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Post-Traumatic Stress Disorder after typhoon disaster and its correlation with platelet 5-HT concentrations

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 890-892页

作者： Jun-Cheng Guo Zhi-liang Tian Xiao-Dan Wang Min Guo meng-Yong-wei li Yun-Suo Gao Xiang-ling Jiang lin-Mei Fu Tao Huang li Xiang Yu Shu-Feng li You People's Hospital of Hainan Province Affiliated Hainan Hospital University of South China The Second Hospital University of South China School of Public Health Hainan Medical University

Objective:To investigate residents' psychological stress factors and research the correlation between Post-Traumatic Stress Disorder(PTSD) and platelet 5-HT concentrations so as to provide scientific bases for diagnosis and treatment of PTSD and psychological intervention for people in the disaster ***:A questionnaire survey of 5 500 residents who have accepted psychological help was conducted by the emphatic investigation *** high performance liquid chromatography were used to detect the platelet serotonin concentration of 100 PTSD patients and 100 healthy ***:(1) Of the 5 114 cases,3 167(61.93%) showed positive results in screening for psychological stress symptoms,and 399(7.8%) were tested with apparent PTSD *** and female prevalence showed no significant difference(X^2=-0.380,P=0.704).The differences of prevalence between different age groups were statistically significant(X^2=381.89,P=0.000).(2) The differences in the level of platelet 5-HT between PTSD patients and normal control group were statistically ***:The typhoon of Hainan province caused relatively large psychological problems to the disaster *** with normal control group,the platelet 5-HT levels of PTSD patients in the disaster areas are *** may be related to incidents exposure levels,cultural background,religious ideas,social concerns and psychological rescue of the residents who live in the disaster areas of Hainan.

关键词： Post-traumatic stress disorder Influential factors 5-HT Typhoon

Design and Implementation of Visual Dynamic Display Software of Gene Expression Based on GTK

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Journal of Northeast Agricultural University(English Edition) 2009年第1期16卷 69-72页

作者： JIANG wei meng Fanjiang li Yong YU Xiao Engineering College Northeast Agricultural University Harbin 150030 China

The paper presented an implement method for a dynamic gene expression display software based on the GTK. This method established the dynamic presentation system of gene expression which according to gene expression data from gene chip hybridize at different time, adopted a linearity combination model and Pearson correlation coefficient algorithm. The system described the gene expression changes in graphic form, the gene expression changes with time and the changes in characteristics of the gene expression, also the changes in relations of the gene expression and regulation relationships among genes. The system also provided an integrated platform for analysis on gene chips data, especially for the research on the network ofgene regulation.

关键词： visualization gene expression gene chip gene regulation

Using aripiprazole to reduce antipsychotic-induced hyperprolactinemia： meta-analysis of currently available randomized controlled trials

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上海精神医学 2015年第1期27卷 4-17页

作者： Meiling meng wei li Shaowei ZHANG Hongyan WANG Jianhua SHENG Jijun WANG Chunbo li ShanghaiKeyLaboratoryofPsychoticDisorders ShanghaiMentalHealthCenterShanghaiJiaoTongUniversitySchoolofMedicine

BACKGROUND:Hyperprolactinemia (HPL) is a common side effect of antipsychotic medications. Recent reports suggest that aripiprazole can ameliorate antipsychotic-induced HPL, but results are inconsistent and the single available systematic review only considered five studies.;OBJECTIVE:Conduct an updated meta-analysis of all randomized controlled trials (RCTs) about the efficacy and safety of aripiprazole as an adjunctive treatment for antipsychotic-induced hyperprolactinemia.;METHODS:English and Chinese databases were searched for RCTs about the use of aripiprazole in treating antipsychotic-induced HPL published by January 20, 2015. Studies were selected using pre-defined inclusion and exclusion criteria. The Cochrane Risk of Bias tool was used to evaluate risk of biases, the Cochrane GRADE measure was used to assess the quality of evidence, and Review Manager 5.3 software was used for data analysis.;RESULTS:A total of 21 studies, 19 of which were conducted in mainland China, were included in the analysis. Meta-analysis of data from 8 of the studies with a pooled sample of 604 individuals found that compared to the control condition adjunctive aripiprazole significantly increased the proportion of participants who experienced HPL recovery (risk ratio [RR]=19.2, 95%CI=11.0-33.5). The proportion who experienced any adverse effect during follow-up did not differ between the two groups, but the aripiprazole group was more likely to report somnolence (RR=2.76, 95%CI=1.34-5.69) and headaches (RR=2.31, 95%CI=1.08-4.92). High-dose aripiprazole (>5mg/day) was more effective than low-dose (lity of evidence was rated as 'high' for only 7 of the 57 outcome measures assessed.;CONCLUSIONS:This study systematically reviewed and evaluated al

关键词：随机对照试验抗精神病药阿立哌唑催乳素药物血症辅助治疗中国大陆

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孤岛微电网的分布式固定时间二次协调控制

控制与决策 2019年第1期34卷 205-212页

作者：陈刚李志勇韦梦立重庆大学自动化学院重庆400044

孤岛微电网的下垂控制策略会导致系统稳态的频率和电压偏离额定值.为此,提出一种分布式固定时间二次协调控制策略以实现系统频率和电压的恢复控制,并实现期望的有功功率分配.所提出的控制方法能在固定时间内完成二次控制目标,而不依赖... 详细信息

孤岛微电网的下垂控制策略会导致系统稳态的频率和电压偏离额定值.为此,提出一种分布式固定时间二次协调控制策略以实现系统频率和电压的恢复控制,并实现期望的有功功率分配.所提出的控制方法能在固定时间内完成二次控制目标,而不依赖于系统的初始状态.该优势使得根据任务需求来离线预设整定时间成为可能.同时,采用固定时间Lyapunov方法分析二次协调控制系统的稳定性.最后,通过Matlab/Simulink仿真实验验证分布式固定时间二次控制策略的有效性.

关键词：孤岛微电网下垂控制分布式控制二次控制有功功率分配固定时间

阻塞性睡眠呼吸暂停低通气综合征患者糖代谢异常的研究

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中华内科杂志 2011年第9期50卷 738-742页

作者：孟炜丽郭兮恒首都医科大学附属北京朝阳医院北京呼吸疾病研究所睡眠中心 100020

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者糖代谢异常的发生情况及与OSAHS严重程度的关系；短期持续气道正压（CPAP）通气治疗后，糖代谢异常是否会有所改善。方法监测214例OSAHS者的睡眠和糖代谢，对糖代谢异常者行CPAP通... 详细信息

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者糖代谢异常的发生情况及与OSAHS严重程度的关系；短期持续气道正压（CPAP）通气治疗后，糖代谢异常是否会有所改善。方法监测214例OSAHS者的睡眠和糖代谢，对糖代谢异常者行CPAP通气治疗。结果糖代谢异常者OSAHS组88例（54．3％），对照组17例（32．7％）。Logistic回归分析显示，糖代谢异常与OSAHS相关。OSAHS患者[呼吸暂停低通气指数（AHI）≥10次／h]发生糖代谢异常的风险是普通人群的2．44倍（95％CI1．201～4．958）。7例患者行CPAP通气治疗，治疗前后血糖变化差异无统计学意义（P〉0．05）。结论OSAHS患者（AHI≥10次／h）糖代谢异常的发生率高，OSAHS是糖代谢异常的独立危险因素之一；超重和（或）肥胖在糖代谢异常的发生、发展中起主要作用，排除超重和（或）肥胖的干扰，OSAHS患者的血糖水平与AHI、最长呼吸暂停时间相关；短期CPAP通气治疗改善OSAHS患者糖代谢异常的效果不明显。

关键词：睡眠呼吸暂停阻塞性葡萄糖代谢障碍持续气道正压通气

单侧甲状腺微小乳头状癌合并对侧甲状腺小结节患者的临床分析

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中华耳鼻咽喉头颈外科杂志 2012年第10期47卷 827-830页

作者：孟利伟黄黎明徐潮阳章蔚浙江省绍兴市人民医院乳腺甲状腺外科江省绍兴市312000

目的总结单侧甲状腺微小乳头状癌（papillary thyroid microcarcinoma，PTMC）合并对侧甲状腺小结节（最大径〈1cm）患者的临床特点及处理方法。方法回顾性分析253例单侧PTMC对侧腺叶合并有术前B超诊断为良性小结节患者的临床资料。25... 详细信息

目的总结单侧甲状腺微小乳头状癌（papillary thyroid microcarcinoma，PTMC）合并对侧甲状腺小结节（最大径〈1cm）患者的临床特点及处理方法。方法回顾性分析253例单侧PTMC对侧腺叶合并有术前B超诊断为良性小结节患者的临床资料。253例患者均行甲状腺一侧腺叶切除、对侧近全切除或全切除术。对患者相关临床特征采用X2检验进行单因素分析，采用Logistic回归进行多因素分析。结果53例（20．9％）患者对侧小结节术后病理诊断为PTMC，其余200例（79．1％）为良性结节。单因素分析发现，对侧结节PTMC发生与合并桥本甲状腺炎和一侧多发癌灶有关（X^2=24．834，X^2=5．182，P值均〈0．05），与年龄、性别、病灶大小、被膜侵犯、淋巴转移、结节数量及甲状腺球蛋白水平无关。多因素分析显示只有一侧多发癌灶是对侧结节PTMC发生的独立危险因素（OR=5．352，P〈0．05）。结论甲状腺多发小结节患者若一侧为多灶性的PTMC，对侧小结节发生B超难以分辨的PTMC的概率较高，宜采取甲状腺全切除术的治疗策略。

关键词：甲状腺肿瘤癌乳头状甲状腺结节危险因素

参与草菇子实体分化的VvHox1基因的鉴定及表达分析(英文)

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菌物学报 2018年第3期37卷 352-360页

作者：孟丽王威李壮王丽朱孟娟李玉谢宝贵山东农业大学植物保护学院山东省农业微生物重点实验室山东泰安271018 吉林农业大学食药用菌教育部工程研究中心吉林长春130118 福建农林大学生命科学学院菌物研究中心福建福州350002

通过草菇基因组注释,得到一含有同源框(homeobox)保守结构域的转录因子VvHox1,根据其在草菇不同生长发育阶段的基因表达量变化,推测其可能与草菇的子实体分化相关。利用转录组数据分析该基因结构,发现VvHox1由2 856个碱基组成,包含4个... 详细信息

通过草菇基因组注释,得到一含有同源框(homeobox)保守结构域的转录因子VvHox1,根据其在草菇不同生长发育阶段的基因表达量变化,推测其可能与草菇的子实体分化相关。利用转录组数据分析该基因结构,发现VvHox1由2 856个碱基组成,包含4个外显子和3个内含子。荧光定量PCR和数字基因表达谱结果显示VvHox1在草菇的异核菌丝体、原基期和蛋形期的表达量不断升高,并且在蛋形期表达量达到最高,但是,在伸长期的表达量却显著下降。因此,我们推测转录因子VvHox1可能调控子实体发育过程中的相关基因,从而影响草菇子实体的形态发生。

关键词：草菇形态发生转录因子

军民合用机场鸟击风险评价及防范措施改进研究

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科学技术与工程 2017年第2期17卷 16-21页

作者：王维孟丽娜中国民航大学机场学院天津300300

为了掌握军民合用机场及周边地区威胁飞行安全的鸟类动态,2015年6月至2016年5月,对某军民合用机场在机场周围半径8 km范围内展开鸟情生态调研工作。根据调查结果引入鸟的体长、飞行高度及相对重量并结合鸟的相对数量、遇见频次为影响因... 详细信息

为了掌握军民合用机场及周边地区威胁飞行安全的鸟类动态,2015年6月至2016年5月,对某军民合用机场在机场周围半径8 km范围内展开鸟情生态调研工作。根据调查结果引入鸟的体长、飞行高度及相对重量并结合鸟的相对数量、遇见频次为影响因子进行鸟类威胁程度分析。首次提出军民合用机场的鸟击防范特征;并根据分析结果,结合军民合用的机场性质,在现有的鸟击防范工作基础上提出了具有针对性鸟击防范对策。

关键词：鸟情调查鸟击风险评估鸟击防范军民合用机场

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao lingyan meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein