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Detection of a novel panel of 24 genes with high frequencies of mutation in gastric cancer based on next-generation sequencing

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World Journal of Clinical Cases 2022年第15期10卷 4761-4775页

作者： Hui-Hui zeng ze Yang Ye-Bei Qiu Shoaib Bashir Yin Li meng xu Department of Oncology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233004Anhui ProvinceChina Department of Oncology Jinan UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Gastric cancer is a leading cause of cancer-related mortality *** somatic mutations have been identified based on next-generation sequencing;they likely play a vital role in cancer treatment ***,nextgeneration sequencing has not been widely used to diagnose and treat gastric cancer in the *** To test the mutant gene frequency as a guide for molecular diagnosis and personalized therapy in gastric cancer by use of next-generation *** We constructed a panel of 24 mutant genes to detect somatic nucleotide variations and copy number variations based on a next-generation sequencing *** custom panel included high-mutation frequency cancer driver and tumour suppressor *** genes were also analyzed using the cBioPortal *** clinical annotation of important variant mutation sites was evaluated in the ClinVar *** searched for candidate drugs for targeted therapy and immunotherapy from the OncoKB *** In our study,the top 16 frequently mutated genes were TP53(58%),ERBB2(28%),BRCA2(23%),NF1(19%),PIK3CA(14%),ATR(14%),MSH2(12%),FBXW7(12%),BMPR1A(12%),ERBB3(11%),ATM(9%),FGFR2(8%),MET(8%),PTEN(6%),CHD4(6%),and KRAS(5%).TP53 is a commonly mutated gene in gastric cancer and has a similar frequency to that in the cBioPortal database.33 gastric cancer patients(51.6%)with microsatellite stability and eight patients(12.5%)with microsatellite instability-high were *** analyses demonstrated that high-frequency mutated genes had transmembrane receptor protein kinase *** discovered that BRCA2,PIK3CA,and FGFR2 gene mutations represent promising biomarkers in gastric *** We developed a powerful panel of 24 genes with high frequencies of mutation that could detect common somatic *** observed mutations provide potential targets for the clinical treatment of gastric cancer.

关键词： Gastric cancer Next-generation sequencing Mutated genes Target sites Microsatellite instability

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Analyses of surrogate models for calculating thermophysical properties of aviation kerosene RP-3 at supercritical pressures

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Science China(Technological Sciences) 2015年第3期58卷 510-518页

作者： xu KeKe meng Hua School of Aeronautics and Astronautics Zhejiang University

Aviation kerosene is commonly used in combustion and regenerative engine cooling processes in propulsion and power-generation systems,including rocket,scramjet,and advanced gas turbine *** this paper,many surrogate models proposed in the open literature are examined for their applicability and accuracy in calculating thermodynamic and transport properties of the China aviation kerosene RP-3 at supercritical pressures,based on the extended corresponding-states *** enthalpy change from endothermic decomposition and low heating value from combustion of the jet fuel are also *** from a number of simple and representative surrogate models,which contain species components ranging from 1 to10,are analyzed in *** analyses indicate that a surrogate model with four species is the best choice for thermophysical property calculations under the tested conditions,with fluid temperature up to 650 K at various supercritical *** surrogate model is particularly accurate in predicting the pseudo-critical temperature of aviation kerosene RP-3 at a supercritical pressure.A simple surrogate model containing the n-decane species and a surrogate model containing 10 species are the other two acceptable *** work conducted herein is of practical importance for theoretical analyses and numerical simulations of various physicochemical processes at engine operating conditions.

关键词： thermodynamic property transport property hydrocarbon fuel combustion heat transfer pyrolysis

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Design of A Novel Wheel-Legged Robot with Rim Shape Changeable Wheels

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 62-72页

作者： ze Fu Hao xu Yinghui Li Weizhong Guo State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China

The wheel-legged hybrid structure has been utilized by ground mobile platforms in recent years to achieve good mobility on both flat surfaces and rough ***,most of the wheel-legged robots only have one-directional obstacle-crossing *** the motion,most of the wheel-legged robots’centroid fluctuates violently,which damages the stability of the ***’s more,many designs of the obstacle-crossing part and transformation-driving part of this structure are highly coupled,which limits its optimal performance in both *** paper presents a novel wheel-legged robot with a rim-shaped changeable wheel,which has a bi-directional and smooth obstacle-crossing *** on the kinematic model,the geometric parameters of the wheel structure and the design variables of the driving four-bar mechanism are optimized *** kinetostatics model of the mobile platform when climbing stairs is established to determine the body length and angular velocity of the driving wheels.A pro-totype is made according to the optimal *** show that the prototype installed with the novel transformable wheels can overcome steps with a height of 1.52 times of its wheel radius with less fluctuation of its centroid and performs good locomotion capabilities in different environments.

关键词： Mobile platform Transformable wheel-legged robot Kinematics analysis Mechanical design Obstacle

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AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

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Science China(Life Sciences) 2024年第7期67卷 1468-1478页

作者： Jiang Deng Jia-Cheng Yang Yue Feng ze-Jing xu Kamil Kuča meng Liu Lv-Hui Sun State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic

Dietary exposure to aflatoxin B1(AFB1)is harmful to the health and performance of domestic *** hepatic cytochrome P450s(CYPs),CYP1A1 and CYP2A6,are the primary enzymes responsible for the bioactivation of AFB1to the highly toxic exo-AFB1-8,9-epoxide(AFBO)in ***,the transcriptional regulation mechanism of these CYP genes in the liver of chicks in AFB1metabolism remains ***-luciferase reporter assay,bioinformatics and site-directed mutation results indicated that specificity protein 1(SP1)and activator protein-1(AP-1)motifs were located in the core region-1,063/-948,-606/-541 of the CYP1A1 promoter as well as-636/-595,-503/-462,-147/-1 of the CYP2A6 ***,overexpression and decoy oligodeoxynucleotide technologies demonstrated that SP1 and AP-1 were pivotal transcriptional activators regulating the promoter activity of CYP1A1 and ***,bioactivation of AFB1to AFBO could be increased by upregulation of CYP1A1 and CYP2A6 expression,which was trans-activated owing to the upregulation of AP-1,rather than SP1,stimulated by AFB1-induced reactive oxygen ***,nano-selenium could reduce ROS,downregulate AP-1 expression and then decrease the expression of CYP1A1 and CYP2A6,thus alleviating the toxicity of *** conclusion,AP-1 and SP1 played important roles in the transactivation of CYP1A1 and CYP2A6 expression and further bioactivated AFB1to AFBO in chicken liver,which could provide novel targets for the remediation of aflatoxicosis in chicks.

关键词： aflatoxin B1 CYP1A1 CYP2A6 SP1 AP-1 transcriptional activation

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Multiscale spatiotemporal meteorological drought prediction:A deep learning approach

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Advances in Climate Change Research 2024年第2期15卷 211-221页

作者： Jia-Li ZHANG Xiao-meng HUANG Yu-ze SUN Department of Earth System Science Ministry of Education Key Laboratory for Earth System ModellingInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China

Reliable monitoring and thorough spatiotemporal prediction of meteorological drought are crucial for early warning and decision-making regarding drought-related *** utilisation of multiscale methods is effective for a comprehensive evaluation of drought occurrence and progression,given the complex nature of meteorological ***,the nonlinear spatiotemporal features of meteorological droughts,influenced by various climatological,physical and environmental factors,pose significant challenges to integrated prediction that considers multiple indicators and time *** address these constraints,we introduce an innovative deep learning framework based on the shifted window transformer,designed for executing spatiotemporal prediction of meteorological drought across multiple *** formulate four prediction indicators using the standardized precipitation index and the standard precipitation evaporation index as core methods for drought definition using the ERA5 reanalysis *** indicators span time scales of approximately 30 d and one ***-term indicators capture more anomalous variations,whereas long-term indicators attain comparatively higher accuracy in predicting future *** focus on the East Asian region,notable for its diverse climate conditions and intricate terrains,to validate the model's efficacy in addressing the complexities of nonlinear spatiotemporal *** model's performance is evaluated from diverse spatiotemporal viewpoints,and practical application values are analysed by representative drought *** results substantiate the effectiveness of our proposed model in providing accurate multiscale predictions and capturing the spatiotemporal evolution characteristics of *** of the four drought indicators accurately delineates specific facets of the meteorological drought ***,three representative drought events,namely flash drought,sustained drought and severe drought,

关键词： Meteorological drought Spatiotemporal prediction Multiscale Swim transformer Deep learning

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A survey of photon mapping state-of-the-art research and future challenges

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Frontiers of Information Technology & Electronic Engineering 2016年第3期17卷 185-199页

作者： Chun-meng KANG Lu WANG Yan-ning xu Xiang-xu meng Department of Computer Science and Technology Shandong University Engineering Research Center of Digital Media Technology Ministry of Education

Global illumination is the core part of photo-realistic rendering. The photon mapping algorithm is an effective method for computing global illumination with its obvious advantage of caustic and color bleeding rendering. It is an active research field that has been developed over the past two decades. The deficiency of precise details and efficient rendering are still the main challenges of photon mapping. This report reviews recent work and classifies it into a set of categories including radiance estimation, photon relaxation, photon tracing, progressive photon mapping, and parallel methods. The goals of our report are giving readers an overall introduction to photon mapping and motivating further research to address the limitations of existing methods.

关键词： Global illumination Photon mapping Radiance estimation Photon relaxation Progressive photon mapping

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Complete Composition Tunability of Cu(Ni)-Ti-Zr Alloys for Bulk Metallic Glass Formation

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Journal of Materials Science & Technology 2009年第1期25卷 39-47页

作者： ze-xiu Zhang Chun-li Dai Jian xu Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences 72 Wenhua Road Shenyang 110016 China

In the Cu-Zr-Ti ternary system, a new composition zone of bulk metallic glasses （BMGs） formation was discovered, locating at the 55-57 at. pct Cu, 30-31 at. pct Ti and 13-14 at. pct Zr, and near Cu-Ti binary subsystem rather than the Cu-Zr binary. For these alloys, BMG rods of 2 mm in diameter can be fabricated by using copper mould casting. It is expected that these 13MG-forming alloys correlate with （L →CuTi＋Cu2TiZr＋Cu51Zr14） eutectic reaction that the undercooled melt undergoes during solidification. Adopting ＂3D pinpointing approach＂, compositional dependence of glass-forming ability （GFA） in Cu（Ni）-Ti-Zr pseudo ternary system was revisited. Optimized BMG-forming composition is located at Cu50.4Ni5.6Ti31Zr13, with a critical diameter of 6 mm for complete BMG formation. Its GFA is significantly superior to Vit 101 （Cu47Ni8Ti34Zr11） previously developed by Caltech group. The effect that the GFA of the ternary base alloy was improved by substitution of Ni for Cu is attributed to a role of retarding the crystallization of Cu51Zr14 intermetallics.

关键词： Bulk metallic glasses Amorphous alloys Eutectic Copper

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SOLVING SYSTEMS OF QUADRATIC EQUATIONS VIA EXPONENTIAL-TYPE GRADIENT DESCENT ALGORITHM

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Journal of Computational Mathematics 2020年第4期38卷 638-660页

作者： meng Huang Zhiqiang xu LSEC Inst.Comp.Math.Academy of Mathematics and System ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

We consider the rank minimization problem from quadratic measurements,i.e.,recovering a rank r matrix X 2 Rn×r from m scalar measurements yi=ai XX⊤ai,ai 2 Rn,i=1,...,*** problem arises in a variety of applications such as quadratic regression and quantum state *** present a novel algorithm,which is termed exponential-type gradient descent algorithm,to minimize a non-convex objective function f(U)=14m Pm i=1(yi−a⊤i UU⊤ai)*** algorithm starts with a careful initialization,and then refines this initial guess by iteratively applying exponential-type gradient ***,we can obtain a good initial guess of X as long as the number of Gaussian random measurements is O(nr),and our iteration algorithm can converge linearly to the true X(up to an orthogonal matrix)with m=O(nr log(cr))Gaussian random measurements。

关键词： Low-rank matrix recovery Non-convex optimization Phase retrieval

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Effect of temperature on antioxidant defense and innate immunity in Brandt’s voles

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Zoological Research 2019年第4期40卷 305-316页

作者： De-Li xu meng-meng xu De-Hua Wang College of Life Sciences Qufu Normal UniversityQufu Shandong 273165China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Ambient temperature is an importa nt factor in flue ncing many physiological processes, in eluding antioxidant defense and immunity. In the present study, we tested the hypothesis that antioxidant defense and immunity are suppressed by high and low temperature treatme nt in Bran dt's voles (Lasiopodomys brandtii). Thirty male voles were randomly assigned into different temperature groups (4, 23, and 32℃, n=10 for each group), with the treatment course lasting for 27 d. Results showed that low temperature in creased gross en ergy in take (GEI) and liver, heart, and kidney mass, but decreased body fat mass and dry carcass mass. With the decline in temperature, hydrogen peroxide (H2O2) concentration, which is indicative of reactive oxyge n species (ROS) levels, in creased in the liver, decreased in the heart, and was unchanged in the kidney, testis, and small intestine. Lipid peroxidation indicated by malonaldehyde (MDA) content in the liver, heart, kidney, testis, and small intestine did not differ among groups, implying that high and low temperature did not cause oxidative damage. Similarly, superoxide dismutase (SOD) and catalase (CAT) activities and total antioxidant capacity (TAOC) in the five tissues did not respond to low or high temperature, except for elevation of CAT activity in the testis upon cold exposure. Bacteria killing capacity, which is indicative of innate immunity, was nearly suppressed in the 4℃ group in contrast to the 23℃ group, whereas spleen mass and white blood cells were un affected by temperature treatment. The levels of testosterone, but not corticostero ne, were in flue need by temperature treatment, though neither were correlated with innate immunity, H2O2 and MDA levels, or SOD, CAT, and TAOC activity in any detected tissues. Overall, these results showed that temperature had different in flue nces on oxidative stress, an tioxida nt en zymes, and immunity, which depended on the tissues and parameters tested. Up-regulation or maintenance

关键词： Antioxidant defense Brandt's voles(Lasiopodomys brandtii) Immunity Temperature

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Enhanced CO2 Electrolysis with Metal-oxide Interface Structures

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Chinese Journal of Structural Chemistry 2021年第1期40卷 31-41,1页

作者： xu ze-Tong XIE Kui College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

The ever-decreasing fossil fuels and the increasing greenhouse effect have caused substantial *** oxide electrolyser cell(SOEC)with La_(0.75)Sr_(0.25)Cr_(0.5 )Mn_(0.5)O_(3-δ)(LSCM)as a cathode was used for CO_(2) electrolysis to *** this work,the metal-oxide interface was constructed on the LSCM framework by in-situ exsolution and impregnation,and the uniform distribution of metal nanoparticles on the LSCM framework was confirmed by spectroscopy techniques and electron microscopy *** existence of three-phase boundary promoted the absorption and electrolysis of CO_(2).(La_(0.75) Sr_(0.25))0.9(Cr_(0.5 )Mn_(0.5))_(0.9)(Ni_(0.5) Cu_(0.5))_(0.1) O_(3-δ)(LSCMNC)showed the best electrolytic CO_(2) performance at 850℃and exhibited excellent electrocatalytic activity after 100 hours of long-term testing and 8 redox cycles.

关键词： solid oxide electrolyser cell LSCM metal nanoparticles CO_(2)electrolysis

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