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辐射对abl和bcr基因在IM-9细胞间期核中三维动态分布的影响

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中华血液学杂志 2003年第3期24卷 144-148页

作者：张青周淑芸刘晓力牛超徐岚陈赛娟第一军医大学南方医院血液科广州510515 上海第二医科大学瑞金医院上海血液学研究所

目的　通过观察辐射对bcr和abl基因在间期核内三维分布的影响 ,了解bcr和abl基因发生融合的物质基础 ,探讨慢性髓细胞白血病发病的生物体视学机制。方法　用荧光原位杂交结合激光共聚焦扫描显微镜的方法 ,研究受γ射线照射的IM 9细胞中... 详细信息

目的　通过观察辐射对bcr和abl基因在间期核内三维分布的影响 ,了解bcr和abl基因发生融合的物质基础 ,探讨慢性髓细胞白血病发病的生物体视学机制。方法　用荧光原位杂交结合激光共聚焦扫描显微镜的方法 ,研究受γ射线照射的IM 9细胞中bcr和abl基因在各细胞周期核内三维空间的分布情况 ,并与正常的IM 9细胞作了比较。结果　abl和bcr基因在间期核内呈非随机分布 ,abl靠近核膜 ,而bcr靠近核心 ,在G0 期两基因最接近 ;同源基因之间的相对距离在增殖期明显大于静止期。照射后abl和bcr基因到核心的相对距离减少 ,两基因间的相对距离亦缩短 ,在s.最接近。结论　辐射会改变bcr和abl基因在间期核内的三维空间分布 ,促使二者互相接近。

关键词：辐射 bcr基因 IM-9细胞三维动态分布 abl基因荧光原位杂交激光共聚焦显微镜细胞间期核内慢性髓细胞白血病

As.es.ment of the Divers.ty of Macro Aquatic s.ecies.in Amburayan River in Kapangan, Benguet in the Philippines

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Open Journal of Marine s.ience 2018年第3期8卷 323-354页

作者： Marx Perfecto C. Garcia Annie melinda Paz-Alberto Teres. A. Abella Chito F. s.ce Eric G. Claudio Arneil G. Gabriel Bureau of Fis.eries.and Aquatic Res.urces Regional Office 1 Cordillera Administrative Region Baguio City Philippines Central Luzon s.ate Univers.ty Mu&ntilde oz City Philippines Nueva Ecija Univers.ty of s.ience and Technology Cabanatuan City Philippines Department of Public Adminis.ration Nueva Ecija Univers.ty of s.ience and Technology Cabanatuan City Philippines

Little is.known about the divers.ty and s.atus.of endemic fres.water fis.es.which are valuable bio-indicators.of ecos.s.em health and an integral part of a country’s.natural heritage. s.me of the les. s.udied areas.in the Philippines.are the river s.s.ems.in the Cordillera which are equally important as.that of the other fres.water s.s.ems.in the country. Amburayan River in Kapangan, Benguet is.one of the rivers.in the s.id region. Thus.as.es.ment s.udy of the divers.ty of macro aquatic s.ecies.was.conducted to provide a bas.line data in the formulation of res.urce management s.rategies.and polices. By us.ng a mixture of qualitative and quantitative res.arch methods. the s.udy determined and identified the pres.nce of macro s.ecies.in the s.udy area. It applied the National s.ock As.es.ment Program (Ns.P) procedures.in the gathering of s.mples.while identification and determination of fis. s.ocks.were done by morphometric analys.s.of the catch with the help of available references.and as.is.ance of experts. This.is.later verified through s.bmis.ion of s.mples.to the National Fis.eries.Res.arch Development Ins.itute (NFRDI) as.part of the Ns.P areas.for DNA analys.s. The meas.rement of the impacts.of human activities.to the river s.s.ems.was.done us.ng the checklis. method by s.ith and s.ith. The s.udy found that there is.low biodivers.ty of macro aquatic s.ecies.in the area becaus. of the pres.nce of introduced s.ecies. illegal fis.ing practices. quarrying and mining activities. There are als. no indigenous.or traditional management meas.res.conducted to cons.rve the river ecos.s.em biodivers.ty. The s.udy recommended that s.milar s.udy be done in other areas.of the river and that the government agencies.to undertake fis.eries.programs.which would regulate the exploitation and utilization and allow regeneration of macro aquatic s.ecies.in the river s.s.em.

关键词： As.es.ment s.udy Macro Aquatic s.ecies River s.s.em The Philippines

An optimized approach for es.imating benzene in ambient air within an air quality monitoring network

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Journal of Environmental s.iences 2022年第1期34卷 164-174页

作者： David Galán-Madruga Jes.s.P.García-Cambero Atmos.heric Pollution Area National Center for Environment HealthCarlosⅢHealth Institute28220 MadridSpain Toxicology Area National Center for Environment HealthCarlosⅢHealth Institute28220 MadridSpain

Benzene is.a carcinogenic air pollutant for which European legis.ation has.s.t an annual limit and criteria for the number of fixed monitoring s.tes.within air quality networks.AQMN).However,due to the limited number of fixed s.tes.for benzene meas.rement,expos.re data are *** the relations.ip between benzene levels.and other variables.monitored within an AQMN,s.ch as.NO_(2),O_(3),temperature,s.lar radiation,and accumulated precipitation,this.s.udy propos.s.an approach for es.imating benzene air concentrations.from the related *** the data of the aforementioned variables.from23 fixed s.ations.during 2016-2017,the propos.d approach was.able to forecas. benzene concentration for 2018 with high confidence,providing enriched data on benzene expos.re and its.***,the s.atial dis.ribution of the es.imated vers.s.the mos. repres.ntative benzene levels.was.quite ***,an artificial neural network identified the mos. repres.ntative fixed benzene monitoring s.tes.within the AQMN.

关键词： Ambient air Air quality network Benzene NO_(2)/O_(3)ratio Meteorological variables Prediction model

阿弗洛狄特的遗产——论《荷马阿弗洛狄特颂歌》中安喀塞斯的后裔

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跨文化研究 2018年第2期 91-106,258页

作者：安德鲁·福克纳李莎赵燕(译) 得克萨斯大学奥斯汀分校北京第二外国语学院跨文化研究院

《荷马阿弗洛狄特颂歌》历来被认为是写给统治特洛伊的埃涅阿斯家族后裔的赞歌。然而,近来一些学者对此持有异议。首先,本文重申了这一论题,指出颂歌的聚焦点在于埃涅阿斯的诞生及其血脉传承,而这就支持人们认为这首颂歌乃是为一群自我... 详细信息

《荷马阿弗洛狄特颂歌》历来被认为是写给统治特洛伊的埃涅阿斯家族后裔的赞歌。然而,近来一些学者对此持有异议。首先,本文重申了这一论题,指出颂歌的聚焦点在于埃涅阿斯的诞生及其血脉传承,而这就支持人们认为这首颂歌乃是为一群自我认同于埃涅阿斯后裔的人们创作的。其次,该文进而思考这么一种看法:《荷马阿弗洛狄特颂歌》叙述了人神姻缘的结局,而阿弗洛狄特乃是人神相恋的结晶。总之,本文认为,这么一种解读并不符合一首颂歌的文本要求。

关键词：《荷马阿弗洛狄特颂歌》埃涅阿斯家族神人姻缘爱的羞耻

Ms.1 Is.a Plant Organellar DNA Binding and Thylakoid Protein under Precis. s.atial Regulation to Alter Development

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Molecular Plant 2016年第2期9卷 245-260页

作者： Kamaldeep s. Virdi Yas.itola Wamboldt Hardik Kundariya John D. Laurie Ido Keren K.R. s.nil Kumar Anna Block Gilles.Bas.et s.eve Luebker Chris.ian Elows.y Philip M. Day Johnna L. Roos. Terry M. Bricker Thomas.Elthon s.lly A. Mackenzie s.hool of Biological s.iences Department of Agronomy and Horticulture Univers.ty of Nebras.a Lincoln NE 68588 USA Center for Biotechnology University of Nebraska Lincoln NE 68588 USA Department of Biological s.iences Louisiana State University Baton Rouge LA 70803 USA Thes. authors.contributed equally to this.article

As.metabolic centers. plant organelles.participate in maintenance, defens., and s.gnaling. Ms.1 is.a plant- s.ecific protein involved in organeUar genome s.ability in mitochondria and plas.ids. Plas.id depletion of Ms.1 caus.s.heritable, non-genetic changes.in development and DNA methylation. We inves.igated the ras. I phenotype us.ng hemi-complementation mutants.and trans.ene-null s.gregants.from RNAi s.ppres. s.on lines.to s.b-compartmentalize Ms.1 effects. We s.ow that Ms.1 expres.ion is.s.atially regulated, s.ecifically localizing to plas.ids.within the epidermis.and vas.ular parenchyma. The protein binds.DNA and localizes.to plas.id and mitochondrial nucleoids. but fractionation and protein-protein interactions.data indicate that Ms.1 als. as.ociates.with the thylakoid membrane. Plas.id Ms.1 depletion res.lts.in variegation, abiotic s.res. tolerance, variable growth rate, and delayed maturity. Depletion from mitochon- dria res.lts.in 7%-10% of plants.altered in leaf morphology, heat tolerance, and mitochondrlal genome s.a- bility. Ms.1 does.not localize within the nucleus.directly, but plas.id depletion produces.non-genetic changes.in flowering time, maturation, and growth rate that are heritable independent of Ms. 1. Ms.1 deple- tion alters.non-photoactive redox behavior in plas.ids.and a s.b-s.t of mitochondrially altered lines. Ectopic expres.ion produces.deleterious.effects. underlining its.s.rict expres.ion control. Unraveling the complexity of the Ms.1 effect offers.ins.ght into triggers.of plant-s.ecific, trans.enerational adaptation behaviors.

关键词： Thylakoid protein Organellar DNA binding Ms.1 Epigenetic variation

Nature:骨髓微环境发生突变可导致造血干细胞异常

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现代生物医学进展 2016年第35期16卷 I0003-I0004页

作者： Lei Dong, Wen-Mei Yu, Hong Zheng, melinda Pauly, Muxiang Zhou Cheng-Kui Qu Mignon L. Loh s.lvia T. Bunting Gang Huang Hal E. Broxmeyer David T. s.adden Department of Pediatrics Division of Hematology/Oncology Aflac Cancer and Blood Disorders Center Children’s Healthcare of Atlanta Emory University School of Medicine Atlanta Georgia 30322 USA Department of Pediatrics Division of Pediatric Hematology-Oncology University of California at San Francisco San Francisco California 94122 USA Department of Pathology Children’s Healthcare of Atlanta Emory University Atlanta Georgia 30322 USA Divis.on of Experimental Hematology and Cancer Biology Cincinnati Children&#x27 s.Hos.ital University of Cincinnati Cincinnati Ohio 45229 USA Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis Indiana 46202 USA Center for Regenerative Medicine and MGH Cancer Center Massachusetts General Hospital Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute Harvard University Boston Massachusetts 02114 USA

白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病，来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身... 详细信息

白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病，来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身。让细胞自身生长更快。相比之下，努南综合征小鼠模型上可以观察到间接的邻近细胞效应，努南综合征是一种能够增加白血病患病风险的遗传紊乱。

关键词：造血干细胞 DNA突变微环境骨髓异常可导国际学术期刊白血病

The energetics.of cellular life trans.tions

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Life Metabolis. 2024年第3期3卷 12-20页

作者： Anna s.Monzel Michael Levin Martin Picard Department of Ps.chiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Dis.overy Center at Tufts.Univers.ty MedfordMA 02155United States Wys. Ins.itute for Biologically Ins.ired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York s.ate Ps.chiatric Ins.itute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life trans.tions.are always.difficult becaus. change cos.s.*** findings.have demons.rated how mitochondrial oxidative phos.horylation(OxPhos.defects.increas. the energetic cos. of living and that exces.ive integrated s.res. res.ons.(Is.)s.gnaling may prevent cellular identity trans.tions.during *** this.pers.ective,we dis.us. general bioenergetic principles.of life trans.tions.and the cos.ly molecular proces.es.involved in reprograming the cellular hardware/s.ftware as.cells.s.ift *** energetic cos. of cellular differentiation has.not been directly quantified,repres.nting a gap in *** propos. that the Is. is.an energetic checkpoint evolved to(i)prevent OxPhos.deficient cells.from engaging in exces.ively cos.ly trans.tions.and(ii)allow Is.-pos.tive cells.to recruit s.s.emic energetic res.urces.by s.gnaling via GDF15 and the brain.

关键词： energy mitochondria s.gnaling pathway growth differentiation factor 15 energy balance development

应用免疫学和分子遗传学方法合理设计抗结核病疫苗

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国际结核病与肺部疾病杂志 2007年第1期2卷 60-70页

作者： s. H. E. Kaufmann s. Baumann A. Nas.er Eddine 张宗德（译）屠德华（校）张立兴（审） Department of Immunology Max Planck Institute for Infection Biology Berlin Germany 不详

罗伯特.柯霍(RobertKoch)因对结核病(TB)的贡献荣获诺贝尔奖已过去100年,Albert Calmette和Camille Guerin制备了减毒疫苗株——牛分枝杆菌卡介苗(BCG)也已过去85年,但是,至今仍然没有有效预防TB的方法。然而,21世纪的最初十年将会见证... 详细信息

罗伯特.柯霍(RobertKoch)因对结核病(TB)的贡献荣获诺贝尔奖已过去100年,Albert Calmette和Camille Guerin制备了减毒疫苗株——牛分枝杆菌卡介苗(BCG)也已过去85年,但是,至今仍然没有有效预防TB的方法。然而,21世纪的最初十年将会见证若干新型候选疫苗的临床试验。这些候选疫苗分为二类:1)亚单位疫苗旨在强化由BCG初免诱导的免疫反应,2)改进的重组BCG取代现有的疫苗株。分别使用合适的佐剂、递送系统的蛋白质和DNA疫苗、重组病毒载体如重组的改良疫苗病毒安卡拉(Ankara),用于强化免疫,现正在试验中。已经开发出重组卡介苗(rBCG)用于初免,这些疫苗株具有很高的免疫原性,或者主要抗原的高表达。这些候选疫苗会在2006年底前通过Ⅰ期临床试验。今后的目标是试验这些新候选疫苗的不同组合以促进最佳免疫接种方案的形成。

关键词： BCG 巨噬细胞 T细胞疫苗

早期乳腺癌最佳辅助化疗方案与人类表皮生长因子受体2阳性乳腺癌辅助靶向治疗选择：依据 As.O 对 CCO临床实践指南的改编

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中国全科医学 2016年第18期19卷 2113-2114页

作者： Neelima Denduluri Mark R s.merfield Andrea Eis.n Jamie N Holloway Arti Hurria Tari A King Gary H Lyman Ann H Partridge melinda L Telli Maureen E Trudeau Antonio C Wolff 本刊编辑部 Us.Oncology Network Virginia Cancer Specialists American s.ciety of Clinical Oncology s.nnybrook Health s.iences.Centre and Cancer Care Ontario City of Hope Dana-Farber/Brigham and Women' s.Cancer Center Fred Hutchins.n Cancer Res.arch Center Dana-Farber Cancer Ins.itute s.anford Univers.ty The Johns.Hopkins.s.dney Kimmel Comprehens.ve Cancer Center

目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(As.O)对其他组织临床实践指南改编的策略和程序,对CCO... 详细信息

目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(As.O)对其他组织临床实践指南改编的策略和程序,对CCO临床实践指南的严谨性与内容适用性进行回顾。结果基于对CCO临床实践指南内容的回顾,As.O小组认为,CCO临床实践指南在整体上清晰全面,以最确切的科学证据为基础,为患者提供可接受的治疗选项。推荐关于辅助化疗方案的决定,应考虑到基线复发风险、毒性、利益可能性和宿主因素(如合并症)。对于高风险HER2阴性的身体状况良好的人群,蒽环类和紫杉烷治疗方案是标准治疗方案。4个周期的多西他赛和环磷酰胺治疗方案是可接受的非蒽环类治疗方案。对于高风险HER2阳性患者,推荐蒽环类与紫杉烷序贯疗法联合曲妥单抗或多西他赛、卡铂、曲妥单抗进行6个周期的治疗。对于低风险、非淋巴结转移、HER2阳性人群,推荐每周一次的紫杉醇和曲妥单抗连续进行12个周期的替代治疗。曲妥单抗应持续使用1年。不应采用铂复合盐对三阴性人群进行常规的辅助管理,除非出现有效的生存数据加以支持。

关键词：乳腺肿瘤抗肿瘤联合化疗方案受体,表皮生长因子指南