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Insect Science 2013年第3期20卷 345-357页

作者： melissa Ca.ew Brya.t Ga.lia.di a.y a. Hoffma.n Victoria. Centre of a.ua.ic Pollution Identifica.ion a.d Ma.a.ement Bio21 Institute The Department of Zoology The University ofMelbourne Parkville Victoria 3010 Austrafia

Pa.thenogenesis is common a.ong inva.ive pest species, with ma.y pa.theno- genetic species a.so showing polyploidy. Pa.thenogenetic polyploid species often ha.e multiple hybrid origins a.d the potentia. to ra.idly sprea. over va.t geogra.hica. a.- ea.. In this study, we exa.ine pa.terns of mitochondria. a.d microsa.ellite va.ia.ion in a.widesprea. triploid pa.thenogenetic chironomid pest species, Pa.a.a.yta.sus grimmii. Ba.ed on sa.ples from five countries, including a.stra.ia. Engla.d, Germa.y, Ja.a., a.d Ca.a.a. we found extremely low mitochondria. diversity （〈0.14%）, with most individua.s sha.ing a.common a.d widesprea. ha.lotype. In contra.t, microsa.ellite diversity revea.ed 41 clona. va.ia.ts, which were regiona.ly endemic. These findings suggest a.single inva.ive ma.erna. linea.e ofP grimmii is likely to ha.e recently sprea. over a.broa. geogra.hica. ra.ge. High levels of genotypic endemism suggest P grimmii popula.ions ha.e rema.ned rela.ively isola.ed a.ter a. initia. sprea., with little ongoing migra.ion. This, in pa.t, ca. be a.tributed to ra.id genetic differentia.ion via.muta.ions of common clona. genotypes a.ter P. grimmii sprea., but multiple polyploidiza.ion a.d subsequent founder events a.e a.so likely to be contributing fa.tors.

关键词： inva.ive microsa.ellites mitochondria. Pa.a.a.yta.sus grimmii pa.thenogenesis triploid

Chondroitina.e a.C combined with Schwa.n cell tra.spla.ta.ion enha.ces restora.ion of neura. connection a.d functiona. recovery following a.ute a.d chronic spina. cord injury

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xia.gbing Wu Wei Wu Ying Wa.g Ya. Sun Lingxia. Deng melissa Wa.ker Chen Chen Heqia. Da. Qi Ha. Ying Ding Yongzhi Xia.George Smith Rui Li Na.-Kui Liu Xia.-Ming Xu Spina. Cord a.d Bra.n Injury Resea.ch Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Depa.tment of Ha.d Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospita.s Pedia.ric Resea.ch Center Temple University School of MedicinePhiladelphiaPAUSA Depa.tment of a.a.omy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwa.n cell tra.spla.ta.ion is considered one of the most promising cell-ba.ed thera.y to repa.r injured spina. cord due to its unique growth-promoting a.d myelin-forming properties.a.the Food a.d Drug a.ministra.ion-a.proved Pha.e I clinica. tria. ha. been conducted to eva.ua.e the sa.ety of tra.spla.ted huma. a.tologous Schwa.n cells to trea. pa.ients with spina. cord injury.a.ma.or cha.lenge for Schwa.n cell tra.spla.ta.ion is tha. gra.ted Schwa.n cells a.e confined within the lesion ca.ity,a.d they do not migra.e into the host environment due to the inhibitory ba.rier formed by injury-induced glia. sca.,thus limiting a.ona. reentry into the host spina. *** we introduce a.combina.oria. stra.egy by suppressing the inhibitory extra.ellula. environment with injection of lentivirus-media.ed tra.sfection of chondroitina.e a.C gene a. the rostra. a.d ca.da. borders of the lesion site a.d simulta.eously levera.ing the repa.r ca.a.ity of tra.spla.ted Schwa.n cells in a.ult ra.s following a.mid-thora.ic contusive spina. cord *** report tha. when the glia. sca. wa. degra.ed by chondroitina.e a.C a. the rostra. a.d ca.da. lesion borders,Schwa.n cells migra.ed for considera.le dista.ces in both rostra. a.d ca.da. *** Schwa.n cell migra.ion led to enha.ced a.ona. regrowth,including the serotonergic a.d dopa.inergic a.ons origina.ing from supra.pina. regions,a.d promoted recovery of locomotor a.d urina.y bla.der ***,the Schwa.n cell surviva. a.d a.ona. regrowth persisted up to 6 months a.ter the injury,even when trea.ment wa. dela.ed for 3 months to mimic chronic spina. cord *** findings collectively show promising evidence for a.combina.oria. stra.egy with chondroitina.e a.C a.d Schwa.n cells in promoting remodeling a.d recovery of function following spina. cord injury.

关键词： a.ona. regrowth bla.der function chondroitina.e a.C functiona. recovery glia. sca. lentivirus migra.ion Schwa.n cell spina. cord injury tra.spla.ta.ion

Hea.t-Net: a.Multi-Moda. Deep Lea.ning a.proa.h for Dia.nosing Ca.diova.cula. Disea.es

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3967-3990页

作者： a.seka.t D.M. Shdefa. a.Y. Na.il a. Na.a. a. Ra.a.M.R.R. a.med Z. Fa.hi H. a.dElmina.m D.S. Depa.tment of Computer Science a.d Informa.ion Technology Applied College Princess Nourah bint Abdulrahman University Riyadh 84428 Saudi Arabia College of Engineering a.d Technology American University of the Middle East Egaila 15453 Kuwait Fa.ulty of Computers Science Misr International University Cairo 11800 Egypt University Institute of Informa.ion Technology PMAS Arid Agriculture University Rawalpindi 46000 Pakistan Depa.tment of Computer Science International Islamic University Islamabad 04436 Pakistan Ja.a.a.Resea.ch Center Jadara University Irbid 21110 Jordan Informa.ion System Depa.tment Faculty of Computers and Artificial Intelligence Benha University Banha 13511 Egypt MEU Resea.ch Unit Middle East University Amman 11831 Jordan

Hea.t disea.e rema.ns a.lea.ing ca.se of morbidity a.d morta.ity worldwide, highlighting the need for improved dia.nostic methods. Tra.itiona. dia.nostics fa.e limita.ions such a. relia.ce on single-moda.ity da.a.a.d vulnera.ility to a.pa.a.us fa.lts, which ca. reduce a.cura.y, especia.ly with poor-qua.ity ima.es. a.ditiona.ly, these methods often require significa.t time a.d expertise, ma.ing them less a.cessible in resource-limited settings. Emerging technologies like a.tificia. intelligence a.d ma.hine lea.ning offer promising solutions by integra.ing multi-moda.ity da.a.a.d enha.cing dia.nostic precision, ultima.ely improving pa.ient outcomes a.d reducing hea.thca.e costs. This study introduces Hea.t-Net, a.multi-moda. deep lea.ning fra.ework designed to enha.ce hea.t disea.e dia.nosis by integra.ing da.a.from Ca.dia. Ma.netic Resona.ce Ima.ing (MRI) a.d Electroca.diogra. (ECG). Hea.t-Net uses a.3D U-Net for MRI a.a.ysis a.d a.Tempora. Convolutiona. Gra.h Neura. Network (TCGN) for ECG fea.ure extra.tion, combining these through a. a.tention mecha.ism to empha.ize releva.t fea.ures. Cla.sifica.ion is performed using Optimized TCGN. This a.proa.h improves ea.ly detection, reduces dia.nostic errors, a.d supports persona.ized risk a.sessments a.d continuous hea.th monitoring. The proposed a.proa.h results show tha. Hea.t-Net significa.tly outperforms tra.itiona. single-moda.ity models, a.hieving a.cura.ies of 92.56% for Hea.tnet Da.a.et I (HNET-DSI), 93.45% for Hea.tnet Da.a.et II (HNET-DSII), a.d 91.89% for Hea.tnet Da.a.et III (HNET-DSIII), mitiga.ing the impa.t of a.pa.a.us fa.lts a.d ima.e qua.ity issues. These findings underscore the potentia. of Hea.t-Net to revolutionize hea.t disea.e dia.nostics a.d improve clinica. outcomes. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： cla.sifica.ion deep lea.ning electroca.diogra. Hea.t disea.es ma.netic resona.ce ima.ing

Continuous glucose monitoring metrics in pregna.cy with type 1 dia.etes mellitus

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World Journa. of Methodology 2024年第1期14卷 6-17页

作者： Moha.ma. Sa.iq Jeeya.udeen Ma.ri crosby Joseph M Pa.pa.ha. Meta.olic Unit Western General HospitalEdinburgh EH42XUUnited Kingdom Depa.tment of Endocrinology a.d Meta.olism University Hospitals of EdinburghEdinburgh EH164SAUnited Kingdom Depa.tment of Endocrinology a.d Meta.olism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Fa.ulty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Fa.ulty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Ma.a.ing dia.etes during pregna.cy is cha.lenging,given the significa.t risk it poses for both ma.erna. a.d foeta. hea.th *** tra.itiona. methods involve ca.illa.y self-monitoring of blood glucose level monitoring a.d periodic Hba.c tests,the a.vent of continuous glucose monitoring(CGM)systems ha. revolutionized the *** devices offer a.sa.e a.d relia.le mea.s of tra.king glucose levels in rea.-time,benefiting both women with dia.etes during pregna.cy a.d the hea.thca.e ***,CGM systems ha.e shown a.low ra.e of side effects a.d high fea.ibility when used in pregna.cies complica.ed by dia.etes,especia.ly when pa.red with continuous subcuta.eous insulin infusion pump a. hybrid closed loop *** a.combined a.proa.h ha. been demonstra.ed to improve overa.l blood suga. control,lessen the occurrence of preecla.psia.a.d neona.a. hypoglyca.mia.a.d minimize the dura.ion of neona.a. intensive ca.e unit *** pa.er a.ms to offer a.comprehensive eva.ua.ion of CGM metrics specifica.ly ta.lored for pregna.cies impa.ted by type 1 dia.etes mellitus.

关键词： Type 1 dia.etes mellitus Continuous glucose monitoring Pregna.cy Glyca.mic control Continuous glucose monitoring system

Mimicking the physica. cues of the ECM in a.giogenic bioma.eria.s

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Regenera.ive Bioma.eria.s 2019年第2期6卷 61-73页

作者： Cody O.crosby Ja.et Zolda. Depa.tment of Biomedica. Engineering The University of Texas at AustinAustinTX 78751USA

a.functiona. microva.cula. system is impera.ive to build a.d ma.nta.n hea.thy *** microva.cula.ure results in ischemia.thereby limiting the tissue’s intrinsic regenera.ion ***,the a.ility to regenera.e microva.cula. networks is key to the development of effective ca.diova.cula. *** stimula.e the forma.ion of new microva.cula.ure,resea.chers ha.e focused on fa.rica.ing ma.eria.s tha. mimic the a.giogenic properties of the na.ive extra.ellula. ma.rix(ECM).Here,we will review bioma.eria.s tha. seek to imita.e the physica. cues tha. a.e na.ively provided by the ECM to encoura.e the forma.ion of microva.cula.ure in engineered constructs a.d ischemic tissue in the body.

关键词： a.giogenesis bioma.eria.–cell intera.tion ma.eria.s signa. va.cula.

Rodent biology a.d ecologica.ly ba.ed rodent ma.a.ement(EBRM)-25 yea.s of progress through promoting multidisciplina.y resea.ch

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Integra.ive Zoology 2024年第1期19卷 2-7页

作者： Gra.t R. SINGLETON Lyn a. HINDS Rhodes Ma.UNDI Steven R. BELMa.N Na.ura. Resources Institute University of Greenwich Kent UK CSIRO Hea.th a.d Biosecurity Canberra ACT Australia a.rica. Centre of Excellence for Innova.ive Rodent Pest Ma.a.ement a.d Biosensor Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Ma.a.ement Sokoine University of Agriculture Morogoro Tanzania

“During rodent outbrea. yea.s in ea.tern a.rica.lo-ca.ly,more tha. 80%of the potentia. ha.vest ma. be lost,but even in non-outbrea. periods,rodents ca.se chronic da.a.e to crops….The pest rodent story in a.rica.in-volves severa. species embedded in a.broa. a.d va.ia.le la.dsca.e with highly va.ia.le densities.”(Leirs et a..2010).

关键词： da.a.e crops

Trea.ment of intermedia.e-risk prosta.e ca.cer with a.tive surveilla.ce in the routine ca.e-Long-term outcomes of a.prospective noninterventiona. study (Ha.OW)

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CURRENT UROLOGY 2024年第2期18卷 115-121页

作者： Weissba.h, Lotha. Schwa.te, a.drea. Boedefeld, Edith a. Herden, Ja. Hlth Res Men GmbH Berlin Germany Urol Pra.tice Borken Borken Germany Univ Cologne Fac Med & Univ Hosp Cologne Dept Urol Urooncol Robot Assisted & Reconstruct Ur Cologne Germany Pa. Clin Urol Practice Cologne Germany Univ Hosp Cologne Dept Urol Kerpener Str 62 Cologne Germany

Ba.kgroundWe report here the long-term outcomes of pa.ients with intermedia.e-risk prosta.e ca.cer (PCa. trea.ed with a.tive surveilla.ce (a.) in a.da.ly routine *** a.d methodsHa.OW (2008-2013) wa. a.noninterventiona., hea.th service resea.ch study investiga.ing the ma.a.ement of loca.ized PCa.in a.community setting. a.substa.tia. proportion of the study centers were office-ba.ed urologists. a.follow-up exa.ina.ion of a.l intermedia.e-risk pa.ients with a. wa. conducted. Overa.l, ca.cer-specific, meta.ta.is-free, a.d trea.ment-free surviva. ra.es, a. well a. rea.ons for discontinua.ion, were determined a.d *** the 2957 pa.ients enrolled, 52 with intermedia.e-risk PCa.were ma.a.ed with a. a.d were a.a.la.le for eva.ua.ion. The media. follow-up wa. 6.8 yea.s (interqua.tile ra.ge, 3.4-8.6 yea.s). Seven pa.ients (13.5%) died of ca.ses unrela.ed to PCa. of whom 4 were under a. or under wa.chful wa.ting. Two pa.ients (3.8%) developed meta.ta.is. The estima.ed 8-yea. overa.l, ca.cer-specific, meta.ta.is-free, a.d trea.ment-free surviva. ra.es were 85% (95% confidence interva. [CI], 72%-96%), 100%, 93% (95% CI, 82%-100%), a.d 31% (95% CI, 17%-45%), respectively. On multiva.ia.le a.a.ysis, prosta.e-specific a.tigen density of >= 0.2 ng/mL2 wa. significa.tly predictive of receiving inva.ive trea.ment (ha.a.d ra.io, 3.29; p = 0.006). Rea.ons for discontinua.ion were more often due to pa.ient's or physicia.'s concerns (36%) tha. due to observed clinica. *** surviva. outcome da.a.for intermedia.e-risk pa.ients ma.a.ed with a. in rea.-life hea.th ca.e conditions were promising, ra.es of discontinua.ion were high, a.d discontinua.ion wa. often a.pa.ient's decision, even when the signs of disea.e progression were a.sent. This might be a. indica.ion of higher levels of menta. burden a.d a.xiety in this specific subgroup of pa.ients, which should be considered when ma.ing trea.ment decisions. From a.psychologica. perspective,

关键词： a.tive surveilla.ce Intermedia.e-risk prosta.e ca.cer Ha.OW study Conserva.ive ma.a.ement Outcomes resea.ch TREa.MENT OPTIONS GUIDELINES Ma.a.EMENT GRa.E

Weeks-a.ea. Epidemiologica. Predictions of Va.icella.Ca.es From Univa.ia.e Time Series Da.a.a.plying a.tificia. Intelligence

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Infectious Disea.es & Immunity 2024年第1期4卷 25-34页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Ba.kground:"Chickenpox"is a.highly infectious disea.e ca.sed by the va.icella.zoster virus,influenced by sea.ona. a.d spa.ia. *** with va.icella.zoster epidemics ca. be a.substa.tia. dra.n on hea.th-a.thority *** tha. improve the a.ility to loca.ly predict ca.e numbers from time-series da.a.sets every week a.e therefore worth ***:Simple-to-extra.t trend a.tributes from published univa.ia.e weekly ca.e-number univa.ia.e da.a.sets were used to genera.e multiva.ia.e da.a.for Hunga.y covering 10 *** a.tribute-enha.ced da.a.set wa. a.sessed by ma.hine lea.ning(ML)a.d deep lea.ning(DL)models to genera.e weekly ca.e foreca.ts from next week(t0)to 12 weeks forwa.d(t+12).The ML a.d DL predictions were compa.ed with those genera.ed by multilinea. regression a.d univa.ia.e prediction ***:Support vector regression genera.es the best predictions for weeks t0 a.d t+1,wherea. extreme gra.ient boosting genera.es the best predictions for weeks t+3 to t+***-short-term memory only provides compa.a.le prediction a.cura.y to the ML models for week t+***-K-fold cross va.ida.ion revea.s tha. overa.l the lowest prediction uncerta.nty is a.socia.ed with the tree-ensemble ML ***:The novel trend-a.tribute method offers the potentia. to reduce prediction errors a.d improve tra.spa.ency for chickenpox timeseries.

关键词： Va.icella.zoster virus infection Disea.e-ca.e weekly predictions Weeks-a.ea. foreca.ting Univa.ia.e time-series enha.cements Tree-ensemble ma.hine lea.ning Time-series a.tribute extra.tion

The Effect of Wa.er a.d Sa.t Stress on Pa.pa.um dila.a.um, a.Constituent of Pa.pa. Na.ura. Gra.sla.ds

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PHYTON-INTERNa.IONa. JOURNa. OF EXPERIMENTa. BOTa.Y 2024年第8期93卷 2009-2018页

作者： Porcelli, Cla.dia.a. Rubio, Gera.do Boem, Fla.io H. Gutierrez La.a.o, Ra.l S. Univ Buenos a.res Fac Agron Dept Quim RA-C1417DSE Buenos Aires Argentina Univ Buenos a.res Fac Agron Inst Invest Biociencias Agr & Ambientales INBA RA-C1417DSE Buenos Aires Argentina

The effects of the sa.t stress on pla.t growth a.e usua.ly increa.ed by the wa.er stress. We studied the impa.t of both stresses in simulta.eous pulses of drought a.d sa.inity on Pa.pa.um dila.a.um. This fora.e species is na.ive to South a.erica. sprea. in gra.sla.ds in ma.y tropica., subtropica., a.d tempera.e a.ea. of the world, a.d very common in gra.sla.ds of the Flooding Pa.pa. of a.gentina. Mimicking wha. ha.pens in na.ure. We compa.ed a.pot experiment, a.non-stressed control a.a.nst wa.er stress for a.month (midpoint between field ca.a.ity a.d wilting point), a.d two sa.ine stresses (modera.e, 6 dSm-1 a.d strong, 12 dSm-1), a.so for a.month. a.ria. bioma.s (green lea.; non-lea. green ma.eria., a.d dry ma.eria.) a.d roots were ha.vested, weighed, a.d a.a.yzed for nitrogen, phosphorus, a.d ca.ions. The bioma.s of a.l components significa.tly decrea.ed when both stresses were a.plied. Wa.er plus strong sa.ine stress reduced by ha.f the tota. bioma.ses, compa.ed to the control. The proportion of a.ria. bioma.s/root bioma.s ra.io a. well a. a.ria. green component/dry ma.eria.s ra.io tend to decrea.e when subjected to both stresses. Nitrogen concentra.ion in pla.ts wa. not significa.tly a.fected, but phosphorus concentra.ion increa.ed in a.ria. bioma.s components, from 0.10 to 0.18 mgkg-1 between the extreme trea.ments, but did not cha.ge in roots. Sodium concentra.ion in pla.ts increa.ed (i.e., in green lea.e sodium (Na. increa.ed from 0.27 to 2.01 mgkg-1 between the extreme trea.ments), wherea. other ca.ions either did not cha.ge or decrea.ed, a.fecting the ra.ios between them. Sodium performa.ce a.lows us to infer tha. the Na.a.cumula.ion of P. dila.a.um beha.es in a. intermedia.e ra.ge, compa.ed to very tolera.t to sa.ts or non-sa.t tolera.t species of the Pa.pa.um genus. In a.reement, when sa.ts were a.plied in the form of a.pulse, P. dila.a.um tolera.ed higher sa.inity tha. tha. found by other a.thors for the sa

关键词： Da.lis gra.s sa.inity drought sodium in pla.ts phosphorus in pla.ts pota.sium/sodium ra.io Sa.INITY GROWTH RESPONSES DROUGHT

First-principles ca.cula.ions to investiga.e structura.,electronic,ma.netic,optica. a.d thermodyna.ic properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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Journa. of Ra.e Ea.ths 2024年第7期42卷 1385-1393,I0007页

作者： a.Eza.er R.Ma.rour M.Ha.edoun J.Kha.ba.h a.Rezzouk a.Hourma.a.la. N.Benza.our K.Bouslykha.e La.ora.ory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this pa.er,we a.a.yzed the physica. cha.a.teristics of the terna.y a.loys RE_(2)Rh_(3)Ge(RE=Pr a.d Sm)using the first principles ca.cula.ion ba.ed on functiona. density theory integra.ed in the Wien2k *** ca.cula.ed forma.ion energies of Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge a.e−5.3827 a.d−5.2782 eV/a.om,respectively,showing tha. these a.loys ma. exist *** results of the ba.d structure a.d density of sta.es indica.e tha. a.l of the compounds tested a.e ma.netic meta.s,a.d their ma.netism is mostly rela.ed to the contribution of Pr a.d Sm *** tota. ma.netic moments of Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge a.e 4.07245 a.d 11.16161μB/f.u,*** pa.a.eters such a. hea. ca.a.ity a. consta.t pressure,entropy,Debye tempera.ure,la.tice volume,compressibility coefficients,a.d Grüneisen pa.a.eter a.loys were ca.cula.ed using the Gibbs a.gorithm a.d studied in depth over a.la.ge tempera.ure ra.ge of 0-900 *** Debye tempera.ure increa.es with increa.ing pressure a.d decrea.es with decrea.ing ***,the Debye tempera.ures ca.cula.ed a. p=0 GPa.a.d T=300 K a.e equa. to be 342 a.d 322 K for Pr_(2)Rh_(3)Ge a.d Sm_(2)Rh_(3)Ge,*** optica. cha.a.teristics such a. the rea. a.d ima.ina.y portions of the dielectric function,the a.sorption coefficient,the energy-loss function,a.d the refra.tive index were investiga.ed a.d discussed in more depth.

关键词： Ma.netic meta.s Functiona. density theory Density of sta.es Ma.netic moment Optica. a.d thermodyna.ic properties Ra.e ea.ths