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Novel assays for quality evaluation of XueBiJing:Quality variability of a Chinese herbal injection for sepsis management

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Journal of Pharmaceutical Analysis 2022年第4期12卷 664-682页

作者： Xuan Yu Wei Niu Ya-Ya Wang Olajide E.Olaleye Jia-Nan Wang meng-yuan duan Jun-Ling Yang Rong-Rong He Zi-Xuan Chu Kai Dong Gui-Ping Zhang Chang-Xiao Liu Chen Cheng Chuan Li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China Graduate School Tianjin University of Traditional Chinese MedicineTianjin300193China Research Institute Tianjin Chasesun Pharmaceutical Co.Ltd.Tianjin301700China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics and Tianjin Key Laboratory of Quality-Marker of Traditional Chinese Medicines Tianjin Institute of Pharmaceutical ResearchTianjin300193China

XueBiJing is an intravenous five-herb injection used to treat sepsis in *** study aimed to develop a liquid chromatography-tandem mass spectrometry(LC-MS/MS)-or liquid chromatography-ultraviolet(LC-UV)-based assay for quality evaluation of *** development involved identifying marker constituents to make the assay therapeutically relevant and building a reliable one-point calibrator for monitoring the various analytes in *** marker constituents from the five herbs were selected based on XueBiJing's chemical composition,pharmacokinetics,and pharmacodynamics.A selectivity test(for“similarity of response”)was developed to identify and minimize interference by nontarget ***,an intercept test was developed to fulfill“linearity through zero”for each analyte(absolute ratio of intercept to C response,<2%).Using the newly developed assays,we analyzed samples from 33 batches of XueBiJing,manufactured over three years,and found small batch-to-batch variability in contents of the marker constituents(4.1%-14.8%),except for senkyunolide I(26.5%).

关键词： XueBiJing Chinese herbal medicine Quality variability Quality marker One-point calibration

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli yuan Tianjie Lyu Ling Zhang meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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Stochastic Control for Optimal Execution:Fast Approximation Solution Scheme Under Nested Mean-semi Deviation and Conditional Value at Risk

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Journal of the Operations Research Society of China 2017年第2期5卷 161-176页

作者： meng-Fei He duan Li yuan-yuan Chen China International Fund Management Ltd Shanghai 200120China Department of Systems Engineering and Engineering Management The Chinese University of Hong KongHong KongChina Risk Management Institute National University of SingaporeSingaporeSingapore

When executing a large order of stocks in a market,one important factor in forming the optimal trading strategy is to consider the price impact of large-volume trading *** a risk measure of the implementation shortfall,i.e.,the difference between the value of a trader’s initial equity position and the sum of cash flow he receives from his trading process,is essentially a stochastic control *** this study,we investigate such a practical problem under a dynamic coherent risk measure in a market in which the stock price dynamics has a feature of momentum *** develop a fast approximation solution scheme,which is critical in highfrequency *** demonstrate some prominent features of our derived solution algorithm in providing useful guidance for real implementation.

关键词： Nested coherent risk measure Momentum effect Approximation solution scheme Stochastic dynamic programming

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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Selective Oxidation of PM over Li Doped Potassium Titanate Catalysts

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China Petroleum Processing & Petrochemical Technology 2012年第2期14卷 50-54页

作者： meng Xiuhong Gao yuan Wang Qiang duan Linhai Key Laboratory of Petrochemical Catalytic Science and Technology Liaoning Shihua University Fushun113001 P. R. China Department of Chemistry University of Oxford Oxford OX1 3TA United Kingdom)

K2Ti2O5 and LixK2-xTi2O5 samples with varying K contents （x=0.125, 0.15, 0.3）, targeted on removal of two main environmental pollutants： PM and NOx, were synthesized by the solid state method using TiO2, KNO3 and LiOH-H2O as starting materials and were characterized by X-ray diffractometry, scanning electron microscopy, and BET. The catalytic activity of titanate catalysts on PM oxidation was evaluated using the temperature programmed oxidation （TPO） method. The test results showed that the perovskite structure of K2Ti205 was still retained after doping a small amount of Li, and the catalytic performance of LixK2-xTi2O5 had been improved significantly compared with that of K2Ti2O5. Li0.15K1.85Ti205 catalyst had the highest catalytic activity with an ignition temperature of 210℃ and a peak temperature of 290℃. The catalytic activity of both K2Ti2O5 and LixK2-xTi2O5 under intimate contact was higher than that under loose contact. When the exhaust gas flow rate was around 100 mL/min, the catalyst samples showed a highest activity. The Li doped K2Ti2O5 could be an excellent candidate for PM oxidation due to its high oxidation activity, water stability, resistance to sulfur poisoning and economical advantages.

关键词： potassium titanates diesel PM PM oxidation Li doping

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Preparation and Catalytic Performance of Potassium Titanate Used as Soot Oxidation Catalyst

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China Petroleum Processing & Petrochemical Technology 2013年第2期15卷 31-36页

作者： Gao yuan meng Xiuhong Pan Lihong Song Lijuan duan Linhai Key Laboratory of Petrochemical Catalytic Science and Technology Liaoning Shihua University Shandong Tianhong New Energy Chemical Co. Ltd

To prepare potassium titanate catalyst, a novel citrate acid complex-combustion method using CH3COOK and Ti（OC4H9）4 as raw materials was developed. The crystalline phase and surface morphology of K2Ti205 were investigated by X-ray diffraction （XRD）, field emission scanning electron microscope （FE-SEM） and transmission electron microscope （TEM）. The impact of some factors, such as the type of contact between K2Ti205 and soot, the content of water vapor and SO2 in exhaust, and the repeated use on catalytic activity of K2Ti205 were studied by temperature programmed reaction （TPR）. A comparison between the new method and the reported ones on catalytic activity of potassium titanate was investigated. The results showed that K2Ti205 had high catalytic activity and good stability.

关键词： citrate acid complex-combustion method diesel exhaust potassium titanate soot oxidation

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Phase evolution of binary immiscible Al-Sn film

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Rare Metals 2022年第12期41卷 4241-4247页

作者： Xiao-meng Pan Hui-Ping duan School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Binary immiscible Al-Sn alloy is a very important potential anode material for lithium ion *** phase stability and separation process of Al-Sn film,fabricated by magnetron co-sputtering method,was investigated by X-ray diffractometer(XRD),differential scanning calorimetry(DSC) and in situ transmission electron microscopy(TEM) and explained by Miedema theoretical *** analysis reveals that the asdeposited Al-Sn film will decompose spontaneously into Al-riched areas and Sn-riched areas because of the positive mixing *** crystallization process takes place when the Al content in the Al-riched area or Sn content in the Sn-riched area *** results show that Al-Sn thin film is composed of an amorphous matrix and well-dispersed composite *** particle contains an Al-riched area and a Sn-riched *** Snriched area crystallizes and swallows up the Al-riched area gradually during heating through uphill diffusion of the Sn *** on the theoretical analysis and experimental results,an empirical model to explain the phase evolution process in the Al-Sn film was proposed.

关键词： Immiscible alloy Uphill diffusion Phase evolution Miedema theory

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Extremum seeking control for UAV close formation flight via improved pigeon-inspired optimization

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Science China(Technological Sciences) 2024年第2期67卷 435-448页

作者： yuan GuangSong duan HaiBin State Key Laboratory of Virtual Reality Technology and Systems School of Automation Science and Electrical EngineeringBeihang University(BUAA)Beijing 100083China

This paper proposes a comprehensive design scheme for the extremum seeking control(ESC)of the unmanned aerial vehicle(UAV)close formation *** proposed design scheme combines a Newton-Raphson method with an extended Kalman filter(EKF)to dynamically estimate the optimal position of the following UAV relative to the leading *** reflect the wake vortex effects reliably,the drag coefficient induced by the wake vortex is considered as a performance ***,the performance function is parameterized by the first-order and second-order terms of its Taylor series *** the excellent performance of nonlinear estimation,the EKF is used to estimate the gradient and the Hessian matrix of the parameterized performance *** output feedback of the proposed scheme is determined by iterative calculation of the Newton-Raphson *** with the traditional ESC and the classic ESC,the proposed design scheme avoids the slow continuous time integration of the *** allows a faster convergence of relative position ***,the proposed method can provide a smoother command during the seeking process as the second-order term of the performance function is taken into *** convergence analysis of the proposed design scheme is accomplished by showing that the output feedback is a supermartingale *** improve estimation performance of the EKF,a improved pigeon-inspired optimization(IPIO)is proposed to automatically tune the noise covariance *** Carlo simulations for a three-UAV close formation show that the proposed design scheme is robust to the initial position of the following UAV.

关键词： unmanned aerial vehicle close formation extremum seeking control Newton-Raphson method improved pigeon-inspired optimization

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COLOR CORRECTION FOR HIGH-DEFINITION ELECTRONIC ENDOSCOPE

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 57-63页

作者： CHEN JING WANG LI-QIANG meng ZI-BO yuan BO duan HUI-LONG State Key Laboratory of Modern Optical Instrumentation Zhejiang University HangzhouZhejiang 310027P.R.China Biomedical Engineering Institute Zhejiang University HangzhouZhejiang 310027P.R.China

The subtle color distinction is the important function of electronic endoscope imaging ***,after image acquisition,transmission and display,color distortions of intracorporeal organs or tissues occur inevitably,which are adverse to analyze image features accurately or to diagnose early pathological changes.A real-time color correction algorithm based on fourneighborhood and polynomial regression in YUV color space is *** on polynomial regression the color correction matrix is calculated in YUV color space according to the dierences between standard values of color checker and measured values of that imaged by the *** the correction is only executed on U and V components in YUV color space,the defect that the color of corrected images in RGB color space will change along with luminance can be avoided,and then the stability of image color is *** to four-neighborhood processing,the signal-to-noise ratio of corrected images is enhanced and the processing speed of correction algorithm is *** average color dierence is reduced from 0.3944 to 0.2850 by application of the proposed algorithm in high-denition electronic endoscope.A total of 17 frames per second can be achieved at the resolution of 1280800,and the color characteristics of the image after processing match that of human visual system.

关键词： High-de¯nition electronic endoscope color correction polynomial regression fourneighborhood

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