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Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong wang wang Kai-Yu Qian shuai Yuan Gang wang Fang Yu Jun Luo meng‑Xin Lu Zhong‑Hua Yang Tao Liu Xing Huang Hang Zheng Xing-Huan wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

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TransTM:A device-free method based on time-streaming multiscale transformer for human activity recognition

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Defence Technology（防务技术） 2024年第2期32卷 619-628页

作者： Yi Liu Weiqing Huang Shang Jiang Bobai Zhao shuai wang Siye wang Yanfang Zhang Institute of Information Engineering Chinese Academy of Sciences School of Cyber SecurityUniversity of Chinese Academy of SciencesBeijingChina School of Information Management Beijing Information Science and Technology UniversityBeijingChina

RFID-based human activity recognition(HAR)attracts attention due to its convenience,noninvasiveness,and privacy *** RFID-based HAR methods use modeling,CNN,or LSTM to extract features ***,they have shortcomings:1)requiring complex hand-crafted data cleaning processes and 2)only addressing single-person activity recognition based on specific RF *** solve these problems,this paper proposes a novel device-free method based on Time-streaming Multiscale Transformer called *** model leverages the Transformer's powerful data fitting capabilities to take raw RFID RSSI data as input without ***,we propose a multiscale convolutional hybrid Transformer to capture behavioral features that recognizes singlehuman activities and human-to-human *** with existing CNN-and LSTM-based methods,the Transformer-based method has more data fitting power,generalization,and ***,using RF signals,our method achieves an excellent classification effect on human behaviorbased classification *** results on the actual RFID datasets show that this model achieves a high average recognition accuracy(99.1%).The dataset we collected for detecting RFID-based indoor human activities will be published.

关键词： Human activity recognition RFID Transformer

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Advances of high-performance LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathode materials and their precursor particles via co-precipitation process

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Particuology 2024年第3期86卷 67-85页

作者： Wenbiao Liang Yin Zhao Liyi Shi Zhuyi wang Yi wang Meihong Zhang shuai Yuan School of Materials Science and Engineering Shanghai UniversityShanghai200444China Research Center of Nanoscience and Nanotechnology Shanghai UniversityShanghai200444China Emerging Industries Institute Shanghai UniversityJiaxingZhejiang314006China

Layered LiNi_(1-x-y)Co_(x)M_(y)O_(2)(M=Mn or Al)is a promising cathode material for lithium-ion batteries due to its high specific capacity and acceptable manufacturing ***,the polycrystalline LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathode material suffers from disordered orientation of primary particles and poor geometric symmetry of secondary particles,which severely hampers the migration of Lit ***,the resulting anisotropy accelerates the disintegration of the secondary particle structure,significantly affecting the electrochemical performance of the polycrystalline *** spite of less grain boundary,the single-crystal LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathodes still suffer from severe microcracks generated by repeated planar gliding during cycling,which poses a great challenge to the cycling stability of single-crystal ***'s worth noting that the microstructure of the cathode material is mainly inherited from its ***,it is necessary to deeply understand the influence of the microstructure of Ni_(1-x-y)Co_(x)M_(y)(OH)2 on the electrochemical properties of LiNi_(1-x-y)Co_(x)M_(y)O_(2) cathode materials,so as to optimize the production process of preparing high-performance cathode *** this review,we summarize recent advances in the research and development of Ni-rich cathode precursor ***,the challenges faced by the Ni-rich hydroxide precursor materials are presented,including the effect of primary particle morphology and arrangement on the electrochemical performance of cathode materials,the influence of secondary particle morphology on lithium insertion reactions in cathode,and the effect of particle size on the microcracking of single-crystal ***,the presentation of the conventional co-precipitation reactor,the mechanism of precursor particle growth,and the influence of coprecipitation parameters are described in ***,the strategies are systematically discussed to solve the cha

关键词： Lithium-ion batteries Cathode materials Co-precipitation Ni-rich layered oxides Single crystal Precursor particles

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Insight into the adsorption behavior and mechanism of trace impurities from H_(2)O_(2) solution on functionalized zirconia by tuning the structure of amino groups

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 83-94页

作者： Yu meng Yitong wang Guozhu Li Guozhu Liu Li wang Key Laboratory for Green Chemical Technology of Ministry Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Primary,secondary and tertiary amino-functionalized zirconia(ZrO_(2)-NH_(2),ZrO_(2)-NH and ZrO_(2)-N)was synthesized by the postgrafting method for the adsorption removal of typical metallic ions,phosphate and total oxidizable carbon from a real H_(2)O_(2) ***_(2)-NH_(2),ZrO_(2)-NH and ZrO_(2)-N exhibited similar pore sizes and sequentially increased zeta *** adsorption results of single and binary simulated solutions showed that the removal efficiency increased in the order of Fe^(3+)>Al^(3+)>Ca^(2+)>Na^(+).There is competitive adsorption between metallic ions,and Fe^(3+) has an advantage over the other metals,with a removal efficiency of 90.7%.The coexisting phosphate could promote the adsorption of metallic ions,while total oxidizable carbon had no effect on *** adsorption results of the real H_(2)O_(2)solution showed that ZrO_(2)-NH_(2) exhibited the best adsorption affinity for metallic ions,as did phosphate and total oxidizable carbon,with a total adsorption capacity of 120.9 mg·g_(-1).Density functional theory calculations revealed that the adsorption process of metallic ions involves electron transfer from N atoms to metals and the formation of N-metal bonds.

关键词： adsorption metallic ion phosphate total oxidizable carbon zirconia H_(2)O_(2)

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A Review on Particle Reinforced Mg Matrix Composites Fabricated by Powder Metallurgy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 391-400页

作者： Zhiyuan Liu Li Jin Jian Zeng Fulin wang Fenghua wang shuai Dong Jie Dong National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper provides a comprehensive review of research progress in particle-reinforced Mg matrix composites prepared via powder *** article discusses different strategies,such as micro-sized,nano-sized particles,and multi-particle hybridization,which has been employed to enhance the performance of the *** addition,a range of preparation techniques that optimize the dispersion of the reinforcing particles are *** paper also highlights how the different configurations between the reinforcements and matrix alloy impact the composites’***,the article outlines the prospects of particles reinforced Mg matrix composites fabricated via powder metallurgy and recommends modification methods that could be explored to further develop these materials for various applications.

关键词： Magnesium matrix composites Reinforcing particle Powder metallurgy Mechanical properties Configuration

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Kinematic-mapping-model-guided analysis and optimization of 2-PSS&1-RR circular-rail parallel mechanism for fully steerable phased array antennas

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Defence Technology 2024年第8期38卷 136-154页

作者： Guodong Tan Xiangfei meng Xuechao Duan Lulu Cheng Dingchao Niu shuai He Dan Zhang Laboratory of Electromechanical Coupling in Electronic Equipment Xidian University Department of Mechanical Engineering The Hong Kong Polytechnic University

This paper presents a systematic methodology for analyzing and optimizing an innovative antenna mount designed for phased array antennas, implemented through a novel 2-PSS&1-RR circular-rail parallel mechanism. Initially, a comparative motion analysis between the 3D model of the mount and its full-scale prototype is conducted to validate effectiveness. Given the inherent complexity, a kinematic mapping model is established between the mount and the crank-slider linkage, providing a guiding framework for subsequent analysis and optimization. Guided by this model, feasible inverse and forward solutions are derived, enabling precise identification of stiffness singularities. The concept of singularity distance is thus introduced to reflect the structural stiffness of the mount. Subsequently, also guided by the mapping model, a heuristic algorithm incorporating two backtracking procedures is developed to reduce the mount's mass. Additionally, a parametric finite-element model is employed to explore the relation between singularity distance and structural stiffness. The results indicate a significant reduction(about 16%) in the antenna mount's mass through the developed algorithm, while highlighting the singularity distance as an effective stiffness indicator for this type of antenna mount.

关键词： Backtracking Circular rail Crank-slider linkage Innovative antenna mount Kinematic mapping model Stiffness singularity

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Single transmembrane GPCR modulating proteins:neither single nor simple

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Protein & Cell 2024年第6期15卷 395-402页

作者： meng wang Jianjun Lyu Chao Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co. LtdEast Lake High-Tech Development ZoneWuhan 430205China Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)Tongji UniversityShanghai 200092China

The discovery of G-protein coupled receptor(GPCR)accessory proteins has fundamentally redefined the pharmacological concept of GPCR signaling,demonstrating a more complex molecular basis for receptor specificity on the plasma membrane and impressionable downstream intracellular *** accessory proteins not only contribute to the proper folding and trafficking of receptors but also exhibit selectable receptor preferences.

关键词： specificity GPCR neither

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WEAK APPROXIMATIONS OF STOCHASTIC PARTIAL DIFFERENTIAL EQUATIONS WITH FRACTIONAL NOISE

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Journal of Computational Mathematics 2024年第3期42卷 735-754页

作者： meng Cai Siqing Gan Xiaojie wang School of Mathematics and Statistics HNP-LAMACentral South UniversityChangshaChina

This paper aims to analyze the weak approximation error of a fully discrete scheme for a class of semi-linear parabolic stochastic partial differential equations(SPDEs)driven by additive fractional Brownian motions with the Hurst parameter H∈(1/2,1).The spatial approximation is performed by a spectral Galerkin method and the temporal discretization by an exponential Euler *** far as we know,the weak error analysis for approximations of fractional noise driven SPDEs is absent in the literature.A key difficulty in the analysis is caused by the lack of the associated Kolmogorov *** the present work,a novel and efficient approach is presented to carry out the weak error analysis for the approximations,which does not rely on the associated Kolmogorov equations but relies on the Malliavin *** the best of our knowledge,the rates of weak convergence,shown to be higher than the strong convergence rates,are revealed in the fractional noise driven SPDE setting for the first *** examples corroborate the claimed weak orders of convergence.

关键词： Parabolic SPDEs Fractional Brownian motion Weak convergence rates Spec-tral Galerkin method Exponential Euler method Malliavin calculus

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Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy

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Nano Research 2024年第3期17卷 1804-1817页

作者： Fazhan wang meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming wang Rui Xue Wenjing Deng shuai Shao Zhihai Qin Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Translational Medical Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Department of Neuro-Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450052China

Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA *** expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA *** by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered *** the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA *** mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in *** with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma *** natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy.

关键词： mRNA vaccine lipid nanoparticles spleen long-chain saturated fatty acid cancer immunotherapy

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Synthesis,structure,and luminescence properties of melilite Dy^(3+):Lu_(x)CaLa_(0.98-x)Ga_(3)O_(7) phosphors for use in yellow light-emitting devices

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Journal of Rare Earths 2024年第8期42卷 1489-1495,I0003页

作者： Yunyun Liu Chuanxin Huang meng wang Xihu wang Yan wang Ju Gao School of Opto-Electronic Engineering Zaozhuang UniversityZaozhuang277160China Key Laboratory of Functional Materials and Devices for Informatics of Anhui Educational Institutions Department of PhysicsFuyang Normal UniversityFuyang236037China Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002.China

Dy^(3+) and Lu^(3+) co-doped CaLaGa_(3)O_(7) phosphors were prepared via high-temperature solid-phase *** electronic structures of LuxCaLa_(0.98-x)Ga_(3)O_(7) were investigated by the first-principles *** influence of Lu^(3+) on yellow light emission was studied using X-ray diffraction(XRD)and photoluminescence(PL) *** XRD results indicate that compared to Dy^(3+):CaLaGa_(3)O_(7),the cell parameters of Dy^(3+):LuCaLaGa_(3)O_(7) tend to decrease,which is due to the smaller radius of Lu^(3+).When pumped by blue GaN laser diode(LD),the emission peaks of phosphors with different Lu^(3+)doping concentrations in the visible region are similar,with the strongest peak at 574 nm in the yellow light region,which is sensitive to human *** optimal doping concentration of Lu^(3+) is confirmed to be1 at%,when all emission spectra and measured fluorescence lifetimes are taken into ***,the optimal phosphor composition Dy^(3+):Lu_(x)CaLa_(0.98-x)Ga_(3)O_(7)(x=0.01) has an internal quantum efficiency(IQE) of 46.94% and an external quantum efficiency(EQE) of 15.19%.Most notably,the prepared phosphor demonstrates excellent thermal stability and a high activation energy(0.203 eV).In addition,the International Illumination Commission color coordinates of the Dy^(3+):LuxCaLa_(0.98-x)Ga_(3)O_(7) phosphors are in the yellow light *** above analysis indicates that the Dy^(3+):LuxCaLa_(0.98-x)Ga_(3)O_(7)(x=0.001)phosphor has promising application prospects in yellow light-emitting devices.

关键词： Dy^(3+):Lu_(x)CaLa_(0.98-x)Ga_(3)O_(7)phosphors Yellow emission Structure characteristics Luminescent properties Rare earths

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