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Molecular mechanisms of *** associated gastric carcinogenesis

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World Journal of Gastroenterology 1999年第5期5卷 369-374页

作者： Zhang ZW Farthing mj St Bartholomew's & the Royal London School of Medicine & Dentistry 英国

Does in-house availability of multidisciplinary teams increase survival in upper gastrointestinal-cancer?

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World Journal of Gastrointestinal Oncology 2013年第3期5卷 60-67页

作者： Christian Kersten Milada Cvancarova Svein mjland Odd mjland Department of Oncology Southern Hospital Trust the Centre for Cancer Treatment Department of Oncology Southern Hospital Trust the Section of Abdominal Surgery Department of Abdominal Surgery Southern Hospital Trust

AIM: To investigate the effect of the establishment of in-house multidisciplinary team (MDT) availability (iMDTa) on survival in upper gastrointestinal cancer (UGI) patients. METHODS: In 2001, a cancer centre with irradiation and chemotherapy facilities was established in the Norwegian county of West Agder with a change of iMDTa (WA/MDT-Change). "iMDTa"-status was defined according to the availability of the necessary specialists within one institution on one campus, serving the population of one county. We compared survival rates during 2000-2008 for UGI patients living in counties with (MDT-Yes), without (MDT-No), with a mix (MDT-Mix) and WA/MDT-Change. Survival was calculated with Kaplan-Meier method. Cox model was used to uncover differences between counties with different MDT status when adjusted for age, sex and stage. RESULTS: We analyzed 395 patients from WA/MDT-Change and compared their survival to 12 135 UGIpatients from four other Norwegian regions. Median overall survival for UGI patients in WA/MDT-Change increased from 129 to 300 d from 2000-2008, P = 0.001. The regions with the highest level of iMDTa achieved the largest decrease in risk of death for UGI cancers (compared to the county with MDT-Mix: MDT-Yes 11%, P <0.05 and WA/MDT-Change 15%, P < 0.05). Analyzing the different tumour entities separately, patients living in the WA/MDT-Change county reached a statisti-cally significant reduction in the risk of death [hazard ratios (HR)] compared to patients in the county with MDT-Mix for oesophageal and gastric, but not for pan-creatic cancer. HR for the study period 2000-2004 are given first and then for the period 2005-2008: The HR for oesophageal cancers was reduced from [HR = 1.12; 95%CI: 0.75-1.68 to HR = 0.60, 95%CI: 0.38-0.95] and for gastric cancers from [HR = 0.87, 95%CI: 0.66-1.15 to HR = 0.63, 95%CI: 0.43-0.93], but not for pancreatic cancer [HR = 1.04-, 95%CI: 0.83-1.3 for 2000-2004 and HR = 1.01, 95%CI: 0.78-1.3 for 2005-2008]. UGI patients

关键词： Gastric cancer Gastroesophageal cancer Oesophageal cancer Pancreatic cancer Multidisci-plinary treatment Multidisciplinary team Survival

ON SEVERAL NEW METHODS TO POLAR DECOMPOSITION COMPUTATION

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Acta Mechanica Solida Sinica 1998年第4期11卷 329-340页

作者： Huang, mj Li, M Fu, MF Nanchang Univ Inst Engn Mech Nanchang 330029 Peoples R China

In this paper, the polar decomposition of a deformation gradient tensor is analyzed in detail. The four new methods for polar decompositioncomputation are given: (1) the iterated method, (2) the principal invariant's method, (3) the principal rotation axis' s method, (4) the coordinate transformation's method. The iterated method makes it possible to establish the nonlinear finite element method based on polar decomposition. Furthermore, the material time derivatives of the stretch tensor and the rotation tensor are obtained by explicit and simple expressions.

关键词： polar decomposition deformation gradient stretch tensor rotation tensor large deformation and large rotation

Hip prosthetic loosening:A very personal review

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World Journal of Orthopedics 2021年第9期12卷 629-639页

作者： Bengt mjöberg Department of Orthopedics Lund UniversityLund SE-22100Sweden

Hip prosthetic loosening is often difficult to detect at an early stage,and there has been uncertainty for a long time as to when the loosening occurs and thus to the basic *** comparing different diagnostic methods,we found that loosening is best defined as prosthetic migration and measured by radiostereometric *** evidence indicates that poor interlock,poor bone quality,and resorption of a necrotic bone bed may initiate loosening during or shortly after surgery;this forms the basis of the theory of early *** factors do affect the subsequent progression of loosening,which may increase subclinically during a long period of ***,the loosening may be detected on standard radiographs and may be interpreted as late loosening but should to be interpreted as late detection of *** theory of early loosening explains the rapid early migration,the development of periprosthetic osteolysis and granulomas,the causality between wear and loosening,and largely the epidemiology of clinical failure of hip *** discussed are definition of loosening,the pattern of early migration,the choice of migration threshold,the current understanding of loosening,a less exothermic bone cement,cemented taper-slip stems,a new exciting computed tomography-based technique for simpler implant migration studies,and research suggestions.

关键词： Hip prosthesis Prosthesis failure Radiostereometric analysis Bone resorption Bone cements Radionuclide imaging

In Memorium John ***(1919-2002)

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Episodes 2003年第1期26卷 47-48页

作者： Gryc, G Terman, mj US Geol Survey MS 975 Menlo Pk CA 94025 USA US Geol Survey MS 917 Reston VA USA

Hip prosthetic loosening and periprosthetic osteolysis:A commentary

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World Journal of Orthopedics 2022年第6期13卷 574-577页

作者： Bengt mjöberg Department of Orthopedics Lund UniversityLund SE-22100Sweden

Prosthetic loosening and periprosthetic osteolysis have been debated for decades,both in terms of the timing and nature of the triggering *** hypothesis of wear-particle-induced loosening states that wear particles cause a foreign-body response leading to periprosthetic osteolysis and ultimately to late prosthetic loosening,i.e.,that the osteolysis precedes the *** theory of early loosening,on the other hand,postulates that the loosening is already initiated during or shortly after surgery,i.e.,that the osteolysis is secondary to the *** commentary focuses on the causal relationship between prosthetic loosening and periprosthetic osteolysis.

关键词： Hip prosthesis Radiostereometric analysis Prosthesis failure Osteoclasts Bone resorption Alarmins

The　Fallacy　of　Using　Chiral　Shift　Reagents　to　Differentiate　d，l　and　meso　Isomers

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Chinese Chemical Letters 1996年第11期7卷 1003-1004页

作者： Zhang, JW Guo, JY Liang, XT Lu, mj CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION MED COLL BEIJING 100050PEOPLES R CHINA BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

A d,I mixture (R-R and S-S) can be resolved into the d and the I enantiomers. while the mesoisomer (R-S, identical with S-R) cannot be physically separated. This fact has occasionally been 'extrapolated' to differentiate d,l and meso isomers with a chiral shift reagent where the meso isomer is presumed not to show any signal 'doubling' during the (usually) downfield shift. This assumption hasbeen shown to be incorrect by the behavior of a meso molecule which does give signal 'doubling'.

关键词： Fallacy Using The Differentiate Chiral

Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： mj Mahesh Kumar Shailendra Arindkar Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk

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World Journal of Gastroenterology 2009年第36期15卷 4561-4565页

作者： Juliёt H Hoff Rene HM te Morsche Hennie mj Roelofs Elise mj van der Logt Fokko M Nagengast Wilbert HM Peters Department of Gastroenterology Radboud University Nijmegen Medical Center6500 HB NijmegenThe Netherlands

AIM： TO determine the possible modulating effect of the COX-2 polymorphisms, -765G→C and -1195A→G, on the risk of colorectal cancer （CRC） in a Dutch population. METHODS： This case-control study includes 326 patients with CRC and 369 age- and gender-matched controls. Genotypes of the COX-2 polymorphisms -7dEG→C and -1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism. COX-2 genotypes and haplotypes were analyzed and odds ratios with 95% confidence intervals were estimated by logistic regression. RESULTS： The -765GG genotype was associated with an increased risk of developing CRC （OR, 1.45; 95% CI, 1.03-2.04）. No significant difference was observed in the genotype distribution of the -1195A→G polymorphism between patients and controls. The GG/AC haplotype was present significantly less often in patients than in controls （OR 0.44; 95% CI, 0.22-0.85）. When the AC, AG and GG haplotypes were investigated separately, the AC haplotype showed a tendency to be less frequent in patients than in controls （OR（AG/AC） 0.78; 95% CI, 0.57-1.06）. CONCLUSION： The -765GG genotype is associated with an increased risk of developing CRC and the G6/ AC haplotype seems to protect against CRC. These findings suggest a modulating role for the COX-2 polymorphisms -765G→C and -1195A→G in the development of CRC in a Dutch population.

关键词： Colorectal carcinoma Cyclooxygenase-2 Genetic polymorphism