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Photopic pupil size change in myopic orthokeratology and its influence on axial length elongation

International Journal of Ophthalmology(English edition) 2022年第8期15卷 1322-1330页

作者： meng-Jun zhu Li Ding Lin-Lin Du Jun Chen Xian-Gui He Shan-Shan Li Hai-Dong Zou Shanghai Eye Disease Prevention&Treatment Center/Shanghai Eye Hospital Shanghai 200040China Shanghai General Hospital National Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China

AIM:To explore the photopic pupil size behavior in myopic children undergoing overnight orthokeratology(ortho-k)over 1-year period and its effects on the axial ***:A total of 202 Chinese myopic children were enrolled in this prospective clinical *** subjects in ortho-k group and eighty-eight subjects in spectacle group completed the 1-year *** length(AL)was measured before enrollment and every 6mo after the start of *** photopic pupil diameter(PPD)was determined using the Pentacam AXL and measured in an examination room with lighting of 300-310 *** multiple linear regression analysis was used to identify variables contribution to axial ***:Compared with spectacle group,the average 1-year axial elongation was significantly slower in the ortho-k group(0.25±0.27 vs 0.44±0.23 mm,P0.05,Bonferroni correction).The 4.81 mm PPD may be a possible cutoff point in the ortho-k *** with PPD below or equal to 4.81 mm tended to have smaller axial elongation compared to subjects with PPD above 4.81 mm after 1-year period(t=-3.09,P=0.003).In ortho-k group,univariate analyses indicated that those with older age,greater degree of myopia,longer AL,smaller baseline PPD(PPDbaseline)experienced a smaller change in *** multivariate analyses,older age,greater AL and smaller PPDbaseline were associated with smaller increases in *** spectacle group,PPD tended to be stable(P>0.05,Bonferroni correction)and did not affect axial ***:PPDs experience significantly decreases at 1-month and 3-month ortho-k *** with smaller PPD tend to experience slower axial elongation and may benefit more from ortho-k.

关键词： orthokeratology myopia axial length pupil diameter accommodation

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PagGRF12a interacts with PagGIF1b to regulate secondary xylem development through modulating PagXND1a expression in Populus alba×***

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Journal of Integrative Plant Biology 2021年第10期63卷 1683-1694页

作者： Jinnan Wang Houjun Zhou Yanqiu Zhao Cheng Jiang Jihong Li Fang Tang Yingli Liu Shutang Zhao Jianjun Hu Xueqin Song mengzhu Lu State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of the State ForestryAdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China Key Laboratory of Agricultural Ecology and Environment College of ForestryShandong Agricultural UniversityTai'an 271018China School of Agriculture Ludong UniversityYantai 264025China State Key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang Agriculture&Forestry UniversityHangzhou 311300China CoInnovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037China

Growth-regulating factors(GRFs)are important regulators of plant development and growth,but their possible roles in xylem development in woody plants remain ***,we report that Populus alba×Papulus glandulosa PagGRF12a negatively regulates xylem development in ***12a is expressed in vascular *** to non-transgenic control plants,transgenic poplar plants overexpressing PagGRF12a exhibited reduced xylem width and plants with repressed expression of PagGRF12a exhibited increased xylem *** NAC domain 1(XND1)encodes a NAC domain transcription factor that regulates xylem development and transcriptional analyses revealed that PagXND1a is highly upregulated in PagGRF12a-overexpressing plants and downregulated in PagGRF12a-suppressed plants,indicating that PagGRF12a may regulate xylem development through *** transcriptional assays and chromatin immunoprecipitation-polymerase chain reaction assays confirmed that PagGRF12a directly upregulates *** addition,PagGRF12a interacts with the GRF-Interacting Factor(GIF)PagGIF1b,and this interaction enhances the effects of PagGRF12a on *** results indicate that PagGRF12a inhibits xylem development by upregulating the expression of PagXND1a.

关键词： GRF GIF1 Populus wood formation XND1 xylem development

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Several Applications of MEMS in Fluid Area

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International Journal of Plant Engineering and Management 2017年第2期22卷 84-90页

作者： zhu meng-nan CAO Yun zhu Hui-jun School of Energy and Power Engineering Jiangsu University

In order to discuss the several applications of MEMS in fluid area,study the components of *** introduce the principles,types and applications based on flow sensor and pressure sensor. In the last,discuss the problems... 详细信息

关键词： MEMS fluid flow sensor pressure sensor applications

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3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking

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Bioactive Materials 2020年第4期5卷 808-818页

作者： Tian Hu Xiaoliang Cui meng zhu Man Wu Ye Tian Bin Yao Wei Song Zhongwei Niu Sha Huang Xiaobing Fu Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College28 Fu Xing RoadBeijing100853PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU05151 Fu Cheng RoadBeijing100048PR China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Chinese Academy of Medical Sciences(CAMS)Oxford Institute Nuffield Department of MedicineUniversity of OxfordOxford OX39DSUK School of Future Technology University of Chinese Academy of SciencesBeijing100049PR China

3-dimensional(3D)bioprinting technology provides promising strategy in the fabrication of artificial tissues and *** the fundamental element in bioprinting process,preparation of bioink with ideal mechanical properties without sacrifice of biocompatibility is a great *** this study,a supramolecular hydrogel-based bioink is prepared by polyethylene glycol(PEG)grafted chitosan,α-cyclodextrin(α-CD)and *** has a primary crosslinking structure through the aggregation of the pseudo-polyrotaxane-like side chains,which are formed from the host-guest interactions betweenα-CD and PEG side *** viscosity measurement shows the shear-shinning property of this bioink,which might be due to the reversibility of the physical ***,withβ-glycerophosphate at different concentrations as the secondary crosslinking agent,the printed constructs demonstrate different Young's modulus(p<0.001).They could also maintain the Young's modulus in cell culture condition for at least 21 days(p<0.05).By co-culturing each component with fibroblasts,CCK-8 assay demonstrate cellular viability is higher than 80%.After bioprinting and culturing,immunofluorescence staining with quantification indicate the expression of Ki-67,Paxillin,and N-cadherin is higher in day 14 than those in day 3(p<0.05).Oil red O and Nissl body specific staining reflect strength tunable bioink may have impact on the cell fate of mesenchymal stem cells(p<0.05).This work might provide new idea for advanced bioink in the application of re-establishing complicated tissues and organs.

关键词： Supramolecular hydrogel Bioink Tunable strength 3D bioprinting

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Design,synthesis and evaluation of PPAR gamma binding activity of 2-thioxo-4-thiazolidinone derivatives

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Chinese Chemical Letters 2015年第1期26卷 63-68页

作者： Li Zhou Ye Zhong meng-zhu Xue Dong Kuang Xian-Wen Cao Zhen-Jiang Zhao Hong-Lin Li Yu-Fang Xu Rui Wang Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and Technology

We designed and synthesized a series of 2-thioxo-4-thiazolidinone derivatives and evaluated them on peroxisome proliferator activated receptor γ（PPARγ） binding *** the biological assays,compounds 18 and 38 were highlighted with K_i values of 12.15 nmol/Land 14.46 nmol/L,*** structure-activity relationship（SAR） was analyzed to screen privileged structural ***,molecular fitting of these compounds onto the approved drug Rosightazone in the PPARγligand binding domain was performed to elucidate the SAR and explore potential receptor-ligand *** results demonstrate that the 2-thioxo-4-thiazolidinones can be considered as new promising molecular probes with excellent binding activities to PPARγ.

关键词： 2-Thioxo-4-thiazolidinone Peroxisome proliferator activated receptorγ Binding activities SAR Molecular docking

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The Ca^(2+)-dependent DNases are Involved in Secondary Xylem Development in Eucommia ulmoides

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Journal of Integrative Plant Biology 2012年第7期54卷 456-470页

作者： Hui-Min Chen Yu Pang Jun Zeng Qi Ding Shen-Yi Yin Chao Liu meng-zhu Lu Ke-Ming Cui Xin-Qiang He State KeyLaboratory of Protein and Plant Gene Research College of Life SciencesPeking UniversityBeijing 100871China Laboratory of Biotechnology Research Institute of ForestryChinese Academy of ForestryBeijing 100091China

Secondary xylem development has long been recognized as a typical case of programmed cell death （PCD） in plants. During PCD, the degradation of genomic DNA is catalyzed by endonucleases. However, to date, no endonuclease has been shown to participate in secondary xylem development. Two novel Ca^2＋-dependent DNase genes, EuCaN1 and EuCaN2, were identified from the differentiating secondary xylem of the tree Eucommia ulmoides Oliv., their functions were studied by DNase activity assay, in situ hybridization, protein immunolocalization and virus-induced gene silencing experiments. Full-length cDNAs of EuCaN1 and EuCaN2 contained an open reading frame of 987 bp, encoding two proteins of 328 amino acids with SNase-like functional domains. The genomic DNA sequence for EuCaN1 had no introns, while EuCaN2 had 8 introns. EuCaN1 and EuCaN2 digested ssDNA and dsDNA with Ca^2＋-dependence at neutral pH. Their expression was confined to differentiating secondary xylem cells and the proteins were localized in the nucleus. Their activity dynamics was closely correlated with secondary xylem development. Secondary xylem cell differentiation is influenced by RNAi of endonuclease genes. The results provide evidence that the Ca^2＋-dependent DNases are involved in secondary xylem development.

关键词： Ca^2+-dependent DNase programmed cell death secondary xylem development secondary wall formation Eucommia ulmoides.

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The role of senescence-associated gene101 (PagSAG101a) in the regulation of secondary xylem formation in poplar

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Journal of Integrative Plant Biology 2022年第1期64卷 73-86页

作者： Hui He Xue-Qin Song Cheng Jiang Ying-Li Liu Dian Wang Shuang-Shuang Wen Guo-Hua Chai Shu-Tang Zhao meng-zhu Lu State Key Laboratory of Tree Genetics and Breeding Research Institute of ForestryChinese Academy of ForestryBeijing 100091China State Key Laboratory of Subtropical Silviculture College of Forestry and BiotechnologyZhejiang A&F UniversityHangzhou 311300China College of Agronomy Qingdao Agricultural UniversityQingdao 266109China College of Resources and Environment Qingdao Agricultural UniversityQingdao 266109China Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037China

Wood is produced by the accumulation of secondary xylem via proliferation and differentiation of the cambium cells in woody plants. Identifying the regulators involved in this process remains a challenging task. In this study, we isolated Pag SAG101 a,the homolog of Arabidopsis thaliana SAG101, from a hybrid poplar(Populus alba × Populus glandulosa)clone 84 K and investigated its role in secondary xylem development. Pag SAG101 a was expressed predominantly in lignified stems and localized in thenucleus. Compared with non-transgenic 84 K plants,transgenic plants overexpressing Pag SAG101 a displayed increased plant height, internode number,stem diameter, xylem width, and secondary cell wall thickness, while opposite phenotypes were observed for Pag SAG101 a knock-out *** analyses revealed that differentially expressed genes were enriched for those controlling cambium cell division activity and subsequent secondary cell wall deposition during xylem *** addition, the tandem CCCH zinc finger protein Pag C3 H17, which positively regulates secondary xylem width and secondary wall thickening in poplar, could bind to the promoter of Pag SAG101 a and mediate the regulation of xylem *** results support that Pag SAG101 a, downstream of Pag C3 H17, functions in wood development.

关键词： cambium PagSAG101a Populus secondary cell wall xylem formation

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Modelling State Foreign Exchange Reserves under the Managed Floating Exchange Rate System in China

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Systems Science and Systems Engineering 2000年第3期10卷 280-289页

作者： WEI Wei\|xian,\ zhu meng\|nan Institute of Finance, Xiamen University, Xiamen 361005, China

The purpose of this paper is to investigate China′s state foreign exchange reserves growth using monthly data in the period January 1994 to December 1998. An economic model is constructed, with a view from its formation mechanism. Time series techniques are used to examine the long run relationship between foreign exchange reserves and the variables included in the model. Our empirical investigation revealed existence of a systematic long run relationship among foreign exchange reserves, exports, imports, and foreign direct investment. In the short run, the Asian financial crises have not significant effect on China′s foreign exchange reserves. Moreover, the recursive tests results indicated that the error correction model was structurally stable over the sample period, implying that the reserve holdings play a significant role in the balance payments adjustment process and separating China economy from the Asian financial crises.

关键词： China′s foreign exchange reserves managed floating exchange rate domestic foreign exchange market

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基于冲突预测的多自动导引小车避碰决策优化

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计算机集成制造系统 2020年第8期26卷 2092-2098页

作者：曹小华朱孟武汉理工大学物流工程学院湖北武汉430063

为有效解决路径冲突和避碰问题,提高多自动导引小车(AGV)系统的作业效率,提出基于冲突预测的多AGV避碰决策优化方法。结合图论提出一种基于顶点属性和实时位姿信息的冲突预测方法,在考虑路网全局状态的基础上建立避碰决策的数学评价模型... 详细信息

为有效解决路径冲突和避碰问题,提高多自动导引小车(AGV)系统的作业效率,提出基于冲突预测的多AGV避碰决策优化方法。结合图论提出一种基于顶点属性和实时位姿信息的冲突预测方法,在考虑路网全局状态的基础上建立避碰决策的数学评价模型,提出一种适用于多AGV系统避碰决策优化的改进粒子群优化算法,通过优化粒子运动的速度和方向避免优化算法过早收敛。采用融合遗传算法的变异思想为粒子引入变异操作,改善优化算法的全局搜索能力。最后通过实验测试表明,该优化方法可以有效解决多AGV系统路径冲突问题,还能缩短避碰过程中AGV的等待总时长,提高多AGV系统运行的安全性与效率。

关键词：多自动导引小车冲突预测顶点属性改进粒子群优化算法

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Allosteric regulation of Keap1 by 8β-hydroxy-acyclocostunolide for the treatment of acute lung injury

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4174-4178页

作者： Juan Zhang Min Zhang Qi-meng zhu Xin-Rong Xu Yan-Li Feng Sheng Lin Feng Qiu Cheng-Peng Sun School of Chinese Materia Medic1 Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

To the Editor:Acute lung injury(ALI)is a debilitating lung disease characterized by pulmonary edema,diffuse alveolar damage,and uncontrolled neutrophil infiltration^(1).Severe cases of ALI can potentially lead to the development of acute respiratory distress syndrome(ARDS),which can lead to impaired respiratory function,multiorgan dysfunction,and an extremely high mortality rate^(2-4).ALI may be caused by various factors,including aspiration,severe pneumonia,sepsis,trauma,fatty embolism,pancreatitis,and blood transfusion^(3).Current clinical approaches to treating ALI/ARDS include mechanical ventilation,extracorporeal membrane oxygenation(ECMO),and other supportive therapies^(5,6).Therefore,ALI/ARDS is an urgent problem that needs to be addressed in the field of respiratory critical care and innovative mechanisms and therapies^(6).

关键词： Macrophage overactivation Keap1 8β-Hydroxy-a-cyclocostunolide Nrf2 Acute lung injury

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