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大黄中抗氧化物质的提取工艺优化

食品工业科技 2018年第19期39卷 147-149,155页

作者：袁诗俊龚梦瑀李梦林顺远枫黄毅西南科技大学生命科学与工程学院四川绵阳621010

目的:采用正交试验优化大黄中抗氧化活性物质的提取工艺。方法:以抗氧化活性为考察指标,采用超声辅助提取大黄中的抗氧化活性物质,考察乙醇浓度、固液比和提取时间对大黄抗氧化活性提取效果的影响。通过单因素实验和正交实验对提取条件... 详细信息

目的:采用正交试验优化大黄中抗氧化活性物质的提取工艺。方法:以抗氧化活性为考察指标,采用超声辅助提取大黄中的抗氧化活性物质,考察乙醇浓度、固液比和提取时间对大黄抗氧化活性提取效果的影响。通过单因素实验和正交实验对提取条件进行优化。结果:在乙醇浓度60%,固液比为1∶30,提取时间为30 min的条件下,获得的提取物DPPH自由基清除率最高,达到96.02%±1.36%。结论:该提取工艺简便快捷,可为工业生产提供参考。

关键词：正交试验大黄抗氧化活性提取工艺

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli yuan Tianjie Lyu Ling Zhang meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, Yingjie Sun, Yicheng Pei, Chaoxin Yin, Xing Li, Xinyi Hao, Yi Zhang, mengru yuan, meng Zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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新质人才需求背景下学校教育供给变革研究

教学与管理 2025年第1期 15-18页

作者：孟志远李永梅曲阜师范大学教育学院山东曲阜273165

新质生产力的蓬勃发展呼唤新质人才并为其培养提供了重要的时域与场域,面向新质人才需求的学校教育供给变革成为教育的基础性命题。当前面向新质人才需求的学校供给变革存在“传统型”供给主体与“新质型”主体需求、“标准化”供给内... 详细信息

新质生产力的蓬勃发展呼唤新质人才并为其培养提供了重要的时域与场域,面向新质人才需求的学校教育供给变革成为教育的基础性命题。当前面向新质人才需求的学校供给变革存在“传统型”供给主体与“新质型”主体需求、“标准化”供给内容与“个性化”内容需求、“统一性”供给方式与“数智化”方式需求之间的矛盾。鉴于此,提出面向新质人才需求的学校教育供给遵循从“人类教师主体”到“人机智能联合主体”、从“统一与他主内容”到“开放与自主内容”、从“前置性预设方式”到“发展性按需方式”的变革理路,以期为学校教育供给变革与新质人才培养提供一定的理论借鉴和实践启示。

关键词：学校教育供给变革新质人才需求新质生产力新质人才培养

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Feedforward compensation of the insertion devices effects in the SSRF storage ring

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Nuclear Science and Techniques 2022年第6期33卷 34-44页

作者： Xin-Zhong Liu shun-Qiang Tian Xu Wu meng Wang Zhen-Tang Zhao Bo-yuan Feng University of Chinese Academy of Sciences Shanghai 201800China Shanghai Institute of Applied Physics Chinese Academy of SciencesBeijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China Shanghai University Shanghai 200444China Tsinghua University Beijing 100084China

The lattice of the Shanghai Synchrotron Radiation Facility(SSRF) storage ring was upgraded in the Phase-II beamline project, and thus far, 18 insertion devices(IDs) have been installed. The IDs cause closed-orbit distortions, tune drift, and coupling distortions in the SSRF storage ring, all of which are significant issues that require solutions. In this study, an ID orbit feedforward compensation system based on a response matrix using corrector coils was developed, and it was applied to all commissioned IDs in the SSRF storage ring. After correction, the maximum ID-induced horizontal and vertical orbit distortions were less than 5.0 and 3.5 μm, respectively. Some interesting phenomena observed during the measurement process were explained. Additionally, optical and coupling feedforward systems were developed using quadrupole and skew quadrupole magnets installed on the front and back of elliptically polarizing undulators(EPUs). Moreover, over nearly four months of operation, the developed strategy delivered a satisfactory performance in the SSRF storage ring.

关键词： Shanghai Synchrotron Radiation Facility(SSRF) Insertion devices(IDs) Closed-orbit distortion Tune shift Coupling Feedforward

Modeling of drag reduction in turbulent channel flow with hydrophobic walls by FVM method and weakly-compressible flow equations

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Acta Mechanica Sinica 2011年第2期27卷 200-207页

作者： Ling Li Ming-shun yuan State Key Laboratory of Hydroscience and Engineering Tsinghua University 100084 Beijing China

In this paper the effects of hydrophobic wall on skin-friction drag in the channel flow are investigated through large eddy simulation on the basis of weaklycompressible flow equations with the MacCormack’s scheme on collocated mesh in the FVM framework. The slip length model is adopted to describe the behavior of the slip velocities in the streamwise and spanwise directions at the interface between the hydrophobic wall and turbulent channel flow. Simulation results are presented by analyzing flow behaviors over hydrophobic wall with the Smagorinky subgrid-scale model and a dynamic model on computational meshes of different resolutions. Comparison and analysis are made on the distributions of timeaveraged velocity, velocity fluctuations, Reynolds stress as well as the skin-friction drag. Excellent agreement between the present study and previous results demonstrates the accuracy of the simple classical second-order scheme in representing turbulent vertox near hydrophobic wall. In addition, the relation of drag reduction efficiency versus time-averaged slip velocity is established. It is also foundthat the decrease of velocity gradient in the close wall region is responsible for the drag reduction. Considering its advantages of high calculation precision and efficiency, the present method has good prospect in its application to practical projects.

关键词： Wall turbulences · Large eddy simulation · Drag reduction · Hydrophobic wall · Weakly compressible flow