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Effect of defects properties on InP-based high electron mobility transistors

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Chinese Physics B 2019年第7期28卷 529-533页

作者： Shu-Xiang Sun Ming-Ming Chang meng-ke li liu-Hong Ma Ying-Hui Zhong Yu-Xiao li Peng Ding Zhi Jin Zhi-Chao Wei School of Physics and Engineering Zhengzhou University Zhengzhou 450001 China Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China China Academy of Space Technology Beijing 100086 China

The performance damage mechanism of InP-based high electron mobility transistors(HEMTs) after proton irradiation has been investigated comprehensively through induced *** effects of the defect type, defect energy level with respect to conduction band ET, and defect concentration on the transfer and output characteristics of the device are discussed based on hydrodynamic model and Shockley–Read–Hall recombination *** results indicate that only acceptorlike defects have a significant influence on device ***, as defect energy level ETshifts away from conduction band, the drain current decreases gradually and finally reaches a saturation value with ETabove 0.5 *** can be attributed to the fact that at sufficient deep level, acceptor-type defects could not be ionized any ***,the drain current and transconductance degrade more severely with larger acceptor *** changes of the electrical characteristics with proton radiation could be accounted for by the electron density reduction in the channel region from induced acceptor-like defects.

关键词： InP-based high electron mobility transistor proton radiation defects properties output and transfer characteristics

Enhancement of radiation hardness of InP-based HEMT with double Si-doped plane

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Chinese Physics B 2020年第3期29卷 455-459页

作者： Ying-Hui Zhong Bo Yang Ming-Ming Chang Peng Ding liu-Hong Ma meng-ke li Zhi-Yong Duan Jie Yang Zhi Jin Zhi-Chao Wei School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China China Academy of Space Technology Beijing 100086China

An anti-radiation structure of In P-based high electron mobility transistor(HEMT) has been proposed and optimized with double Si-doped planes. The additional Si-doped plane under channel layer has made a huge promotion in channel current, transconductance, current gain cut-off frequency, and maximum oscillation frequency of In P-based HEMTs. Moreover, direct current(DC) and radio frequency(RF) characteristic properties and their reduction rates have been compared in detail between single Si-doped and double Si-doped structures after 75-keV proton irradiation with dose of 5× 10^(11) cm^(-2),1× 10^(12) cm^(-2), and 5× 10^(12) cm^(-2). DC and RF characteristics for both structures are observed to decrease gradually as irradiation dose rises, which particularly show a drastic drop at dose of 5× 10^(12) cm^(-2). Besides, characteristic degradation degree of the double Si-doped structure is significantly lower than that of the single Si-doped structure, especially at large proton irradiation dose. The enhancement of proton radiation tolerance by the insertion of another Si-doped plane could be accounted for the tremendously increased native carriers, which are bound to weaken substantially the carrier removal effect by irradiation-induced defects.

关键词： InP-based HEMT anti-radiation proton irradiation Si-doped plane

Fast Fourier Transform-based Support Vector Machine for Prediction of G-protein Coupled Receptor Subfamilies

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 759-766页

作者： Yan-Zhi GUO meng-Long li ke-Long WANG Zhi-Ning WEN Min-Chun LU li-Xia liU lin JIANG College of Chemistry,Sichuan University,Chengdu 610064,China College of Chemistry Sichuan UniversityChengdu 610064China

Although the sequence information on G-protein coupled receptors(GPCRs)continues togrow,many GPCRs remain orphaned(*** specificity unknown)or poorly characterized with littlestructural information available,so an automated and reliable method is badly needed to facilitate the identifi-cation of novel *** this study,a method of fast Fourier transform-based support vector machinehas been developed for predicting GPCR subfamilies according to protein’s *** classifyingClass B,C,D and F subfamilies,the method achieved an overall Matthew’s correlation coefficient andaccuracy of 0.95 and 93.3%,respectively,when evaluated using the jackknife *** method achieved anaccuracy of 100% on the Class B independent *** results show that this method can classify GPCRsubfamilies as well as their functional classification with high accuracy.A web server implementing theprediction is available at http://***/blast/Pred-GPCR.

关键词： G-protein coupled receptor subfamily fast Fourier transform support vector machine prediction

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI ke XIE meng XIA Huarong CHENG Anyu liU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao lingyan meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu Zhu Rong-Hua Yu Shuai Zhou Pei-Pei Tang Rui Zhang Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-li Zhang meng-ke li Xiao-Jing Shi Yu-Wei Zhang Guang-Zhi liu Rick FThorne Xu Dong Zhang Mian Wu Song Chen School of life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research Institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China Institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical Sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

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不同工况蚯蚓人工湿地表层污泥处理效果

环境科学 2017年第3期38卷 1159-1166页

作者：董梦珂李怀正徐一啸同济大学环境科学与工程学院上海200092

通过在传统污泥干化湿地中投加蚯蚓,研究了蚯蚓人工湿地处理污泥技术的可操作性;同时研究了不同污泥负荷48、65、80 kg·(m^2·a)^(-1)、不同蚯蚓投放密度0、0.43、0.54、0.65 kg·m^(-2)以及不同进泥频率等工况条件下,该模拟湿地装置... 详细信息

通过在传统污泥干化湿地中投加蚯蚓,研究了蚯蚓人工湿地处理污泥技术的可操作性;同时研究了不同污泥负荷48、65、80 kg·(m^2·a)^(-1)、不同蚯蚓投放密度0、0.43、0.54、0.65 kg·m^(-2)以及不同进泥频率等工况条件下,该模拟湿地装置表层污泥的脱水和稳定化效果.结果表明,通过设置入土深度为10 mm的挡板,能够提供蚯蚓在进泥期间的栖身之所,保证蚯蚓湿地的正常运行;蚯蚓的加入能够显著改善人工湿地污泥干化和稳定化的效能,使表层污泥脱氢酶活性(dehydrogenase activity,DHA)更低,含水率和VS分别下降了15%和10%左右,并且在0.65 kg·m^(-2)的蚯蚓投放密度下,蚯蚓人工湿地的稳定化效果最好.随着污泥负荷的增加以及进泥频率的降低,蚯蚓人工湿地运行效能会变差.

关键词：人工湿地污泥干化床蚯蚓污泥脱水污泥稳定化

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing li Zixuan He Weitai Chai meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can Zhu Yiyang Wang Lei meng Beibei Qiu Jing li Shucheng Qin ke Hu Xin Jiang Wenbin Lai Minchao liu Zhe liu Chenxing Lu Jinyuan Zhang Yongfang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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