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A multiscale adaptive framework based on convolutional neural network:Application to fluid catalytic cracking product yield prediction

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Petroleum Science 2024年第4期21卷 2849-2869页

作者： Nan Liu Chun-meng Zhu meng-xuan zhang Xing-Ying Lan College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing102249China

Since chemical processes are highly non-linear and multiscale,it is vital to deeply mine the multiscale coupling relationships embedded in the massive process data for the prediction and anomaly tracing of crucial process parameters and production *** the integrated method of adaptive signal decomposition combined with time series models could effectively predict process variables,it does have limitations in capturing the high-frequency detail of the operation state when applied to complex chemical *** light of this,a novel Multiscale Multi-radius Multi-step Convolutional Neural Network(Msrt Net)is proposed for mining spatiotemporal multiscale ***,the industrial data from the Fluid Catalytic Cracking(FCC)process decomposition using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)extract the multi-energy scale information of the feature ***,convolution kernels with varying stride and padding structures are established to decouple the long-period operation process information encapsulated within the multi-energy scale ***,a reconciliation network is trained to reconstruct the multiscale prediction results and obtain the final *** Net is initially assessed for its capability to untangle the spatiotemporal multiscale relationships among variables in the Tennessee Eastman Process(TEP).Subsequently,the performance of Msrt Net is evaluated in predicting product yield for a 2.80×10^(6) t/a FCC unit,taking diesel and gasoline yield as *** conclusion,Msrt Net can decouple and effectively extract spatiotemporal multiscale information from chemical process data and achieve a approximately reduction of 30%in prediction error compared to other time-series ***,its robustness and transferability underscore its promising potential for broader applications.

关键词： Fluid catalytic cracking Product yield Data-driven modeling Multiscale prediction Data decomposition Convolution neural network

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绿色金融背景下吉林省商业银行的业务创新

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科技创新与生产力 2017年第1期 19-21页

作者：任萌张璇长春工业大学经济管理学院吉林长春130012

基于绿色金融与区域经济发展理论,分析了吉林省商业银行绿色金融业务存在的问题及其制约因素,在探讨影响吉林省商业银行绿色金融业务发展的动因基础上,提出了促进吉林省商业银行绿色金融业务发展的对策。

关键词：绿色金融商业银行低碳信贷吉林

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无锡市2006-2015年梅毒流行特征与趋势分析

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中国艾滋病性病 2016年第11期22卷 904-907页

作者：孟晓军张轩成浩顾静无锡市疾病预防控制中心江苏无锡214023

目的了解无锡市2006-2015年梅毒的流行特征及趋势,为制定梅毒防控策略提供科学依据。方法用描述性流行病学方法,对2006-2015年无锡市的梅毒病例报告资料进行＂三间分布＂分析。结果 2006-2015年,无锡市梅毒报告发病率呈现先上升后下降... 详细信息

目的了解无锡市2006-2015年梅毒的流行特征及趋势,为制定梅毒防控策略提供科学依据。方法用描述性流行病学方法,对2006-2015年无锡市的梅毒病例报告资料进行＂三间分布＂分析。结果 2006-2015年,无锡市梅毒报告发病率呈现先上升后下降的趋势,2006-2009年年均增长32.6%（由25.19/10万增长到58.66/10万）,2009-2015年年均下降10.0%（由58.66/10万下降到31.08/10万）。男女性别比呈下降趋势,由2006年的1.22∶1下降到2015年的0.99∶1。25-34岁组报告发病率最高,2006-2009年年均增长29.1%,2009-2015年年均下降15.0%。〈15岁组报告发病率最低,2006-2012年年均增长28.4%,2012-2015年年均下降17.0%。发病人数最多的职业人群分别为家务及待业和农民,分别占32.5%和29.4%。以无锡市户籍为主,占93.2%。报告单位以综合医院为主,占69.1%,社区卫生服务中心/卫生院所占比例由2006年的7.6%上升到2015年的13.5%。结论无锡市梅毒报告发病率呈先上升后下降的趋势,但老年人群报告病例数逐年增多,且胎传梅毒报告发病率仍较高,需采取有针对性的措施进一步控制梅毒的流行。

关键词：梅毒流行特征趋势

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Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei zhang Liang Li Hao-Yu Qu Guang-Yu Chen meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling zhang meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian zhang Zi-Han Li Yi-Xin zhang Rong-xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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改进型并行双非线性模型的ROF系统非线性建模

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微波学报 2018年第2期34卷 43-46,55页

作者：惠明张萌张选顺朱晓维申东娅东南大学毫米波国家重点实验室南京210096 南阳师范学院物理与电子工程学院石油装备智能化河南省工程实验室南阳473061 云南大学信息学院昆明650091

包含光载无线通信（ROF）链路和射频功放的ROF前传系统存在严重的静态非线性和记忆效应,提出了改进型并行双非线性广义记忆效应模型（APTGMEM）,以准确建模ROF前传系统的强静态非线性和记忆效应。所提出的APTGMEM包含无记忆和广义记忆... 详细信息

包含光载无线通信（ROF）链路和射频功放的ROF前传系统存在严重的静态非线性和记忆效应,提出了改进型并行双非线性广义记忆效应模型（APTGMEM）,以准确建模ROF前传系统的强静态非线性和记忆效应。所提出的APTGMEM包含无记忆和广义记忆效应两个独立部分,其中无记忆部分只考虑高阶静态非线性,广义记忆效应部分只考虑低阶次超前广义非线性。文中采用带宽为20 MHz的4G LTE（Long Term Evolution长期演进）信号为测试信号,光模块和峰值输出功率为51d Bm的Doherty功放被用于模型有效性验证。测试结果表明,APTGMEM相比广义记忆多项式模型（GMPM）,模型系数减少40%,而建模精度相似,同时比并行双非线性两厢模型（PDNTBM）建模精度提高了3.6 d B,其在建模精度、系数数量和训练复杂度上取得了良好折中。

关键词：功放记忆多项式非线性光载无线通信

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第01期 174-180页

作者： Fan-Xiao meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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On Holder Dependence of the Parameterized Hartman–Grobman Theorem

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Acta Mathematica Sinica,English Series 2022年第1期38卷 137-147页

作者： Wen meng zhang Peng LIU xuan LEI School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331P.R.China

The well-known Hartman-Grobman Theorem says that a C~1 hyperbolic diffeomorphism F can be locally linearized by a homeomorphismΦ.For parameterized systems F_(θ),known results show that the corresponding homeomorphismsΦ_(θ)exist uniquely in a functional space equipped with the supremum norm and depend continuously on the parameterθ.In this paper,we further extend the results to Holder dependence ofΦ_(θ)onθby Pugh's strategy,but introducing a kind of special Holder norm instead of the usual supremum norm in the proof to control the linear parts of F_(θ).This requires a new Holder linearization result for every F_(θ).

关键词： Holder linearization dependence on parameter hyperbolicity

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