抗肿瘤中药创制技术湖南省工程研究中心湖南省长沙市410007 深圳大学第一附属医院老年医学研究所广东省深圳市518035 广东医学院附属福田医院广东省深圳市518033

目的:筛选胃癌患者与慢性胃炎患者及健康志愿者的唾液蛋白质组差异表达谱,并建立胃癌患者与慢性胃炎唾液无创伤分子诊断(判别)模型.方法:采集57例胃癌患者(术前且无放化疗)和28例慢性胃炎患者的唾液标本,用WCX(弱阳离子交换型)纳米磁珠... 详细信息

目的:筛选胃癌患者与慢性胃炎患者及健康志愿者的唾液蛋白质组差异表达谱,并建立胃癌患者与慢性胃炎唾液无创伤分子诊断(判别)模型.方法:采集57例胃癌患者(术前且无放化疗)和28例慢性胃炎患者的唾液标本,用WCX(弱阳离子交换型)纳米磁珠联合基质辅助激光解析离子化飞行时间质谱(matrix assisted laser desorption ionization time-offlight mass spectrometry,MALDI-TOF-MS)技术进行检测,获得各标本的蛋白指纹图谱.用Biomarker Wizard软件分析所获得的蛋白指纹图谱找出差异蛋白,再用Biomarker Patterns 5.0.2建立鉴别诊断模型.结果:优化筛选建立了由m/z为4267.09、6564.85、2138.14等3个差异蛋白峰组成的胃癌与慢性胃炎的鉴别诊断模型,经临床回代检验该分子诊断模型对鉴别胃癌与慢性胃炎的灵敏度和特异度分别为96%(55/57)和86%(24/28),通过交叉验证法进一步验证诊断模型的可靠性,结果该模型的灵敏度和特异度分别为89%(51/57)和75%(21/28).结论:基于WCX结合MALDI-TOF-MS技术建立的唾液蛋白组分子诊断模型为胃癌与慢性胃炎的鉴别诊断提供了一种敏感无创的新方法.

关键词：胃癌慢性胃炎鉴别诊断唾液蛋白质组

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan xie Jian Yu Kun-Ning Zhang zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan zhou Zhijian xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Joint formation mechanism of high depth-to-width ratio friction stir welding

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Journal of Materials Science & Technology 2019年第7期35卷 1261-1269页

作者： Yongxian Huang Yuming xie Xiangchen meng Junchen Li Li zhou State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

High depth-to-width ratio friction stir welding is an attractive method for the joining demands of alum inum profiles, which is sparked with its extrem ely low heat input and high mechanical performance. In this study, the joint form ation mechanism was studied by a num erical model of plastic flow combined with experim ental approaches. A fluid-solid-interaction algorithm was proposed to establish the coupling model, and the material to be welded was treated as non-New tonian fluid. The thread structure and the milling facets on tool pin prom oted drastic turbulence of material. The thread structure converged the plasticized material by its inclined plane, and then drove the attached material to refill the welds. The milling facets brought about the periodic dynamic material flow. The thread structure and the milling facets increased the strain rate greatly under the extremely low heat input, which avoided the welding defects. The condition of the peak tem perature of 648 K and the strain rate of 151 s^-1 attributed to the lowest coarsening degree of precipitate. The tensile strength of the joint reached 265 MPa, equivalent to 86% of base material. The amelioration via the material flow model inhibits the welding defects and optimizes the param eter intervals, providing references to extracting process-structure-property linkages for friction stir welding.

关键词： Friction stir welding Joint formation Material flow Al-Mg-Si alloy Microstructure Mechanical properties

The atmospheric hinder for intraseasonal sea-air interaction over the Bay of Bengal during Indian summer monsoon in CMIP6

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Acta Oceanologica Sinica 2022年第10期41卷 119-130页

作者： Ze meng Lei zhou Baosheng Li Jianhuang Qin Juncheng xie School of Oceanography Shanghai Jiao Tong UniversityShanghai200030China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519080China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou310012China College of Oceanography Hohai UniversityNanjing266071China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan316000China

The surroundings of the Bay of Bengal(Bo B)suffer a lot from the extreme rainfall events during Indian summer monsoon(ISM).Previous studies have proved that the sea-air interaction is an important factor for the monsoonal *** the 6th Coupled Modol Inter-comparison Project(CMIP6)models,this study examined the biases of surface heat flux,which is the main connection between atmosphere and *** show that although CMIP6 have a better simulation of intraseasonal sea surface temperature(SST)anomalies over Bo B than the previous ones,the“atmospheric blockage”still delays the response of latent heat flux to the oceanic ***,during the increment of positive latent heat flux in CMIP6,the negative contribution from wind effects covers most of the positive contribution from humidity effects,due to the underestimate of humidity *** diagnostic analysis denote that the surface air humidity has a quarter of a phase ahead of warm SST in observation,but gets wet along with the warm SST accordingly in most CMIP6 *** a result,the simulated transfer of intraseasonal moisture flux is hindered between ocean and ***,as a bridge between both sides,the atmospheric boundary layer is essential for a better sea-air coupled simulation,especially when the atmospheric and the oceanic variabilities involved in a climate model becomes increasingly *** surface air humidity and boundary layer processes require more attention as well as better simulations.

关键词： Bay of Bengal ocean-atmosphere interaction CMIP6 latent heat flux intraseasonal variability